ECSP066983A - Un método fácil para sintetizar compuestos de bacatina iii - Google Patents
Un método fácil para sintetizar compuestos de bacatina iiiInfo
- Publication number
- ECSP066983A ECSP066983A EC2006006983A ECSP066983A ECSP066983A EC SP066983 A ECSP066983 A EC SP066983A EC 2006006983 A EC2006006983 A EC 2006006983A EC SP066983 A ECSP066983 A EC SP066983A EC SP066983 A ECSP066983 A EC SP066983A
- Authority
- EC
- Ecuador
- Prior art keywords
- synthesizing
- nitrogen
- formula
- compound
- bacatine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 230000002194 synthesizing effect Effects 0.000 title abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- -1 nitrogen containing compound Chemical class 0.000 abstract 3
- 239000003223 protective agent Substances 0.000 abstract 3
- OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 1
- 229930014667 baccatin III Natural products 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000003216 pyrazines Chemical class 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005270 trialkylamine group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Un proceso para sintetizar un compuesto de la bacatina III C-7 protegido representado por la fórmula (A), que comprende reaccionar un compuesto de 10-deacetilbacatina III representado por la fórmula (B) con un agente de protección y un agente de acilación en la presencia de una amina secundaria y un compuesto que contiene nitrógeno. También, un procedimiento para sintetizar un compuesto de 10-deacetilbacatina III C-7 protegido representado por la fórmula (C), que comprende reaccionar un compuesto de 10-deacetilbacatina III representado por la fórmula (B) con un agente de protección en la presencia de una amina secundaria y compuesto que contiene nitrógeno. En ambos procedimientos el compuesto que contiene nitrógeno se selecciona de un heterociclo que contiene nitrógeno o una tiralquilamina. Cuando se selecciona el heterociclo que contiene nitrógeno, puede ser una piridina no sustituida o sustituida, o una pirazina no sustituida o sustituida. Cuando se selecciona una trialquilamina, puede ser, por ejemplo trietilamina o diisopropiletilamina. (A, B, C) en donde PG1 representa el residuo orgánico del agente de protección, PG2 representa el residuo orgánico del agente de acilación, y R representa un grupo arilo simple o sustituido o un grupo heterocíclico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57083404P | 2004-05-14 | 2004-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP066983A true ECSP066983A (es) | 2006-12-29 |
Family
ID=35428370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2006006983A ECSP066983A (es) | 2004-05-14 | 2006-11-09 | Un método fácil para sintetizar compuestos de bacatina iii |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7186851B2 (es) |
| EP (1) | EP1747209A4 (es) |
| JP (1) | JP2007537271A (es) |
| KR (1) | KR20070013300A (es) |
| CN (1) | CN1942459A (es) |
| AU (1) | AU2005245396A1 (es) |
| BR (1) | BRPI0511109A (es) |
| CA (1) | CA2563905A1 (es) |
| EA (1) | EA200601898A1 (es) |
| EC (1) | ECSP066983A (es) |
| IL (1) | IL178415A0 (es) |
| MX (1) | MXPA06012606A (es) |
| WO (1) | WO2005113528A1 (es) |
| ZA (1) | ZA200608075B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1688415A1 (en) * | 2004-12-07 | 2006-08-09 | Aventis Pharma S.A. | Cytotoxic agents comprising new C-2 modified taxanes |
| JP5588983B2 (ja) | 2008-08-11 | 2014-09-10 | ウェルズ ファーゴ バンク ナショナル アソシエイション | マルチアームポリマーアルカノエートコンジュゲート |
| US9199954B2 (en) | 2010-12-22 | 2015-12-01 | Nektar Therapeutics | Non-ring hydroxy substituted taxanes and methods for synthesizing the same |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| PL2760848T3 (pl) | 2011-09-26 | 2019-07-31 | Fresenius Kabi Oncology Limited | Sposoby otrzymywania kabazytakselu powiązane z sililowaniem c(7)-oh i c(13)-oh lub z sililowaniem tylko c(7)-oh |
| CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| CN106414465B (zh) | 2014-02-28 | 2021-11-16 | 杭州多禧生物科技有限公司 | 带电荷链接体及其在共轭反应上的应用 |
| NZ739830A (en) | 2015-07-12 | 2021-12-24 | Hangzhou Dac Biotech Co Ltd | Bridge linkers for conjugation of cell-binding molecules |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| CN116143678A (zh) | 2016-11-14 | 2023-05-23 | 杭州多禧生物科技有限公司 | 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用 |
| WO2022078524A2 (en) | 2021-11-03 | 2022-04-21 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation of an antibody |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5274124A (en) * | 1991-09-23 | 1993-12-28 | Florida State University | Metal alkoxides |
| IL108444A0 (en) * | 1993-01-29 | 1994-04-12 | Univ Florida State | C2 taxane derivatives and pharmaceutical compositions containing them |
| US5948919A (en) * | 1993-02-05 | 1999-09-07 | Napro Biotherapeutics, Inc. | Paclitaxel synthesis from precursor compounds and methods of producing the same |
| TW467896B (en) * | 1993-03-19 | 2001-12-11 | Bristol Myers Squibb Co | Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes |
| FR2718137B1 (fr) * | 1994-04-05 | 1996-04-26 | Rhone Poulenc Rorer Sa | Procédé de préparation de trialcoylsilyl-7 baccatine III. |
| US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| US5914411A (en) * | 1998-01-21 | 1999-06-22 | Napro Biotherapeutics, Inc. | Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position |
-
2005
- 2005-05-11 KR KR1020067023847A patent/KR20070013300A/ko not_active Withdrawn
- 2005-05-11 WO PCT/US2005/016497 patent/WO2005113528A1/en not_active Ceased
- 2005-05-11 EP EP05754136A patent/EP1747209A4/en not_active Withdrawn
- 2005-05-11 AU AU2005245396A patent/AU2005245396A1/en not_active Abandoned
- 2005-05-11 MX MXPA06012606A patent/MXPA06012606A/es not_active Application Discontinuation
- 2005-05-11 EA EA200601898A patent/EA200601898A1/ru unknown
- 2005-05-11 BR BRPI0511109-9A patent/BRPI0511109A/pt not_active IP Right Cessation
- 2005-05-11 CA CA002563905A patent/CA2563905A1/en not_active Abandoned
- 2005-05-11 JP JP2007513315A patent/JP2007537271A/ja not_active Withdrawn
- 2005-05-11 CN CNA2005800117122A patent/CN1942459A/zh active Pending
- 2005-05-12 US US11/127,234 patent/US7186851B2/en not_active Expired - Fee Related
-
2006
- 2006-09-28 ZA ZA200608075A patent/ZA200608075B/xx unknown
- 2006-10-03 IL IL178415A patent/IL178415A0/en unknown
- 2006-11-09 EC EC2006006983A patent/ECSP066983A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005113528A1 (en) | 2005-12-01 |
| US7186851B2 (en) | 2007-03-06 |
| AU2005245396A1 (en) | 2005-12-01 |
| JP2007537271A (ja) | 2007-12-20 |
| MXPA06012606A (es) | 2007-01-31 |
| EP1747209A1 (en) | 2007-01-31 |
| EP1747209A4 (en) | 2007-12-12 |
| EA200601898A1 (ru) | 2007-02-27 |
| KR20070013300A (ko) | 2007-01-30 |
| US20050256323A1 (en) | 2005-11-17 |
| ZA200608075B (en) | 2008-05-28 |
| BRPI0511109A (pt) | 2007-11-27 |
| CA2563905A1 (en) | 2005-12-01 |
| CN1942459A (zh) | 2007-04-04 |
| IL178415A0 (en) | 2007-02-11 |
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