HRP20100088T1 - Postupak priprave derivata tetrazola od organskih bor i organskih aluminij azida - Google Patents
Postupak priprave derivata tetrazola od organskih bor i organskih aluminij azida Download PDFInfo
- Publication number
- HRP20100088T1 HRP20100088T1 HR20100088T HRP20100088T HRP20100088T1 HR P20100088 T1 HRP20100088 T1 HR P20100088T1 HR 20100088 T HR20100088 T HR 20100088T HR P20100088 T HRP20100088 T HR P20100088T HR P20100088 T1 HRP20100088 T1 HR P20100088T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- compound
- image
- azide
- boron
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 19
- 229910052796 boron Inorganic materials 0.000 title claims abstract 12
- 238000002360 preparation method Methods 0.000 title claims abstract 11
- 150000003536 tetrazoles Chemical class 0.000 title claims abstract 6
- -1 organo boron Chemical compound 0.000 title claims 7
- 125000002370 organoaluminium group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 40
- 229910052782 aluminium Chemical group 0.000 claims abstract 11
- 150000003839 salts Chemical class 0.000 claims abstract 11
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims abstract 10
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract 10
- 150000001540 azides Chemical class 0.000 claims abstract 5
- 125000002723 alicyclic group Chemical group 0.000 claims abstract 2
- 125000001931 aliphatic group Chemical group 0.000 claims abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 claims abstract 2
- 238000006243 chemical reaction Methods 0.000 claims 8
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 7
- 238000002955 isolation Methods 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 3
- 125000005997 bromomethyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- UWNADWZGEHDQAB-UHFFFAOYSA-N 2,5-dimethylhexane Chemical group CC(C)CCC(C)C UWNADWZGEHDQAB-UHFFFAOYSA-N 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 230000000269 nucleophilic effect Effects 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims 1
- PBSPEQJOIRYRHU-UHFFFAOYSA-N azido(dibutyl)borane Chemical compound CCCCB(N=[N+]=[N-])CCCC PBSPEQJOIRYRHU-UHFFFAOYSA-N 0.000 claims 1
- SOXZLBKYJILYBM-UHFFFAOYSA-N azido(dicyclohexyl)borane Chemical compound C1CCCCC1B(N=[N+]=[N-])C1CCCCC1 SOXZLBKYJILYBM-UHFFFAOYSA-N 0.000 claims 1
- DQGZQAJIHKWEIU-UHFFFAOYSA-N azido(diethyl)alumane Chemical compound [N-]=[N+]=[N-].CC[Al+]CC DQGZQAJIHKWEIU-UHFFFAOYSA-N 0.000 claims 1
- ABCYVPTWWXZRBV-UHFFFAOYSA-N azido(diethyl)borane Chemical compound CCB(CC)N=[N+]=[N-] ABCYVPTWWXZRBV-UHFFFAOYSA-N 0.000 claims 1
- MWMPSUHRZSGXIO-UHFFFAOYSA-N azido(dimethyl)alumane Chemical compound C[Al+]C.[N-]=[N+]=[N-] MWMPSUHRZSGXIO-UHFFFAOYSA-N 0.000 claims 1
- OIQMKWGYLILBKD-UHFFFAOYSA-N azido(diphenyl)borane Chemical compound C=1C=CC=CC=1B(N=[N+]=[N-])C1=CC=CC=C1 OIQMKWGYLILBKD-UHFFFAOYSA-N 0.000 claims 1
- HVSQIYXWVABOJJ-UHFFFAOYSA-N azido(dipropyl)borane Chemical compound CCCB(CCC)N=[N+]=[N-] HVSQIYXWVABOJJ-UHFFFAOYSA-N 0.000 claims 1
- HPCKBIRWBBMNTK-UHFFFAOYSA-N azido-bis(2-methylpropyl)borane Chemical compound CC(C)CB(CC(C)C)N=[N+]=[N-] HPCKBIRWBBMNTK-UHFFFAOYSA-N 0.000 claims 1
- YUGZSAQRWBVQJN-UHFFFAOYSA-N azido-di(propan-2-yl)borane Chemical compound CC(C)B(C(C)C)N=[N+]=[N-] YUGZSAQRWBVQJN-UHFFFAOYSA-N 0.000 claims 1
- HMTULCHRSAPXGU-UHFFFAOYSA-N bis(2-methylpropyl)alumanylium;azide Chemical compound CC(C)C[Al](CC(C)C)N=[N+]=[N-] HMTULCHRSAPXGU-UHFFFAOYSA-N 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- HOSFFWYIXMAFER-UHFFFAOYSA-N di(propan-2-yl)alumanylium;azide Chemical compound [N-]=[N+]=[N-].CC(C)[Al+]C(C)C HOSFFWYIXMAFER-UHFFFAOYSA-N 0.000 claims 1
- ZSTBDNYVSIKSIA-UHFFFAOYSA-N dibutylalumanylium;azide Chemical compound [N-]=[N+]=[N-].CCCC[Al+]CCCC ZSTBDNYVSIKSIA-UHFFFAOYSA-N 0.000 claims 1
- CXXRJSVONCZUJK-UHFFFAOYSA-N dicyclohexylalumanylium;azide Chemical compound [N-]=[N+]=[N-].C1CCCCC1[Al+]C1CCCCC1 CXXRJSVONCZUJK-UHFFFAOYSA-N 0.000 claims 1
- DCELNKRTTMTUKK-UHFFFAOYSA-N dipropylalumanylium;azide Chemical compound [N-]=[N+]=[N-].CCC[Al+]CCC DCELNKRTTMTUKK-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910017604 nitric acid Inorganic materials 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 125000005385 peroxodisulfate group Chemical group 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/06—Aluminium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/06—Aluminium compounds
- C07F5/061—Aluminium compounds with C-aluminium linkage
- C07F5/066—Aluminium compounds with C-aluminium linkage compounds with Al linked to an element other than Al, C, H or halogen (this includes Al-cyanide linkage)
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0316546.1A GB0316546D0 (en) | 2003-07-15 | 2003-07-15 | Process for the manufacture of organic compounds |
| PCT/EP2004/007980 WO2005014602A1 (en) | 2003-07-15 | 2004-07-15 | Process for the preparation of tetrazole derivatives from organo boron and organo aluminium azides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100088T1 true HRP20100088T1 (hr) | 2010-06-30 |
Family
ID=27763861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100088T HRP20100088T1 (hr) | 2003-07-15 | 2010-02-18 | Postupak priprave derivata tetrazola od organskih bor i organskih aluminij azida |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US7943647B2 (ja) |
| EP (2) | EP2116548A1 (ja) |
| JP (2) | JP5052132B2 (ja) |
| KR (5) | KR20130127011A (ja) |
| CN (1) | CN100475823C (ja) |
| AR (1) | AR045995A1 (ja) |
| AT (1) | ATE450541T1 (ja) |
| AU (1) | AU2004263265C1 (ja) |
| BR (1) | BRPI0412558A (ja) |
| CA (1) | CA2532175A1 (ja) |
| CO (1) | CO5670370A2 (ja) |
| CY (1) | CY1109809T1 (ja) |
| DE (1) | DE602004024402D1 (ja) |
| DK (1) | DK1646636T3 (ja) |
| EC (2) | ECSP066282A (ja) |
| ES (1) | ES2336333T3 (ja) |
| GB (1) | GB0316546D0 (ja) |
| HK (1) | HK1093509A1 (ja) |
| HR (1) | HRP20100088T1 (ja) |
| IL (2) | IL172946A (ja) |
| IS (1) | IS8303A (ja) |
| MA (1) | MA27906A1 (ja) |
| MX (1) | MXPA06000561A (ja) |
| MY (1) | MY176840A (ja) |
| NO (1) | NO20060729L (ja) |
| NZ (1) | NZ544644A (ja) |
| PE (2) | PE20091786A1 (ja) |
| PL (1) | PL1646636T3 (ja) |
| PT (1) | PT1646636E (ja) |
| RU (2) | RU2006104322A (ja) |
| SI (1) | SI1646636T1 (ja) |
| TN (1) | TNSN06008A1 (ja) |
| TW (2) | TWI372754B (ja) |
| WO (1) | WO2005014602A1 (ja) |
| ZA (1) | ZA200600312B (ja) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
| JP4537678B2 (ja) * | 2003-09-04 | 2010-09-01 | 住友化学株式会社 | ２’−（１ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒド結晶およびその製造方法 |
| EP1661891A1 (en) * | 2004-11-30 | 2006-05-31 | KRKA, D.D., Novo Mesto | A process for the synthesis of valsartan |
| GB0514206D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| GB0514686D0 (en) * | 2005-07-18 | 2005-08-24 | Novartis Ag | Organic compounds |
| US7923566B2 (en) | 2005-08-16 | 2011-04-12 | Suven Life Sciences Limited | Alternative process for the preparation of losartan |
| WO2007026375A1 (en) * | 2005-08-31 | 2007-03-08 | Suven Life Sciences | Process for the preparation of losartan |
| KR100795589B1 (ko) * | 2006-05-29 | 2008-01-21 | 주식회사 대희화학 | 2-부틸-4-클로로-1-[[2'-(1ｈ-테트라졸-5-일)바이페닐-4-일]메틸]이미다졸-5-카르복스알데하이드의 제조방법 |
| CN101200455B (zh) * | 2007-09-29 | 2010-08-18 | 泰兴市江神化工有限公司 | 沙坦类治疗高血压药物主环5-(4'-甲酰基联苯-2-基)-1h-四氮唑的制备方法 |
| JP4792128B2 (ja) | 2007-10-12 | 2011-10-12 | アークル インコーポレイテッド | 癌に対するｈｓｐ９０阻害剤としての５−（２−ヒドロキシフェニル）テトラゾール |
| EP2316821A1 (en) | 2009-10-27 | 2011-05-04 | Novartis AG | Process for the manufacture of organic compounds |
| CN102712606A (zh) * | 2009-11-17 | 2012-10-03 | 田边三菱制药株式会社 | 联苯基衍生物的制备方法 |
| US10368340B2 (en) * | 2010-04-01 | 2019-07-30 | Hon Hai Precision Industry Co., Ltd. | Network service exposure method and apparatus utilizing the same |
| KR101942064B1 (ko) * | 2011-04-25 | 2019-01-24 | 주식회사 엘지화학 | 신규한 아연 아지드 착물 및 이를 이용한 테트라졸 유도체의 제조방법 |
| CN102351804B (zh) * | 2011-09-30 | 2013-07-31 | 浙江新赛科药业有限公司 | 一种缬沙坦消旋体的回收方法 |
| CN102702117B (zh) * | 2012-06-01 | 2016-04-13 | 浙江沙星医药化工有限公司 | 一种制备5-(4’-溴代甲基-2-联苯基)-1-三苯甲基四氮唑的方法 |
| CN103265560B (zh) * | 2013-05-17 | 2016-05-04 | 中国科学院上海高等研究院 | 棉酚/棉酮衍生物及其制备方法和抗肿瘤药物中的应用 |
| KR101956281B1 (ko) * | 2013-08-13 | 2019-03-08 | 삼성전기주식회사 | 수지 조성물, 이를 이용한 인쇄회로기판 및 그 제조방법 |
| KR102090155B1 (ko) * | 2019-11-22 | 2020-03-17 | 국방과학연구소 | 베타인 수용액 내에서 5-치환-1h-테트라졸의 제조방법 |
| US11655220B2 (en) | 2020-10-22 | 2023-05-23 | Hetero Labs Limited | Process for the preparation of angiotensin II receptor blockers |
| CN116375687A (zh) * | 2021-12-22 | 2023-07-04 | 浙江华海药业股份有限公司 | 一种高纯度的氯沙坦钾及其制备方法 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2977372A (en) | 1958-04-09 | 1961-03-28 | William G Finnegan | Process for preparing substituted tetrazoles |
| US3394142A (en) | 1966-01-19 | 1968-07-23 | Minnesota Mining & Mfg | Substituted tetrazoles and process therefor |
| CH499526A (de) | 1968-06-06 | 1970-11-30 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Tetrazolderivaten |
| SU497775A3 (ru) | 1970-01-16 | 1975-12-30 | Циба-Гейги Аг (Фирма) | Способ получени производных тетразола |
| DE2650231A1 (de) | 1976-11-02 | 1978-05-11 | Hoechst Ag | Neue imidazolverbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4097479A (en) | 1977-03-11 | 1978-06-27 | Miles Laboratories, Inc. | Synthesis of 5-substituted tetrazoles |
| US4122274A (en) | 1977-05-25 | 1978-10-24 | Bristol-Myers Company | 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones |
| US4288352A (en) | 1979-03-26 | 1981-09-08 | Exxon Research & Engineering Co. | Electrically conductive polymeric compositions |
| FI73423C (fi) * | 1980-02-29 | 1987-10-09 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av farmakologiskt verksamma tetrazolderivat. |
| JPS56158781A (en) | 1980-05-10 | 1981-12-07 | Kaken Pharmaceut Co Ltd | Tetrazolecoumarin derivative, its preparation and antiallergic agent containing the same as active constitutent |
| US4338452A (en) * | 1980-09-17 | 1982-07-06 | Eli Lilly And Company | 1-and 2-(1-Alkyl-1H-tetrazol-5-yl-methyl)-1H-tetrazol-5-thiols and 1-cyanomethyl tetrazole-5-thiol |
| US4735948A (en) | 1983-03-25 | 1988-04-05 | Merrell Dow Pharmaceuticals Inc. | (1H-tetrazol-5-yl)-2(1H)-quinolinones and-naphthyridones and antiallergic use thereof |
| JPS6073028A (ja) | 1983-09-29 | 1985-04-25 | Japan Electronic Control Syst Co Ltd | 電子制御燃料噴射式内燃機関の始動時の噴射量の学習制御装置 |
| US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| CA1334092C (en) | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| GB8708459D0 (en) | 1987-04-09 | 1987-05-13 | Avdel Ltd | Fastener installation apparatus |
| US4874867A (en) | 1987-05-22 | 1989-10-17 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| US4820843A (en) | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| US4870186A (en) | 1987-05-22 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| US4831192A (en) | 1987-12-31 | 1989-05-16 | Boc, Inc. | Methods of preparing 4-heteropentacyclic-4-(N-phenyl)amido) piperidine derivatives and intermediate compounds |
| US5210079A (en) | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
| US5128069A (en) * | 1989-03-22 | 1992-07-07 | Nippon Zoki Pharmaceutical Co., Ltd. | Luciferin derivatives |
| DK0443983T3 (da) | 1990-02-19 | 1996-03-18 | Ciba Geigy Ag | Acrylforbindelser |
| TW201738B (ja) | 1990-03-20 | 1993-03-11 | Sanofi Co | |
| US5270317A (en) | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| JPH04297466A (ja) | 1990-06-22 | 1992-10-21 | Nippon Shinyaku Co Ltd | テトラゾール誘導体及び医薬 |
| US5284954A (en) | 1990-09-10 | 1994-02-08 | Abbott Laboratories | Process for the preparation of tetrazoles |
| JP3214856B2 (ja) | 1990-12-14 | 2001-10-02 | スミスクライン・ビーチャム・コーポレイション | イミダゾリル−アルケン酸 |
| US5602127A (en) | 1991-02-06 | 1997-02-11 | Karl Thomae Gmbh | (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists |
| US5591762A (en) | 1991-02-06 | 1997-01-07 | Dr. Karl Thomae Gmbh | Benzimidazoles useful as angiotensin-11 antagonists |
| US5594003A (en) | 1991-02-06 | 1997-01-14 | Dr. Karl Thomae Gmbh | Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists |
| SI9210098B (sl) | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo |
| CA2061607C (en) | 1991-02-21 | 1999-01-19 | Hiroaki Yanagisawa | 1-biphenylimidazole derivatives, their preparation and their therapeutic use |
| JP2524842Y2 (ja) | 1991-02-28 | 1997-02-05 | 三菱重工業株式会社 | 原紙供給装置 |
| US5447949A (en) | 1991-05-15 | 1995-09-05 | Smithkline Beecham Corporation | N-(heteroaryl) imidazolyl-alkenoic acids having angiotension II receptor antagonist activity |
| AU2494792A (en) | 1991-08-19 | 1993-03-16 | E.I. Du Pont De Nemours And Company | Angiotensin ii receptor blocking imidazolinone derivatives |
| ATE144501T1 (de) | 1991-08-22 | 1996-11-15 | Warner Lambert Co | Tetrazolamide als acat inhibitoren |
| EP0550313A1 (fr) | 1991-12-30 | 1993-07-07 | Synthelabo | Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse |
| WO1993014086A1 (en) | 1992-01-17 | 1993-07-22 | Syntex (U.S.A.) Inc. | Substituted 1-isoquinolone derivatives as angiotensin ii antagonists |
| DE4203872A1 (de) * | 1992-02-11 | 1993-08-12 | Thomae Gmbh Dr K | Imidazo(1,2-a)pyridine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4206045A1 (de) | 1992-02-27 | 1993-09-02 | Bayer Ag | Sulfonylbenzyl substituierte pyridone |
| US5484955A (en) | 1992-07-06 | 1996-01-16 | Takeda Chemical Industries, Ltd. | Tri-higher alkyl tin azide and its use |
| JP2990566B2 (ja) * | 1992-07-06 | 1999-12-13 | 武田薬品工業株式会社 | トリ高級アルキルスズアジドおよびその用途 |
| JPH06107658A (ja) | 1992-09-28 | 1994-04-19 | Kanebo Ltd | 新規なピラジン誘導体 |
| US5256658A (en) | 1993-01-15 | 1993-10-26 | Ortho Pharmaceutical Corporation | Angiotensin II inhibitors |
| US5502191A (en) | 1993-07-01 | 1996-03-26 | American Cyanamid Company | Method of synthesizing sterically hindered 5-substituted-1H-tetrazoles from nitriles using a lewis acid and an azide |
| CA2179067A1 (en) | 1993-12-23 | 1995-06-29 | Gordon Creston Campbell, Jr. | Polymorphs of losartan and the process for the preparation of form ii of losartan |
| CA2184694A1 (en) | 1994-03-25 | 1995-10-05 | Kay K. Olmstead | Process for preparing (1h-tetrazol-5-yl)tetrazolo [1,5-a] quinolines andnaphthyridines |
| ES2119377T3 (es) | 1994-03-28 | 1998-10-01 | Pfizer | Derivados bencisotiazoles inhibidores de la biosintesis de la 5-lipoxigenasa. |
| US5541209A (en) | 1994-08-22 | 1996-07-30 | Bristol-Myers Squibb Company | Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative |
| JPH08325248A (ja) | 1995-05-26 | 1996-12-10 | Chugoku Kayaku Kk | テトラゾール類の新規な合成試薬及びそれを用いたテトラゾール類の製造方法 |
| JP3671266B2 (ja) | 1996-03-21 | 2005-07-13 | 東洋化成工業株式会社 | ５−置換テトラゾール類の製造方法 |
| JPH10218868A (ja) | 1997-02-12 | 1998-08-18 | Toyo Kasei Kogyo Co Ltd | ５ーメチルテトラゾールの製造方法 |
| JP4450881B2 (ja) | 1998-12-28 | 2010-04-14 | 株式会社日本ファインケム | ５，５’−ビ−１ｈ−テトラゾール塩の製造方法 |
| JP2000281662A (ja) | 1999-03-31 | 2000-10-10 | Masuda Kagaku Kogyo Kk | テトラゾール類の製造方法 |
| DE19935219A1 (de) * | 1999-07-27 | 2001-02-01 | Boehringer Ingelheim Pharma | Carbonsäureamide, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung |
| AU6525500A (en) * | 1999-09-27 | 2001-04-30 | Dow Chemical Company, The | Supported catalyst comprising expanded anions |
| US20040072886A1 (en) * | 2002-04-15 | 2004-04-15 | Dr. Reddy's Laboratories Limited | Novel crystalline forms of (S)-N- (1-Carboxy-2-methyl-prop-1-yl) -N-pentanoyl-N- [2' -(1H-tetrazol-5-yl)- biphenyl-4-yl methyl] amine (Valsartan) |
| GB0222056D0 (en) * | 2002-09-23 | 2002-10-30 | Novartis Ag | Process for the manufacture of organic compounds |
| US6934312B2 (en) * | 2002-09-30 | 2005-08-23 | Agilent Technologies, Inc. | System and method for fabricating efficient semiconductor lasers via use of precursors having a direct bond between a group III atom and a nitrogen atom |
| GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
| EP1660463B1 (en) * | 2003-08-08 | 2007-12-05 | Dipharma Francis S.r.l. | A process for the preparation of phenyltetrazole derivatives |
| CA2558230A1 (en) | 2004-03-17 | 2005-09-29 | Kennecott Utah Copper Corporation | Monitoring electrolytic cell currents |
-
2003
- 2003-07-15 GB GBGB0316546.1A patent/GB0316546D0/en not_active Ceased
-
2004
- 2004-07-14 TW TW093121028A patent/TWI372754B/zh not_active IP Right Cessation
- 2004-07-14 TW TW099123665A patent/TWI340742B/zh not_active IP Right Cessation
- 2004-07-14 MY MYPI20042814A patent/MY176840A/en unknown
- 2004-07-14 PE PE2009001025A patent/PE20091786A1/es not_active Application Discontinuation
- 2004-07-14 PE PE2004000667A patent/PE20050710A1/es not_active Application Discontinuation
- 2004-07-15 CN CNB2004800264381A patent/CN100475823C/zh not_active Expired - Fee Related
- 2004-07-15 KR KR1020137029233A patent/KR20130127011A/ko not_active Application Discontinuation
- 2004-07-15 US US10/564,337 patent/US7943647B2/en not_active Expired - Fee Related
- 2004-07-15 PT PT04801815T patent/PT1646636E/pt unknown
- 2004-07-15 AU AU2004263265A patent/AU2004263265C1/en not_active Ceased
- 2004-07-15 EP EP09167254A patent/EP2116548A1/en not_active Withdrawn
- 2004-07-15 SI SI200431336T patent/SI1646636T1/sl unknown
- 2004-07-15 JP JP2006519892A patent/JP5052132B2/ja not_active Expired - Fee Related
- 2004-07-15 KR KR1020137032383A patent/KR20130140915A/ko not_active Application Discontinuation
- 2004-07-15 DE DE602004024402T patent/DE602004024402D1/de active Active
- 2004-07-15 ES ES04801815T patent/ES2336333T3/es active Active
- 2004-07-15 KR KR1020127002953A patent/KR20120018826A/ko not_active Application Discontinuation
- 2004-07-15 WO PCT/EP2004/007980 patent/WO2005014602A1/en active Application Filing
- 2004-07-15 DK DK04801815.4T patent/DK1646636T3/da active
- 2004-07-15 AR ARP040102491A patent/AR045995A1/es not_active Application Discontinuation
- 2004-07-15 PL PL04801815T patent/PL1646636T3/pl unknown
- 2004-07-15 EP EP04801815A patent/EP1646636B1/en active Active
- 2004-07-15 CA CA002532175A patent/CA2532175A1/en not_active Abandoned
- 2004-07-15 AT AT04801815T patent/ATE450541T1/de active
- 2004-07-15 KR KR1020117015621A patent/KR101336435B1/ko not_active IP Right Cessation
- 2004-07-15 RU RU2006104322/04A patent/RU2006104322A/ru unknown
- 2004-07-15 BR BRPI0412558-4A patent/BRPI0412558A/pt not_active IP Right Cessation
- 2004-07-15 NZ NZ544644A patent/NZ544644A/en not_active IP Right Cessation
- 2004-07-15 MX MXPA06000561A patent/MXPA06000561A/es active IP Right Grant
- 2004-07-15 KR KR1020067000855A patent/KR20060038994A/ko not_active Application Discontinuation
-
2006
- 2006-01-02 IL IL172946A patent/IL172946A/en not_active IP Right Cessation
- 2006-01-06 MA MA28712A patent/MA27906A1/fr unknown
- 2006-01-09 TN TNP2006000008A patent/TNSN06008A1/en unknown
- 2006-01-12 ZA ZA200600312A patent/ZA200600312B/xx unknown
- 2006-01-13 EC EC2006006282A patent/ECSP066282A/es unknown
- 2006-02-14 IS IS8303A patent/IS8303A/is unknown
- 2006-02-15 CO CO06014919A patent/CO5670370A2/es unknown
- 2006-02-15 NO NO20060729A patent/NO20060729L/no not_active Application Discontinuation
- 2006-10-09 HK HK06111075.9A patent/HK1093509A1/xx not_active IP Right Cessation
-
2010
- 2010-02-10 CY CY20101100128T patent/CY1109809T1/el unknown
- 2010-02-18 HR HR20100088T patent/HRP20100088T1/hr unknown
-
2011
- 2011-04-07 US US13/081,881 patent/US20110184187A1/en not_active Abandoned
- 2011-05-09 JP JP2011104199A patent/JP2011184451A/ja active Pending
- 2011-07-22 EC EC2011006282A patent/ECSP11006282A/es unknown
- 2011-11-17 IL IL216449A patent/IL216449A0/en unknown
-
2012
- 2012-09-05 US US13/603,770 patent/US8569528B2/en not_active Expired - Fee Related
- 2012-11-19 RU RU2012149012/04A patent/RU2012149012A/ru unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20100088T1 (hr) | Postupak priprave derivata tetrazola od organskih bor i organskih aluminij azida | |
| CZ20032451A3 (cs) | Nové spirotricyklické deriváty a jejich použití jako inhibitorů fosfodiesterasy-7 | |
| NO20052781L (no) | Forbindelser og prosesser | |
| TW200633991A (en) | Chemical compounds | |
| IL225002A (en) | Aza-bicycloalkyl derivatives, processes for their preparation, pharmaceutical preparations containing them and their use as pharmaceuticals | |
| CA2755268A1 (en) | Erbb inhibitors | |
| IE913307A1 (en) | Process for the preparation of imidazo[4,5-c]quinolin-4-amines | |
| NO20091242L (no) | Fremgangsmate for fremstilling av biarylsubstituerte 4-aminosmorsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer | |
| HRP20150700T1 (hr) | Postupak za pripravu bifenil-2-il karbaminske kiseline | |
| JP2009513555A5 (ja) | ||
| AU742497B2 (en) | Process for preparing a protected 4-aminomethyl-pyrrolidin- 3-one | |
| CN108864051A (zh) | 用于制备纯的尼洛替尼及其盐的方法 | |
| CN109336792A (zh) | 一种4-甲基-n-苯基-n-（2-苯基烯丙基）苯磺酰胺类化合物的合成方法 | |
| NO20043951L (no) | 3-cyklyl-5-(nitrogenholdig 5-leddet ring) metyl-oksazolidinon-derivater og deres anvendelse som antibakterielle midler | |
| EP3365332A1 (en) | Preparation method of intermediate for oxazolidinone derivative | |
| JP2008532946A5 (ja) | ||
| MY140571A (en) | Mercaptoimidazoles as ccr2 receptor antagonists | |
| MY139783A (en) | Mercaptoimidazoles as ccr2 receptor antagonists | |
| CN101948418B (zh) | 含羟脯氨酸结构的hiv-1蛋白酶抑制剂及其制备方法与应用 | |
| IL139530A0 (en) | Pyrimidin-aminomethyl-pyridine derivatives, methods for preparation thereof and pharmaceutical compositions containing the same | |
| MX2009012566A (es) | Sintesis de oligonucleotidos. | |
| ES2628155T3 (es) | Preparación de bisamidas metálicas en complejo con metales alcalinotérreos a partir de monoamidas metálicas | |
| CN114129570B (zh) | 噁唑烷酮类化合物在制备抗冠状病毒药物中的应用 | |
| RU2011126609A (ru) | Способ получения производных тетразола из борорганических и алюминийорганических азидов | |
| RU2009134310A (ru) | Способ получения производных тетразола из борорганических и алюминийорганических азидов |