HRP980314B1 - 4"-substituted-9-deoxo-9a-aza-9a-homeoerythromycin a derivatives - Google Patents

4"-substituted-9-deoxo-9a-aza-9a-homeoerythromycin a derivatives

Info

Publication number
HRP980314B1
HRP980314B1 HR980314A HRP980314A HRP980314B1 HR P980314 B1 HRP980314 B1 HR P980314B1 HR 980314 A HR980314 A HR 980314A HR P980314 A HRP980314 A HR P980314A HR P980314 B1 HRP980314 B1 HR P980314B1
Authority
HR
Croatia
Prior art keywords
homeoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
HR980314A
Other languages
English (en)
Inventor
Brian Scott Bronk
Takushi Kaneko
Michael Anthony Letavic
Edward Alan Glazer
Bingwei Vera Yang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP980314(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HRP980314A2 publication Critical patent/HRP980314A2/hr
Publication of HRP980314B1 publication Critical patent/HRP980314B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR980314A 1997-06-11 1998-06-11 4"-substituted-9-deoxo-9a-aza-9a-homeoerythromycin a derivatives HRP980314B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11

Publications (2)

Publication Number Publication Date
HRP980314A2 HRP980314A2 (en) 1999-04-30
HRP980314B1 true HRP980314B1 (en) 2004-04-30

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
HR980314A HRP980314B1 (en) 1997-06-11 1998-06-11 4"-substituted-9-deoxo-9a-aza-9a-homeoerythromycin a derivatives

Country Status (50)

Country Link
US (4) US6420536B1 (it)
EP (1) EP0988310B9 (it)
JP (2) JP3315704B2 (it)
KR (1) KR100396168B1 (it)
CN (4) CN1793155B (it)
AP (1) AP1231A (it)
AR (1) AR013086A1 (it)
AT (1) ATE251173T1 (it)
AU (1) AU749816B2 (it)
BG (1) BG64391B1 (it)
BR (1) BRPI9810519B8 (it)
CA (1) CA2293823C (it)
CO (1) CO4950611A1 (it)
CZ (1) CZ298556B6 (it)
DE (2) DE122004000018I2 (it)
DK (1) DK0988310T3 (it)
DZ (1) DZ2514A1 (it)
EA (1) EA002441B1 (it)
EG (1) EG24081A (it)
ES (1) ES2205487T3 (it)
FR (1) FR04C0013I2 (it)
GT (1) GT199800077A (it)
HK (3) HK1028048A1 (it)
HN (1) HN1998000086A (it)
HR (1) HRP980314B1 (it)
HU (2) HU228005B1 (it)
ID (1) ID22992A (it)
IL (1) IL132809A0 (it)
IS (1) IS1998B (it)
LU (1) LU91076I9 (it)
MA (1) MA24564A1 (it)
ME (1) ME00876B (it)
MY (1) MY123354A (it)
NL (1) NL300150I2 (it)
NO (1) NO316911B1 (it)
NZ (2) NZ514871A (it)
OA (1) OA11224A (it)
PA (1) PA8452201A1 (it)
PE (1) PE79699A1 (it)
PL (1) PL191601B1 (it)
PT (1) PT988310E (it)
RS (1) RS49675B (it)
SI (1) SI0988310T1 (it)
SK (1) SK284171B6 (it)
TN (1) TNSN98082A1 (it)
TW (1) TW472060B (it)
UA (1) UA67744C2 (it)
UY (1) UY25040A1 (it)
WO (1) WO1998056802A1 (it)
ZA (1) ZA985017B (it)

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HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
NZ502861A (en) * 1997-09-10 2001-03-30 Merck & Co Inc Method of treating livestock bacterial respiratory or enteric infections using 9a-azalides
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2411293A1 (en) * 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
DE60038610T2 (de) 1999-05-18 2009-06-25 Pfizer Products Inc., Groton Neue kristalline formen eines makrolidantibiotikums
PL352720A1 (en) * 1999-05-24 2003-09-08 Pfizer Products Inc. 13-methyl-erythromycin derivatives
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
DK1206476T3 (da) * 1999-08-24 2006-05-15 Abbott Lab 9a-azalider med antibakteriel virkning
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
DK1250343T3 (da) * 2000-01-27 2003-09-22 Pfizer Prod Inc Sammensætninger med et azalid antibiotikum
AP2002002652A0 (en) * 2000-04-27 2002-12-31 Pfizer Prod Inc The use of azalide antibiotic composition for treating or preventing a bacterial or protozoal infection in mammals.
JP4104463B2 (ja) * 2001-04-27 2008-06-18 ファイザー・プロダクツ・インク ４’’−置換された−９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシン誘導体を製造するための方法
AU2002317415A1 (en) * 2001-08-01 2003-02-17 Pfizer Products Inc. Azalide antibiotic compositions
WO2004080391A2 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
WO2005049081A1 (en) * 2003-11-21 2005-06-02 Pfizer Products Inc. The use of anti biotics as vaccine adjuvants
CN103030617A (zh) * 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
US20080227730A1 (en) * 2005-01-14 2008-09-18 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9A-Carbamoyl and Thiocarbamoyl Azalides With Antimalarial Activity
US9453042B2 (en) 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2010048600A1 (en) * 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
WO2012034058A1 (en) 2010-09-10 2012-03-15 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
ES2532455T3 (es) * 2010-09-20 2015-03-27 Novartis Tiergesundheit Ag Nuevo procedimiento de preparación de 9-desoxo-9a-aza-9a-homoeritromicina modificada en el C-4'' del anillo de cladinosa por un grupo epóxido
EP2625185A4 (en) * 2010-10-10 2014-03-26 Synovo Gmbh INFLAMMATORY MAKROLIDE
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
RU2658050C2 (ru) 2012-03-27 2018-06-19 Семпра Фармасьютикалз, Инк. Парентеральные составы для введения макролидных антибиотиков
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
EP3027634B1 (en) * 2013-07-31 2018-03-21 Farma GRS, d.o.o. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
UA67744C2 (uk) 2004-07-15
HUP0002209A3 (en) 2003-05-28
HUP0002209A2 (hu) 2000-12-28
US20020061858A1 (en) 2002-05-23
HUS1200028I1 (hu) 2016-08-29
NZ514871A (en) 2003-08-29
CN1566129A (zh) 2005-01-19
MY123354A (en) 2006-05-31
BRPI9810519B8 (pt) 2022-11-16
US20040180842A1 (en) 2004-09-16
EP0988310B1 (en) 2003-10-01
NL300150I1 (nl) 2004-08-02
ZA985017B (en) 1999-12-17
JP3315704B2 (ja) 2002-08-19
FR04C0013I2 (it) 2005-10-21
US20040023896A1 (en) 2004-02-05
TW472060B (en) 2002-01-11
CZ442199A3 (cs) 2000-07-12
EA002441B1 (ru) 2002-04-25
DK0988310T3 (da) 2003-12-15
ATE251173T1 (de) 2003-10-15
ES2205487T3 (es) 2004-05-01
EA199901015A1 (ru) 2000-06-26
PL337505A1 (en) 2000-08-28
CN1793155A (zh) 2006-06-28
EP0988310B9 (en) 2006-03-08
AP9801255A0 (en) 1998-06-30
RS49675B (sr) 2007-11-15
CO4950611A1 (es) 2000-09-01
BRPI9810519A (pt) 2000-09-19
KR20010013632A (ko) 2001-02-26
ME00876B (me) 2012-06-20
TNSN98082A1 (fr) 2005-03-15
NL300150I2 (nl) 2004-09-01
HK1088014A1 (en) 2006-10-27
ID22992A (id) 1999-12-23
FR04C0013I1 (it) 2004-06-11
HU228005B1 (en) 2012-08-28
JP2002316933A (ja) 2002-10-31
NO996106D0 (no) 1999-12-10
NZ500660A (en) 2002-03-01
WO1998056802A1 (en) 1998-12-17
PE79699A1 (es) 1999-08-25
CZ298556B6 (cs) 2007-11-07
NO996106L (no) 2000-02-10
AR013086A1 (es) 2000-12-13
HK1028048A1 (en) 2001-02-02
CA2293823C (en) 2004-02-17
IL132809A0 (en) 2001-03-19
IS5252A (is) 1999-11-16
IS1998B (is) 2005-03-15
CN1172947C (zh) 2004-10-27
DE69818665T2 (de) 2004-04-29
CN1243766C (zh) 2006-03-01
DZ2514A1 (fr) 2003-02-01
CN1259136A (zh) 2000-07-05
DE69818665D1 (de) 2003-11-06
AU7347598A (en) 1998-12-30
US6936592B2 (en) 2005-08-30
CN1793155B (zh) 2010-05-12
SI0988310T1 (en) 2004-02-29
CA2293823A1 (en) 1998-12-17
EG24081A (en) 2008-05-11
MA24564A1 (fr) 1998-12-31
BRPI9810519B1 (pt) 2012-02-22
US6420536B1 (en) 2002-07-16
BG103945A (en) 2000-07-31
PA8452201A1 (es) 2000-05-24
LU91076I2 (fr) 2004-07-05
GT199800077A (es) 1999-12-02
PL191601B1 (pl) 2006-06-30
HN1998000086A (es) 1999-03-08
JP2000514098A (ja) 2000-10-24
OA11224A (en) 2003-07-16
SK168399A3 (en) 2000-11-07
UY25040A1 (es) 2000-09-29
LU91076I9 (en) 2018-07-02
CN101691390A (zh) 2010-04-07
EP0988310A1 (en) 2000-03-29
KR100396168B1 (ko) 2003-08-27
DE122004000018I2 (de) 2011-01-13
DE122004000018I1 (de) 2004-09-30
AP1231A (en) 2003-12-11
HK1068893A1 (en) 2005-07-29
US6777393B2 (en) 2004-08-17
NO316911B1 (no) 2004-06-21
YU58699A (it) 2002-08-12
SK284171B6 (sk) 2004-10-05
BG64391B1 (bg) 2004-12-30
AU749816B2 (en) 2002-07-04
PT988310E (pt) 2003-12-31
HRP980314A2 (en) 1999-04-30

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