PT2723771T - Proteínas de ligação à albumina sérica - Google Patents
Proteínas de ligação à albumina séricaInfo
- Publication number
- PT2723771T PT2723771T PT127276582T PT12727658T PT2723771T PT 2723771 T PT2723771 T PT 2723771T PT 127276582 T PT127276582 T PT 127276582T PT 12727658 T PT12727658 T PT 12727658T PT 2723771 T PT2723771 T PT 2723771T
- Authority
- PT
- Portugal
- Prior art keywords
- serum albumin
- binding proteins
- albumin binding
- proteins
- serum
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500464P | 2011-06-23 | 2011-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2723771T true PT2723771T (pt) | 2019-12-11 |
Family
ID=46298413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127276582T PT2723771T (pt) | 2011-06-23 | 2012-06-14 | Proteínas de ligação à albumina sérica |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9573992B2 (pt) |
| EP (3) | EP3466972A1 (pt) |
| JP (3) | JP6324887B2 (pt) |
| CN (2) | CN106046168A (pt) |
| AU (1) | AU2012271974B2 (pt) |
| CA (1) | CA2839779C (pt) |
| CY (1) | CY1122691T1 (pt) |
| DK (1) | DK2723771T3 (pt) |
| ES (1) | ES2759936T3 (pt) |
| HR (2) | HRP20170535T4 (pt) |
| HU (1) | HUE047238T2 (pt) |
| IN (1) | IN2014CN00414A (pt) |
| LT (1) | LT2723771T (pt) |
| PL (1) | PL2723771T3 (pt) |
| PT (1) | PT2723771T (pt) |
| SI (1) | SI2723771T1 (pt) |
| WO (1) | WO2012175400A1 (pt) |
Families Citing this family (58)
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|---|---|---|---|---|
| EP2621953B1 (en) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| IL293155A (en) | 2011-06-23 | 2022-07-01 | Ablynx Nv | Techniques for predicting, detecting, and reducing A-specific protein interference in assays involving single immunoglobulin variable domains |
| LT2723771T (lt) * | 2011-06-23 | 2019-12-10 | Ablynx Nv | Serumo albuminą surišantys baltymai |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| WO2013045707A2 (en) * | 2011-09-30 | 2013-04-04 | Ablynx Nv | Biological materials related to c-met |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| SG10201805288QA (en) | 2014-05-16 | 2018-07-30 | Ablynx Nv | Improved immunoglobulin variable domains |
| EP3143403B1 (en) | 2014-05-16 | 2021-10-27 | Ablynx N.V. | Methods for detecting and/or measuring anti-drug antibodies, in particular treatment-emergent anti-drug antibodies |
| NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
| PL3233910T3 (pl) | 2014-12-19 | 2020-06-01 | Ablynx N.V. | Dimery nanociał połączone cysteiną |
| WO2016120843A1 (en) | 2015-01-29 | 2016-08-04 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders |
| EP3297672B1 (en) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| NO2768984T3 (pt) | 2015-11-12 | 2018-06-09 | ||
| AU2016351710B2 (en) | 2015-11-13 | 2023-08-03 | Ablynx Nv | Improved serum albumin-binding immunoglobulin variable domains |
| PE20181532A1 (es) | 2015-11-18 | 2018-09-26 | Merck Sharp & Dohme | Enlazadores de pd1 y/o lag3 |
| US11332519B2 (en) * | 2015-11-18 | 2022-05-17 | Ablynx N.V. | Serum albumin binders |
| JP6768800B2 (ja) | 2015-11-18 | 2020-10-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｃｔｌａ４結合性物質 |
| CA3003777A1 (en) | 2015-11-18 | 2017-05-26 | Merck Sharp & Dohme Corp. | Pd1/ctla4 binders |
| CA3006398A1 (en) * | 2015-11-27 | 2017-06-01 | Ablynx Nv | Polypeptides inhibiting cd40l |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| MX2018014228A (es) | 2016-05-20 | 2019-08-12 | Harpoon Therapeutics Inc | Proteina de union de albumina sérica de dominio unico. |
| BR112018076569A2 (pt) | 2016-06-23 | 2019-04-02 | Ablynx Nv | ensaios farmacocinéticos melhorados para domínios variáveis simples de imunoglobulina |
| MX2019005696A (es) | 2016-11-16 | 2019-08-14 | Ablynx Nv | Polipeptidos de reclutamiento de celulas t capaces de unir cd123 y tcr alfa/beta. |
| US11414480B2 (en) * | 2016-12-07 | 2022-08-16 | Ablynx N.V. | Serum albumin binding immunoglobulin single variable domains |
| CN107674122A (zh) * | 2016-12-28 | 2018-02-09 | 天津天锐生物科技有限公司 | 一种识别人血清白蛋白的单域抗体 |
| SG11201906264YA (en) | 2017-01-17 | 2019-08-27 | Ablynx Nv | Improved serum albumin binders |
| KR20230165374A (ko) * | 2017-01-17 | 2023-12-05 | 아블린쓰 엔.브이. | 개선된 혈청 알부민 결합제 |
| US11535668B2 (en) | 2017-02-28 | 2022-12-27 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| CN110546506B (zh) | 2017-03-31 | 2023-04-04 | 埃博灵克斯股份有限公司 | 改进的免疫原性测定法 |
| US10543271B2 (en) | 2017-05-12 | 2020-01-28 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
| MX2020003915A (es) | 2017-10-13 | 2020-10-08 | Harpoon Therapeutics Inc | Proteinas trispecificas y metodos de uso. |
| CA3078799A1 (en) | 2017-10-13 | 2019-04-18 | Harpoon Therapeutics, Inc. | B cell maturation antigen binding proteins |
| WO2019162521A1 (en) * | 2018-02-26 | 2019-08-29 | Ablynx Nv | Improved nucleotide sequences encoding peptide linkers |
| JP7425049B2 (ja) | 2018-09-25 | 2024-01-30 | ハープーン セラピューティクス，インク． | Ｄｌｌ３結合タンパク質および使用方法 |
| CN110964107B (zh) * | 2018-09-30 | 2022-08-09 | 苏州康宁杰瑞生物科技有限公司 | Met结合分子、其组合和用途 |
| CN111138536B (zh) * | 2018-11-06 | 2021-07-09 | 瑞阳(苏州)生物科技有限公司 | 抗人血清白蛋白单域抗体的制备及其应用 |
| CN111138537B (zh) * | 2018-11-06 | 2021-07-09 | 瑞阳(苏州)生物科技有限公司 | 一种抗人血清白蛋白抗体片段、制备方法和应用 |
| BR112022010231A2 (pt) | 2019-12-06 | 2022-09-06 | Ablynx Nv | Polipeptídeos compreendendo domínios variáveis únicos de imunoglobulina direcionados a tnfalfa e ox40l |
| CA3163877A1 (en) | 2019-12-06 | 2021-06-10 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting tnf.alpha. and il-23 |
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| CN110988361B (zh) * | 2019-12-13 | 2020-09-18 | 山东民康生物科技有限公司 | 人血清白蛋白去除试剂盒 |
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| EP4237438A1 (en) | 2020-10-27 | 2023-09-06 | Beijing QL Biopharmaceutical Co., Ltd. | Fusion proteins of gdf15 and use thereof |
| IL303783A (en) | 2020-12-18 | 2023-08-01 | Sanofi Sa | Polypeptides comprising single immunoglobulin variable sites targeting GLYPICAN-3 and the T-cell receptor |
| WO2022129572A1 (en) | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha |
| CA3203141A1 (en) | 2020-12-18 | 2022-06-23 | Ablynx Nv | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
| CA3224743A1 (en) * | 2021-07-14 | 2023-01-19 | Beijing Ql Biopharmaceutical Co., Ltd. | Fusion polypeptides for metabolic disorders |
| WO2023088295A1 (zh) * | 2021-11-17 | 2023-05-25 | 江苏先声药业有限公司 | 一种多特异性抗体及其药物用途 |
| WO2023111266A1 (en) | 2021-12-17 | 2023-06-22 | Ablynx Nv | POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123 |
| CN118139892A (zh) * | 2022-01-14 | 2024-06-04 | 浙江道尔生物科技有限公司 | 一种三靶点抗肿瘤药物、其制备方法及其应用 |
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| WO2024084203A1 (en) | 2022-10-18 | 2024-04-25 | Isogenica Limited | Single domain antibodies binding to albumin |
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| EA201201273A1 (ru) | 2010-03-10 | 2013-02-28 | Генмаб А/С | Моноклональные антитела к с-мет |
| EP2621953B1 (en) * | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| LT2723771T (lt) * | 2011-06-23 | 2019-12-10 | Ablynx Nv | Serumo albuminą surišantys baltymai |
| US20150344568A1 (en) | 2011-06-23 | 2015-12-03 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| IL293155A (en) | 2011-06-23 | 2022-07-01 | Ablynx Nv | Techniques for predicting, detecting, and reducing A-specific protein interference in assays involving single immunoglobulin variable domains |
| PE20141522A1 (es) | 2011-08-17 | 2014-11-17 | Glaxo Group Ltd | Proteinas y peptidos modificados |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
-
2012
- 2012-06-14 LT LT12727658T patent/LT2723771T/lt unknown
- 2012-06-14 CA CA2839779A patent/CA2839779C/en active Active
- 2012-06-14 SI SI201231696T patent/SI2723771T1/sl unknown
- 2012-06-14 DK DK12727658T patent/DK2723771T3/da active
- 2012-06-14 CN CN201610392570.9A patent/CN106046168A/zh active Pending
- 2012-06-14 US US14/128,719 patent/US9573992B2/en active Active
- 2012-06-14 EP EP18205150.8A patent/EP3466972A1/en active Pending
- 2012-06-14 JP JP2014516279A patent/JP6324887B2/ja active Active
- 2012-06-14 CN CN201280030647.8A patent/CN103619878B/zh active Active
- 2012-06-14 PT PT127276582T patent/PT2723771T/pt unknown
- 2012-06-14 EP EP12727658.2A patent/EP2723771B1/en active Active
- 2012-06-14 HU HUE12727658A patent/HUE047238T2/hu unknown
- 2012-06-14 PL PL12727658T patent/PL2723771T3/pl unknown
- 2012-06-14 AU AU2012271974A patent/AU2012271974B2/en active Active
- 2012-06-14 EP EP23159592.7A patent/EP4218933A1/en active Pending
- 2012-06-14 WO PCT/EP2012/061304 patent/WO2012175400A1/en active Application Filing
- 2012-06-14 ES ES12727658T patent/ES2759936T3/es active Active
- 2012-06-14 IN IN414CHN2014 patent/IN2014CN00414A/en unknown
- 2012-06-25 HR HRP20170535TT patent/HRP20170535T4/hr unknown
-
2017
- 2017-01-03 US US15/397,313 patent/US20170210789A1/en not_active Abandoned
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2018
- 2018-04-11 JP JP2018076201A patent/JP6843090B2/ja active Active
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2019
- 2019-11-29 HR HRP20192160TT patent/HRP20192160T1/hr unknown
- 2019-12-10 CY CY20191101299T patent/CY1122691T1/el unknown
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2021
- 2021-02-22 JP JP2021026177A patent/JP7304375B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20170535T4 (hr) | 2022-08-19 |
| JP2014520129A (ja) | 2014-08-21 |
| PL2723771T3 (pl) | 2020-04-30 |
| AU2012271974A1 (en) | 2013-12-12 |
| EP2723771B1 (en) | 2019-09-11 |
| CN106046168A (zh) | 2016-10-26 |
| SI2723771T1 (sl) | 2019-12-31 |
| JP2021088585A (ja) | 2021-06-10 |
| HRP20170535T1 (hr) | 2017-06-16 |
| EP2723771A1 (en) | 2014-04-30 |
| ES2759936T3 (es) | 2020-05-12 |
| US20140228546A1 (en) | 2014-08-14 |
| JP7304375B2 (ja) | 2023-07-06 |
| HUE047238T2 (hu) | 2020-04-28 |
| EP3466972A1 (en) | 2019-04-10 |
| WO2012175400A1 (en) | 2012-12-27 |
| CY1122691T1 (el) | 2021-03-12 |
| LT2723771T (lt) | 2019-12-10 |
| JP2018127478A (ja) | 2018-08-16 |
| AU2012271974B2 (en) | 2017-01-12 |
| US9573992B2 (en) | 2017-02-21 |
| CN103619878B (zh) | 2016-10-26 |
| CN103619878A (zh) | 2014-03-05 |
| HRP20192160T1 (hr) | 2020-02-21 |
| DK2723771T3 (da) | 2019-12-02 |
| CA2839779C (en) | 2020-10-06 |
| US20170210789A1 (en) | 2017-07-27 |
| JP6324887B2 (ja) | 2018-05-16 |
| CA2839779A1 (en) | 2012-12-27 |
| IN2014CN00414A (pt) | 2015-04-03 |
| EP4218933A1 (en) | 2023-08-02 |
| JP6843090B2 (ja) | 2021-03-17 |
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