MX2019008593A - Azolopirimidina para el tratamiento de trastornos relacionados con el cancer. - Google Patents
Azolopirimidina para el tratamiento de trastornos relacionados con el cancer.Info
- Publication number
- MX2019008593A MX2019008593A MX2019008593A MX2019008593A MX2019008593A MX 2019008593 A MX2019008593 A MX 2019008593A MX 2019008593 A MX2019008593 A MX 2019008593A MX 2019008593 A MX2019008593 A MX 2019008593A MX 2019008593 A MX2019008593 A MX 2019008593A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- related disorders
- cancer
- compound
- azolopyrimidine
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- KCTZOTUQSGYWLV-UHFFFAOYSA-N N1C=NC=C2N=CC=C21 Chemical compound N1C=NC=C2N=CC=C21 KCTZOTUQSGYWLV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 2
- 102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
- 102000007470 Adenosine A2B Receptor Human genes 0.000 abstract 1
- 108010085273 Adenosine A2B receptor Proteins 0.000 abstract 1
- 101150051188 Adora2a gene Proteins 0.000 abstract 1
- 101150078577 Adora2b gene Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen en el presente documento un compuesto que es un inhibidor de al menos uno de los receptores de adenosina A2A y A2B, y las composiciones que contienen el compuesto y los métodos para sintetizar el compuesto. El uso de dicho compuesto y composiciones para el tratamiento de una amplia gama de enfermedades, trastornos y afecciones, incluidos los trastornos relacionados con el cáncer y el sistema inmunitario, que se encuentran mediados, al menos en parte, por el receptor A2A de adenosina y/o el receptor A2B de adenosina.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762448608P | 2017-01-20 | 2017-01-20 | |
| US201762479005P | 2017-03-30 | 2017-03-30 | |
| PCT/US2018/014352 WO2018136700A1 (en) | 2017-01-20 | 2018-01-19 | Azolopyrimidine for the treatment of cancer-related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019008593A true MX2019008593A (es) | 2019-11-21 |
Family
ID=62908757
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019008593A MX2019008593A (es) | 2017-01-20 | 2018-01-19 | Azolopirimidina para el tratamiento de trastornos relacionados con el cancer. |
| MX2022001360A MX2022001360A (es) | 2017-01-20 | 2019-07-18 | Azolopirimidina para el tratamiento de trastornos relacionados con el cancer. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022001360A MX2022001360A (es) | 2017-01-20 | 2019-07-18 | Azolopirimidina para el tratamiento de trastornos relacionados con el cancer. |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10399962B2 (es) |
| EP (2) | EP4310082A3 (es) |
| JP (4) | JP6697091B2 (es) |
| KR (1) | KR102611446B1 (es) |
| CN (2) | CN116768859A (es) |
| AU (3) | AU2018210272C1 (es) |
| BR (1) | BR112019014193A2 (es) |
| CA (1) | CA3047600A1 (es) |
| CL (1) | CL2019002003A1 (es) |
| DK (1) | DK3570844T3 (es) |
| ES (1) | ES2971271T3 (es) |
| FI (1) | FI3570844T3 (es) |
| HR (1) | HRP20231157T1 (es) |
| HU (1) | HUE064141T2 (es) |
| IL (2) | IL267924B (es) |
| LT (1) | LT3570844T (es) |
| MX (2) | MX2019008593A (es) |
| NZ (1) | NZ754731A (es) |
| PH (1) | PH12019501671A1 (es) |
| PL (1) | PL3570844T3 (es) |
| PT (1) | PT3570844T (es) |
| SG (1) | SG11201905812WA (es) |
| SI (1) | SI3570844T1 (es) |
| TW (2) | TWI781136B (es) |
| UA (1) | UA126863C2 (es) |
| UY (1) | UY37574A (es) |
| WO (1) | WO2018136700A1 (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3570844T3 (pl) | 2017-01-20 | 2024-02-26 | Arcus Biosciences, Inc. | Azolopirymidyna do leczenia zaburzeń związanych z nowotworami |
| LT3601296T (lt) | 2017-03-30 | 2022-09-26 | iTeos Belgium SA | 2-okso-tiazolo derivatai kaip a2a inhibitoriai ir junginiai, skirti naudoti gydant vėžį |
| RU2019133646A (ru) | 2017-03-30 | 2021-04-30 | Ф. Хоффманн-Ля Рош Аг | Изохинолины в качестве ингибиторов hpk1 |
| ES2951809T3 (es) | 2017-05-17 | 2023-10-25 | Arcus Biosciences Inc | Derivados de quinazolina-pirazol para el tratamiento de trastornos relacionados con el cáncer |
| SG11202000431PA (en) | 2017-07-18 | 2020-02-27 | Nuvation Bio Inc | 1,8-naphthyridinone compounds and uses thereof |
| SG11202000418XA (en) | 2017-07-18 | 2020-02-27 | Nuvation Bio Inc | Heterocyclic compounds as adenosine antagonists |
| CA3090922A1 (en) | 2018-02-16 | 2019-08-22 | Arcus Biosciences, Inc. | Dosing with an azolopyrimidine compound |
| EP3823614A4 (en) * | 2018-07-18 | 2022-03-30 | Arcus Biosciences, Inc. | SOLID FORMS OF AN AZOLOPYRIMIDINE COMPOUND |
| WO2020023846A1 (en) | 2018-07-27 | 2020-01-30 | Arcus Biosciences, Inc. | Pyridone a2r antagonists |
| US11376255B2 (en) | 2018-09-11 | 2022-07-05 | iTeos Belgium SA | Thiocarbamate derivatives as A2A inhibitors, pharmaceutical composition thereof and combinations with anticancer agents |
| TWI820209B (zh) * | 2018-09-12 | 2023-11-01 | 大陸商迪哲（江蘇）醫藥股份有限公司 | 三唑并－嘧啶化合物及其用途 |
| BE1026612B1 (fr) | 2018-09-27 | 2020-07-02 | Iteos Therapeutics S A | Utilisation d’un inhibiteur d’un transporteur de la famille ent dans le traitement du cancer et combinaison de celui-ci avec un antagoniste de recepteur de l’adenosine |
| JP2022503879A (ja) | 2018-09-27 | 2022-01-12 | アイテオ ベルギウム エスエー | がん治療におけるｅｎｔファミリートランスポーター阻害剤の使用及びそのアデノシン受容体アンタゴニストとの組み合わせ |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
| MX2021006329A (es) | 2018-11-30 | 2021-08-11 | Merck Sharp & Dohme Llc | Derivados de amino triazolo quinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmaceuticas y su uso. |
| EP3911324A4 (en) | 2019-01-18 | 2022-08-17 | Nuvation Bio Inc. | 1,8-NAPHTHYRIDINONE COMPOUNDS AND THEIR USES |
| CA3126702A1 (en) | 2019-01-18 | 2020-07-23 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
| TW202045493A (zh) * | 2019-02-02 | 2020-12-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | ２－胺基嘧啶類衍生物、其製備方法及其在醫藥上的應用 |
| JP2022524559A (ja) * | 2019-03-12 | 2022-05-06 | アーカス バイオサイエンシーズ，インコーポレーテッド | がん遺伝子によって促進されるがんの処置 |
| KR20210144821A (ko) * | 2019-03-29 | 2021-11-30 | 아르커스 바이오사이언시즈 인코포레이티드 | 규명된 아데노신 지문을 이용한 암의 치료방법 |
| JP2022534561A (ja) * | 2019-06-06 | 2022-08-02 | アーカス バイオサイエンシズ インコーポレイティド | アミノピリミジン化合物の調製方法 |
| KR102443873B1 (ko) * | 2019-09-06 | 2022-09-19 | 비욘드바이오주식회사 | 피리미딘일 바이피리딘 화합물의 제조방법 및 그를 위한 중간체 |
| CN113121502A (zh) * | 2019-12-31 | 2021-07-16 | 山东铂源生物医药有限公司 | 一种杂芳烃类化合物、中间体、组合物及应用 |
| EP4110784A1 (en) | 2020-02-26 | 2023-01-04 | iTeos Belgium SA | Pyrimido[5,4-d]pyrimidine derivatives as ent inhibitors for the treatment of cancers, and combination thereof with adenosine receptor antagonists |
| EP4122927A1 (en) * | 2020-03-16 | 2023-01-25 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Substituted pyrimidine or pyridine amine derivative, composition thereof, and medical use thereof |
| AU2021240068A1 (en) | 2020-03-19 | 2022-09-08 | Arcus Biosciences, Inc. | Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha |
| CN113429410B (zh) * | 2020-03-23 | 2022-10-04 | 上海海雁医药科技有限公司 | 多杂环取代的嘧啶或吡啶胺衍生物、其组合物及医药上的用途 |
| AU2021242143A1 (en) * | 2020-03-27 | 2022-10-20 | Dong-A St Co., Ltd. | Aminopyrimidine derivatives and their use as Aryl hydrocarbon receptor modulators |
| WO2021204626A1 (en) | 2020-04-06 | 2021-10-14 | Almirall, S.A. | Aryl and heteroaryl-carboxamide substituted heteroaryl compounds as tyk2 inhibitors |
| WO2021204896A1 (en) | 2020-04-07 | 2021-10-14 | iTeos Belgium SA | Macrocyclic diamine derivatives as ent inhibitors for the treatment of cancers, and combination thereof with adenosine receptor antagonists |
| AR122493A1 (es) | 2020-06-02 | 2022-09-14 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
| JP2023530456A (ja) | 2020-06-17 | 2023-07-18 | アーカス バイオサイエンシズ インコーポレイティド | Ｃｄ７３阻害剤の結晶形態及びその使用 |
| CN112812095A (zh) * | 2021-01-29 | 2021-05-18 | 成都安满生物医药科技有限公司 | 一种巴洛沙韦酯中间体的合成方法 |
| TW202245774A (zh) * | 2021-02-05 | 2022-12-01 | 大陸商上海齊魯製藥研究中心有限公司 | 嘧啶或吡啶並雜環類腺苷受體抑制劑及其製備方法和用途 |
| EP4294948A1 (en) | 2021-02-17 | 2023-12-27 | iTeos Belgium SA | Compounds, compositions and methods of treatment thereof |
| KR102646627B1 (ko) * | 2021-03-24 | 2024-03-13 | 주식회사 스탠다임 | 아데노신 a2a 수용체 및 아데노신 a2b 수용체의 이중 길항제, 및 이의 용도 |
| WO2022236256A1 (en) * | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| CN117295741A (zh) | 2021-05-21 | 2023-12-26 | 艾库斯生物科学有限公司 | Axl化合物 |
| JP2024521712A (ja) | 2021-05-21 | 2024-06-04 | アーカス バイオサイエンシーズ，インコーポレーテッド | Ａｘｌ阻害化合物 |
| CN117794913A (zh) * | 2021-09-15 | 2024-03-29 | 上海海雁医药科技有限公司 | 嘧啶衍生物及其药学上可接受的盐的多晶型物和应用 |
| CN117915919A (zh) * | 2021-09-15 | 2024-04-19 | 上海海雁医药科技有限公司 | 氮杂芳环类化合物及其药学上可接受的盐的多晶型物、药物组合物和应用 |
| IL312348A (en) | 2021-10-29 | 2024-06-01 | Arcus Biosciences Inc | HIF-2ALPHA inhibitors and methods of using it |
| WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| WO2023215719A1 (en) | 2022-05-02 | 2023-11-09 | Arcus Biosciences, Inc. | Anti-tigit antibodies and uses of the same |
| CN114907273A (zh) * | 2022-06-09 | 2022-08-16 | 乐威医药（江苏）股份有限公司 | 2-氨基嘧啶-6-芳基化合物的制备方法 |
| WO2024015251A1 (en) | 2022-07-15 | 2024-01-18 | Arcus Biosciences, Inc. | Inhibitors of hpk1 and methods of use thereof |
| WO2024020034A1 (en) | 2022-07-20 | 2024-01-25 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| WO2024059142A1 (en) | 2022-09-14 | 2024-03-21 | Arcus Biosciences, Inc. | Dispersions of etrumadenant |
| WO2024081385A1 (en) | 2022-10-14 | 2024-04-18 | Arcus Biosciences, Inc. | Hpk1 inhibitors and methods of use thereof |
| US20240180947A1 (en) | 2022-10-20 | 2024-06-06 | Arcus Biosciences, Inc. | Lyophilized formulations of cd73 compounds |
| WO2024097736A1 (en) | 2022-11-02 | 2024-05-10 | Arcus Biosciences, Inc. | Processes for preparing azolopyrimidine compounds |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5952294A (en) | 1996-07-31 | 1999-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peptidyl prodrugs and methods of making and using the same |
| AU2002314773B2 (en) | 2001-05-09 | 2008-05-01 | Celmed Oncology (Usa), Inc. | Peptide deformylase activated prodrugs |
| TWI330183B (es) * | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| EA010568B1 (ru) * | 2003-12-15 | 2008-10-30 | Ньюрокрайн Байосайнсиз Инк. | 2,6-бисгетероарил-4-аминопиримидины в качестве антагонистов аденозиновых рецепторов |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| PT2343320T (pt) | 2005-03-25 | 2018-01-23 | Gitr Inc | Anticorpos anti-gitr e as suas utilizações |
| KR101607288B1 (ko) | 2005-07-01 | 2016-04-05 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| WO2008005457A2 (en) | 2006-06-30 | 2008-01-10 | Sunesis Pharmaceuticals | Pyridinonyl pdk1 inhibitors |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| AU2008275589B2 (en) | 2007-07-12 | 2013-11-21 | Gitr, Inc. | Combination therapies employing GITR binding molecules |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| JP2011511778A (ja) | 2008-01-30 | 2011-04-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | エステルに基づいたペプチドプロドラッグ |
| GB0906579D0 (en) | 2009-04-16 | 2009-05-20 | Vernalis R&D Ltd | Pharmaceuticals, compositions and methods of making and using the same |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| ES2548141T3 (es) * | 2008-11-20 | 2015-10-14 | Glaxosmithkline Llc | Compuestos químicos |
| EP3929216A1 (en) | 2008-12-09 | 2021-12-29 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| BR112012004823B1 (pt) | 2009-09-03 | 2021-11-30 | Merck Sharp & Dohme Corp | Anticorpo ou fragmento de ligação de antígeno do mesmo, uso de um anticorpo ou um fragmento de ligação de antígeno do mesmo, e composição farmacêutica |
| RS54596B1 (en) | 2009-12-10 | 2016-08-31 | F. Hoffmann-La Roche Ag | Antibodies Binding to Extracellular Domain 4 of Human CSF1R and Their Use |
| BR112012022210B1 (pt) | 2010-03-04 | 2021-08-17 | Macrogenics, Inc | Anticorpo isolado ou seu fragmento imunorreativo, molécula de ácido nucleico, composição farmacêutica, e, uso do anticorpo isolado |
| KR101647871B1 (ko) | 2010-03-05 | 2016-08-11 | 에프. 호프만-라 로슈 아게 | 인간 ｃｓｆ-1ｒ에 대한 항체 및 이의 용도 |
| MX2012010014A (es) | 2010-03-05 | 2012-09-21 | Hoffmann La Roche | Anticuerpos contra csf-1r humano y sus usos. |
| TR201900368T4 (tr) | 2010-05-04 | 2019-02-21 | Five Prime Therapeutics Inc | Csf1r'ye bağlanan antikorlar. |
| MY177065A (en) | 2010-09-09 | 2020-09-03 | Pfizer | 4-1bb binding molecules |
| DE102011008352A1 (de) * | 2011-01-12 | 2012-07-12 | Merck Patent Gmbh | 5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate |
| JP6072771B2 (ja) | 2011-04-20 | 2017-02-01 | メディミューン，エルエルシー | Ｂ７−ｈ１およびｐｄ−１に結合する抗体およびその他の分子 |
| PT2785375T (pt) | 2011-11-28 | 2020-10-29 | Merck Patent Gmbh | Anticorpos anti-pd-l1 e usos destes |
| MX356337B (es) | 2011-12-15 | 2018-05-23 | Hoffmann La Roche | Anticuerpos contra csf-1r humano y sus usos. |
| KR20140127855A (ko) | 2012-02-06 | 2014-11-04 | 제넨테크, 인크. | Csf1r 억제제를 사용하는 조성물 및 방법 |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| US20130269017A1 (en) * | 2012-04-04 | 2013-10-10 | Salesforce.Com, Inc. | Centralized single sign on service for websites and online services |
| BR112014028013A2 (pt) | 2012-05-11 | 2018-02-27 | Five Prime Therapeutics Inc | métodos para tratar uma condição associada com artrite reumatoide, artrite reumatoide, lesões de pele, nefrite lúpica, lúpus, uma condição inflamatória, distúrbio de cd16+, método para reduzir o número de monócitos cd16+, métodos para desacelerar a progressão de uma condição renal,de formação de panos e de perda óssea |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| SG11201501413YA (en) | 2012-08-31 | 2015-03-30 | Five Prime Therapeutics Inc | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| CN103664908A (zh) * | 2013-12-10 | 2014-03-26 | 苏州大学 | 一种具有腺苷受体拮抗活性的氨基嘧啶杂环化合物 |
| WO2017088755A1 (en) * | 2015-11-23 | 2017-06-01 | Suzhou Yunxuan Yiyao Keji Youxian Gongsi | Aminopyrimidine heterocyclic compound with adenosine receptor antagonistic activity |
| PL3570844T3 (pl) | 2017-01-20 | 2024-02-26 | Arcus Biosciences, Inc. | Azolopirymidyna do leczenia zaburzeń związanych z nowotworami |
| US20200055883A1 (en) | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
| RU2019133646A (ru) | 2017-03-30 | 2021-04-30 | Ф. Хоффманн-Ля Рош Аг | Изохинолины в качестве ингибиторов hpk1 |
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| JOP20180029A1 (ar) | 2017-03-30 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب حلقي غير متجانس |
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