HRP20170535T1 - Tehnike za predviđanje, otkrivanje i smanjenje nespecifičnog ometanja proteina u testovima koji uključuju imunoglobulinske jednostruke varijabilne domene - Google Patents
Tehnike za predviđanje, otkrivanje i smanjenje nespecifičnog ometanja proteina u testovima koji uključuju imunoglobulinske jednostruke varijabilne domene Download PDFInfo
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- HRP20170535T1 HRP20170535T1 HRP20170535TT HRP20170535T HRP20170535T1 HR P20170535 T1 HRP20170535 T1 HR P20170535T1 HR P20170535T T HRP20170535T T HR P20170535TT HR P20170535 T HRP20170535 T HR P20170535T HR P20170535 T1 HRP20170535 T1 HR P20170535T1
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- 102000004169 proteins and genes Human genes 0.000 title claims 25
- 108090000623 proteins and genes Proteins 0.000 title claims 25
- 108060003951 Immunoglobulin Proteins 0.000 title claims 2
- 102000018358 immunoglobulin Human genes 0.000 title claims 2
- 238000003556 assay Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims 24
- 235000018102 proteins Nutrition 0.000 claims 24
- 102000007562 Serum Albumin Human genes 0.000 claims 10
- 108010071390 Serum Albumin Proteins 0.000 claims 10
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims 6
- 210000004899 c-terminal region Anatomy 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 241000282412 Homo Species 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 208000017667 Chronic Disease Diseases 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (17)
1. Protein ili polipeptid za uporabu za liječenje, te navedeni protein ili polipeptid sadrži imunoglobulinsku jednostruku varijabilnu domenu (ISV) na njezinom C-terminalnom kraju, pri čemu navedena ISV je bilo VHH, sekvencno optimizirana VHH, humanizirana VHH ili kamelizirana VH, ili je ISV koja sadrži VH sekvencu različitu od VHH, sekvencno optimizirana VHH, humanizirana VHH ili kamelizirana VH ili koja je izvedena iz VH sekvence, koja ISV ima C-terminalni kraj sekvence VTVSS(X)n, gdje:
- n = 1, 2 ili 3 gdje je svaki X = Ala ili Gly; ili
- n = 1, 2 ili 3 gdje je svaki X = Ala; ili
- n = 1, 2 ili 3 gdje je svaki X = Gly; ili
- n = 2 ili 3 gdje je barem jedan X = Ala ili Gly; ili
- n = 2 ili 3 gdje svi osim jednog X = Ala ili Gly,
i koji protein ili polipeptid sadrži vezujući peptid serumskog albumina ili vezujuću domenu serumskog albumina i ima poluvijek izražen kao t1/2-beta kod ljudskog subjekta od barem 3 dana.
2. Protein ili polipeptid za uporabu prema zahtjevu 1, naznačen time da vezujući peptid serumskog albumina ili vezujuća domena serumskog albumina je vezujuća ISV serumskog albumina.
3. Protein ili polipeptid za uporabu prema zahtjevu 1, naznačen time da n = 1 ili n = 2.
4. Protein ili polipeptid za uporabu prema zahtjevu 1, naznačen time da n = 2 ili 3 i barem jedan X = Ala ili Gly ili n = 2 ili 3 i svi osim jednog X = Ala ili Gly, sa preostalim aminokiselinskim ostatkom X koji je neovisno odabran od bilo koje amino kiseline koja se javlja u prirodi.
5. Protein ili polipeptid za uporabu prema zahtjevu 4, naznačen time da je preostali aminokiselinski ostatak X neovisno odabran od Val, Leu i/ili Ile.
6. Protein ili polipeptid za uporabu prema zahtjevu 1, naznačen time da:
- n = 1, 2 ili 3 gdje je svaki X = Ala ili Gly; ili
- n = 1, 2 ili 3 gdje je svaki X = Ala; ili
- n = 1, 2 ili 3 gdje je svaki X = Gly.
7. Protein ili polipeptid za uporabu prema zahtjevu 1, naznačen time da X nije cistein.
8. Protein ili polipeptid za uporabu u terapiji koji navedeni protein ili polipeptid sadrži ISV na njegovom C-terminalnom kraju, naznačen time da je navedena ISV bilo VHH, sekvencno optimizirana VHH, humanizirana VHH ili kamelizirana VH, ili je ISV koja sadrži VH sekvencu različitu od VHH, sekvencno optimiziranu VHH, humaniziranu VHH ili kameliziranu VH ili koja je dobivena iz VH sekvence, koja ISV ima C-terminalni kraj sekvence VTVSS(X)n, u kojoj n je 1 do 5, kao što je 1, 2, 3, 4 ili 5, te u kojoj svaki X je aminokiselinski ostatak koji je neovisno odabran, pod uvjetom da X nije cistein, te koji protein ili polipeptid sadrži vezujući peptid serumskog albumina ili vezujuću domenu serumskog albumina i ima poluvijek izražen kao t1/2-beta kod ljudskog subjekta od barem 3 dana.
9. Protein ili polipeptid za uporabu prema zahtjevu 8, naznačen time da n je 1 ili 2.
10. Protein ili polipeptid za uporabu prema zahtjevu 8 ili 9, naznačen time da svaki X je amino kiselina koja se javlja u prirodi.
11. Protein ili polipeptid za uporabu prema bilo kojem od zahtjeva 8-10, naznačen time da je svaki X odabran iz skupine koju čine alanin (A), glicin (G), valin (V), leucin (L) ili izoleucin (I).
12. Protein ili polipeptid za uporabu prema bilo kojem od zahtjeva 1-11, naznačen time da navedeni C-terminalni kraj ISV je VHH, sekvencno optimizirana VHH, humanizirana VHH ili kamelizirana VH.
13. Protein ili polipeptid za uporabu prema zahtjevu 8, naznačen time da vezujući peptid serumskog albumina ili vezujuća domena serumskog albumina je vezujuća ISV serumskog albumina.
14. Farmaceutski pripravak za uporabu u terapiji, naznačen time da sadrži protein ili polipeptid prema bilo kojem od zahtjeva 1-13, te barem jedan prikladan nosač, razrjeđivač ili pomoćnu tvar.
15. Farmaceutski pripravak za uporabu u terapiji prema patentnom zahtjevu 14, naznačen time da:
- navedeni pripravak, protein ili polipeptid je namijenjen za liječenje kronične bolesti kod čovjeka, i/ili
- navedeni protein, polipeptid je namijenjen da bude prisutan u cirkulaciji subjekta kojemu se on daje tijekom perioda barem od jednog tjedna; i/ili
- navedeni protein, polipeptid je takav da ima poluvijek izražen kao t1/2-beta kod subjekta koji je čovjek od barem 3 dana; i/ili
- navedeni protein, polipeptid ili farmaceutski pripravak je namijenjen da se daje čovjeku kao dvije ili više doza koje se primjenjuju tijekom perioda od barem 3 dana.
16. Farmaceutski pripravak za uporabu u terapiji prema patentnom zahtjevu 15, naznačen time da navedeni protein, polipeptid je namijenjen da bude prisutan u cirkulaciji u farmakološki aktivnim razinama kod subjekta na kojeg se primjenjuje u terapijski aktivnoj dozi barem tijekom perioda od jednog tjedna.
17. Farmaceutski pripravak za uporabu u terapiji prema patentnom zahtjevu 15 ili 16, naznačen time da je navedeni protein, polipeptid ili farmaceutski pripravak namijenjen da se primjenjuje na ljudskom biću kao dvije ili više doza koje su kronično primjenjuju.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500360P | 2011-06-23 | 2011-06-23 | |
| US201161500464P | 2011-06-23 | 2011-06-23 | |
| US201161541368P | 2011-09-30 | 2011-09-30 | |
| PCT/EP2011/067132 WO2012042026A1 (en) | 2010-09-30 | 2011-09-30 | Biological materials related to c-met |
| US13/435,567 US8703135B2 (en) | 2010-09-30 | 2012-03-30 | Biological materials related to c-Met |
| PCT/EP2012/061304 WO2012175400A1 (en) | 2011-06-23 | 2012-06-14 | Serum albumin binding proteins |
| PCT/EP2012/062251 WO2012175741A2 (en) | 2011-06-23 | 2012-06-25 | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP12729968.3A EP2723769B2 (en) | 2011-06-23 | 2012-06-25 | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20170535T1 true HRP20170535T1 (hr) | 2017-06-16 |
| HRP20170535T4 HRP20170535T4 (hr) | 2022-08-19 |
Family
ID=46298413
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170535TT HRP20170535T4 (hr) | 2011-06-23 | 2012-06-25 | Tehnike za predviđanje, otkrivanje i smanjenje nespecifičnog ometanja proteina u testovima koji uključuju imunoglobulinske jednostruke varijabilne domene |
| HRP20192160TT HRP20192160T1 (hr) | 2011-06-23 | 2019-11-29 | Vezujući proteini serumskog albumina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20192160TT HRP20192160T1 (hr) | 2011-06-23 | 2019-11-29 | Vezujući proteini serumskog albumina |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9573992B2 (hr) |
| EP (3) | EP2723771B1 (hr) |
| JP (3) | JP6324887B2 (hr) |
| CN (2) | CN106046168A (hr) |
| AU (1) | AU2012271974B2 (hr) |
| CA (1) | CA2839779C (hr) |
| CY (1) | CY1122691T1 (hr) |
| DK (1) | DK2723771T3 (hr) |
| ES (1) | ES2759936T3 (hr) |
| HR (2) | HRP20170535T4 (hr) |
| HU (1) | HUE047238T2 (hr) |
| IN (1) | IN2014CN00414A (hr) |
| LT (1) | LT2723771T (hr) |
| PL (1) | PL2723771T3 (hr) |
| PT (1) | PT2723771T (hr) |
| SI (1) | SI2723771T1 (hr) |
| WO (1) | WO2012175400A1 (hr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| WO2012175741A2 (en) | 2011-06-23 | 2012-12-27 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2621953B1 (en) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| US9573992B2 (en) * | 2011-06-23 | 2017-02-21 | Ablynx N.V. | Serum albumin binding proteins |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| CA2850261C (en) * | 2011-09-30 | 2021-04-20 | Ablynx Nv | C-met immunoglobulin single variable domains |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| EP3143403B1 (en) | 2014-05-16 | 2021-10-27 | Ablynx N.V. | Methods for detecting and/or measuring anti-drug antibodies, in particular treatment-emergent anti-drug antibodies |
| JP7325928B2 (ja) | 2014-05-16 | 2023-08-15 | アブリンクス エン．ヴェー． | 改善された免疫グロブリン可変ドメイン |
| NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
| WO2016097313A1 (en) | 2014-12-19 | 2016-06-23 | Ablynx N.V. | Cysteine linked nanobody dimers |
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