PE20091786A1 - Proceso para preparar tetrazoles antagonistas del receptor de angiotensina ii - Google Patents

Proceso para preparar tetrazoles antagonistas del receptor de angiotensina ii

Info

Publication number
PE20091786A1
PE20091786A1 PE2009001025A PE2009001025A PE20091786A1 PE 20091786 A1 PE20091786 A1 PE 20091786A1 PE 2009001025 A PE2009001025 A PE 2009001025A PE 2009001025 A PE2009001025 A PE 2009001025A PE 20091786 A1 PE20091786 A1 PE 20091786A1
Authority
PE
Peru
Prior art keywords
tetrazoles
receptor antagonists
formula
angiotensin
ckyls
Prior art date
Application number
PE2009001025A
Other languages
English (en)
Inventor
Sedelmeier Gottfried
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20091786A1 publication Critical patent/PE20091786A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/06—Aluminium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/06—Aluminium compounds
    • C07F5/061—Aluminium compounds with C-aluminium linkage
    • C07F5/066—Aluminium compounds with C-aluminium linkage compounds with Al linked to an element other than Al, C, H or halogen (this includes Al-cyanide linkage)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA A UN PROCESO DE PREPARACION DE UN ANTAGONISTA DEL RECEPTOR DE ANGIOTENSINA II, EL CUAL ES UN DERIVADO DE TETRAZOL DE FORMULA (IVb), DONDE DICHO PROCESO CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (IVc) O UN ALQUILESTER C1-C7 O UN BENCILESTER DEL MISMO, CON UNA AZIDA DE FORMULA (R1)(R2)M-N3 PARA LUEGO AISLAR EL COMPUESTO (IVb), DONDE R1 Y R2 SON UN RESIDUO ALIFATICO TAL COMO ALQUILO C1-C20, ALQUENILO C3-C20, UN RESIDUO AROMATICO CARBOCICLICO TAL COMO FENILO, NAFTILO O BIFENILO, ENTRE OTROS Y M ES BORO O ALUMINIO
PE2009001025A 2003-07-15 2004-07-14 Proceso para preparar tetrazoles antagonistas del receptor de angiotensina ii PE20091786A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0316546.1A GB0316546D0 (en) 2003-07-15 2003-07-15 Process for the manufacture of organic compounds

Publications (1)

Publication Number Publication Date
PE20091786A1 true PE20091786A1 (es) 2009-12-14

Family

ID=27763861

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2009001025A PE20091786A1 (es) 2003-07-15 2004-07-14 Proceso para preparar tetrazoles antagonistas del receptor de angiotensina ii
PE2004000667A PE20050710A1 (es) 2003-07-15 2004-07-14 Proceso para la preparacion de derivados de tetrazoles utilizando azidas de organo boro y organo aluminio

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2004000667A PE20050710A1 (es) 2003-07-15 2004-07-14 Proceso para la preparacion de derivados de tetrazoles utilizando azidas de organo boro y organo aluminio

Country Status (35)

Country Link
US (3) US7943647B2 (es)
EP (2) EP2116548A1 (es)
JP (2) JP5052132B2 (es)
KR (5) KR101336435B1 (es)
CN (1) CN100475823C (es)
AR (1) AR045995A1 (es)
AT (1) ATE450541T1 (es)
AU (1) AU2004263265C1 (es)
BR (1) BRPI0412558A (es)
CA (1) CA2532175A1 (es)
CO (1) CO5670370A2 (es)
CY (1) CY1109809T1 (es)
DE (1) DE602004024402D1 (es)
DK (1) DK1646636T3 (es)
EC (2) ECSP066282A (es)
ES (1) ES2336333T3 (es)
GB (1) GB0316546D0 (es)
HK (1) HK1093509A1 (es)
HR (1) HRP20100088T1 (es)
IL (2) IL172946A (es)
IS (1) IS8303A (es)
MA (1) MA27906A1 (es)
MX (1) MXPA06000561A (es)
MY (1) MY176840A (es)
NO (1) NO20060729L (es)
NZ (1) NZ544644A (es)
PE (2) PE20091786A1 (es)
PL (1) PL1646636T3 (es)
PT (1) PT1646636E (es)
RU (2) RU2006104322A (es)
SI (1) SI1646636T1 (es)
TN (1) TNSN06008A1 (es)
TW (2) TWI372754B (es)
WO (1) WO2005014602A1 (es)
ZA (1) ZA200600312B (es)

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GB0316546D0 (en) * 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
JP4537678B2 (ja) * 2003-09-04 2010-09-01 住友化学株式会社 ２’−（１ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒド結晶およびその製造方法
EP1661891A1 (en) * 2004-11-30 2006-05-31 KRKA, D.D., Novo Mesto A process for the synthesis of valsartan
GB0514206D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
GB0514686D0 (en) * 2005-07-18 2005-08-24 Novartis Ag Organic compounds
WO2007020654A1 (en) * 2005-08-16 2007-02-22 Suven Life Sciences An improved process for the preparation of losartan
WO2007026375A1 (en) * 2005-08-31 2007-03-08 Suven Life Sciences Process for the preparation of losartan
KR100795589B1 (ko) * 2006-05-29 2008-01-21 주식회사 대희화학 2-부틸-4-클로로-1-[[2'-(1ｈ-테트라졸-5-일)바이페닐-4-일]메틸]이미다졸-5-카르복스알데하이드의 제조방법
CN101200455B (zh) * 2007-09-29 2010-08-18 泰兴市江神化工有限公司 沙坦类治疗高血压药物主环5-(4'-甲酰基联苯-2-基)-1h-四氮唑的制备方法
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EP2316821A1 (en) * 2009-10-27 2011-05-04 Novartis AG Process for the manufacture of organic compounds
JPWO2011061996A1 (ja) * 2009-11-17 2013-04-04 田辺三菱製薬株式会社 ビフェニル誘導体の製法
US10368340B2 (en) * 2010-04-01 2019-07-30 Hon Hai Precision Industry Co., Ltd. Network service exposure method and apparatus utilizing the same
WO2012148148A2 (en) * 2011-04-25 2012-11-01 Lg Life Sciences Ltd. Novel zinc azide complex and a process for preparing tetrazole derivatives using the same
CN102351804B (zh) * 2011-09-30 2013-07-31 浙江新赛科药业有限公司 一种缬沙坦消旋体的回收方法
CN102702117B (zh) * 2012-06-01 2016-04-13 浙江沙星医药化工有限公司 一种制备5-(4’-溴代甲基-2-联苯基)-1-三苯甲基四氮唑的方法
CN103265560B (zh) * 2013-05-17 2016-05-04 中国科学院上海高等研究院 棉酚/棉酮衍生物及其制备方法和抗肿瘤药物中的应用
KR101956281B1 (ko) * 2013-08-13 2019-03-08 삼성전기주식회사 수지 조성물, 이를 이용한 인쇄회로기판 및 그 제조방법
KR102090155B1 (ko) * 2019-11-22 2020-03-17 국방과학연구소 베타인 수용액 내에서 5-치환-1h-테트라졸의 제조방법
US11655220B2 (en) 2020-10-22 2023-05-23 Hetero Labs Limited Process for the preparation of angiotensin II receptor blockers
CN116375687A (zh) * 2021-12-22 2023-07-04 浙江华海药业股份有限公司 一种高纯度的氯沙坦钾及其制备方法

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Also Published As

Publication number Publication date
SI1646636T1 (sl) 2010-03-31
AU2004263265B2 (en) 2007-09-06
TWI340742B (en) 2011-04-21
PL1646636T3 (pl) 2010-05-31
AU2004263265C1 (en) 2008-09-25
GB0316546D0 (en) 2003-08-20
CN100475823C (zh) 2009-04-08
EP1646636A1 (en) 2006-04-19
CY1109809T1 (el) 2014-09-10
HRP20100088T1 (hr) 2010-06-30
MXPA06000561A (es) 2006-03-30
ZA200600312B (en) 2007-02-28
EP1646636B1 (en) 2009-12-02
JP5052132B2 (ja) 2012-10-17
EP2116548A1 (en) 2009-11-11
US8569528B2 (en) 2013-10-29
TWI372754B (en) 2012-09-21
KR20120018826A (ko) 2012-03-05
ECSP066282A (es) 2006-07-28
NO20060729L (no) 2006-04-04
DE602004024402D1 (de) 2010-01-14
WO2005014602A1 (en) 2005-02-17
KR20110082096A (ko) 2011-07-15
RU2006104322A (ru) 2007-09-20
US20070043098A1 (en) 2007-02-22
US20120330026A1 (en) 2012-12-27
DK1646636T3 (da) 2010-04-06
JP2009513555A (ja) 2009-04-02
CA2532175A1 (en) 2005-02-17
KR20130140915A (ko) 2013-12-24
TW201038540A (en) 2010-11-01
IL172946A (en) 2012-01-31
IL172946A0 (en) 2006-06-11
CN1852908A (zh) 2006-10-25
IL216449A0 (en) 2011-12-29
TW200510347A (en) 2005-03-16
TNSN06008A1 (en) 2007-10-03
ATE450541T1 (de) 2009-12-15
US20110184187A1 (en) 2011-07-28
JP2011184451A (ja) 2011-09-22
US7943647B2 (en) 2011-05-17
NZ544644A (en) 2008-07-31
CO5670370A2 (es) 2006-08-31
ECSP11006282A (es) 2011-08-31
IS8303A (is) 2006-02-14
KR20130127011A (ko) 2013-11-21
PT1646636E (pt) 2010-01-29
HK1093509A1 (en) 2007-03-02
PE20050710A1 (es) 2005-09-28
MY176840A (en) 2020-08-24
AU2004263265A1 (en) 2005-02-17
KR20060038994A (ko) 2006-05-04
RU2012149012A (ru) 2014-05-27
ES2336333T3 (es) 2010-04-12
KR101336435B1 (ko) 2013-12-04
MA27906A1 (fr) 2006-05-02
AR045995A1 (es) 2005-11-23
BRPI0412558A (pt) 2006-09-19

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