AR038055A1 - Proceso para preparar 2- (fenilo sustituido) - 2 - hidroxi - etil carbamatos. - Google Patents
Proceso para preparar 2- (fenilo sustituido) - 2 - hidroxi - etil carbamatos.Info
- Publication number
- AR038055A1 AR038055A1 ARP020105084A ARP020105084A AR038055A1 AR 038055 A1 AR038055 A1 AR 038055A1 AR P020105084 A ARP020105084 A AR P020105084A AR P020105084 A ARP020105084 A AR P020105084A AR 038055 A1 AR038055 A1 AR 038055A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- alcohol
- carbamates
- compound
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1786—Unsaturated ethers containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se refiere a un nuevo proceso para preparar 2-(fenilo sustituido)-2-hidroxi-etil carbamatos y a intermediarios novedosos utilizados en este proceso. Asimismo se refiere a formas polimórficas de dichos carbamatos y a procesos para preparar dichas formas polimórficas. Reivindicación 1 . Un proceso para preparar un compuesto de fórmula (1) en el cual: R es halógeno, R1 y R2 son en forma independiente halógeno o C1-4 alquilo, sustituido en forma opcional con fenilo o fenilo sustituido, en donde el fenilo sustituido posee sustituyentes seleccionados entre halógeno, C1-4 alquilo, C1-4 alquiloxi, amino, nitro y ciano; caracterizados por a) reducción de un éster de la fórmula (2) en el cual P es un grupo protector de alcoholes apropiado; R3 es C1-4 alquilo; con un agente reductor de éster a alcohol apropiado, obteniéndose así un alcohol de fórmula (3), b) hacer reaccionar el alcohol de fórmula (3) con un compuesto carbonílico de fórmula (4) en el cual X e Y son grupos salientes adecuados; y posteriormente con una amina de fórmula (5) obteniéndose así un compuesto de fórmula(6) C9 eliminación del grupo protector P, obteniéndose así un compuesto de fórmula (1). v
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01205097 | 2001-12-21 | ||
| US41808402P | 2002-10-11 | 2002-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038055A1 true AR038055A1 (es) | 2004-12-22 |
Family
ID=26077052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020105084A AR038055A1 (es) | 2001-12-21 | 2002-12-23 | Proceso para preparar 2- (fenilo sustituido) - 2 - hidroxi - etil carbamatos. |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP2248799B1 (es) |
| JP (1) | JP4610899B2 (es) |
| KR (1) | KR20090097966A (es) |
| CN (1) | CN100457723C (es) |
| AR (1) | AR038055A1 (es) |
| AU (3) | AU2002358806B2 (es) |
| BG (1) | BG108759A (es) |
| BR (1) | BR0215237A (es) |
| CA (2) | CA2681964A1 (es) |
| CZ (1) | CZ2004718A3 (es) |
| EE (1) | EE05381B1 (es) |
| HR (1) | HRP20040557A2 (es) |
| HU (1) | HUP0402491A2 (es) |
| IL (3) | IL162405A0 (es) |
| MX (1) | MXPA04006135A (es) |
| MY (1) | MY142415A (es) |
| NO (1) | NO20043105L (es) |
| NZ (1) | NZ533592A (es) |
| PL (1) | PL370977A1 (es) |
| SK (1) | SK2572004A3 (es) |
| TW (1) | TWI333944B (es) |
| WO (1) | WO2003053916A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767843B2 (en) * | 2006-03-02 | 2010-08-03 | Apotex Pharmachem Inc. | Process for the preparation of phenylcarbamates |
| US7632963B2 (en) * | 2006-10-06 | 2009-12-15 | Janssen Pharmaceutica Nv | Crystal of (S)-(+)-2-(2-chlorophenyl)-2-hydroxy-ethyl carbamate |
| US20090105498A1 (en) * | 2007-10-18 | 2009-04-23 | Porstmann Frank | Improved process for preparing 2-(substituted phenyol)-2-hydroxy-ethyl-carbamates |
| US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
| ES2710902T3 (es) * | 2011-12-27 | 2019-04-29 | Bio Pharm Solutions Co Ltd | Compuesto derivado de carbamatos de fenilalquilo y composición farmacéutica que contiene el mismo |
| KR102421006B1 (ko) * | 2016-05-19 | 2022-07-14 | 에스케이바이오팜 주식회사 | 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR5671M (es) * | 1965-04-23 | 1968-01-02 | ||
| US5504108A (en) * | 1990-01-12 | 1996-04-02 | The Ohio State University Research Foundation | Optically pure 4-aryl-2-hydroxytetronic acids |
| JP3010497B2 (ja) * | 1990-05-31 | 2000-02-21 | チッソ株式会社 | 光学活性α―ヒドロキシエステル類の製造方法 |
| EP0734370B1 (fr) | 1994-10-19 | 1999-10-20 | Firmenich Sa | Procede pour la preparation d'alcools |
| US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
| JP3960801B2 (ja) * | 1999-11-29 | 2007-08-15 | 三菱レイヨン株式会社 | アセタールスルホネート誘導体およびその製造方法ならびにスチレンオキサイド誘導体の製造方法 |
-
2002
- 2002-12-19 WO PCT/EP2002/014843 patent/WO2003053916A1/en active Application Filing
- 2002-12-19 PL PL02370977A patent/PL370977A1/xx not_active Application Discontinuation
- 2002-12-19 JP JP2003554633A patent/JP4610899B2/ja not_active Expired - Lifetime
- 2002-12-19 EP EP20100174144 patent/EP2248799B1/en not_active Expired - Lifetime
- 2002-12-19 SK SK257-2004A patent/SK2572004A3/sk unknown
- 2002-12-19 EP EP02793127A patent/EP1461309A1/en not_active Ceased
- 2002-12-19 EE EEP200400098A patent/EE05381B1/xx not_active IP Right Cessation
- 2002-12-19 CA CA002681964A patent/CA2681964A1/en not_active Abandoned
- 2002-12-19 BR BR0215237-1A patent/BR0215237A/pt not_active Application Discontinuation
- 2002-12-19 MX MXPA04006135A patent/MXPA04006135A/es active IP Right Grant
- 2002-12-19 CN CNB028281128A patent/CN100457723C/zh not_active Expired - Lifetime
- 2002-12-19 AU AU2002358806A patent/AU2002358806B2/en not_active Expired
- 2002-12-19 CA CA2471485A patent/CA2471485C/en not_active Expired - Lifetime
- 2002-12-19 HU HU0402491A patent/HUP0402491A2/hu unknown
- 2002-12-19 KR KR1020097016975A patent/KR20090097966A/ko active Application Filing
- 2002-12-19 CZ CZ2004718A patent/CZ2004718A3/cs unknown
- 2002-12-19 NZ NZ533592A patent/NZ533592A/en not_active IP Right Cessation
- 2002-12-19 IL IL16240502A patent/IL162405A0/xx unknown
- 2002-12-20 TW TW091137385A patent/TWI333944B/zh not_active IP Right Cessation
- 2002-12-20 MY MYPI20024814A patent/MY142415A/en unknown
- 2002-12-23 AR ARP020105084A patent/AR038055A1/es unknown
-
2004
- 2004-06-08 IL IL162405A patent/IL162405A/en active IP Right Grant
- 2004-06-11 BG BG108759A patent/BG108759A/bg active Pending
- 2004-06-16 HR HR20040557A patent/HRP20040557A2/xx not_active Application Discontinuation
- 2004-07-20 NO NO20043105A patent/NO20043105L/no not_active Application Discontinuation
-
2009
- 2009-09-04 AU AU2009212987A patent/AU2009212987A1/en not_active Withdrawn
-
2011
- 2011-04-08 AU AU2011201613A patent/AU2011201613A1/en not_active Abandoned
- 2011-07-06 IL IL213960A patent/IL213960A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009212987A1 (en) | 2009-10-01 |
| CA2471485A1 (en) | 2003-07-03 |
| CZ2004718A3 (cs) | 2004-12-15 |
| CN1620425A (zh) | 2005-05-25 |
| EE05381B1 (et) | 2011-02-15 |
| JP2005513126A (ja) | 2005-05-12 |
| BG108759A (bg) | 2005-03-31 |
| WO2003053916A1 (en) | 2003-07-03 |
| EE200400098A (et) | 2004-10-15 |
| SK2572004A3 (sk) | 2005-02-04 |
| IL162405A0 (en) | 2005-11-20 |
| AU2002358806A1 (en) | 2003-07-09 |
| EP2248799B1 (en) | 2015-05-20 |
| AU2002358806B2 (en) | 2009-09-10 |
| CA2471485C (en) | 2011-05-24 |
| PL370977A1 (en) | 2005-06-13 |
| CA2681964A1 (en) | 2003-07-03 |
| MXPA04006135A (es) | 2004-11-01 |
| BR0215237A (pt) | 2004-11-16 |
| IL162405A (en) | 2011-08-31 |
| TW200405809A (en) | 2004-04-16 |
| AU2011201613A1 (en) | 2011-04-28 |
| HRP20040557A2 (en) | 2005-04-30 |
| EP2248799A1 (en) | 2010-11-10 |
| IL213960A0 (en) | 2011-08-31 |
| CN100457723C (zh) | 2009-02-04 |
| KR20090097966A (ko) | 2009-09-16 |
| NZ533592A (en) | 2006-05-26 |
| MY142415A (en) | 2010-11-30 |
| TWI333944B (en) | 2010-12-01 |
| EP1461309A1 (en) | 2004-09-29 |
| HUP0402491A2 (hu) | 2005-04-28 |
| JP4610899B2 (ja) | 2011-01-12 |
| NO20043105L (no) | 2004-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY37399A (es) | Proceso químico para la elaboración de determinados derivados de pirimidina | |
| PE20040164A1 (es) | Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas | |
| AR032113A1 (es) | Novedosas carboxamidas | |
| ES2543607T3 (es) | Ciertas amidas sustituidas, método de obtención, y método de su uso | |
| CA2495967A1 (fr) | Nouveau procede de synthese et nouvelle forme cristalline de l'agomelatine ainsi que les compositions pharmaceutiques qui la contiennent | |
| WO2007044895A3 (en) | Diaromatic amines | |
| AR051373A1 (es) | Procedimiento para la preparacion de analogos aciclicos de nucleotidos de fosfonatos | |
| PE20091359A1 (es) | Proceso de preparacion de compuestos organicos intermediarios de inhibidores de renina | |
| ECSP066983A (es) | Un método fácil para sintetizar compuestos de bacatina iii | |
| AR054849A1 (es) | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas | |
| AR045868A1 (es) | Proceso para preparar compuestos de ocarbamoilo en presencia de grupo amina activa | |
| AR056695A1 (es) | Tetrahidroquinolinas, su sintesis e intermediarios | |
| AR038055A1 (es) | Proceso para preparar 2- (fenilo sustituido) - 2 - hidroxi - etil carbamatos. | |
| AR060962A1 (es) | Proceso de preparacion de derivados de quinazolina e intermediarios de sintesis | |
| AR043825A1 (es) | Procesos de preparacion de 5-(haloacetil)-8-(oxisustituidos)-(1h)-quinolin-2-onas | |
| AR053722A2 (es) | Procedimiento para preparar secretagogos de hormonas del crecimiento y poliformo de los compuestos obtenidos | |
| AR044966A1 (es) | Proceso para la produccion de diesteres vecinales a partir de epoxidos | |
| BRPI0519948A2 (pt) | composto, processo para a preparação de um composto, composição farmacêutica e método de tratamento de cáncer em um mamìfero | |
| AR044676A1 (es) | Pirrolidinas y piperidinas sustituidas, compuestos relacionados, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. | |
| AR034609A1 (es) | Proceso para la preparacion de derivados del ciclohexanol | |
| PE20080312A1 (es) | Metodos para preparar derivados de acido glutamico e intermediarios del mismo | |
| BR0100039A (pt) | Processo aperfeiçoado para a preparação de mercaptometilfenóis | |
| AR004015A1 (es) | Procedimiento para preparar compuestos de quinolina o sales farmaceuticamente aceptables de los mismos, y compuestos intermediarios | |
| BRPI0509324A (pt) | processo para a preparação de um composto | |
| AR046627A1 (es) | Procesos para la preparacion de ftalimidas n- sustituidas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |