BR0012093A - Composto tricìclico tendo união espiro - Google Patents
Composto tricìclico tendo união espiroInfo
- Publication number
- BR0012093A BR0012093A BR0012093-6A BR0012093A BR0012093A BR 0012093 A BR0012093 A BR 0012093A BR 0012093 A BR0012093 A BR 0012093A BR 0012093 A BR0012093 A BR 0012093A
- Authority
- BR
- Brazil
- Prior art keywords
- spiro union
- tricyclic compound
- compound
- useful
- relates
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000003003 spiro group Chemical group 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 230000010100 anticoagulation Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96444—Factor X (3.4.21.6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Prostheses (AREA)
- External Artificial Organs (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"COMPOSTO TRICìCLICO TENDO UNIãO ESPIRO". A presente invenção refere-se a compostos tricíclicos que possuem união espiro representados pelo fórmula (I) seguinte ou seus sais que são úteis como uma droga e, em particular, como um inibidor para fator X de coagulação sang³ínea ativada, que podem ser administrados oralmente e que exibem forte ação de anticoagulação. A presente invenção também se refere a um farmacóforo que foi derivado do composto e é útil no projeto molecular do inibidor Fxa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22288399 | 1999-06-30 | ||
PCT/JP2000/004374 WO2001002397A1 (fr) | 1999-06-30 | 2000-06-30 | Composes tricycliques presentant une jonction spiro |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0012093A true BR0012093A (pt) | 2002-07-16 |
Family
ID=16789385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0012093-6A BR0012093A (pt) | 1999-06-30 | 2000-06-30 | Composto tricìclico tendo união espiro |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1191028B1 (pt) |
JP (1) | JP4890707B2 (pt) |
KR (1) | KR20020015061A (pt) |
CN (1) | CN1371375A (pt) |
AT (1) | ATE281457T1 (pt) |
AU (1) | AU774397B2 (pt) |
BR (1) | BR0012093A (pt) |
CA (1) | CA2380852C (pt) |
CZ (1) | CZ20014696A3 (pt) |
DE (1) | DE60015541T2 (pt) |
HK (1) | HK1049157A1 (pt) |
HU (1) | HUP0202188A3 (pt) |
IL (1) | IL147348A0 (pt) |
MX (1) | MXPA02000003A (pt) |
NO (1) | NO20016402L (pt) |
NZ (1) | NZ516363A (pt) |
PL (1) | PL352862A1 (pt) |
SK (1) | SK19292001A3 (pt) |
TR (1) | TR200103853T2 (pt) |
WO (1) | WO2001002397A1 (pt) |
ZA (1) | ZA200110558B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030187023A1 (en) * | 2000-07-17 | 2003-10-02 | Keiji Kubo | Sulfone derivatives, process for their production and use thereof |
WO2002053568A1 (fr) * | 2000-12-28 | 2002-07-11 | Mochida Pharmaceutical Co., Ltd. | Inhibiteurs de la biosynthese du cholesterol contenant comme principe actif des composes spiro tricycliques |
CN100513398C (zh) | 2002-12-03 | 2009-07-15 | Axys药物公司 | 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物 |
TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
WO2006006490A1 (ja) * | 2004-07-08 | 2006-01-19 | Ono Pharmaceutical Co., Ltd. | スピロ化合物 |
US20090076015A1 (en) | 2005-03-31 | 2009-03-19 | Hidemitsu Nishida | Tricyclic Spiro Compound Comprising Acyl Group Bound to Nitrogen Atom in the Ring |
CA2651420A1 (en) | 2006-05-23 | 2007-11-29 | Mochida Pharmaceutical Co., Ltd. | Spiro tetracyclic compound |
US7739434B2 (en) | 2008-01-11 | 2010-06-15 | International Business Machines Corporation | Performing a configuration virtual topology change and instruction therefore |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3855147D1 (de) * | 1987-07-20 | 1996-05-02 | Duphar Int Res | 8,9-Anellierte 1,2,3,4-Tetrahydro-beta-carbolin-Derivate |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
-
2000
- 2000-06-30 PL PL00352862A patent/PL352862A1/xx not_active Application Discontinuation
- 2000-06-30 TR TR2001/03853T patent/TR200103853T2/xx unknown
- 2000-06-30 EP EP00940912A patent/EP1191028B1/en not_active Expired - Lifetime
- 2000-06-30 HU HU0202188A patent/HUP0202188A3/hu unknown
- 2000-06-30 AU AU55720/00A patent/AU774397B2/en not_active Ceased
- 2000-06-30 WO PCT/JP2000/004374 patent/WO2001002397A1/ja not_active Application Discontinuation
- 2000-06-30 BR BR0012093-6A patent/BR0012093A/pt not_active IP Right Cessation
- 2000-06-30 KR KR1020017016658A patent/KR20020015061A/ko not_active Application Discontinuation
- 2000-06-30 AT AT00940912T patent/ATE281457T1/de not_active IP Right Cessation
- 2000-06-30 SK SK1929-2001A patent/SK19292001A3/sk unknown
- 2000-06-30 IL IL14734800A patent/IL147348A0/xx unknown
- 2000-06-30 DE DE60015541T patent/DE60015541T2/de not_active Expired - Lifetime
- 2000-06-30 MX MXPA02000003A patent/MXPA02000003A/es unknown
- 2000-06-30 JP JP2001507834A patent/JP4890707B2/ja not_active Expired - Fee Related
- 2000-06-30 NZ NZ516363A patent/NZ516363A/en unknown
- 2000-06-30 CZ CZ20014696A patent/CZ20014696A3/cs unknown
- 2000-06-30 CA CA002380852A patent/CA2380852C/en not_active Expired - Fee Related
- 2000-06-30 CN CN00811976A patent/CN1371375A/zh active Pending
-
2001
- 2001-12-21 ZA ZA200110558A patent/ZA200110558B/en unknown
- 2001-12-28 NO NO20016402A patent/NO20016402L/no not_active Application Discontinuation
-
2003
- 2003-01-28 HK HK03100716.0A patent/HK1049157A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1191028A4 (en) | 2002-10-23 |
AU774397B2 (en) | 2004-06-24 |
EP1191028B1 (en) | 2004-11-03 |
HUP0202188A3 (en) | 2004-04-28 |
TR200103853T2 (tr) | 2002-11-21 |
JP4890707B2 (ja) | 2012-03-07 |
HK1049157A1 (zh) | 2003-05-02 |
IL147348A0 (en) | 2002-08-14 |
WO2001002397A9 (fr) | 2001-04-05 |
HUP0202188A2 (en) | 2002-10-28 |
CN1371375A (zh) | 2002-09-25 |
PL352862A1 (en) | 2003-09-08 |
NO20016402L (no) | 2002-02-27 |
MXPA02000003A (es) | 2003-07-21 |
ZA200110558B (en) | 2002-09-12 |
CA2380852A1 (en) | 2001-01-11 |
NO20016402D0 (no) | 2001-12-28 |
CA2380852C (en) | 2009-10-20 |
NZ516363A (en) | 2004-05-28 |
CZ20014696A3 (cs) | 2002-05-15 |
DE60015541D1 (de) | 2004-12-09 |
KR20020015061A (ko) | 2002-02-27 |
DE60015541T2 (de) | 2005-12-08 |
SK19292001A3 (sk) | 2002-06-04 |
ATE281457T1 (de) | 2004-11-15 |
WO2001002397A1 (fr) | 2001-01-11 |
AU5572000A (en) | 2001-01-22 |
EP1191028A1 (en) | 2002-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008. |