HRP20110640T1 - Derivati cikličkih amida i njihova proizvodnja te njihova uporaba kao antitromboznih sredstava - Google Patents
Derivati cikličkih amida i njihova proizvodnja te njihova uporaba kao antitromboznih sredstava Download PDFInfo
- Publication number
- HRP20110640T1 HRP20110640T1 HR20110640T HRP20110640T HRP20110640T1 HR P20110640 T1 HRP20110640 T1 HR P20110640T1 HR 20110640 T HR20110640 T HR 20110640T HR P20110640 T HRP20110640 T HR P20110640T HR P20110640 T1 HRP20110640 T1 HR P20110640T1
- Authority
- HR
- Croatia
- Prior art keywords
- optionally substituted
- salt
- chloronaphthalen
- sulfonyl
- hydroxypropanoyl
- Prior art date
Links
- 150000003950 cyclic amides Chemical class 0.000 title abstract 2
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229960004676 antithrombotic agent Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract 17
- 150000001875 compounds Chemical class 0.000 claims 17
- VYODSGGBJPHDPS-OAQYLSRUSA-N (2s)-3-(6-chloronaphthalen-2-yl)sulfonyl-2-hydroxy-1-[4-(2-iminopiperidin-1-yl)piperidin-1-yl]propan-1-one Chemical compound O=C([C@@H](CS(=O)(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)O)N(CC1)CCC1N1CCCCC1=N VYODSGGBJPHDPS-OAQYLSRUSA-N 0.000 claims 2
- GEHAEMCVKDPMKO-HXUWFJFHSA-N 1-[1-[(2s)-3-(6-chloronaphthalen-2-yl)sulfonyl-2-hydroxypropanoyl]piperidin-4-yl]-1,3-diazinan-2-one Chemical compound O=C([C@@H](CS(=O)(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)O)N(CC1)CCC1N1CCCNC1=O GEHAEMCVKDPMKO-HXUWFJFHSA-N 0.000 claims 2
- MPARUNUPLMAFHO-LJQANCHMSA-N 1-[4-[(2s)-3-(6-chloronaphthalen-2-yl)sulfonyl-2-hydroxypropanoyl]piperazin-1-yl]-1,3-diazinan-2-one Chemical compound O=C([C@@H](CS(=O)(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)O)N(CC1)CCN1N1CCCNC1=O MPARUNUPLMAFHO-LJQANCHMSA-N 0.000 claims 2
- RFFCBPYHPAOSQL-HXUWFJFHSA-N 1-[4-[(2s)-3-(6-chloronaphthalen-2-yl)sulfonyl-2-hydroxypropanoyl]piperazin-1-yl]piperidin-2-one Chemical compound O=C([C@@H](CS(=O)(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)O)N(CC1)CCN1N1CCCCC1=O RFFCBPYHPAOSQL-HXUWFJFHSA-N 0.000 claims 2
- XYAFLQBDIAOLNN-UHFFFAOYSA-N 1-[4-[3-(6-chloronaphthalen-2-yl)sulfonylpropanoyl]piperazin-1-yl]-1,3-diazinan-2-one Chemical compound C1=CC2=CC(Cl)=CC=C2C=C1S(=O)(=O)CCC(=O)N(CC1)CCN1N1CCCNC1=O XYAFLQBDIAOLNN-UHFFFAOYSA-N 0.000 claims 2
- DCLWQEKIJZKZQP-XMMPIXPASA-N 2-[1-[(2s)-3-(6-chloronaphthalen-2-yl)sulfonyl-2-hydroxypropanoyl]piperidin-4-yl]-3h-isoindol-1-one Chemical compound C1C2=CC=CC=C2C(=O)N1C(CC1)CCN1C(=O)[C@H](O)CS(=O)(=O)C1=CC=C(C=C(Cl)C=C2)C2=C1 DCLWQEKIJZKZQP-XMMPIXPASA-N 0.000 claims 2
- ZNBLPBAPIPKQEP-HXUWFJFHSA-N 4-[1-[(2s)-3-(6-chloronaphthalen-2-yl)sulfonyl-2-hydroxypropanoyl]piperidin-4-yl]morpholin-3-one Chemical compound O=C([C@@H](CS(=O)(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)O)N(CC1)CCC1N1CCOCC1=O ZNBLPBAPIPKQEP-HXUWFJFHSA-N 0.000 claims 2
- DJHQIIXBVWGNBK-OAQYLSRUSA-N 1-[1-[(2s)-3-(6-chloronaphthalen-2-yl)sulfonyl-2-hydroxypropanoyl]piperidin-4-yl]piperidin-2-one Chemical compound O=C([C@@H](CS(=O)(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)O)N(CC1)CCC1N1CCCCC1=O DJHQIIXBVWGNBK-OAQYLSRUSA-N 0.000 claims 1
- -1 6-chloronaphthalen-2-yl Chemical group 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004152000 | 2004-05-21 | ||
| PCT/JP2005/009711 WO2005113504A1 (en) | 2004-05-21 | 2005-05-20 | Cyclic amide derivatives, and their production and use as antithrombotic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110640T1 true HRP20110640T1 (hr) | 2011-10-31 |
Family
ID=34968275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110640T HRP20110640T1 (hr) | 2004-05-21 | 2011-09-07 | Derivati cikličkih amida i njihova proizvodnja te njihova uporaba kao antitromboznih sredstava |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US7745623B2 (sr) |
| EP (2) | EP1748985B1 (sr) |
| JP (2) | JP4129047B2 (sr) |
| KR (1) | KR101248637B1 (sr) |
| CN (2) | CN1989104B (sr) |
| AT (1) | ATE513813T1 (sr) |
| AU (1) | AU2005245298B2 (sr) |
| BR (1) | BRPI0511186A (sr) |
| CA (1) | CA2567506C (sr) |
| CY (1) | CY1111850T1 (sr) |
| DK (1) | DK1748985T3 (sr) |
| ES (1) | ES2368155T3 (sr) |
| HK (1) | HK1100666A1 (sr) |
| HR (1) | HRP20110640T1 (sr) |
| IL (1) | IL178896A (sr) |
| MX (1) | MXPA06013243A (sr) |
| MY (1) | MY154461A (sr) |
| NO (1) | NO20065929L (sr) |
| NZ (1) | NZ550985A (sr) |
| PL (1) | PL1748985T3 (sr) |
| PT (1) | PT1748985E (sr) |
| RS (1) | RS51925B (sr) |
| RU (1) | RU2361861C2 (sr) |
| SI (1) | SI1748985T1 (sr) |
| TW (1) | TWI396686B (sr) |
| WO (1) | WO2005113504A1 (sr) |
Families Citing this family (55)
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|---|---|---|---|---|
| US20030187023A1 (en) * | 2000-07-17 | 2003-10-02 | Keiji Kubo | Sulfone derivatives, process for their production and use thereof |
| CA2507026A1 (en) * | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | Imidazole derivatives, their production and use |
| TWI396686B (zh) * | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| WO2007114861A2 (en) * | 2005-11-28 | 2007-10-11 | Zymogenetics, Inc. | Il-21 receptor antagonists |
| JPWO2008066102A1 (ja) * | 2006-11-30 | 2010-03-11 | 武田薬品工業株式会社 | 徐放性製剤 |
| UY32126A (es) | 2008-09-25 | 2010-04-30 | Takeda Pharmaceutical | Composición farmacéutica sólida |
| EP2351743A4 (en) | 2008-10-27 | 2012-05-09 | Takeda Pharmaceutical | BICYCLIC CONNECTION |
| EP2371826A4 (en) | 2008-12-29 | 2012-06-27 | Takeda Pharmaceutical | NEW CONNECTION WITH CONDENSED RINGS AND ITS USE |
| US20100190747A1 (en) | 2009-01-27 | 2010-07-29 | Hideo Suzuki | Fused ring compound and use thereof |
| WO2010126168A2 (en) | 2009-04-30 | 2010-11-04 | Takeda Pharmaceutical Company Limited | Solid preparation |
| JP5657578B2 (ja) | 2009-06-09 | 2015-01-21 | 武田薬品工業株式会社 | 新規な縮合環化合物およびその用途 |
| US20120129878A1 (en) | 2009-07-28 | 2012-05-24 | Takeda Pharmaceutical Company Limited | Tablet |
| US8221489B2 (en) * | 2009-08-20 | 2012-07-17 | Stentys | Device and method for treating a body lumen |
| NZ603777A (en) | 2010-04-27 | 2013-08-30 | Takeda Pharmaceutical | Bicyclic compound derivatives and their use as acc inhibitors. |
| EA022094B1 (ru) | 2010-06-16 | 2015-10-30 | Такеда Фармасьютикал Компани Лимитед | Кристаллическая форма амидного соединения |
| WO2012011591A1 (ja) | 2010-07-23 | 2012-01-26 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
| JP5816626B2 (ja) | 2010-09-17 | 2015-11-18 | 武田薬品工業株式会社 | 糖尿病治療剤 |
| AR084032A1 (es) | 2010-11-30 | 2013-04-17 | Takeda Pharmaceutical | Compuesto biciclico |
| EP2675774A1 (en) | 2011-02-17 | 2013-12-25 | Takeda Pharmaceutical Company Limited | Production method of optically active dihydrobenzofuran derivative |
| EP2772485A4 (en) | 2011-10-24 | 2015-06-10 | Takeda Pharmaceutical | BICYCLIC CONNECTION |
| US9365540B2 (en) | 2012-01-12 | 2016-06-14 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as MCH receptor antagonists |
| JP6095580B2 (ja) | 2012-02-13 | 2017-03-15 | 武田薬品工業株式会社 | 芳香環化合物 |
| US9181186B2 (en) | 2012-02-13 | 2015-11-10 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| JP6077555B2 (ja) | 2012-02-15 | 2017-02-08 | 武田薬品工業株式会社 | 錠剤 |
| EP2838891B1 (en) | 2012-02-24 | 2017-08-02 | Takeda Pharmaceutical Company Limited | Aromatic ring compound as ghrelin o-acyltransferase inhibitor |
| JPWO2013147026A1 (ja) | 2012-03-29 | 2015-12-14 | 武田薬品工業株式会社 | 芳香環化合物 |
| WO2013168760A1 (ja) | 2012-05-10 | 2013-11-14 | 武田薬品工業株式会社 | 芳香環化合物 |
| EP2848621A4 (en) | 2012-05-10 | 2016-06-01 | Takeda Pharmaceutical | AROMATIC CYCLIC COMPOUND |
| KR102145641B1 (ko) | 2012-06-05 | 2020-08-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 고형 제제 |
| JP2015127299A (ja) | 2012-07-19 | 2015-07-09 | 武田薬品工業株式会社 | 固形製剤 |
| EP2889291A4 (en) | 2012-08-24 | 2015-10-14 | Takeda Pharmaceutical | HETEROCYCLIC CONNECTION |
| CN103936763B (zh) * | 2013-01-18 | 2017-10-31 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物及其制备方法和用途 |
| WO2014142363A1 (en) | 2013-03-14 | 2014-09-18 | Takeda Pharmaceutical Company Limited | Spiro azetidine isoxazole derivatives and their use as sstr5 antagonists |
| WO2014165816A1 (en) | 2013-04-05 | 2014-10-09 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
| TW201536767A (zh) | 2013-07-09 | 2015-10-01 | Takeda Pharmaceutical | 雜環化合物 |
| ES2672992T3 (es) | 2013-08-09 | 2018-06-19 | Takeda Pharmaceutical Company Limited | Compuesto aromático |
| JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
| US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US10100027B2 (en) * | 2014-09-26 | 2018-10-16 | Changzhou Yinsheng Pharmaceutical Co., Ltd. | Benzofuran analogue as NS4B inhibitor |
| JP6986446B2 (ja) | 2014-12-23 | 2021-12-22 | クロッシング エスアールエル | ２−ハロ−４，６−ジアルコキシ−１，３，５−トリアジンの工業的生産方法およびアミンの存在下でのそれらの使用 |
| CA3058578A1 (en) | 2017-03-31 | 2018-10-04 | Takeda Pharmaceutical Company Limited | Aromatic compound |
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| AU2019237507A1 (en) | 2018-03-23 | 2020-10-08 | Carmot Therapeutics, Inc. | Modulators of G-protein coupled receptors |
| JP6773938B2 (ja) | 2018-08-27 | 2020-10-21 | 株式会社スコヒアファーマ | 安息香酸エステル化合物 |
| US20220016215A1 (en) | 2018-09-24 | 2022-01-20 | Takeda Phaarmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| JP2022503793A (ja) | 2018-09-24 | 2022-01-12 | 武田薬品工業株式会社 | Ｇｉｐ受容体アゴニストペプチド化合物及びその使用 |
| IL296592A (en) | 2020-03-25 | 2022-11-01 | Takeda Pharmaceuticals Co | One-day doses of gip receptor agonistic peptides and their uses |
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| TW202313666A (zh) | 2021-05-13 | 2023-04-01 | 美商卡默療法股份有限公司 | G-蛋白偶聯受體之調節劑 |
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