BR0317693A - Derivados de epotilona - Google Patents

Derivados de epotilona

Info

Publication number
BR0317693A
BR0317693A BR0317693-2A BR0317693A BR0317693A BR 0317693 A BR0317693 A BR 0317693A BR 0317693 A BR0317693 A BR 0317693A BR 0317693 A BR0317693 A BR 0317693A
Authority
BR
Brazil
Prior art keywords
epothilone derivatives
epothilones
derivatives
epotilone
bisnor
Prior art date
Application number
BR0317693-2A
Other languages
English (en)
Inventor
Donatienne Denni-Dischert
Andreas Floersheimer
Ernst K Sters
Lukas Oberer
Gottfried Sedelmeier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0317693A publication Critical patent/BR0317693A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/215—Saturated compounds having only one carboxyl group and containing keto groups containing singly bound oxygen containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE EPOTILONA". A presente invenção refere-se a C4-desmetil-epotilonas ou C4-bisnor-epotilonas da fórmula I seu uso farmacêutico, composições farmacêuticas que as contêm e métodos para sua preparação.
BR0317693-2A 2002-12-23 2003-12-22 Derivados de epotilona BR0317693A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0230024.2A GB0230024D0 (en) 2002-12-23 2002-12-23 Organic compounds
PCT/EP2003/014747 WO2004056832A2 (en) 2002-12-23 2003-12-22 Epothilone derivatives

Publications (1)

Publication Number Publication Date
BR0317693A true BR0317693A (pt) 2005-11-22

Family

ID=9950327

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317693-2A BR0317693A (pt) 2002-12-23 2003-12-22 Derivados de epotilona

Country Status (9)

Country Link
US (1) US7317100B2 (pt)
EP (1) EP1581536A2 (pt)
JP (1) JP4590268B2 (pt)
CN (1) CN100384851C (pt)
AU (1) AU2003294938A1 (pt)
BR (1) BR0317693A (pt)
CA (1) CA2510620A1 (pt)
GB (1) GB0230024D0 (pt)
WO (1) WO2004056832A2 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
KR101173510B1 (ko) 2002-08-23 2012-08-21 슬로안-케테링인스티튜트퍼캔서리서치 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도
US20060121511A1 (en) 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
JP2008536479A (ja) 2005-02-11 2008-09-11 ユニバーシティ オブ サザン カリフォルニア ジスルフィド架橋を有するタンパク質の発現法
JP2009516753A (ja) * 2005-11-22 2009-04-23 ザ スクリップス リサーチ インスティテュート 高度に効力を持つエポチロンの化学合成
EP2029156A4 (en) * 2006-05-01 2010-07-21 Univ Southern California POLY THERAPY FOR TREATING CANCER
US8802394B2 (en) 2008-11-13 2014-08-12 Radu O. Minea Method of expressing proteins with disulfide bridges with enhanced yields and activity
EP3566719A1 (en) 2010-05-18 2019-11-13 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0348641A (ja) 1989-07-18 1991-03-01 Mitsubishi Kasei Corp 光学活性ヒドロキシケトエステル及びその製造方法
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
US6605599B1 (en) * 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
DK1005465T3 (da) 1997-08-09 2007-11-05 Bayer Schering Pharma Ag Nye epothilon-derivater, fremgangsmåde til fremstilling heraf og deres farmaceutiske anvendelse
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
JP2002316977A (ja) * 2000-08-24 2002-10-31 Mitsubishi Chemicals Corp 光学活性１ｈ−３−アミノピロリジン化合物の製造方法
JO2390B1 (en) * 2001-04-06 2007-06-17 شركة جانسين فارماسوتيكا ان. في Diphenylcarboxamides act as lipid-lowering agents
WO2003022844A2 (en) 2001-09-06 2003-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones intermediates thereto and analogues thereof

Also Published As

Publication number Publication date
CA2510620A1 (en) 2004-07-08
EP1581536A2 (en) 2005-10-05
JP4590268B2 (ja) 2010-12-01
AU2003294938A8 (en) 2004-07-14
AU2003294938A1 (en) 2004-07-14
WO2004056832A2 (en) 2004-07-08
CN1732172A (zh) 2006-02-08
JP2006514025A (ja) 2006-04-27
US7317100B2 (en) 2008-01-08
GB0230024D0 (en) 2003-01-29
US20060014796A1 (en) 2006-01-19
WO2004056832A3 (en) 2004-09-10
CN100384851C (zh) 2008-04-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.