WO2020159905A1 - Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors - Google Patents

Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors Download PDF

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Publication number
WO2020159905A1
WO2020159905A1 PCT/US2020/015294 US2020015294W WO2020159905A1 WO 2020159905 A1 WO2020159905 A1 WO 2020159905A1 US 2020015294 W US2020015294 W US 2020015294W WO 2020159905 A1 WO2020159905 A1 WO 2020159905A1
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Prior art keywords
alkyl
cycloalkyl
membered heterocycloalkyl
aryl
membered heteroaryl
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English (en)
French (fr)
Inventor
Taisheng Huang
Xiaozhao Wang
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Incyte Corp
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Incyte Corp
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Priority to IL285127A priority Critical patent/IL285127B2/en
Priority to PL20709807.0T priority patent/PL3917925T3/pl
Priority to AU2020215673A priority patent/AU2020215673B2/en
Priority to FIEP20709807.0T priority patent/FI3917925T3/fi
Priority to EP20709807.0A priority patent/EP3917925B1/en
Priority to BR112021014865-5A priority patent/BR112021014865A2/pt
Priority to ES20709807T priority patent/ES2984519T3/es
Priority to CA3127939A priority patent/CA3127939A1/en
Priority to PE2021001245A priority patent/PE20212071A1/es
Priority to RS20240533A priority patent/RS65495B1/sr
Priority to CR20210456A priority patent/CR20210456A/es
Priority to EA202192093A priority patent/EA202192093A1/ru
Priority to MX2021009117A priority patent/MX2021009117A/es
Priority to KR1020217027429A priority patent/KR102854890B1/ko
Priority to SG11202108180VA priority patent/SG11202108180VA/en
Application filed by Incyte Corp filed Critical Incyte Corp
Priority to HRP20240491TT priority patent/HRP20240491T1/hr
Priority to CN202080021651.2A priority patent/CN113906022B/zh
Priority to JP2021544217A priority patent/JP7447128B2/ja
Priority to SM20240170T priority patent/SMT202400170T1/it
Priority to LTEPPCT/US2020/015294T priority patent/LT3917925T/lt
Priority to PH1/2021/551817A priority patent/PH12021551817A1/en
Priority to MA54870A priority patent/MA54870B1/fr
Priority to SI202030433T priority patent/SI3917925T1/sl
Priority to DK20709807.0T priority patent/DK3917925T3/da
Priority to MDE20211171T priority patent/MD3917925T2/ro
Publication of WO2020159905A1 publication Critical patent/WO2020159905A1/en
Priority to ZA2021/05353A priority patent/ZA202105353B/en
Anticipated expiration legal-status Critical
Priority to CONC2021/0011253A priority patent/CO2021011253A2/es
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Definitions

  • each R 2B is independently selected from D, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 aryl, C 3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 aryl-C 1-6 alkyl-, C 3-10 cycloalkyl-C 1-6 alkyl-, (5-10 membered heteroaryl)-C 1-6 alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 alkyl-, CN, NO 2 , OR a22 , SR a22 , NHOR a22 , C(O)R b22 , C(O)NR c22 R d22 , C(O)NR c22 (OR a22 ), C(O)OR a22 , OC(O)R b22 ,
  • OS(O)( NR e24 )R b24 , OS(O) 2 R b24 , SF 5 , P(O)R f24 R g24 , OP(O)(OR h24 )(OR i24 ),
  • each R f24 and R g24 is independently selected from H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 2-6 alkenyl, C 2-6 alkynyl, phenyl, C 3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 alkyl-, C 3-7 cycloalkyl-C 1-6 alkyl-, (5- 6 membered heteroaryl)-C 1-6 alkyl-, and (4-7 membered heterocycloalkyl)-C 1-6 alkyl-;
  • R j24 and R k24 attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C 1-6 alkyl and C 1-6 haloalkyl;
  • Cy 1 is C 6-10 aryl or 5-10 membered heteroaryl, wherein the C 6- 10 aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R 5 substituents.
  • Cy 1 is phenyl optionally substituted with 1, 2, 3, or 4 independently selected R 5 substituents;
  • each R 6 is independently selected from halo, C 1-6 alkyl, and C 1-6 haloalkyl, wherein the C 1-6 alkyl is optionally substituted with OH,
  • R 2 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1- 6 haloalkyl, C 6-10 aryl, C 3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 aryl-C 1-6 alkyl-, C 3-10 cycloalkyl-C 1-6 alkyl-, (5-10 membered heteroaryl)-C 1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 6-10 aryl, C 3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 aryl-C 1-6 alkyl-, C 3-10 cycloalkyl, wherein
  • R 4 is selected from H, D, halo, OH, CN, NO 2 , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 haloalkoxy, cyano-C1-3 alkyl, HO-C1-3 alkyl, C1-3 alkoxy-C1-3 alkyl, C3-5 cycloalkyl, amino, C1-3 alkylamino, di(C1-3 alkyl)amino, thio, C1-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(C1-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-3 alkylcarbonylamino, C1-3
  • any R c5 and R d5 attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R 5A substituents;
  • each R 5A is independently selected from OH, NO 2 , CN, halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, cyano-C 1-6 alkyl, HO-C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, C3-6 cycloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, thio, C1- 6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, carbamyl, C 1-6 alkylcarbamyl, di(C 1-6 alkyl)carbamyl, carboxy, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkoxycarbony
  • R 2 is selected from C 6-10 aryl-C 1-6 alkyl-, C 3-10 cycloalkyl-C 1-6 alkyl-, (5-10 membered heteroaryl)-C 1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the C 6-10 aryl-C 1-6 alkyl-, C 3-10 cycloalkyl-C 1-6 alkyl-, (5-10 membered heteroaryl)-C 1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C 1-6 alkyl- of R 2 are each optionally substituted with 1, 2, 3, or 4 independently selected R 2A substituents;
  • each R 5 is independently selected from F and CN.
  • C n-m alkoxy refers to a group of formula -O-alkyl, wherein the alkyl group has n to m carbons.
  • Example alkoxy groups include, but are not limited to, methoxy, ethoxy, propoxy (e.g., n- propoxy and isopropoxy), butoxy (e.g., n-butoxy and tert-butoxy), and the like.
  • the alkyl group has 1 to 6, 1 to 4, or 1 to 3 carbon atoms.
  • aryl refers to an aromatic hydrocarbon group, which may be monocyclic or polycyclic (e.g., having 2, 3 or 4 fused rings).
  • C n-m aryl refers to an aryl group having from n to m ring carbon atoms.
  • Aryl groups include, e.g., phenyl, naphthyl, anthracenyl, phenanthrenyl, indanyl, indenyl, and the like. In some embodiments, aryl groups have from 5 to 10 carbon atoms. In some embodiments, the aryl group is phenyl or naphthyl.
  • di(C n-m alkyl)aminosulfonyl refers to a group of formula -S(O) 2 N(alkyl) 2 , wherein each alkyl group independently has n to m carbon atoms. In some embodiments, each alkyl group has, independently, 1 to 6, 1 to 4, or 1 to 3 carbon atoms.
  • cyano-C 1-n alkyl refers to a group of formula -(C 1-n alkylene)-CN, wherein the alkyl group has 1 to n carbon atoms. In some embodiments, the alkyl group has 1 to 6, 1 to 4, or 1 to 3 carbon atoms, e.g., -(C1-3 alkylene)-CN.
  • the term“di(C n-m -alkyl)carbamyl” refers to a group of formula– C(O)N(alkyl) 2 , wherein the two alkyl groups each has, independently, n to m carbon atoms. In some embodiments, each alkyl group independently has 1 to 6, 1 to 4, or 1 to 3 carbon atoms.
  • the heterocycloalkyl is a monocyclic or bicyclic 5-10 membered heterocycloalkyl having 1, 2, 3, or 4 heteroatoms independently selected from N, O, S, and B and having one or more oxidized ring members. In some embodiments, the heterocycloalkyl is a monocyclic or bicyclic 5 to 10 membered heterocycloalkyl having 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S and having one or more oxidized ring members. In some embodiments, the heterocycloalkyl is a monocyclic 5 to 6 membered heterocycloalkyl having 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S and having one or more oxidized ring members.
  • heterocycloalkyl groups include pyrrolidin-2-one, 1,3- isoxazolidin-2-one, pyranyl, tetrahydropyran, oxetanyl, azetidinyl, morpholino,
  • “alkyl linking groups” or“alkylene groups” include methylene, ethan-1,1-diyl, ethan-1,2-diyl, propan-1,3-dilyl, propan-1,2-diyl, propan-1,1-diyl and the like.
  • the term“independently selected from” means that each occurrence of a variable or substituent, e.g., R 2A , are independently selected at each occurrence from the applicable list.
  • An example method includes fractional recrystallizaion using a chiral resolving acid which is an optically active, salt-forming organic acid.
  • Suitable resolving agents for fractional recrystallization methods are, for example, optically active acids, such as the D and L forms of tartaric acid, diacetyltartaric acid, dibenzoyltartaric acid, mandelic acid, malic acid, lactic acid or the various optically active camphorsulfonic acids such as b- camphorsulfonic acid.
  • the compounds provided herein can be prepared using known organic synthesis techniques and can be synthesized according to any of numerous possible synthetic routes, such as those provided in the schemes below.
  • Compounds of formula 3-8 can be prepared via the synthetic route outlined in Scheme 3.
  • a coupling reaction, such as a Mitsunobu reaction, between 3-2 and alcohol 1-2 can then be carried out under suitable conditions (such as using DEAD and Ph 3 P) to generate intermediate 3-3.
  • a nucleophilic aromatic substitution (S N Ar) reaction of 3-3 with amine 1-4 (PG is a suitable protecting group, such as 2,4- dimethoxybenzyl) affords compound 3-4.
  • the compounds or salts described herein can be selective. By“selective,” it is meant that the compound binds to or inhibits an adenosine receptor with greater affinity or potency, respectively, compared to at least one other receptor, kinase, etc.
  • the compounds of the present disclosure can also be dual antagonists (i.e., inhibitors) of adenosine receptors, e.g., A2A and A2B adenosine receptors.
  • Adenosine receptor inhibitors can be used to treat, alone or in combination with other therapies, bladder cancer, lung cancer (e.g., non-small cell lung cancer (NSCLC), lung metastasis), melanoma (e.g., metastatic melanoma), breast cancer, cervical cancer, ovarian cancer, colorectal cancer, pancreatic cancer, esophageal cancer, prostate cancer, kidney cancer, skin cancer, thyroid cancer, liver cancer, uterine cancer, head and neck cancer, and renal cell carcinoma (Antonioli, L.
  • NSCLC non-small cell lung cancer
  • melanoma e.g., metastatic melanoma
  • breast cancer cervical cancer
  • ovarian cancer colorectal cancer
  • pancreatic cancer esophageal cancer
  • prostate cancer kidney cancer
  • skin cancer thyroid cancer
  • liver cancer uterine cancer
  • head and neck cancer and renal cell carcinoma
  • MDSC myeloid-derived suppressor cells
  • myeloid lineage a family of cells that originate from bone marrow stem cells.
  • MDSCs strongly expand in pathological situations such as chronic infections and cancer, as a result of an altered haematopoiesis.
  • MDSCs are discriminated from other myeloid cell types in which they possess strong immunosuppressive activities rather than immunostimulatory properties. Similar to other myeloid cells, MDSCs interact with other immune cell types including T cells, dendritic cells, macrophages and natural killer cells to regulate their functions.
  • the compounds, etc. described herein can be used in methods realted to cancer tissue (e.g., tumors) with high infiltration of MDSCs, including Solid tumors with high basal level of macrophage and/or MDSC infiltration.
  • therapeutically effective amount refers to the amount of active compound or pharmaceutical agent that elicits the biological or medicinal response in a tissue, system, animal, individual or human that is being sought by a researcher, veterinarian, medical doctor or other clinician.
  • the inhibitor of an immune checkpoint molecule is an inhibitor of CD20, e.g., an anti-CD20 antibody.
  • the anti-CD20 antibody is obinutuzumab or rituximab.
  • Example suitable Flt-3 inhibitors include midostaurin, lestaurtinib, linifanib, sunitinib, sunitinib, maleate, sorafenib, quizartinib, crenolanib, pacritinib, tandutinib, PLX3397 and ASP2215, and their pharmaceutically acceptable salts.
  • Other example suitable Flt-3 inhibitors include compounds, and their pharmaceutically acceptable salts, as disclosed in WO 03/037347, WO 03/099771, and WO 04/046120.
  • Example suitable RAF inhibitors include dabrafenib, sorafenib, and vemurafenib, and their pharmaceutically acceptable salts.
  • Other example suitable RAF inhibitors include compounds, and their pharmaceutically acceptable salts, as disclosed in WO 00/09495 and WO 05/028444.
  • the compounds of the disclosure can be used in combination with a chemotherapeutic in the treatment of cancer, and may improve the treatment response as compared to the response to the chemotherapeutic agent alone, without exacerbation of its toxic effects.
  • the compounds of the disclosure can be used in combination with a chemotherapeutic provided herein. For example, additional
  • Pathogenic bacteria causing infections treatable by methods of the disclosure include, but are not limited to, chlamydia, rickettsial bacteria, mycobacteria, staphylococci, streptococci, pneumonococci, meningococci and conococci, klebsiella, proteus, serratia, pseudomonas, legionella, diphtheria, salmonella, bacilli, cholera, tetanus, botulism, anthrax, plague, leptospirosis, and Lyme's disease bacteria.
  • compositions can be in the form of tablets, pills, powders, lozenges, sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols (as a solid or in a liquid medium), ointments containing, for example, up to 10% by weight of the active compound, soft and hard gelatin capsules, suppositories, sterile injectable solutions, and sterile packaged powders.
  • the principal active ingredient is mixed with a pharmaceutical excipient to form a solid preformulation composition containing a homogeneous mixture of a compound of the present disclosure.
  • a solid preformulation composition containing a homogeneous mixture of a compound of the present disclosure.
  • the active ingredient is typically dispersed evenly throughout the composition so that the composition can be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules.
  • the therapeutic dosage of a compound of the present disclosure can vary according to, for example, the particular use for which the treatment is made, the manner of
  • a compound of the disclosure in a pharmaceutical composition can vary depending upon a number of factors including dosage, chemical characteristics (e.g., hydrophobicity), and the route of administration.
  • the compounds of the disclosure can be provided in an aqueous physiological buffer solution containing about 0.1 to about 10% w/v of the compound for parenteral administration.
  • Some typical dose ranges are from about 1 ⁇ g/kg to about 1 g/kg of body weight per day. In some embodiments, the dose range is from about 0.01 mg/kg to about 100 mg/kg of body weight per day.
  • Radiopharm.2015, 58, 308-312) substitution at one or more metabolism sites may afford one or more of the therapeutic advantages.
  • the radionuclide that is incorporated in the instant radio-labeled compounds will depend on the specific application of that radio-labeled compound. For example, for in vitro adenosine receptor labeling and competition assays, compounds that incorporate 3 H, 14 C, 82 Br, 125 I, 131 I or 35 S can be useful. For radio-imaging applications 11 C, 18 F, 125 I, 123 I, 124 I, 131 I, 75 Br, 76 Br or 77 Br can be useful.
  • [3H] 8-cyclopentyl-1,3-dipropylxanthine (Perkin Elmer NET974001MC) is diluted in assay buffer + 22% DMSO to 24.2 nM, and then further diluted to 1 nM by addition to the diluted membranes.545 ml of the membrane and ligand mix is added to the assay wells and incubated on a shaker at room temperature for 1 hour.

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PCT/US2020/015294 2019-01-29 2020-01-28 Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors Ceased WO2020159905A1 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
SG11202108180VA SG11202108180VA (en) 2019-01-29 2020-01-28 Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors
AU2020215673A AU2020215673B2 (en) 2019-01-29 2020-01-28 Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors
FIEP20709807.0T FI3917925T3 (fi) 2019-01-29 2020-01-28 Pyratsolopyridiinejä ja triatsolopyridiinejä a2a-/a2b-estäjinä
EP20709807.0A EP3917925B1 (en) 2019-01-29 2020-01-28 Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors
BR112021014865-5A BR112021014865A2 (pt) 2019-01-29 2020-01-28 Pirazolopiridinas e triazolopiridinas como inibidores de a2a/a2b
ES20709807T ES2984519T3 (es) 2019-01-29 2020-01-28 Pirazolopiridinas y triazolopiridinas como inhibidores de A2A / A2B
CA3127939A CA3127939A1 (en) 2019-01-29 2020-01-28 Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors
PE2021001245A PE20212071A1 (es) 2019-01-29 2020-01-28 Pirazolopiridinas y triazolopiridinas como inhibidores de a2a / a2b
RS20240533A RS65495B1 (sr) 2019-01-29 2020-01-28 Pirazolopiridini i triazolopirdini kao inhibitori a2a / a2b
CR20210456A CR20210456A (es) 2019-01-29 2020-01-28 Pirazolopiridinas y triazolopiridinas como inhibidores de a2a / a2b
EA202192093A EA202192093A1 (ru) 2019-01-29 2020-01-28 Пиразолопиридины и триазолопиридины в качестве ингибиторов a2а/a2b
MX2021009117A MX2021009117A (es) 2019-01-29 2020-01-28 Pirazolopiridinas y triazolopiridinas como inhibidores receptores de adenosina a2a / a2b.
KR1020217027429A KR102854890B1 (ko) 2019-01-29 2020-01-28 A2a/a2b 저해제로서의 피라졸로피리딘 및 트라이아졸로피리딘
IL285127A IL285127B2 (en) 2019-01-29 2020-01-28 Pyrazolopyridines and triazolopyridines as A2A/A2B inhibitors
JP2021544217A JP7447128B2 (ja) 2019-01-29 2020-01-28 Ａ２ａ／ａ２ｂ阻害剤としてのピラゾロピリジン及びトリアゾロピリジン
PL20709807.0T PL3917925T3 (pl) 2019-01-29 2020-01-28 Pirazolopirydyny i triazolopirydyny jako inhibitory a2a/a2b
CN202080021651.2A CN113906022B (zh) 2019-01-29 2020-01-28 作为a2a/a2b抑制剂的吡唑并吡啶和三唑并吡啶
HRP20240491TT HRP20240491T1 (hr) 2019-01-29 2020-01-28 Pirazolopiridini i triazolopiridini kao a2a/a2b inhibitori
SM20240170T SMT202400170T1 (it) 2019-01-29 2020-01-28 Pirazolopiridine e triazolopiridine come inibitori di a2a/a2b
LTEPPCT/US2020/015294T LT3917925T (lt) 2019-01-29 2020-01-28 Pirazolopiridinai ir triazolopiridinai kaip a2a / a2b inhibitoriai
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SI202030433T SI3917925T1 (sl) 2019-01-29 2020-01-28 Pirazolopiridini in triazolopiridini kot zaviralci a2a/a2b
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