HRP20240491T1 - Pirazolopiridini i triazolopiridini kao a2a/a2b inhibitori - Google Patents
Pirazolopiridini i triazolopiridini kao a2a/a2b inhibitori Download PDFInfo
- Publication number
- HRP20240491T1 HRP20240491T1 HRP20240491TT HRP20240491T HRP20240491T1 HR P20240491 T1 HRP20240491 T1 HR P20240491T1 HR P20240491T T HRP20240491T T HR P20240491TT HR P20240491 T HRP20240491 T HR P20240491T HR P20240491 T1 HRP20240491 T1 HR P20240491T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- cycloalkyl
- aryl
- membered heteroaryl
- independently selected
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000005229 pyrazolopyridines Chemical class 0.000 title 1
- 150000008523 triazolopyridines Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 226
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 138
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 124
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 78
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 78
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 72
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 60
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 60
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims 55
- 125000001424 substituent group Chemical group 0.000 claims 41
- 150000001875 compounds Chemical class 0.000 claims 38
- 150000003839 salts Chemical class 0.000 claims 36
- 125000000217 alkyl group Chemical group 0.000 claims 32
- -1 aminocarbonyloxy Chemical group 0.000 claims 24
- 229910052736 halogen Inorganic materials 0.000 claims 24
- 150000002367 halogens Chemical class 0.000 claims 24
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 20
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 18
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 17
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 17
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 12
- 125000004429 atom Chemical group 0.000 claims 12
- 101100079340 Rattus norvegicus Nalcn gene Proteins 0.000 claims 11
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 10
- 125000006598 aminocarbonylamino group Chemical group 0.000 claims 10
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 10
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000006601 (C1-C3) alkylcarbamyl group Chemical group 0.000 claims 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims 4
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 claims 4
- 108050000203 Adenosine receptors Proteins 0.000 claims 4
- 102000009346 Adenosine receptors Human genes 0.000 claims 4
- 125000005195 alkyl amino carbonyloxy group Chemical group 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000006599 (C1-C3) alkylaminocarbonylamino group Chemical group 0.000 claims 3
- 125000006603 (C1-C3) alkylaminosulfonyl group Chemical group 0.000 claims 3
- 125000006597 (C1-C3) alkylcarbonylamino group Chemical group 0.000 claims 3
- 125000006595 (C1-C3) alkylsulfinyl group Chemical group 0.000 claims 3
- 125000006594 (C1-C3) alkylsulfony group Chemical group 0.000 claims 3
- 125000006602 (C1-C3) alkylsulfonylamino group Chemical group 0.000 claims 3
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 3
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000006596 (C1-C3) alkylcarbonyloxy group Chemical group 0.000 claims 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 2
- 125000006592 (C2-C3) alkenyl group Chemical group 0.000 claims 2
- 125000006593 (C2-C3) alkynyl group Chemical group 0.000 claims 2
- MSXIFXOIITVIOS-UHFFFAOYSA-N 3-[4-amino-2-[(3-fluoropyridin-2-yl)methyl]-7-pyrimidin-4-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC=CC=C1F)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 MSXIFXOIITVIOS-UHFFFAOYSA-N 0.000 claims 2
- 101150078577 Adora2b gene Proteins 0.000 claims 2
- 101100534214 Caenorhabditis elegans sra-21 gene Proteins 0.000 claims 2
- 101100310928 Caenorhabditis elegans sra-6 gene Proteins 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 208000030961 allergic reaction Diseases 0.000 claims 2
- 208000026106 cerebrovascular disease Diseases 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000006624 (C1-C6) alkoxycarbonylamino group Chemical group 0.000 claims 1
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- LJJPYMXBCNMUQS-UHFFFAOYSA-N 3-[4-amino-2-(1-pyridin-2-ylethyl)-7-pyrimidin-4-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)C(C)C1=NC=CC=C1)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 LJJPYMXBCNMUQS-UHFFFAOYSA-N 0.000 claims 1
- RSZLGLXJRHUPFJ-UHFFFAOYSA-N 3-[4-amino-2-(pyridin-2-ylmethyl)-7-pyrimidin-4-ylpyrazolo[4,3-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=CN(N=2)CC1=NC=CC=C1)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 RSZLGLXJRHUPFJ-UHFFFAOYSA-N 0.000 claims 1
- UWNQHIDMVGEEFD-UHFFFAOYSA-N 3-[4-amino-2-(pyridin-2-ylmethyl)-7-pyrimidin-4-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound N1=C(C=2C(C(C1=C1C=C(C#N)C=C[CH]1)=C1C=CN=C[N]1)=NN(N=2)CC1=CC=CC=N1)N UWNQHIDMVGEEFD-UHFFFAOYSA-N 0.000 claims 1
- HISRVLQRQZQWHM-UHFFFAOYSA-N 3-[4-amino-2-(pyridin-2-ylmethyl)-7-quinolin-6-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound N1=C(C=2C(C(C1=C1C=C(C#N)C=C[CH]1)=C1C=CC3=NC=C[CH]C3=C1)=NN(N=2)CC1=CC=CC=N1)N HISRVLQRQZQWHM-UHFFFAOYSA-N 0.000 claims 1
- VHJWGRRHCPJQFK-UHFFFAOYSA-N 3-[4-amino-2-(pyridin-2-ylmethyl)-7-quinoxalin-6-yltriazolo[4,5-c]pyridin-6-yl]-2-fluorobenzonitrile Chemical compound N1=C(C=2C(C(C1=C1C(F)=C(C#N)C=C[CH]1)=C1C=CC3=NC=C[N]C3=C1)=NN(N=2)CC1=CC=CC=N1)N VHJWGRRHCPJQFK-UHFFFAOYSA-N 0.000 claims 1
- CMXICQXZUGQZCI-UHFFFAOYSA-N 3-[4-amino-2-(pyridin-2-ylmethyl)-7-quinoxalin-6-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound N1=C(C=2C(C(C1=C1C=C(C#N)C=C[CH]1)=C1C=CC3=NC=C[N]C3=C1)=NN(N=2)CC1=CC=CC=N1)N CMXICQXZUGQZCI-UHFFFAOYSA-N 0.000 claims 1
- JFXOHCSIEUJACF-UHFFFAOYSA-N 3-[4-amino-2-[(1-methylpyrazol-3-yl)methyl]-7-pyrimidin-4-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NN(C=C1)C)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 JFXOHCSIEUJACF-UHFFFAOYSA-N 0.000 claims 1
- SJOYFDLIOKJIPV-UHFFFAOYSA-N 3-[4-amino-2-[(2-fluorophenyl)methyl]-7-pyrimidin-4-ylpyrazolo[4,3-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=CN(N=2)CC1=C(C=CC=C1)F)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 SJOYFDLIOKJIPV-UHFFFAOYSA-N 0.000 claims 1
- OYSQZTKBNXAYBS-UHFFFAOYSA-N 3-[4-amino-2-[(3-fluoropyridin-2-yl)methyl]-7-(1-methyl-6-oxopyridin-3-yl)triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound N1=C(C=2C(C(=C1C1=CC=CC(C#N)=C1)C=1C=CC(=O)N(C=1)C)=NN(N=2)CC1=C(F)C=CC=N1)N OYSQZTKBNXAYBS-UHFFFAOYSA-N 0.000 claims 1
- FQIOFNQTOKOGQM-UHFFFAOYSA-N 3-[4-amino-2-[(3-fluoropyridin-2-yl)methyl]-7-(2-methylpyrazol-3-yl)triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC=CC=C1F)C1=CC=NN1C)C=1C=C(C#N)C=CC=1 FQIOFNQTOKOGQM-UHFFFAOYSA-N 0.000 claims 1
- JMJFRIOFXLYOKI-UHFFFAOYSA-N 3-[4-amino-2-[(3-fluoropyridin-2-yl)methyl]-7-(2-propan-2-ylpyrazol-3-yl)triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC=CC=C1F)C1=CC=NN1C(C)C)C=1C=C(C#N)C=CC=1 JMJFRIOFXLYOKI-UHFFFAOYSA-N 0.000 claims 1
- YORQAJVPPSHHBF-UHFFFAOYSA-N 3-[4-amino-2-[(3-fluoropyridin-2-yl)methyl]-7-(4-methyl-1,3-oxazol-5-yl)triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC=CC=C1F)C1=C(N=CO1)C)C=1C=C(C#N)C=CC=1 YORQAJVPPSHHBF-UHFFFAOYSA-N 0.000 claims 1
- UDTYMQWVZMEAGS-UHFFFAOYSA-N 3-[4-amino-2-[(3-fluoropyridin-2-yl)methyl]-7-pyridin-4-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound N1=C(C=2C(C(C1=C1C=C(C#N)C=C[CH]1)=C1C=CN=C[CH]1)=NN(N=2)CC1=C(F)C=CC=N1)N UDTYMQWVZMEAGS-UHFFFAOYSA-N 0.000 claims 1
- SHCILLFMSNKMJG-UHFFFAOYSA-N 3-[4-amino-2-[(3-fluoropyridin-2-yl)methyl]-7-pyrimidin-4-ylpyrazolo[4,3-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=CN(N=2)CC1=NC=CC=C1F)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 SHCILLFMSNKMJG-UHFFFAOYSA-N 0.000 claims 1
- WHAOWXKRSWIAPM-UHFFFAOYSA-N 3-[4-amino-2-[(3-fluoropyridin-2-yl)methyl]-7-quinoxalin-6-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC=CC=C1F)C=1C=C2N=CC=NC2=CC=1)C=1C=C(C#N)C=CC=1 WHAOWXKRSWIAPM-UHFFFAOYSA-N 0.000 claims 1
- ZOHVIRCGTAKCGS-UHFFFAOYSA-N 3-[4-amino-2-[(6-methylpyridin-2-yl)methyl]-7-pyridin-4-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound N1=C(C=2C(C(C1=C1C=C(C#N)C=C[CH]1)=C1C=CN=C[CH]1)=NN(N=2)CC1=CC=CC(C)=N1)N ZOHVIRCGTAKCGS-UHFFFAOYSA-N 0.000 claims 1
- LJXPHLLWHJOYSO-UHFFFAOYSA-N 3-[4-amino-2-[(6-methylpyridin-2-yl)methyl]-7-pyrimidin-4-ylpyrazolo[4,3-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=CN(N=2)CC1=NC(=CC=C1)C)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 LJXPHLLWHJOYSO-UHFFFAOYSA-N 0.000 claims 1
- ZSMYNSQPYMMGDV-UHFFFAOYSA-N 3-[4-amino-2-[(6-methylpyridin-2-yl)methyl]-7-pyrimidin-4-yltriazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC(=CC=C1)C)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 ZSMYNSQPYMMGDV-UHFFFAOYSA-N 0.000 claims 1
- LVEMXZQJZADZNC-UHFFFAOYSA-N 3-[4-amino-7-(1,3-oxazol-5-yl)-2-(pyridin-2-ylmethyl)triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC=CC=C1)C1=CN=CO1)C=1C=C(C#N)C=CC=1 LVEMXZQJZADZNC-UHFFFAOYSA-N 0.000 claims 1
- QRHRYYOLCHXSNH-UHFFFAOYSA-N 3-[4-amino-7-(1-methyl-6-oxopyridin-3-yl)-2-[(6-methylpyridin-2-yl)methyl]triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound N1=C(C=2C(C(=C1C1=CC(C#N)=CC=C1)C=1C=CC(=O)N(C=1)C)=NN(N=2)CC1=CC=CC(C)=N1)N QRHRYYOLCHXSNH-UHFFFAOYSA-N 0.000 claims 1
- QDPGJDVOYUZJSD-UHFFFAOYSA-N 3-[4-amino-7-(2-ethylpyrazol-3-yl)-2-(pyridin-2-ylmethyl)pyrazolo[4,3-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=CN(N=2)CC1=NC=CC=C1)C1=CC=NN1CC)C=1C=C(C#N)C=CC=1 QDPGJDVOYUZJSD-UHFFFAOYSA-N 0.000 claims 1
- IGMOYJYSLPSDFG-UHFFFAOYSA-N 3-[4-amino-7-(2-ethylpyrazol-3-yl)-2-(pyridin-2-ylmethyl)triazolo[4,5-c]pyridin-6-yl]-2-fluorobenzonitrile Chemical compound N1=C(C=2C(C(=C1C1=C(F)C(C#N)=CC=C1)C1=CC=NN1CC)=NN(N=2)CC1=CC=CC=N1)N IGMOYJYSLPSDFG-UHFFFAOYSA-N 0.000 claims 1
- IOUGHQWADVHARW-UHFFFAOYSA-N 3-[4-amino-7-(2-ethylpyrazol-3-yl)-2-(pyridin-2-ylmethyl)triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC=CC=C1)C1=CC=NN1CC)C=1C=C(C#N)C=CC=1 IOUGHQWADVHARW-UHFFFAOYSA-N 0.000 claims 1
- GAJBEQBVZZZWIC-UHFFFAOYSA-N 3-[4-amino-7-(2-ethylpyrazol-3-yl)-2-[(3-fluoropyridin-2-yl)methyl]triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC=CC=C1F)C1=CC=NN1CC)C=1C=C(C#N)C=CC=1 GAJBEQBVZZZWIC-UHFFFAOYSA-N 0.000 claims 1
- QICZDBAGAQCFGP-UHFFFAOYSA-N 3-[4-amino-7-(2-ethylpyrazol-3-yl)-2-[(6-methylpyridin-2-yl)methyl]triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC(=CC=C1)C)C1=CC=NN1CC)C=1C=C(C#N)C=CC=1 QICZDBAGAQCFGP-UHFFFAOYSA-N 0.000 claims 1
- WDIMPXNTABEEDG-UHFFFAOYSA-N 3-[4-amino-7-(2-methylpyrazol-3-yl)-2-(pyridin-2-ylmethyl)triazolo[4,5-c]pyridin-6-yl]-2-fluorobenzonitrile Chemical compound N1=C(C=2C(C(=C1C1=C(F)C(C#N)=CC=C1)C1=CC=NN1C)=NN(N=2)CC1=CC=CC=N1)N WDIMPXNTABEEDG-UHFFFAOYSA-N 0.000 claims 1
- UEVNJYJAEZBTAI-UHFFFAOYSA-N 3-[4-amino-7-(2-propan-2-ylpyrazol-3-yl)-2-(pyridin-2-ylmethyl)triazolo[4,5-c]pyridin-6-yl]-2-fluorobenzonitrile Chemical compound N1=C(C=2C(C(=C1C1=C(F)C(C#N)=CC=C1)C1=CC=NN1C(C)C)=NN(N=2)CC1=CC=CC=N1)N UEVNJYJAEZBTAI-UHFFFAOYSA-N 0.000 claims 1
- KXZSQJAUTZQXLJ-UHFFFAOYSA-N 3-[4-amino-7-(3-methylpyridin-4-yl)-2-[(6-methylpyridin-2-yl)methyl]triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC(=CC=C1)C)C1=C(C=NC=C1)C)C=1C=C(C#N)C=CC=1 KXZSQJAUTZQXLJ-UHFFFAOYSA-N 0.000 claims 1
- QERMAYDOJNPKTF-UHFFFAOYSA-N 3-[4-amino-7-(4-methyl-1,3-oxazol-5-yl)-2-(1-pyridin-2-ylethyl)triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound N1=C(C=2C(C(=C1C1=CC(C#N)=CC=C1)C=1OC=NC=1C)=NN(N=2)C(C1=CC=CC=N1)C)N QERMAYDOJNPKTF-UHFFFAOYSA-N 0.000 claims 1
- NHBADCSJIGXELM-UHFFFAOYSA-N 3-[4-amino-7-(4-methyl-1,3-oxazol-5-yl)-2-(2-pyridin-2-ylethyl)triazolo[4,5-c]pyridin-6-yl]-2-fluorobenzonitrile Chemical compound N1=C(C=2C(C(=C1C1=C(F)C(C#N)=CC=C1)C=1OC=NC=1C)=NN(N=2)CCC1=NC=CC=C1)N NHBADCSJIGXELM-UHFFFAOYSA-N 0.000 claims 1
- WIFIDIMHKYJYQP-UHFFFAOYSA-N 3-[4-amino-7-(4-methyl-1,3-oxazol-5-yl)-2-(2-pyridin-2-ylethyl)triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound N1=C(C=2C(C(=C1C1=CC(C#N)=CC=C1)C=1OC=NC=1C)=NN(N=2)CCC1=NC=CC=C1)N WIFIDIMHKYJYQP-UHFFFAOYSA-N 0.000 claims 1
- HGPPMDVJKAUARX-UHFFFAOYSA-N 3-[4-amino-7-(4-methyl-1,3-oxazol-5-yl)-2-(pyridin-2-ylmethyl)triazolo[4,5-c]pyridin-6-yl]-2-fluorobenzonitrile Chemical compound N1=C(C=2C(C(=C1C1=C(F)C(C#N)=CC=C1)C=1OC=NC=1C)=NN(N=2)CC1=NC=CC=C1)N HGPPMDVJKAUARX-UHFFFAOYSA-N 0.000 claims 1
- POUHIRRHUQFUHW-UHFFFAOYSA-N 3-[4-amino-7-(4-methyl-1,3-oxazol-5-yl)-2-[(1-methylpyrazol-3-yl)methyl]triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NN(C=C1)C)C1=C(N=CO1)C)C=1C=C(C#N)C=CC=1 POUHIRRHUQFUHW-UHFFFAOYSA-N 0.000 claims 1
- GXRNOGASVXOMRH-UHFFFAOYSA-N 3-[4-amino-7-(4-methyl-1,3-oxazol-5-yl)-2-[(6-methylpyridin-2-yl)methyl]triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC(=CC=C1)C)C1=C(N=CO1)C)C=1C=C(C#N)C=CC=1 GXRNOGASVXOMRH-UHFFFAOYSA-N 0.000 claims 1
- WZOLMLIOTDDXQN-UHFFFAOYSA-N 3-[4-amino-7-[4-(hydroxymethyl)-2-methyl-1,3-oxazol-5-yl]-2-(pyridin-2-ylmethyl)triazolo[4,5-c]pyridin-6-yl]-2-fluorobenzonitrile Chemical compound N1=C(C=2C(C(=C1C1=C(F)C(C#N)=CC=C1)C=1OC(=NC=1CO)C)=NN(N=2)CC1=CC=CC=N1)N WZOLMLIOTDDXQN-UHFFFAOYSA-N 0.000 claims 1
- XTISZAYJNPKACM-UHFFFAOYSA-N 3-[4-amino-7-[4-(hydroxymethyl)-2-methyl-1,3-oxazol-5-yl]-2-(pyridin-2-ylmethyl)triazolo[4,5-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(N=2)CC1=NC=CC=C1)C1=C(N=C(O1)C)CO)C=1C=C(C#N)C=CC=1 XTISZAYJNPKACM-UHFFFAOYSA-N 0.000 claims 1
- UFMBJONZKYMSHU-UHFFFAOYSA-N 3-[4-amino-7-pyridin-4-yl-2-(pyridin-2-ylmethyl)pyrazolo[4,3-c]pyridin-6-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=CN(N=2)CC1=NC=CC=C1)C1=CC=NC=C1)C=1C=C(C#N)C=CC=1 UFMBJONZKYMSHU-UHFFFAOYSA-N 0.000 claims 1
- ZGHJIPAYCDEMPU-UHFFFAOYSA-N 3-[7-amino-2-(pyridin-2-ylmethyl)-4-pyrimidin-4-ylpyrazolo[3,4-c]pyridin-5-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(C=2)CC1=NC=CC=C1)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 ZGHJIPAYCDEMPU-UHFFFAOYSA-N 0.000 claims 1
- SMYYBRLYKXZOQD-UHFFFAOYSA-N 3-[7-amino-2-[(3-fluoropyridin-2-yl)methyl]-4-pyrimidin-4-ylpyrazolo[3,4-c]pyridin-5-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(C=2)CC1=NC=CC=C1F)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 SMYYBRLYKXZOQD-UHFFFAOYSA-N 0.000 claims 1
- IRQCFKVZXCVTAV-UHFFFAOYSA-N 3-[7-amino-2-[(6-methylpyridin-2-yl)methyl]-4-pyrimidin-4-ylpyrazolo[3,4-c]pyridin-5-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(C=2)CC1=NC(=CC=C1)C)C1=NC=NC=C1)C=1C=C(C#N)C=CC=1 IRQCFKVZXCVTAV-UHFFFAOYSA-N 0.000 claims 1
- SBUWSWNIYCNHKS-UHFFFAOYSA-N 3-[7-amino-4-(2-ethylpyrazol-3-yl)-2-(pyridin-2-ylmethyl)pyrazolo[3,4-c]pyridin-5-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(C=2)CC1=NC=CC=C1)C1=CC=NN1CC)C=1C=C(C#N)C=CC=1 SBUWSWNIYCNHKS-UHFFFAOYSA-N 0.000 claims 1
- NRMABQCVPQJDFH-UHFFFAOYSA-N 3-[7-amino-4-(2-ethylpyrazol-3-yl)-2-[(3-fluoropyridin-2-yl)methyl]pyrazolo[3,4-c]pyridin-5-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(C=2)CC1=NC=CC=C1F)C1=CC=NN1CC)C=1C=C(C#N)C=CC=1 NRMABQCVPQJDFH-UHFFFAOYSA-N 0.000 claims 1
- BHHONGWGBJAMCE-UHFFFAOYSA-N 3-[7-amino-4-(2-ethylpyrazol-3-yl)-2-[(6-methylpyridin-2-yl)methyl]pyrazolo[3,4-c]pyridin-5-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(C=2)CC1=NC(=CC=C1)C)C1=CC=NN1CC)C=1C=C(C#N)C=CC=1 BHHONGWGBJAMCE-UHFFFAOYSA-N 0.000 claims 1
- HNLWGFMNUPWJHO-UHFFFAOYSA-N 3-[7-amino-4-(4-methyl-1,3-oxazol-5-yl)-2-(pyridin-2-ylmethyl)pyrazolo[3,4-c]pyridin-5-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(C=2)CC1=NC=CC=C1)C1=C(N=CO1)C)C=1C=C(C#N)C=CC=1 HNLWGFMNUPWJHO-UHFFFAOYSA-N 0.000 claims 1
- LTZPTUZSSPXOIS-UHFFFAOYSA-N 3-[7-amino-4-(4-methyl-1,3-oxazol-5-yl)-2-[(6-methylpyridin-2-yl)methyl]pyrazolo[3,4-c]pyridin-5-yl]benzonitrile Chemical compound NC1=NC(=C(C=2C1=NN(C=2)CC1=NC(=CC=C1)C)C1=C(N=CO1)C)C=1C=C(C#N)C=CC=1 LTZPTUZSSPXOIS-UHFFFAOYSA-N 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 101150051188 Adora2a gene Proteins 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 108010006654 Bleomycin Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101100534215 Caenorhabditis elegans sra-22 gene Proteins 0.000 claims 1
- 101100534216 Caenorhabditis elegans sra-23 gene Proteins 0.000 claims 1
- 101100534217 Caenorhabditis elegans sra-24 gene Proteins 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000032109 Transient ischaemic attack Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000004949 alkyl amino carbonyl amino group Chemical group 0.000 claims 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
- 210000000709 aorta Anatomy 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229960001561 bleomycin Drugs 0.000 claims 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000004802 cyanophenyl group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 230000008105 immune reaction Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000010658 metastatic prostate carcinoma Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 125000004304 oxazol-5-yl group Chemical group O1C=NC=C1* 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000030613 peripheral artery disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
- 125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962798180P | 2019-01-29 | 2019-01-29 | |
| EP20709807.0A EP3917925B1 (en) | 2019-01-29 | 2020-01-28 | Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors |
| PCT/US2020/015294 WO2020159905A1 (en) | 2019-01-29 | 2020-01-28 | Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240491T1 true HRP20240491T1 (hr) | 2024-07-05 |
Family
ID=69771050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240491TT HRP20240491T1 (hr) | 2019-01-29 | 2020-01-28 | Pirazolopiridini i triazolopiridini kao a2a/a2b inhibitori |
Country Status (35)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR122023024273A2 (pt) | 2018-02-27 | 2024-02-20 | Incyte Corporation | Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos |
| WO2019222677A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| GEP20237548B (en) | 2018-07-05 | 2023-10-10 | Incyte Corp | Fused pyrazine derivatives as a2a /a2b inhibitors |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| CA3166536A1 (en) | 2020-01-03 | 2021-07-08 | Incyte Corporation | Cd73 inhibitor and a2a/a2b adenosine receptor inhibitor combination therapy |
| WO2021138467A1 (en) | 2020-01-03 | 2021-07-08 | Incyte Corporation | Anti-cd73 antibodies and uses thereof |
| MX2022008208A (es) * | 2020-01-03 | 2022-10-21 | Incyte Corp | Terapia de combinación que comprende inhibidores de a2a/a2b y proteína de muerte programada 1 /ligando de muerte programada 1 (pd-1/pdl1). |
| CN119173276A (zh) | 2022-04-13 | 2024-12-20 | 吉利德科学公司 | 用于治疗表达Trop-2的癌症的组合疗法 |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
Family Cites Families (272)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5156840A (en) | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| DE69232137T2 (de) | 1991-11-25 | 2002-05-29 | Enzon Inc | Multivalente antigen-bindende proteine |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| AU725609C (en) | 1995-08-18 | 2002-01-03 | Morphosys Ag | Protein/(poly)peptide libraries |
| DE19629378A1 (de) | 1996-07-20 | 1998-01-29 | Boehringer Ingelheim Kg | Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP4195729B2 (ja) | 1997-03-24 | 2008-12-10 | 協和醗酵工業株式会社 | ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体 |
| ATE459616T1 (de) | 1998-08-11 | 2010-03-15 | Novartis Ag | Isochinoline derivate mit angiogenesis-hemmender wirkung |
| IL142128A0 (en) | 1998-09-22 | 2002-03-10 | Kyowa Hakko Kogyo Kk | [1,2,4] triazolo [1,5-c] pyrimidine derivatives |
| US6133031A (en) | 1999-08-19 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense inhibition of focal adhesion kinase expression |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| MXPA01011279A (es) | 1999-05-07 | 2002-07-02 | Genentech Inc | Tratamiento de enfermedades autoinmunes con antagonistas que se unene a los marcadores de superficie, de celulas b. |
| EP1210428B1 (en) | 1999-08-23 | 2015-03-18 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
| EP1210424B1 (en) | 1999-08-23 | 2007-02-07 | Dana-Farber Cancer Institute, Inc. | Novel b7-4 molecules and uses therefor |
| US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
| AU784634B2 (en) | 1999-11-30 | 2006-05-18 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
| US6803192B1 (en) | 1999-11-30 | 2004-10-12 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| AU5914201A (en) | 2000-04-25 | 2001-11-07 | Idec Pharma Corp | Intrathecal administration of rituximab for treatment of central nervous system lymphomas |
| SI1283839T1 (https=) | 2000-05-26 | 2005-08-31 | Schering Corp | |
| ATE273695T1 (de) | 2000-06-28 | 2004-09-15 | Smithkline Beecham Plc | Nassvermahlung |
| EP1360203B1 (en) | 2001-01-17 | 2008-12-24 | Intreat Pty Limited | Antibodies to non-functional p 2 x 7 receptor diagnosis and treatment of cancers and other conditions |
| AU2002258941A1 (en) | 2001-04-20 | 2002-11-05 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
| CA2448306A1 (en) | 2001-05-30 | 2002-12-05 | Alteon Inc. | Method for treating fibrotic diseases or other indications |
| US6806268B2 (en) | 2001-05-30 | 2004-10-19 | Alteon, Inc. | Method for treating glaucoma V |
| IL160915A0 (en) | 2001-09-19 | 2004-08-31 | Aventis Pharma Sa | Indolizines inhibiting kinase proteins |
| JPWO2003028732A1 (ja) | 2001-09-28 | 2005-01-13 | 協和醗酵工業株式会社 | 受容体拮抗剤 |
| AU2002334969A1 (en) | 2001-10-09 | 2003-04-22 | Sylvie Barchechath | Use of stat-6 inhibitors as therapeutic agents |
| ES2269793T3 (es) | 2001-10-30 | 2007-04-01 | Novartis Ag | Derivados de estaurospina como inhibidores de la actividad de tirosina quinasa receptora flt3. |
| WO2003042402A2 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
| US6921762B2 (en) | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
| PE20030739A1 (es) | 2001-11-30 | 2003-08-28 | Schering Corp | Antagonistas del receptor de adenosina a2a |
| ES2251677T3 (es) | 2002-01-22 | 2006-05-01 | Warner-Lambert Company Llc | 2-(piridin-2-ilamino)-pirido(2,3-d)pirimidin-7-onas. |
| AU2003211993A1 (en) | 2002-02-15 | 2003-09-04 | Kyowa Hakko Kogyo Co., Ltd. | (1,2,4)TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVES |
| TW200406374A (en) | 2002-05-29 | 2004-05-01 | Novartis Ag | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| EP1544200A1 (en) | 2002-09-24 | 2005-06-22 | Kyowa Hakko Kogyo Co., Ltd. | 1,2,4 -TRIAZOLO 1,5-c PYRIMIDINE DERIVATIVE |
| CL2003002353A1 (es) | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| JP2006524039A (ja) | 2003-01-09 | 2006-10-26 | マクロジェニクス，インコーポレーテッド | 変異型Ｆｃ領域を含む抗体の同定および作製ならびにその利用法 |
| CA2510003A1 (en) | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
| WO2004072266A2 (en) | 2003-02-13 | 2004-08-26 | Kalobios Inc. | Antibody affinity engineering by serial epitope-guided complementarity replacement |
| GB0303910D0 (en) | 2003-02-20 | 2003-03-26 | Merck Sharp & Dohme | Therapeutic agents |
| WO2004079013A1 (en) | 2003-03-03 | 2004-09-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Ecto-5’-nucleotidase (cd73) used in the diagnosis and the treatment of pancreatic cancer |
| WO2004080966A1 (ja) | 2003-03-14 | 2004-09-23 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
| EP2062916A3 (en) | 2003-04-09 | 2009-08-19 | Genentech, Inc. | Therapy of autoimmune disease in a patient with an inadequate response to a TNF-Alpha inhibitor |
| WO2004092173A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
| US20070010522A1 (en) | 2003-04-09 | 2007-01-11 | Chi Vu | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
| US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| ATE481101T1 (de) | 2003-06-10 | 2010-10-15 | Kyowa Hakko Kirin Co Ltd | Verfahren zur behandlung von angstzuständen |
| EP1639014B1 (en) | 2003-06-13 | 2010-09-22 | Biogen Idec MA Inc. | Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof |
| WO2005016892A1 (en) | 2003-08-14 | 2005-02-24 | F. Hoffmann-La Roche Ag | Gabanergic modulators |
| CN1871259A (zh) | 2003-08-22 | 2006-11-29 | 比奥根艾迪克Ma公司 | 具有改变的效应物功能的经改进的抗体和制备它的方法 |
| EP1663204B1 (en) | 2003-08-29 | 2014-05-07 | Exelixis, Inc. | C-kit modulators and methods of use |
| AR045944A1 (es) | 2003-09-24 | 2005-11-16 | Novartis Ag | Derivados de isoquinolina 1.4-disustituidas |
| GB0403819D0 (en) | 2004-02-20 | 2004-03-24 | Merck Sharp & Dohme | New compounds |
| EP1737459B1 (en) | 2004-03-19 | 2009-08-05 | Warner-Lambert Company LLC | Imidazopyridine and imidazopyrimidine derivatives as antibacterial agents |
| US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
| JP2008501714A (ja) | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
| JP4688876B2 (ja) | 2004-06-10 | 2011-05-25 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
| EP1912643A2 (en) | 2004-06-23 | 2008-04-23 | Idenix (Cayman) Limited | 5-aza-7-deazapurine derivatives for treating infections with flaviviridae |
| CA2570319A1 (en) | 2004-06-25 | 2006-01-12 | Amgen Inc. | Condensed triazoles and indazoles useful in treating citokines mediated diseases and other diseases |
| ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
| JP4938673B2 (ja) | 2004-10-15 | 2012-05-23 | ベリサイン・インコーポレイテッド | ワンタイムパスワード |
| US20060211739A1 (en) | 2005-02-08 | 2006-09-21 | Arturo Perez-Medrano | Use of selective P2X7 receptor antagonists |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| BRPI0612947A2 (pt) | 2005-05-18 | 2010-12-07 | Biogen Idec Inc | método para o tratamento de uma condição fibrótica, método para tratar a fibrose pulmonar, método para tratar a fibrose hepática, método para tratar a fibrose renal, métodos para tratar uma doença fibrótica e método para prevenir uma doença fibrótica |
| WO2006129626A1 (ja) | 2005-05-30 | 2006-12-07 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体の製造法 |
| EP1902716A4 (en) | 2005-06-07 | 2009-05-13 | Kyowa Hakko Kirin Co Ltd | PROPHYLACTIC AND / OR THERAPEUTIC AGENT FOR MOTOR TROUBLESHOOTING |
| US7452892B2 (en) | 2005-06-17 | 2008-11-18 | Bristol-Myers Squibb Company | Triazolopyrimidine cannabinoid receptor 1 antagonists |
| JP4986451B2 (ja) | 2005-06-30 | 2012-07-25 | 信一郎 礒部 | マーキング剤 |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| WO2007011759A2 (en) | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
| TW200804386A (en) | 2005-11-10 | 2008-01-16 | Schering Corp | Imidazopyrazines as protein kinase inhibitors |
| EP2385053B1 (en) | 2005-11-17 | 2013-10-02 | OSI Pharmaceuticals, Inc. | Intermediates for the preparation of fused bicyclic mTOR inhibitors |
| EP1962853A1 (en) | 2005-12-22 | 2008-09-03 | Alcon Research, Ltd. | (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)- pyrazines for treating rho kinase-mediated diseases and conditions |
| EP2010505B1 (en) | 2006-03-28 | 2012-12-05 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| PT2029602E (pt) | 2006-05-31 | 2010-07-08 | Galapagos Nv | Compostos de triazolopirazina uteis para o tratamento de doenãas degenerativas e inflamatërias |
| EP2049518B1 (en) | 2006-05-31 | 2011-08-31 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents. |
| WO2007150025A2 (en) | 2006-06-23 | 2007-12-27 | Incyte Corporation | Purinone derivatives as hm74a agonists |
| CA2656067C (en) | 2006-06-23 | 2014-08-12 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
| EP2975057A1 (en) | 2006-07-10 | 2016-01-20 | Fujita Health University | Novel anti-cd73 antibody |
| EP1889846A1 (en) | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
| EP2044061A2 (en) | 2006-07-20 | 2009-04-08 | Mehmet Kahraman | Benzothiophene inhibitors of rho kinase |
| DE102006041292A1 (de) | 2006-09-01 | 2008-03-06 | Henkel Kgaa | Wasserstoffperoxid-Aktivierung mit N-Heterocyclen |
| WO2008037607A1 (de) | 2006-09-25 | 2008-04-03 | Basf Se | Carbonylgruppen-enthaltende heterocyclische verbindungen und deren verwendung zur bekämpfung von phytopathogenen pilzen |
| WO2008056176A1 (en) | 2006-11-10 | 2008-05-15 | Scottish Biomedical Limited | Pyrazolopyrimidines as phosphodiesterase inhibitors |
| AU2007329480A1 (en) | 2006-12-05 | 2008-06-12 | National Chio Tung University | Indazole compounds |
| DE102007012645A1 (de) | 2007-03-16 | 2008-09-18 | Bayer Healthcare Ag | Substituierte Imidazo- und Triazolopyrimidine |
| BRPI0809567A2 (pt) | 2007-04-10 | 2014-09-23 | Lundbeck & Co As H | Composto, composição farmacêutica, método para modular a atividade de um receptor de p2x7, para tratar uma condição responsiva à modulação do receptor de p2x7 em um paciente, para inibir a morte de células do gânglio retinal em um paciente, e para determinar a presença ou ausência do receptor de p2x7 em uma amostra, preparação farmacêutica acondiciaonada, e, uso de um composto |
| US8039505B2 (en) | 2007-04-11 | 2011-10-18 | University Of Utah Research Foundation | Compounds for modulating T-cells |
| US8133895B2 (en) | 2007-05-10 | 2012-03-13 | Janssen Pharmaceutica N.V. | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| CN101855222A (zh) | 2007-05-10 | 2010-10-06 | 通用电气健康护理有限公司 | 对大麻素cb2受体具有活性的咪唑并(1,2-a)吡啶和相关化合物 |
| HUP0700395A2 (en) | 2007-06-07 | 2009-03-02 | Sanofi Aventis | Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates |
| HRP20131167T1 (hr) | 2007-06-18 | 2014-01-03 | Merck Sharp & Dohme B.V. | Antitijela za humani receptor programirane smrti pd-1 |
| US8053574B2 (en) | 2007-07-18 | 2011-11-08 | Novartis Ag | Organic compounds |
| GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| WO2009023179A2 (en) | 2007-08-10 | 2009-02-19 | Genelabs Technologies, Inc. | Nitrogen containing bicyclic chemical entities for treating viral infections |
| US8062852B2 (en) | 2007-10-01 | 2011-11-22 | The Children's Hospital And Regional Medical Center | Detection and treatment of autoimmune disorders |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| MX2010004246A (es) | 2007-10-18 | 2010-04-30 | Novartis Ag | Inhibidores de csf-1r para el tratamiento de cancer y de enfermedades oseas. |
| US20090118301A1 (en) | 2007-11-02 | 2009-05-07 | Arbor Vita Corporation | Compositions and Methods for Treating Cancer |
| EP2217069A4 (en) | 2007-11-09 | 2012-03-14 | Salk Inst For Biological Studi | INHIBITORS OF NON-NUCLEOSIDE INHIBITORS OF THE REVERSE TRANSCRIPTASE |
| PE20091074A1 (es) | 2007-12-13 | 2009-07-26 | Bayer Healthcare Ag | Triazolotriazinas y triazolopirazinas y su uso |
| BRPI0821209A2 (pt) | 2007-12-19 | 2019-09-24 | Amgen Inc | composto, composição farmacêutica, métodos de tratar câncer, para reduzir o tamanho de tumor, para tratar distúrbios, e para reduzir metástase em um tumor. |
| AU2008343813B2 (en) | 2007-12-19 | 2012-04-12 | Amgen Inc. | Inhibitors of PI3 kinase |
| EP2262811B1 (en) | 2008-03-04 | 2016-04-27 | Merck Sharp & Dohme Corp. | 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e]-1,2,4-triazolo [4,3-c]pyrimidin-3-one compounds for use as adenosine a2a receptor antagonists |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| US8637542B2 (en) | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
| WO2009117421A2 (en) | 2008-03-17 | 2009-09-24 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
| JP5620365B2 (ja) | 2008-03-21 | 2014-11-05 | エンソン インコーポレイテッド | 多官能分子システムを用いた積層体への金属の接着促進 |
| US20090281089A1 (en) | 2008-04-11 | 2009-11-12 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| EP2277881A4 (en) | 2008-04-18 | 2011-09-07 | Shionogi & Co | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K |
| TWI473614B (zh) | 2008-05-29 | 2015-02-21 | Kyowa Hakko Kirin Co Ltd | Anti-analgesic inhibitors |
| NZ590793A (en) | 2008-07-23 | 2012-07-27 | Kyowa Hakko Kirin Co Ltd | Therapeutic agent for migraine |
| WO2010033906A2 (en) | 2008-09-19 | 2010-03-25 | President And Fellows Of Harvard College | Efficient induction of pluripotent stem cells using small molecule compounds |
| WO2010032874A1 (ja) | 2008-09-19 | 2010-03-25 | 住友化学株式会社 | 農業用組成物 |
| KR101814408B1 (ko) | 2008-09-26 | 2018-01-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-ｐｄ-１, ｐｄ-ｌ１, 및 ｐｄ-ｌ2 항체 및 그의 용도 |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| JO2885B1 (en) | 2008-12-22 | 2015-03-15 | ايلي ليلي اند كومباني | Protein kinase inhibitors |
| CA2740193A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| EP2367823A1 (en) | 2008-12-23 | 2011-09-28 | Abbott Laboratories | Anti-viral compounds |
| EP2210891A1 (en) | 2009-01-26 | 2010-07-28 | Domain Therapeutics | New adenosine receptor ligands and uses thereof |
| WO2010089411A2 (en) | 2009-02-09 | 2010-08-12 | Universite De La Mediterranee | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| WO2010104307A2 (ko) | 2009-03-07 | 2010-09-16 | 주식회사 메디젠텍 | 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물 |
| EP2464647B1 (en) * | 2009-08-11 | 2016-09-21 | Bristol-Myers Squibb Company | Azaindazoles as btk kinase modulators and use thereof |
| PE20121148A1 (es) | 2009-08-17 | 2012-09-07 | Intellikine Llc | Compuestos heterociclicos y usos de los mismos |
| US20110105541A1 (en) | 2009-10-29 | 2011-05-05 | Jackson Paul F | ALKYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS |
| EP2509983B1 (en) | 2009-11-16 | 2014-09-17 | Merck Sharp & Dohme Corp. | FUSED TRICYCLIC COMPOUNDS WITH ADENOSINE A2a RECEPTOR ANTAGONIST ACTIVITY |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| WO2011078143A1 (ja) | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | ピリミジン誘導体およびそれらを含有する医薬組成物 |
| WO2011082400A2 (en) | 2010-01-04 | 2011-07-07 | President And Fellows Of Harvard College | Modulators of immunoinhibitory receptor pd-1, and methods of use thereof |
| EP2347769A1 (en) | 2010-01-20 | 2011-07-27 | Glycotope GmbH | Cancer stem cell markers and uses thereof |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
| TW201200518A (en) | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| SG184073A1 (en) | 2010-03-18 | 2012-10-30 | Pasteur Institut Korea | Anti-infective compounds |
| UY33304A (es) | 2010-04-02 | 2011-10-31 | Amgen Inc | Compuestos heterocíclicos y sus usos |
| GB201007187D0 (en) | 2010-04-29 | 2010-06-09 | Iti Scotland Ltd | Ubiquitination modulators |
| WO2011153588A1 (en) | 2010-06-10 | 2011-12-15 | Biota Scientific Management Pty Ltd | Viral polymerase inhibitors |
| US20120083498A1 (en) | 2010-06-17 | 2012-04-05 | Fatah Kashanchi | Modulators of Viral Transcription, and Methods and Compositions Therewith |
| JP2013532153A (ja) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのｔｉｍ−３およびｐｄ−１に対する二重特異性抗体 |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| WO2012025186A1 (en) | 2010-08-27 | 2012-03-01 | Merck Patent Gmbh | Triazolopyrazine derivatives |
| KR102051881B1 (ko) | 2010-10-25 | 2019-12-04 | 쥐원 쎄라퓨틱스, 인크. | Cdk 억제제 |
| EP2651405A2 (en) | 2010-12-14 | 2013-10-23 | Electrophoretics Limited | Casein kinase 1 (ck1 ) inhibitors |
| CN107141309A (zh) | 2011-01-11 | 2017-09-08 | 桑诺维恩药品公司 | 杂芳基化合物及其使用方法 |
| WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
| CN103703000B (zh) | 2011-03-23 | 2015-11-25 | 安姆根有限公司 | Cdk4/6和flt3的稠合三环双重抑制剂 |
| KR20140093610A (ko) | 2011-04-21 | 2014-07-28 | 재단법인 한국파스퇴르연구소 | 소염 화합물 |
| WO2012147890A1 (ja) | 2011-04-27 | 2012-11-01 | 持田製薬株式会社 | 新規アゾール誘導体 |
| DE102011111400A1 (de) | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclische heteroaromatische Verbindungen |
| EP2604265A1 (en) | 2011-12-17 | 2013-06-19 | Royal College of Surgeons in Ireland (RCSI) | P2x7 antagonists as frontline or adjunctive treatment against status epilepticus |
| WO2013106254A1 (en) | 2012-01-11 | 2013-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| SG11201406890YA (en) | 2012-05-30 | 2014-11-27 | Hoffmann La Roche | Triazolo compounds as pde10 inhibitors |
| EP2865671B1 (en) | 2012-06-22 | 2017-11-01 | Sumitomo Chemical Company, Ltd | Fused heterocyclic compound |
| WO2014017938A2 (en) | 2012-07-27 | 2014-01-30 | BIAL - PORTELA & Cª, S.A. | Process for the synthesis of substituted urea compounds |
| US9757379B2 (en) | 2012-11-14 | 2017-09-12 | The Board Of Regents Of The University Of Texas System | Inhibition of HIF-2α heterodimerization with HIF1β (ARNT) |
| WO2014126580A1 (en) | 2013-02-15 | 2014-08-21 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| EP2968304B1 (en) | 2013-03-14 | 2018-10-10 | The Trustees of Columbia University in the City of New York | 4-phenylpiperidines, their preparation and use |
| US9090697B2 (en) | 2013-03-15 | 2015-07-28 | Bayer Healthcare Llc | Methods for treating bleeding disorders |
| WO2014153424A1 (en) | 2013-03-19 | 2014-09-25 | La Jolla Institute For Allergy And Immunology | Reducing diabetes in patients receiving hmg-coa reductase inhibitors (statins) |
| AU2014292888B2 (en) | 2013-07-25 | 2018-03-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| WO2015157955A1 (en) | 2014-04-17 | 2015-10-22 | Abbvie Inc. | Heterocyclic btk inhibit ors |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| ES2916923T3 (es) | 2014-07-11 | 2022-07-06 | Ventana Med Syst Inc | Anticuerpos anti-PD-L1 y usos diagnósticos de los mismos |
| AU2015328307B2 (en) | 2014-10-06 | 2019-11-21 | Apm Therapeutics 1, Inc. | Triazolopyridine compounds and methods for the treatment of cystic fibrosis |
| IL250579B2 (en) | 2014-10-10 | 2023-05-01 | Innate Pharma | blocking cd73 |
| US20180030144A1 (en) | 2014-10-10 | 2018-02-01 | Innate Pharma | Cd73 blockade |
| DK3218406T4 (da) | 2014-11-10 | 2024-12-09 | Medimmune Ltd | Bindingsmolekyler, der er specifikke for cd73, og anvendelser deraf |
| EP3218407A1 (en) | 2014-11-11 | 2017-09-20 | Medimmune Limited | Therapeutic combinations comprising anti-cd73 antibodies and a2a receptor inhibitor and uses thereof |
| MY189836A (en) | 2014-11-21 | 2022-03-11 | Bristol Myers Squibb Co | Antibodies against cd73 and uses thereof |
| MA41090A (fr) | 2014-12-03 | 2017-10-10 | H Lundbeck As | Antagoniste de a2a faiblement dosé pour le traitement du tdah et de la maladie de parkinson |
| PT3257853T (pt) | 2015-02-12 | 2021-12-23 | Nissan Chemical Corp | Composto heterocíclico condensado e agente de controlo de organismos prejudiciais |
| MX373169B (es) * | 2015-02-20 | 2020-04-24 | Incyte Holdings Corp | Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr). |
| JP6697809B2 (ja) | 2015-03-06 | 2020-05-27 | ファーマケア，インク． | フッ素化リシルオキシダーゼ様２阻害剤とその使用 |
| EP3277689B1 (en) | 2015-04-03 | 2019-09-04 | Incyte Corporation | Heterocyclic compounds as lsd1 inhibitors |
| WO2017019846A1 (en) | 2015-07-30 | 2017-02-02 | Macrogenics, Inc. | Pd-1-binding molecules and methods use thereof |
| US11130817B2 (en) | 2015-10-12 | 2021-09-28 | Innate Pharma | CD73 blocking agents |
| EP3365340B1 (en) | 2015-10-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20170145025A1 (en) | 2015-11-19 | 2017-05-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2017100670A1 (en) | 2015-12-09 | 2017-06-15 | Corvus Pharmaceuticals, Inc. | Humanized anti-cd73 antibodies |
| ES2916874T3 (es) | 2015-12-17 | 2022-07-06 | Incyte Corp | Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1 |
| AU2016379372A1 (en) | 2015-12-22 | 2018-08-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| JP6847958B2 (ja) | 2015-12-24 | 2021-03-24 | コーバス・ファーマシューティカルズ・インコーポレイテッド | がんの治療方法 |
| CR20180372A (es) | 2016-02-24 | 2018-09-19 | Pfizer | Derivados de pirazolo [1,5-a] pirazin-4-ilo |
| KR20230038311A (ko) | 2016-03-04 | 2023-03-17 | 브리스톨-마이어스 스큅 컴퍼니 | 항-cd73 항체와의 조합 요법 |
| CN109152784B (zh) | 2016-03-16 | 2021-12-28 | 库拉肿瘤学公司 | 经取代的menin-mll抑制剂及使用方法 |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
| WO2017223414A1 (en) | 2016-06-24 | 2017-12-28 | Incyte Corporation | HETEROCYCLIC COMPOUNDS AS PI3K-γ INHIBITORS |
| WO2018004478A1 (en) | 2016-06-29 | 2018-01-04 | Hayat Kimya San. A. Ş. | An improved method of soft nonwoven fabric production |
| WO2018013611A1 (en) | 2016-07-11 | 2018-01-18 | Corvus Pharmaceuticals, Inc. | Anti-cd73 antibodies |
| MA45669A (fr) | 2016-07-14 | 2019-05-22 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| CR20220309A (es) | 2016-09-02 | 2022-09-16 | Cyclerion Therapeutics Inc | Estimuladores de sgc |
| US11180554B2 (en) | 2016-12-13 | 2021-11-23 | Astellas Pharma Inc. | Anti-human CD73 antibody |
| EP3555064B9 (en) | 2016-12-16 | 2023-03-01 | Pfizer Inc. | Glp-1 receptor agonists and uses thereof |
| ES2899402T3 (es) | 2016-12-22 | 2022-03-11 | Incyte Corp | Derivados de piridina como inmunomoduladores |
| ES2874756T3 (es) | 2016-12-22 | 2021-11-05 | Incyte Corp | Derivados de triazolo[1,5-A]piridina como inmunomoduladores |
| EP3558990B1 (en) | 2016-12-22 | 2022-08-10 | Incyte Corporation | Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers |
| WO2018119263A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds derivatives as pd-l1 internalization inducers |
| WO2018119286A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| AU2017382870B2 (en) | 2016-12-22 | 2022-03-24 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
| MX2019008695A (es) | 2017-01-23 | 2019-09-11 | Revolution Medicines Inc | Compuestos biciclicos como inhibidores alostericos de shp2. |
| EP3383916B1 (en) | 2017-01-24 | 2022-02-23 | I-Mab Biopharma US Limited | Anti-cd73 antibodies and uses thereof |
| CN108467386B (zh) * | 2017-02-23 | 2020-11-17 | 江苏恒瑞医药股份有限公司 | 稠杂芳基取代的1,2,4-三嗪-3-胺类衍生物、其制备方法及其在医药上的应用 |
| CN109963854B (zh) * | 2017-03-16 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 杂芳基并[4,3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用 |
| WO2018187512A1 (en) | 2017-04-04 | 2018-10-11 | Corvus Pharmaceuticals, Inc. | Methods for treating cd73hi tumors |
| PL3611174T3 (pl) | 2017-04-07 | 2022-08-08 | Medshine Discovery Inc. | Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a |
| WO2018215535A1 (en) | 2017-05-23 | 2018-11-29 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Novel cd73 antibody, preparation and uses thereof |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| CN118307674A (zh) | 2017-06-22 | 2024-07-09 | 诺华股份有限公司 | 针对cd73的抗体分子及其用途 |
| JP2020525472A (ja) | 2017-06-30 | 2020-08-27 | ライブ・セラピューティクス・スプウカ・アクツィーナＲｙｖｕ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓ．Ａ． | アデノシンａ２ａ受容体のイミダゾ［１，２−ａ］ピラジン調節剤 |
| CN109535161B (zh) | 2017-09-22 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 三唑并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| CU20200041A7 (es) | 2017-10-24 | 2021-03-11 | Bayer Ag | Amidas de imidazopiridina sustituidas |
| TW201922291A (zh) | 2017-11-16 | 2019-06-16 | 瑞士商諾華公司 | 組合療法 |
| US20210047324A1 (en) | 2018-01-31 | 2021-02-18 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| CN112204031B (zh) | 2018-01-31 | 2024-05-24 | 元羿生物科技(香港)有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| TWI803574B (zh) | 2018-02-17 | 2023-06-01 | 瑞典商阿斯特捷利康公司 | 精胺酸酶抑制劑及其使用方法 |
| BR122023024273A2 (pt) * | 2018-02-27 | 2024-02-20 | Incyte Corporation | Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos |
| WO2019170131A1 (zh) | 2018-03-07 | 2019-09-12 | 复旦大学 | 靶向cd73的抗体及抗体-药物偶联物、其制备方法和用途 |
| KR102804816B1 (ko) | 2018-03-09 | 2025-05-09 | 페인스 테라퓨틱스 인코포레이티드 | 항-cd73 항체 및 이의 용도 |
| TWI823906B (zh) | 2018-03-09 | 2023-12-01 | 美商艾吉納斯公司 | 抗-cd73 抗體及其使用方法 |
| CR20200520A (es) | 2018-03-30 | 2021-03-09 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| US11220510B2 (en) | 2018-04-09 | 2022-01-11 | Incyte Corporation | Pyrrole tricyclic compounds as A2A / A2B inhibitors |
| US20210147570A1 (en) | 2018-04-12 | 2021-05-20 | Bristol-Myers Squibb Company | Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody |
| WO2019217821A1 (en) | 2018-05-11 | 2019-11-14 | Incyte Corporation | Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators |
| WO2019222677A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| CN120714024A (zh) | 2018-06-20 | 2025-09-30 | 因赛特公司 | 抗pd-1抗体及其用途 |
| GEP20237548B (en) | 2018-07-05 | 2023-10-10 | Incyte Corp | Fused pyrazine derivatives as a2a /a2b inhibitors |
| CN112423758A (zh) * | 2018-07-10 | 2021-02-26 | 尼康治疗公司 | 腺苷受体结合化合物 |
| ES2986417T3 (es) | 2018-08-13 | 2024-11-11 | Hoffmann La Roche | Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasa |
| MA53220A (fr) | 2018-08-13 | 2021-11-17 | Hoffmann La Roche | Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs de monoacylglycérol lipase |
| IL280924B2 (en) | 2018-08-22 | 2024-10-01 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
| GB201813678D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Acylated calcitonin mimetics |
| AR116315A1 (es) | 2018-09-12 | 2021-04-21 | Dizal Jiangsu Pharmaceutical Co Ltd | Compuestos de triazolo-pirimidina y usos de los mismos |
| EP3856173A4 (en) | 2018-09-26 | 2022-07-06 | Kura Oncology, Inc. | TREATMENT OF HEMATOLOGICAL MALIGNITIES WITH MENIN INHIBITORS |
| WO2020073945A1 (zh) | 2018-10-10 | 2020-04-16 | 江苏豪森药业集团有限公司 | 双环类衍生物抑制剂、其制备方法和应用 |
| PY1991608A (es) | 2018-11-02 | 2022-02-10 | Aicuris Gmbh & Co Kg | Nueva urea 6,7-dihidro-4h-pirazolo [1,5-a] pirazina activas contra el virus de la hepatitis b (vhb) |
| WO2020106560A1 (en) | 2018-11-20 | 2020-05-28 | Merck Sharp & Dohme Corp. | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
| JP2022510980A (ja) | 2018-11-30 | 2022-01-28 | 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 | ヘテロ芳香族誘導体調節因子、その製造方法及び使用 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| EP4010342A1 (en) | 2019-08-09 | 2022-06-15 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
| US20210061809A1 (en) | 2019-08-26 | 2021-03-04 | Incyte Corporation | Triazolopyrimidines as a2a / a2b inhibitors |
| WO2021067217A1 (en) | 2019-09-30 | 2021-04-08 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
| BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
| WO2021138467A1 (en) | 2020-01-03 | 2021-07-08 | Incyte Corporation | Anti-cd73 antibodies and uses thereof |
| MX2022008208A (es) | 2020-01-03 | 2022-10-21 | Incyte Corp | Terapia de combinación que comprende inhibidores de a2a/a2b y proteína de muerte programada 1 /ligando de muerte programada 1 (pd-1/pdl1). |
| US11866434B2 (en) | 2020-11-06 | 2024-01-09 | Incyte Corporation | Process for making a PD-1/PD-L1 inhibitor and salts and crystalline forms thereof |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| WO2022099075A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Crystalline form of a pd-1/pd-l1 inhibitor |
| MX2023007850A (es) | 2020-12-29 | 2023-09-11 | Incyte Corp | Terapia combinada que comprende inhibidores de adora2a/adora2b (a2a/a2b), inhibidores de muerte programada/ligando 1 de muerte programada (pd-1/pd-l1) y anticuerpos de cumulo de diferenciacion 73 (anti-cd73). |
-
2020
- 2020-01-22 TW TW109102605A patent/TWI829857B/zh active
- 2020-01-28 FI FIEP20709807.0T patent/FI3917925T3/fi active
- 2020-01-28 MA MA54870A patent/MA54870B1/fr unknown
- 2020-01-28 EA EA202192093A patent/EA202192093A1/ru unknown
- 2020-01-28 PH PH1/2021/551817A patent/PH12021551817A1/en unknown
- 2020-01-28 CA CA3127939A patent/CA3127939A1/en active Pending
- 2020-01-28 AU AU2020215673A patent/AU2020215673B2/en active Active
- 2020-01-28 DK DK20709807.0T patent/DK3917925T3/da active
- 2020-01-28 BR BR112021014865-5A patent/BR112021014865A2/pt unknown
- 2020-01-28 US US16/774,086 patent/US11390624B2/en active Active
- 2020-01-28 PL PL20709807.0T patent/PL3917925T3/pl unknown
- 2020-01-28 LT LTEPPCT/US2020/015294T patent/LT3917925T/lt unknown
- 2020-01-28 CN CN202080021651.2A patent/CN113906022B/zh active Active
- 2020-01-28 PT PT207098070T patent/PT3917925T/pt unknown
- 2020-01-28 KR KR1020217027429A patent/KR102854890B1/ko active Active
- 2020-01-28 MD MDE20211171T patent/MD3917925T2/ro unknown
- 2020-01-28 HR HRP20240491TT patent/HRP20240491T1/hr unknown
- 2020-01-28 SG SG11202108180VA patent/SG11202108180VA/en unknown
- 2020-01-28 AR ARP200100211A patent/AR117900A1/es unknown
- 2020-01-28 SI SI202030433T patent/SI3917925T1/sl unknown
- 2020-01-28 EP EP20709807.0A patent/EP3917925B1/en active Active
- 2020-01-28 MX MX2021009117A patent/MX2021009117A/es unknown
- 2020-01-28 CR CR20210456A patent/CR20210456A/es unknown
- 2020-01-28 WO PCT/US2020/015294 patent/WO2020159905A1/en not_active Ceased
- 2020-01-28 HU HUE20709807A patent/HUE066718T2/hu unknown
- 2020-01-28 JP JP2021544217A patent/JP7447128B2/ja active Active
- 2020-01-28 ES ES20709807T patent/ES2984519T3/es active Active
- 2020-01-28 PE PE2021001245A patent/PE20212071A1/es unknown
- 2020-01-28 RS RS20240533A patent/RS65495B1/sr unknown
- 2020-01-28 SM SM20240170T patent/SMT202400170T1/it unknown
- 2020-01-28 IL IL285127A patent/IL285127B2/en unknown
-
2021
- 2021-07-28 CL CL2021001984A patent/CL2021001984A1/es unknown
- 2021-07-28 ZA ZA2021/05353A patent/ZA202105353B/en unknown
- 2021-08-26 CO CONC2021/0011253A patent/CO2021011253A2/es unknown
- 2021-08-26 EC ECSENADI202163186A patent/ECSP21063186A/es unknown
-
2022
- 2022-06-15 US US17/841,166 patent/US11884665B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20240491T1 (hr) | Pirazolopiridini i triazolopiridini kao a2a/a2b inhibitori | |
| JP7654071B2 (ja) | 複素環スピロ化合物及び使用方法 | |
| RU2008110915A (ru) | Новые диазаспироалканы и их применение для лечения заболеваний, опосредованных ccr8 | |
| JP2013521285A5 (https=) | ||
| JP2022502490A5 (https=) | ||
| JP2017527548A5 (https=) | ||
| RU2017139254A (ru) | Пиридопиримидиноны и их применение в качестве модуляторов рецептора n-метил-d-аспартата | |
| HRP20201277T1 (hr) | Novi biciklički derivati dihidroizokinolin-1-ona | |
| JP2016537384A5 (https=) | ||
| JP2014513139A5 (https=) | ||
| RU2015148189A (ru) | ПРОИЗВОДНЫЕ 2-АМИДОПИРИДО[4, 3-d]ПИРИМИДИН-5-ОНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ WEE-1 | |
| JP2021525783A5 (https=) | ||
| HRP20240368T1 (hr) | Heterociklički inhibitori atr kinaze | |
| JP2012515205A5 (https=) | ||
| RU2016140338A (ru) | Азаспиро производные в качестве антагонистов trpm8 | |
| JP2004525149A5 (https=) | ||
| MX383747B (es) | Derivados de pirazolo[1,5-a]pirazin-4-ilo como inhibidores de quinasas janus (jak) | |
| JP2020527174A5 (https=) | ||
| JP2016520116A5 (https=) | ||
| IL279800B1 (en) | Selective allosteric inhibitors of epidermal growth factor receptor mutants, pharmaceutical preparations containing them and their use | |
| HRP20150868T1 (hr) | Derivati kinolina i kinoksalina kao inhibitori kinaze | |
| JP2020526556A5 (https=) | ||
| JP2004527560A5 (https=) | ||
| EP2586780A4 (en) | 2-ARYL-IMIDAZO- [1,2-A] -PYRIDINE-3-ACETAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE | |
| SI3022192T1 (en) | Piperidinyl indole derivatives and their use as inhibitors of complementary factor B |