HRP20201066T1 - Anti-pvrig antitijela i postupci uporabe - Google Patents
Anti-pvrig antitijela i postupci uporabe Download PDFInfo
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- HRP20201066T1 HRP20201066T1 HRP20201066TT HRP20201066T HRP20201066T1 HR P20201066 T1 HRP20201066 T1 HR P20201066T1 HR P20201066T T HRP20201066T T HR P20201066TT HR P20201066 T HRP20201066 T HR P20201066T HR P20201066 T1 HRP20201066 T1 HR P20201066T1
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- Prior art keywords
- cancer
- nucleic acid
- chain variable
- expression vector
- variable domain
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- 238000000034 method Methods 0.000 title claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 239000013604 expression vector Substances 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 3
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102100029740 Poliovirus receptor Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000014828 interferon-gamma production Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 108010048507 poliovirus receptor Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 201000008261 skin carcinoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000002381 testicular Effects 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
Claims (18)
1. Anti-PVRIG (poliovirusni receptor povezan imunoglobulinskom domenom koji sadrži protein) antitijelo koje sadrži
i) varijabilnu domenu teškog lanca SEQ ID NO: 1434 i
ii) varijabilnu domenu lakog lanca SEQ ID NO: 1453, za uporabu u liječenju raka aktiviranjem T-stanica kod pacijenta.
2. Anti-PVRIG antitijelo koje sadrži:
i) varijabilnu domenu teškog lanca SEQ ID NO: 1447 i
ii) varijabilnu domenu lakog lanca SEQ ID NO: 1462,
za uporabu u liječenju raka aktiviranjem T-stanica kod pacijenta.
3. Anti-PVRIG antitijelo za uporabu prema zahtjevu 1 ili 2, naznačeno time što su navedene T-stanice citotoksične T-stanice (CTLs).
4. Anti-PVRIG antitijelo za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačeno time što su navedene T-stanice odabrane iz skupine koja se sastoji od CD4+ T-stanica i CD8+ T-stanica.
5. Anti-PVRIG antitijelo za uporabu prema bilo kojem od zahtjeva 1 do 4, naznačeno time što se navedena aktivacija mjeri kao povećanje proizvodnje interferona-y i / ili povećanje protuupalne sekrecije citokina.
6. Anti-PVRIG antitijelo za uporabu prema bilo kojem od zahtjeva 1 do 5, naznačeno time što je navedeni rak odabran iz skupine koja se sastoji od raka prostate, raka jetre (HCC), kolorektalnog raka, raka jajnika, endometrijskog raka, raka dojke, raka gušterače, raka želuca, raka grlića maternice, raka glave i vrata, raka štitnjače, raka testisa, urotelijalnog raka, raka pluća, melanoma, ne-melanomskog raka kože (raka pločastih i bazalnih stanica), glioma, raka bubrega (RCC), limfoma (NHL ili HL), akutne mijeloidne leukemije (AML), T-stanične akutne limfoblastične leukemije (T-ALL), difuznog limfoma velike B stanice, tumora kiselih stanica testisa, mezotelioma i raka jednjaka.
7. Anti-PVRIG antitijelo koje sadrži:
i) varijabilnu domenu teškog lanca SEQ ID NO: 1434 i
ii) varijabilnu domenu lakog lanca SEQ ID NO: 1453.
8. Pripravak nukleinske kiseline koji sadrži:
a) prvu nukleinsku kiselinu koja kodira varijabilnu domenu teškog lanca SEQ ID NO: 1434; i
b) drugu nukleinsku kiselinu koja kodira varijabilnu domenu lakog lanca SEQ ID NO: 1453.
9. Pripravak vektora ekspresije koji sadrži:
a) prvi vektor ekspresije koji sadrži navedenu prvu nukleinsku kiselinu prema zahtjevu 8; i
b) drugi vektor ekspresije koji sadrži navedenu drugu nukleinsku kiselinu prema zahtjevu 8.
10. Pripravak vektora ekspresije koji sadrži ekspresijski vektor koji sadrži navedenu prvu nukleinsku kiselinu prema zahtjevu 8 i navedenu drugu nukleinsku kiselinu prema zahtjevu 8.
11. Stanica domaćina koja sadrži pripravak vektora ekspresije prema zahtjevu 9 ili 10.
12. Postupak izrade anti-PVRIG antitijela koji sadrži:
a) kultiviranje stanice domaćina prema zahtjevu 11 u uvjetima u kojima je navedeno antitijelo izraženo; i
b) oporavak navedenog antitijela.
13. Anti-PVRIG antitijelo koje sadrži
i) varijabilnu domenu teškog lanca SEQ ID NO: 1447 i
ii) varijabilnu domenu lakog lanca SEQ ID NO: 1462.
14. Pripravak nukleinske kiseline koji sadrži:
a) prvu nukleinsku kiselinu koja kodira varijabilnu domenu teškog lanca SEQ ID NO: 1447; i
b) drugu nukleinsku kiselinu koja kodira varijabilnu domenu lakog lanca SEQ ID NO: 1462.
15. Pripravak vektora ekspresije koji sadrži:
a) prvi vektor ekspresije koji sadrži navedenu prvu nukleinsku kiselinu prema zahtjevu 14; i
b) drugi vektor ekspresije koji sadrži navedenu drugu nukleinsku kiselinu prema zahtjevu 14.
16. Pripravak vektora ekspresije koji sadrži vektor ekspresije koji sadrži navedenu prvu nukleinsku kiselinu prema zahtjevu 14 i navedenu drugu nukleinsku kiselinu prema zahtjevu 14.
17. Stanica domaćina koja sadrži pripravak vektora ekspresije prema zahtjevu 15 ili 16.
18. Postupak izrade anti-PVRIG antitijela koji sadrži:
a) kultiviranje stanice domaćina prema zahtjevu 17 u uvjetima u kojima je navedeno antitijelo izraženo; i
b) oporavak navedenog antitijela.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562118208P | 2015-02-19 | 2015-02-19 | |
US201562141120P | 2015-03-31 | 2015-03-31 | |
US201562235823P | 2015-10-01 | 2015-10-01 | |
EP17192325.3A EP3295951B1 (en) | 2015-02-19 | 2016-02-19 | Anti-pvrig antibodies and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20201066T1 true HRP20201066T1 (hr) | 2021-02-05 |
Family
ID=55453315
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20221284TT HRP20221284T1 (hr) | 2015-02-19 | 2016-02-19 | Anti-pvrig antitijela i postupci uporabe |
HRP20200572TT HRP20200572T1 (hr) | 2015-02-19 | 2020-04-09 | Anti-pvrig antitijela i postupci uporabe |
HRP20201066TT HRP20201066T1 (hr) | 2015-02-19 | 2020-07-07 | Anti-pvrig antitijela i postupci uporabe |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20221284TT HRP20221284T1 (hr) | 2015-02-19 | 2016-02-19 | Anti-pvrig antitijela i postupci uporabe |
HRP20200572TT HRP20200572T1 (hr) | 2015-02-19 | 2020-04-09 | Anti-pvrig antitijela i postupci uporabe |
Country Status (23)
Country | Link |
---|---|
US (7) | US10227408B2 (hr) |
EP (4) | EP3295951B1 (hr) |
JP (2) | JP7115856B2 (hr) |
KR (1) | KR20170137067A (hr) |
CN (2) | CN107580500B (hr) |
AU (2) | AU2016219835B2 (hr) |
CA (1) | CA2976926A1 (hr) |
CY (2) | CY1122970T1 (hr) |
DK (3) | DK3295951T3 (hr) |
ES (3) | ES2929293T3 (hr) |
HK (2) | HK1247568A1 (hr) |
HR (3) | HRP20221284T1 (hr) |
HU (3) | HUE061084T2 (hr) |
IL (2) | IL254039B2 (hr) |
LT (3) | LT3258951T (hr) |
MX (2) | MX2017010667A (hr) |
PL (3) | PL3295951T3 (hr) |
PT (3) | PT3653221T (hr) |
RU (2) | RU2020128686A (hr) |
SG (1) | SG11201706583PA (hr) |
SI (2) | SI3295951T1 (hr) |
WO (1) | WO2016134333A1 (hr) |
ZA (1) | ZA201706323B (hr) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130058957A1 (en) * | 2010-02-23 | 2013-03-07 | The University Of Tokyo | Dendritic cell immunoreceptor agonist |
EP3978929A1 (en) | 2015-02-19 | 2022-04-06 | Compugen Ltd. | Pvrig polypeptides and methods of treatment |
EP3295951B1 (en) | 2015-02-19 | 2020-04-22 | Compugen Ltd. | Anti-pvrig antibodies and methods of use |
US11827904B2 (en) | 2015-04-29 | 2023-11-28 | Fred Hutchinson Cancer Center | Modified stem cells and uses thereof |
WO2016196389A1 (en) * | 2015-05-29 | 2016-12-08 | Bristol-Myers Squibb Company | Treatment of renal cell carcinoma |
US10590198B2 (en) * | 2015-08-28 | 2020-03-17 | Alector Llc | Anti-siglec-7 antibodies and methods of use thereof |
CA2997179A1 (en) * | 2015-09-02 | 2017-03-09 | The Regents Of The Unversity Of Colorado, A Body Corporate | Compositions and methods for modulating t-cell mediated immune response |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
DK3347379T5 (da) | 2016-08-17 | 2020-06-15 | Compugen Ltd | Anti-tigit-antistoffer, anti-pvrig-antistoffer og kombinationer deraf |
EA201990591A1 (ru) | 2016-09-23 | 2019-08-30 | Фред Хатчинсон Кэнсер Рисерч Сентер | Tcr, специфичные к минорному антигену гистосовместимости (h) ha-1, и их применения |
BR112019018863A8 (pt) | 2017-03-15 | 2023-05-02 | Hutchinson Fred Cancer Res | Tcrs de alta afinidade específicos para mage-a1 e usos dos mesmos |
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