HRP20130944T1 - Inhibitori ns5a iz hcv - Google Patents
Inhibitori ns5a iz hcv Download PDFInfo
- Publication number
- HRP20130944T1 HRP20130944T1 HRP20130944AT HRP20130944T HRP20130944T1 HR P20130944 T1 HRP20130944 T1 HR P20130944T1 HR P20130944A T HRP20130944A T HR P20130944AT HR P20130944 T HRP20130944 T HR P20130944T HR P20130944 T1 HRP20130944 T1 HR P20130944T1
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- Croatia
- Prior art keywords
- compound according
- group
- heteroalkyl
- heterocycle
- heteroaryl
- Prior art date
Links
- 101710188663 Non-structural protein 5a Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000002431 hydrogen Chemical group 0.000 claims 4
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000001589 carboacyl group Chemical group 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003456 sulfonamides Chemical class 0.000 claims 2
- -1 -OH Chemical group 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 150000003871 sulfonates Chemical class 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (22)
1. Spoj formule IIIe
[image]
,
naznačen time što
svakog X i X′ se neovisno bira iz skupine koju čine veza, -CH2-, -CH2-CH2-, -CH=CH-, -O-S-, -S(O)1-2-, -CH2O-, -CH2S-, -CH2S(O)1-2- i -CH2N(R1)-, gdje se R1 bira iz skupine koju čine vodik, C1 do C8 alkil, C1 do C8 heteroalkil, cikloalkil, heterocikl, aril, heteroaril, aralkil, alkanoil, alkoksikarbonil, karbamoil i supstitutirani sulfonil;
Xb je neovisno C ili N;
Xc je neovisno C ili N;
svakog Ra se neovisno bira iz skupine koju čine -OH, -CN, -NO2, halogen, C1 do C12 alkil, C1 do C12 heteroalkil, cikloalkil, heterocikl, aril, heteroaril, aralkil, alkoksi, alkoksikarbonil, alkanoil, karbamoil, supstitutirani sulfonil, sulfonat, sulfonamid i amino;
svaki r je neovisno 0, 1, 2 ili 3;
Z i Z′ se neovisno bira iz skupine koju čine C1 do C8 heteroalkil, cikloalkil, heterocikl, aril, heteroaril, aralil, 1-3 aminokiseline, -[U-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-NR7-(CR42)t-R8, -U-(CR42)t-R8 i -[U-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-O-(CR42)t-R8,
gdje,
U se bira iz skupine koju čine -C(O)-, -C(S)- i -S(O)2-,
svakog R4, R5 i R7 se neovisno bira iz skupine koju čine vodik, C1 do C8 alkil, C1 do C8 heteroalkil, cikloalkil, heterocikl, aril, heteroaril i aralkil,
R8 se bira iz skupine koju čine vodik, C1 do C8 alkil, C1 do C8 heteroalkil, cikloalkil, heterocikl, aril, heteroaril, aralkil, -C(O)-R81, -C(S)-R81, -C(O)-O-R81, -C(O)-N-R812, -S(O)2-R81 i -S(O)2-N-R812, gdje se svakog R81 neovisno bira iz skupine koju čine vodik, C1 do C8 alkil, C1 do C8 heteroalkil, cikloalkil, heterocikl, aril, heteroaril i aralkil,
izborno, R7 i R8 zajedno tvore 4-7-eročlani prsten,
svaki t je neovisno 0, 1, 2, 3 ili 4, i
u je 0, 1 ili 2 i
gdje je "supstitutirani sulfonil" u svakom slučaju skupina sa strukturom
[image]
,
gdje se R neovisno bira između vodika, -OH, -CN, -NO2, halogena, C1 do C12 alkila, C1 do C12 heteroalkila, alkenila, alkinila, cikloalkila, heterocikla, arila, heteroarila, aralkila, alkoksi, alkoksikarbonila, alkanoila, karbamoila, sulfonata, kao što je definiran u ovom patentnom zahtjevu, sulfonamida, amino i okso.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što su svaki od Z i Z′ 1-3 aminokiseline.
3. Spoj u skladu s patentnim zahtjevom 2, naznačen time što su aminokiseline u d konfiguraciji.
4. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-3, naznačen time što se svakog od Z i Z′ neovisno bira iz skupine koju čine -[U-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-NR7-(CR42)t-R8, -U-(CR42)t-R8 i -[U-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-O-(CR42)t-R8.
5. Spoj u skladu s patentnim zahtjevom 4, naznačen time što su jedan ili oba od Z i Z′ -[U-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-NR7-(CR42)t-R8.
6. Spoj u skladu s patentnim zahtjevom 5, naznačen time što su jedan ili oba od Z i Z′ -U-(CR42)t-NR5-(CR42)t-U-(CR42)t-NR7-(CR42)t-R8.
7. Spoj u skladu s patentnim zahtjevom 5, naznačen time što su jedan ili oba od Z i Z′ -U-(CR42)t-NR7-(CR42)t-R8.
8. Spoj u skladu s patentnim zahtjevom 5, naznačen time što su bilo koji ili oba od Z i Z′ -[C(O)-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-NR7-(CR42)t-R8.
9. Spoj u skladu s patentnim zahtjevom 8, naznačen time što su jedan ili oba od Z i Z′ -C(O)-(CR42)t-NR5-(CR42)t-U-(CR42)t-NR7-(CR42)t-R8.
10. Spoj u skladu s patentnim zahtjevom 8, naznačen time što su jedan ili oba od Z i Z′ -[C(O)-(CR42)t-NR5-(CR42)t]u-C(O)-(CR42)t-NR7-(CR42)t-R8.
11. Spoj u skladu s patentnim zahtjevom 10, naznačen time što su jedan ili oba od Z i Z′ -C(O)-(CR42)t-NR5-(CR42)t-C(O)-(CR42)t-NR7-(CR42)t-R8.
12. Spoj u skladu s patentnim zahtjevom 8, naznačen time što su jedan ili oba od Z i Z′ -C(O)-(CR42)t-NR7-(CR42)t-R8.
13. Spoj u skladu s patentnim zahtjevom 4, naznačen time što su jedan ili oba od Z i Z′ -U-(CR42)t-R8.
14. Spoj u skladu s patentnim zahtjevom 13, naznačen time što su jedan ili oba od Z i Z′ -C(O)-(CR42)t-R8.
15. Spoj u skladu s patentnim zahtjevom 4, naznačen time što su jedan ili oba od Z i Z′ -[U-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-O-(CR42)t-R8.
16. Spoj u skladu s patentnim zahtjevom 15, naznačen time što su jedan ili oba od Z i Z′ -U-(CR42)t-NR5-(CR42)t-U-(CR42)t-O-(CR42)t-R8.
17. Spoj u skladu s patentnim zahtjevom 16, naznačen time što su jedan ili oba od Z i Z′ -C(O)-(CR42)t-NR5-(CR42)t-C(O)-(CR42)t-O-(CR42)t-R8.
18. Spoj u skladu s patentnim zahtjevom 16, naznačen time što su jedan ili oba od Z i Z′ -U-(CR42)t-O-(CR42)t-R8.
19. Spoj u skladu s patentnim zahtjevom 1, naznačen time što ga se bira iz skupine koju čine
[image]
20. Farmaceutski pripravak, naznačen time što sadrži bilo koji od spojeva u skladu s patentnim zahtjevom 1-19.
21. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-19, naznačen time što je namijenjen upotrebi kao medikament.
22. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-20, naznačen time što je namijenjen upotrebi u liječenju hepatitisa C.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11972308P | 2008-12-03 | 2008-12-03 | |
US21488109P | 2009-04-28 | 2009-04-28 | |
US17359009P | 2009-04-28 | 2009-04-28 | |
US18295209P | 2009-06-01 | 2009-06-01 | |
US18295809P | 2009-06-01 | 2009-06-01 | |
PCT/US2009/066459 WO2010065674A1 (en) | 2008-12-03 | 2009-12-02 | Inhibitors of hcv ns5a |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20130944T1 true HRP20130944T1 (hr) | 2013-11-22 |
Family
ID=42233599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20130944AT HRP20130944T1 (hr) | 2008-12-03 | 2013-10-07 | Inhibitori ns5a iz hcv |
Country Status (27)
Country | Link |
---|---|
US (2) | US8921369B2 (hr) |
EP (2) | EP2682393A1 (hr) |
JP (1) | JP5762971B2 (hr) |
KR (1) | KR101784830B1 (hr) |
CN (2) | CN104163816A (hr) |
AR (1) | AR080263A1 (hr) |
AU (1) | AU2009322393B2 (hr) |
BR (1) | BRPI0922366B8 (hr) |
CA (1) | CA2746004C (hr) |
CL (1) | CL2011001333A1 (hr) |
CO (1) | CO6390077A2 (hr) |
CY (1) | CY1114509T1 (hr) |
DK (1) | DK2373172T3 (hr) |
EA (1) | EA024853B1 (hr) |
ES (1) | ES2437156T3 (hr) |
HK (1) | HK1203929A1 (hr) |
HR (1) | HRP20130944T1 (hr) |
IL (2) | IL213277A (hr) |
MX (1) | MX2011005898A (hr) |
PE (2) | PE20120124A1 (hr) |
PL (1) | PL2373172T3 (hr) |
PT (1) | PT2373172E (hr) |
SG (1) | SG171889A1 (hr) |
SI (1) | SI2373172T1 (hr) |
TW (2) | TWI480278B (hr) |
WO (1) | WO2010065674A1 (hr) |
ZA (1) | ZA201104833B (hr) |
Families Citing this family (134)
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KR20110098779A (ko) * | 2008-12-03 | 2011-09-01 | 프레시디오 파마슈티칼스, 인코포레이티드 | Hcv ns5a의 억제제 |
JP5762971B2 (ja) | 2008-12-03 | 2015-08-12 | プレシディオ ファーマシューティカルズ インコーポレイテッド | Hcvns5aの阻害剤 |
RU2505540C2 (ru) | 2008-12-23 | 2014-01-27 | Эббви Инк. | Антивирусные соединения |
EP2367823A1 (en) | 2008-12-23 | 2011-09-28 | Abbott Laboratories | Anti-viral compounds |
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- 2009-12-02 PL PL09831077T patent/PL2373172T3/pl unknown
- 2009-12-02 CN CN201410221684.8A patent/CN104163816A/zh active Pending
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