HRP20231157T1 - Azolopirimidin za liječenje poremećaja povezanih s rakom - Google Patents
Azolopirimidin za liječenje poremećaja povezanih s rakom Download PDFInfo
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- HRP20231157T1 HRP20231157T1 HRP20231157TT HRP20231157T HRP20231157T1 HR P20231157 T1 HRP20231157 T1 HR P20231157T1 HR P20231157T T HRP20231157T T HR P20231157TT HR P20231157 T HRP20231157 T HR P20231157T HR P20231157 T1 HRP20231157 T1 HR P20231157T1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 15
- 206010028980 Neoplasm Diseases 0.000 title claims 5
- 201000011510 cancer Diseases 0.000 title claims 5
- KCTZOTUQSGYWLV-UHFFFAOYSA-N N1C=NC=C2N=CC=C21 Chemical compound N1C=NC=C2N=CC=C21 KCTZOTUQSGYWLV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 33
- 239000002246 antineoplastic agent Substances 0.000 claims 16
- 229940127089 cytotoxic agent Drugs 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 15
- 229940124597 therapeutic agent Drugs 0.000 claims 15
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 14
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 14
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 14
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 11
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 10
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 10
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 8
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 8
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052805 deuterium Inorganic materials 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- -1 -O-phenyl Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000005345 deuteroalkyl group Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 230000001404 mediated effect Effects 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
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- 101150051188 Adora2a gene Proteins 0.000 claims 4
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- 229940045799 anthracyclines and related substance Drugs 0.000 claims 4
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 4
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- 239000003446 ligand Substances 0.000 claims 4
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- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 4
- 229960002621 pembrolizumab Drugs 0.000 claims 4
- 229910052697 platinum Inorganic materials 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
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- 229950002916 avelumab Drugs 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- MPVDXIMFBOLMNW-UHFFFAOYSA-N chembl1615565 Chemical compound OC1=CC=C2C=C(S(O)(=O)=O)C=C(S(O)(=O)=O)C2=C1N=NC1=CC=CC=C1 MPVDXIMFBOLMNW-UHFFFAOYSA-N 0.000 claims 2
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Classifications
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- C07—ORGANIC CHEMISTRY
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- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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| CN107759690A (zh) | 2012-08-31 | 2018-03-06 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| CN103664908A (zh) * | 2013-12-10 | 2014-03-26 | 苏州大学 | 一种具有腺苷受体拮抗活性的氨基嘧啶杂环化合物 |
| WO2017088755A1 (en) * | 2015-11-23 | 2017-06-01 | Suzhou Yunxuan Yiyao Keji Youxian Gongsi | Aminopyrimidine heterocyclic compound with adenosine receptor antagonistic activity |
| NZ754731A (en) | 2017-01-20 | 2023-02-24 | Arcus Biosciences Inc | Azolopyrimidine for the treatment of cancer-related disorders |
| US20200055883A1 (en) | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
| JOP20180029A1 (ar) | 2017-03-30 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب حلقي غير متجانس |
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| MA48994A (fr) | 2017-03-30 | 2020-02-05 | Hoffmann La Roche | Isoquinoléines utilisées en tant qu'inhibiteurs de hpk1 |
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