ATE281457T1 - Trizyklische verbindungen mit einer spiro-einheit - Google Patents

Trizyklische verbindungen mit einer spiro-einheit

Info

Publication number
ATE281457T1
ATE281457T1 AT00940912T AT00940912T ATE281457T1 AT E281457 T1 ATE281457 T1 AT E281457T1 AT 00940912 T AT00940912 T AT 00940912T AT 00940912 T AT00940912 T AT 00940912T AT E281457 T1 ATE281457 T1 AT E281457T1
Authority
AT
Austria
Prior art keywords
tricyclic compounds
useful
relates
inhibitor
spiro unit
Prior art date
Application number
AT00940912T
Other languages
English (en)
Inventor
Hidemitsu Nishida
Fumihiko Saitoh
Kousuke Harada
Ikuya Shiromizu
Original Assignee
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd
Application granted granted Critical
Publication of ATE281457T1 publication Critical patent/ATE281457T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444—Factor X (3.4.21.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Prostheses (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00940912T 1999-06-30 2000-06-30 Trizyklische verbindungen mit einer spiro-einheit ATE281457T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22288399 1999-06-30
PCT/JP2000/004374 WO2001002397A1 (fr) 1999-06-30 2000-06-30 Composes tricycliques presentant une jonction spiro

Publications (1)

Publication Number Publication Date
ATE281457T1 true ATE281457T1 (de) 2004-11-15

Family

ID=16789385

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00940912T ATE281457T1 (de) 1999-06-30 2000-06-30 Trizyklische verbindungen mit einer spiro-einheit

Country Status (21)

Country Link
EP (1) EP1191028B1 (de)
JP (1) JP4890707B2 (de)
KR (1) KR20020015061A (de)
CN (1) CN1371375A (de)
AT (1) ATE281457T1 (de)
AU (1) AU774397B2 (de)
BR (1) BR0012093A (de)
CA (1) CA2380852C (de)
CZ (1) CZ20014696A3 (de)
DE (1) DE60015541T2 (de)
HK (1) HK1049157A1 (de)
HU (1) HUP0202188A3 (de)
IL (1) IL147348A0 (de)
MX (1) MXPA02000003A (de)
NO (1) NO20016402L (de)
NZ (1) NZ516363A (de)
PL (1) PL352862A1 (de)
SK (1) SK19292001A3 (de)
TR (1) TR200103853T2 (de)
WO (1) WO2001002397A1 (de)
ZA (1) ZA200110558B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2416384A1 (en) * 2000-07-17 2003-01-16 Takeda Chemical Industries, Ltd. Sulfone derivatives, their production and use
EP1346994A4 (de) * 2000-12-28 2005-01-19 Mochida Pharm Co Ltd Inhibitoren der biosynthese von cholesterin, die als wirkstoff tricyclische spiroverbindungen enthalten
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
WO2006006490A1 (ja) * 2004-07-08 2006-01-19 Ono Pharmaceutical Co., Ltd. スピロ化合物
CA2602025A1 (en) 2005-03-31 2006-10-12 Mochida Pharmaceutical Co., Ltd. Tricyclic spiro compound comprising acyl group bound to nitrogen atom in the ring
JPWO2007136085A1 (ja) 2006-05-23 2009-10-01 持田製薬株式会社 スピロ四環系化合物
US7739434B2 (en) 2008-01-11 2010-06-15 International Business Machines Corporation Performing a configuration virtual topology change and instruction therefore

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3855147D1 (de) * 1987-07-20 1996-05-02 Duphar Int Res 8,9-Anellierte 1,2,3,4-Tetrahydro-beta-carbolin-Derivate
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles

Also Published As

Publication number Publication date
AU5572000A (en) 2001-01-22
CN1371375A (zh) 2002-09-25
PL352862A1 (en) 2003-09-08
HK1049157A1 (zh) 2003-05-02
SK19292001A3 (sk) 2002-06-04
MXPA02000003A (es) 2003-07-21
NO20016402D0 (no) 2001-12-28
IL147348A0 (en) 2002-08-14
ZA200110558B (en) 2002-09-12
NZ516363A (en) 2004-05-28
CZ20014696A3 (cs) 2002-05-15
CA2380852A1 (en) 2001-01-11
EP1191028A1 (de) 2002-03-27
DE60015541D1 (de) 2004-12-09
TR200103853T2 (tr) 2002-11-21
WO2001002397A9 (fr) 2001-04-05
EP1191028B1 (de) 2004-11-03
JP4890707B2 (ja) 2012-03-07
HUP0202188A2 (en) 2002-10-28
DE60015541T2 (de) 2005-12-08
AU774397B2 (en) 2004-06-24
CA2380852C (en) 2009-10-20
WO2001002397A1 (fr) 2001-01-11
EP1191028A4 (de) 2002-10-23
BR0012093A (pt) 2002-07-16
KR20020015061A (ko) 2002-02-27
NO20016402L (no) 2002-02-27
HUP0202188A3 (en) 2004-04-28

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