HRP20220748T1 - Anti-vista antitijela i fragmenti - Google Patents
Anti-vista antitijela i fragmenti Download PDFInfo
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- HRP20220748T1 HRP20220748T1 HRP20220748TT HRP20220748T HRP20220748T1 HR P20220748 T1 HRP20220748 T1 HR P20220748T1 HR P20220748T T HRP20220748T T HR P20220748TT HR P20220748 T HRP20220748 T HR P20220748T HR P20220748 T1 HRP20220748 T1 HR P20220748T1
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- Prior art keywords
- antibody
- seq
- antibody fragment
- chain polypeptide
- heavy chain
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- 239000012634 fragment Substances 0.000 title 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 23
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 23
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 210000000066 myeloid cell Anatomy 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000006404 Large Granular Lymphocytic Leukemia Diseases 0.000 claims 1
- 206010023791 Large granular lymphocytosis Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000033759 Prolymphocytic T-Cell Leukemia Diseases 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 201000008717 T-cell large granular lymphocyte leukemia Diseases 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000026651 T-cell prolymphocytic leukemia Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000033581 fucosylation Effects 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
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- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- A—HUMAN NECESSITIES
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Claims (14)
1. Izolirano antitijelo ili njegov fragment antitijela koji se veže za V-domenu Ig supresora aktivacije T stanica (VISTA), gdje spomenuto antitijelo ili njegov fragment antitijela sadrži varijabilni polipeptid teškog lanca SEQ ID NO: 37 i varijabilni polipeptid lakog lanca SEQ ID NO: 44.
2. Antitijelo ili fragment antitijela prema zahtjevu 1, koji dalje sadrži:
(a) humanu konstantnu regiju teškog lanca, koja je opcionalno humana konstantna regija IgG1; i/ili
(b) humanu konstantnu regiju lakog lanca, koja je opcionalno humana konstantna regija kapa lakog lanca.
3. Antitijelo ili fragment antitijela prema zahtjevu 2, gdje spomenuta humana konstantna regija teškog lanca sadrži humanu konstantnu regiju teškog lanca IgG1 koja je modificirana da poveća otpornost na proteazu antitijela ili fragmenta antitijela.
4. Antitijelo ili fragment antitijela prema zahtjevu 1, koji sadrži barem jedan teški lanac i barem jedan laki lanac.
5. Antitijelo ili fragment antitijela prema zahtjevu 1, koji sadrži:
(a) polipeptid teškog lanca SEQ ID NO: 60 ili 61; i
(b) polipeptid lakog lanca SEQ ID NO: 56.
6. Antitijelo ili fragment antitijela prema zahtjevu 1, koji sadrži:
(a) polipeptid teškog lanca SEQ ID NO: 55 ili 59; i
(b) polipeptid lakog lanca SEQ ID NO: 56.
7. Antitijelo ili fragment antitijela prema zahtjevu 1, koji je cijelo IgG antitijelo, gdje:
(i) polipeptid teškog lanca koji se sastoji iz SEQ ID NO: 55 i polipeptid lakog lanca koji se sastoji iz SEQ ID NO: 56; (VSTB112);
(ii) polipeptid teškog lanca koji se sastoji iz SEQ ID NO: 59 i polipeptid lakog lanca koji se sastoji iz SEQ ID NO: 56; (VSTB140);
(iii) polipeptid teškog lanca koji se sastoji iz SEQ ID NO: 60 i polipeptid lakog lanca koji se sastoji iz SEQ ID NO: 56; (VSTB149); ili
(iv) polipeptid teškog lanca koji se sastoji iz SEQ ID NO: 61 i polipeptid lakog lanca koji se sastoji iz SEQ ID NO: 56 (VSTB174).
8. Antitijelo ili fragment antitijela prema bilo kojem od zahtjeva 1-7, pri čemu je antitijelo ili fragment antitijela eksprimiran u stanici koja ima nedostatak enzima fukozilacije, opcionalno gdje je stanica stanica jajnika kineskog hrčka (CHO).
9. Farmaceutski sastav koji sadrži terapeutski efikasnu količinu antitijela ili fragmenta antitijela prema bilo kojem od zahtjeva 1-8 i farmaceutski prihvatljiv nosač.
10. Nukleinska kiselina koja kodira antitijelo ili fragment antitijela prema bilo kojem od zahtjeva 1-8, opcionalno u ekspresijskom vektoru.
11. Rekombinantna stanica koja sadrži nukleinsku kiselinu prema zahtjevu 10.
12. Postupak za ekspresiju antitijela ili fragmenta antitijela prema bilo kojem od zahtjeva 1-8, koji obuhvaća kultiviranje stanice prema zahtjevu 11 pod uvjetima koji promoviraju ekspresiju spomenutog antitijela ili fragmenta antitijela.
13. Antitijelo ili fragment antitijela prema bilo kojem od zahtjeva 1-8, za upotrebu u liječenju karcinoma, pri čemu tretman sadrži davanje spomenutog antitijela ili fragmenta antitijela subjektu kojemu je to potrebno.
14. Antitijelo ili fragment antitijela za upotrebu prema zahtjevu 13, pri čemu je spomenuti karcinom leukemija, limfom, mijelodisplastični sindrom, mijelom, ili solidni tumor,
opcionalno gdje je solidni tumor karcinom mokraćnog mjehura ili karcinom pluća, opcionalno karcinom nemalih stanica pluća (NSCLC),
dalje opcionalno gdje je solidni tumor okružen s tumorskom stromom koja se sastoji iz mijeloidnih stanica, T-stanica, ili kombinacije mijeloidnih stanica i T-stanica ili je infiltriran s mijeloidnim stanicama, T stanicama ili kombinacijom mijeloidnih stanica i T-stanica,
dalje opcionalno gdje je spomenuta leukemija limfocitna leukemija, mijelogena leukemija, akutna limfoblastna leukemija (ALL), kronična limfocitna leukemija (CLL), akutna mijeloična (mijelogena) leukemija (AML), kronična mijelogena leukemija (CML), leukemija dlakavih stanica, T-stanična prolimfocitna leukemija, velika granularna limfocitna leukemija, ili leukemija T-stanica kod odraslih, i dalje opcionalno gdje je subjektu dalje davano cjepivo i/ili drugi tretman karcinoma.
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EP20159500.6A EP3712174B1 (en) | 2013-12-24 | 2014-12-22 | Anti-vista antibodies and fragments |
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