UA93883C2 - Производные пиразина, полезные kak антагонисты аденозинового рецептора - Google Patents
Производные пиразина, полезные kak антагонисты аденозинового рецептораInfo
- Publication number
- UA93883C2 UA93883C2 UAA200802498A UAA200802498A UA93883C2 UA 93883 C2 UA93883 C2 UA 93883C2 UA A200802498 A UAA200802498 A UA A200802498A UA A200802498 A UAA200802498 A UA A200802498A UA 93883 C2 UA93883 C2 UA 93883C2
- Authority
- UA
- Ukraine
- Prior art keywords
- receptor antagonists
- iiа
- adenosine receptor
- derivatives useful
- pyrazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200501876A ES2270715B1 (es) | 2005-07-29 | 2005-07-29 | Nuevos derivados de pirazina. |
Publications (1)
Publication Number | Publication Date |
---|---|
UA93883C2 true UA93883C2 (ru) | 2011-03-25 |
Family
ID=35945119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200802498A UA93883C2 (ru) | 2005-07-29 | 2006-07-25 | Производные пиразина, полезные kak антагонисты аденозинового рецептора |
Country Status (22)
Country | Link |
---|---|
US (2) | US7790728B2 (ru) |
EP (1) | EP1922313A1 (ru) |
JP (1) | JP2009502837A (ru) |
KR (1) | KR20080040681A (ru) |
CN (1) | CN101268064A (ru) |
AR (1) | AR056008A1 (ru) |
AU (1) | AU2006278875A1 (ru) |
CA (1) | CA2616428A1 (ru) |
EC (1) | ECSP088113A (ru) |
ES (1) | ES2270715B1 (ru) |
IL (1) | IL188725A0 (ru) |
MX (1) | MX2008001035A (ru) |
NO (1) | NO20080451L (ru) |
NZ (1) | NZ565150A (ru) |
PE (1) | PE20070407A1 (ru) |
RU (1) | RU2417994C2 (ru) |
SG (1) | SG162805A1 (ru) |
TW (1) | TW200728299A (ru) |
UA (1) | UA93883C2 (ru) |
UY (1) | UY29672A1 (ru) |
WO (1) | WO2007017096A1 (ru) |
ZA (1) | ZA200800353B (ru) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1848435B1 (en) | 2005-01-25 | 2016-01-20 | Synta Pharmaceuticals Corp. | Compounds against inflammations and immune-related uses |
ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
EP2457913B1 (en) * | 2006-10-19 | 2017-04-19 | Signal Pharmaceuticals, LLC | Heteroaryl compounds, compositions thereof, and methods of treatment therewith |
ES2303776B1 (es) * | 2006-12-29 | 2009-08-07 | Laboratorios Almirall S.A. | Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b. |
ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
JP5485178B2 (ja) * | 2008-02-25 | 2014-05-07 | エフ.ホフマン−ラ ロシュ アーゲー | ピロロピラジンキナーゼ阻害剤 |
CN102015712A (zh) | 2008-03-26 | 2011-04-13 | 阿德维纳斯治疗私人有限公司 | 作为腺苷受体拮抗剂的杂环化合物 |
EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
RU2535217C2 (ru) | 2009-02-06 | 2014-12-10 | Ниппон Синяку Ко., Лтд. | Производные аминопиразина и лекарственные средства |
US8859566B2 (en) | 2009-03-13 | 2014-10-14 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds |
WO2011055391A1 (en) | 2009-11-09 | 2011-05-12 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds, its preparation and uses thereof |
EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
EP2338890A1 (en) | 2009-12-22 | 2011-06-29 | Bayer CropScience AG | 4,7-Diazaindole derivatives and their use as fungicides |
PL2531492T3 (pl) * | 2010-02-05 | 2016-10-31 | Pochodne 1,2,4-triazyno-4-aminy | |
CN101817823B (zh) * | 2010-03-31 | 2012-09-12 | 上海毕得医药科技有限公司 | 4,7-二氮杂吲哚及其5位取代物的制备方法 |
PL2593452T3 (pl) | 2010-07-14 | 2017-07-31 | Novartis Ag | Związki heterocykliczne będące agonistami receptora IP |
JP5827998B2 (ja) | 2010-09-13 | 2015-12-02 | アドヴィナス・セラピューティックス・リミテッド | A2bアデノシン受容体アンタゴニストのプロドラッグとしてのプリン化合物、これらの方法および薬剤の適用 |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
TWI659030B (zh) * | 2011-10-26 | 2019-05-11 | 諾華公司 | Ip受體促效劑雜環化合物 |
US20150005311A1 (en) * | 2012-01-13 | 2015-01-01 | Novartis Ag | IP receptor agonist heterocyclic compounds |
TW201335160A (zh) * | 2012-01-13 | 2013-09-01 | Novartis Ag | Ip受體激動劑之雜環化合物 |
CN104169282B (zh) * | 2012-01-13 | 2016-04-20 | 诺华股份有限公司 | Ip受体激动剂的盐 |
EP2802581A1 (en) * | 2012-01-13 | 2014-11-19 | Novartis AG | 7,8- dihydropyrido [3, 4 - b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
EP2802582A1 (en) * | 2012-01-13 | 2014-11-19 | Novartis AG | Fused dihydropyrido [2,3 -b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
WO2013105065A1 (en) * | 2012-01-13 | 2013-07-18 | Novartis Ag | Fused piperidines as ip receptor agonists for the treatment of pah and related disorders |
CA2872645A1 (en) | 2012-05-30 | 2013-12-05 | Nippon Shinyaku Co., Ltd. | Aromatic heterocyclic derivative and pharmaceutical |
LT3495367T (lt) | 2012-06-13 | 2021-02-25 | Incyte Holdings Corporation | Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
WO2014087208A2 (en) * | 2012-12-06 | 2014-06-12 | Enaltec Labs Pvt. Ltd. | A process of preparing alcaftadine |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
WO2014125413A1 (en) | 2013-02-13 | 2014-08-21 | Novartis Ag | Ip receptor agonist heterocyclic compounds |
MY181497A (en) | 2013-04-19 | 2020-12-23 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
CN103364500B (zh) * | 2013-06-29 | 2019-01-22 | 北京万全德众医药生物技术有限公司 | 一种用液相色谱法分离测定比拉斯汀原料及其制剂的方法 |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
CA2967944C (en) * | 2014-11-18 | 2020-11-17 | Merck Sharp & Dohme Corp. | Aminopyrazine compounds with a2a antagonist properties |
CN104402833B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 含有环丁烷取代基的吡嗪类化合物及其组合物及用途 |
CN104447583B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 含有环丁烷取代基的吡嗪类化合物及其组合物及用途 |
CN104447584B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 含有环丁烷取代基的吡嗪类化合物及其组合物及用途 |
CN104447585B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 吡嗪类化合物及其组合物及用途 |
CN104496918B (zh) * | 2014-12-10 | 2016-08-24 | 广东东阳光药业有限公司 | 吡嗪衍生物及其用途 |
EP3240784A2 (en) | 2014-12-23 | 2017-11-08 | BerGenBio ASA | Inhibitors of akt kinase |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
WO2016134320A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
ES2580702B1 (es) * | 2015-02-25 | 2017-06-08 | Palobiofarma, S.L. | Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina |
JP7013213B2 (ja) * | 2017-05-26 | 2022-01-31 | 日本化薬株式会社 | ピラジン化合物 |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
MX2020000690A (es) * | 2017-07-18 | 2020-07-29 | Nuvation Bio Inc | Compuestos heterociclicos como antagonistas de adenosina. |
WO2019018583A1 (en) | 2017-07-18 | 2019-01-24 | GiraFpharma LLC | 1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF |
JP2021523934A (ja) * | 2018-04-20 | 2021-09-09 | バージニア・テック・インテレクチュアル・プロパティーズ・インコーポレイテッドVirginia Tech Intellectual Properties, Inc. | ミトコンドリア脱共役剤として有用なアミノピラジンおよび関連化合物 |
MA52494A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Formes solides d'un inhibiteur de fgfr et leurs procédés de préparation |
EP3788046A1 (en) | 2018-05-04 | 2021-03-10 | Incyte Corporation | Salts of an fgfr inhibitor |
CN109020881B (zh) * | 2018-06-28 | 2020-04-28 | 新发药业有限公司 | 一种阿帕替尼的制备方法 |
CN115181092A (zh) * | 2018-08-17 | 2022-10-14 | 迪哲(江苏)医药股份有限公司 | 吡嗪化合物和其用途 |
US20210395225A1 (en) * | 2018-10-24 | 2021-12-23 | Leadxpro Ag | Functionalized aminotriazines |
CN111377906B (zh) * | 2018-12-28 | 2022-09-02 | 四川科伦博泰生物医药股份有限公司 | 取代的吡嗪化合物及其制备方法和用途 |
KR20210110288A (ko) * | 2018-12-28 | 2021-09-07 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 치환된 아릴 화합물, 및 이의 제조 방법 및 이의 용도 |
CN111377873B (zh) * | 2018-12-28 | 2023-03-28 | 四川科伦博泰生物医药股份有限公司 | 氨基嘧啶化合物及其制备方法和用途 |
EP3911323A4 (en) | 2019-01-18 | 2022-11-16 | Nuvation Bio Inc. | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS |
EP3911324A4 (en) | 2019-01-18 | 2022-08-17 | Nuvation Bio Inc. | 1,8-NAPHTHYRIDINONE COMPOUNDS AND THEIR USES |
WO2020150677A1 (en) * | 2019-01-18 | 2020-07-23 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
CN110407677B (zh) * | 2019-06-17 | 2022-10-11 | 南京先进生物材料与过程装备研究院有限公司 | 二苯乙二酮类化合物的制备方法及应用 |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
CN112500416B (zh) * | 2019-07-30 | 2021-12-17 | 厦门宝太生物科技股份有限公司 | 一种吡唑并三嗪类化合物中间体的制备方法 |
EP4045151A1 (en) | 2019-10-14 | 2022-08-24 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
CA3162010A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
WO2021146629A1 (en) * | 2020-01-17 | 2021-07-22 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
WO2021146631A1 (en) * | 2020-01-17 | 2021-07-22 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
TW202313611A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為fgfr抑制劑之三環雜環 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9309573D0 (en) * | 1993-05-10 | 1993-06-23 | Merck Sharp & Dohme | Therapeutic agents |
US5686470A (en) * | 1995-02-10 | 1997-11-11 | Weier; Richard M. | 2, 3-substituted pyridines for the treatment of inflammation |
US6096748A (en) | 1996-03-13 | 2000-08-01 | Smithkline Beecham Corporation | Pyrimidine compounds useful in treating cytokine mediated diseases |
JP2002514195A (ja) | 1996-12-05 | 2002-05-14 | アムジエン・インコーポレーテツド | 置換ピリミジン化合物およびそれの使用 |
PT1042293E (pt) | 1997-12-19 | 2008-04-18 | Amgen Inc | Compostos de piridazina e piridina substituídos e as suas utilizações farmacêuticas |
CN1312807A (zh) | 1998-06-19 | 2001-09-12 | 希龙公司 | 糖元合成酶激酶3的抑制剂 |
US6545002B1 (en) | 1999-06-01 | 2003-04-08 | University Of Virginia Patent Foundation | Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors |
EP1221444B1 (en) | 1999-07-02 | 2005-08-31 | Eisai Co., Ltd. | Fused imidazole compounds and remedies for diabetes mellitus |
CA2383351C (en) | 1999-08-31 | 2005-11-01 | Vanderbilt University | Xanthine derivatives as selective antagonists of a2b adenosine receptors |
CA2400206A1 (en) | 2000-02-17 | 2001-08-23 | Cv Therapeutics, Inc. | Method for identifying and using a2b adenosine receptor antagonists to mediate mammalian cell proliferation |
BR0108611A (pt) | 2000-02-25 | 2003-05-06 | Hoffmann La Roche | Moduladores de receptor de adenosina |
WO2001080893A1 (fr) | 2000-04-26 | 2001-11-01 | Eisai Co., Ltd. | Compositions medicinales favorisant les mouvements intestinaux |
AU7774101A (en) | 2000-08-11 | 2002-02-25 | Eisai Co Ltd | 2-aminopyridine compounds and use thereof as drugs |
JP2004514656A (ja) | 2000-09-06 | 2004-05-20 | カイロン コーポレイション | グリコゲンシンターゼキナーゼ3のインヒビター |
EP1317452B1 (en) | 2000-09-15 | 2006-05-17 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
AU9290601A (en) | 2000-09-19 | 2002-04-02 | Chiron Corp | Characterization of the gsk-3beta protein and methods of use thereof |
GB0028383D0 (en) | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
ES2247356T3 (es) | 2001-06-29 | 2006-03-01 | Cv Therapeutics, Inc. | Derivados de purina com antagonistas del receptor a2b de adenosina. |
TWI330183B (ru) | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
ATE520694T1 (de) | 2001-11-09 | 2011-09-15 | Gilead Palo Alto Inc | A2b-adenosinrezeptorantagonisten |
US6977300B2 (en) * | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
WO2003057689A1 (en) | 2002-01-02 | 2003-07-17 | Fujisawa Pharmaceutical Co., Ltd. | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them |
EP1469856A4 (en) | 2002-02-01 | 2005-06-22 | King Pharmaceuticals Res & Dev | 8-HETEROARYLXANTHIN-ADENOSINE A SB 2B / SB RECEPTOR ANTAGONISTS |
WO2003068773A1 (en) | 2002-02-12 | 2003-08-21 | Glaxo Group Limited | Pyrazolopyridine derivatives |
WO2003082191A2 (en) | 2002-03-28 | 2003-10-09 | Merck & Co., Inc. | Substituted 2,3-diphenyl pyridines |
RS107404A (en) | 2002-06-12 | 2007-02-05 | Biogen Idec Ma Inc., | Method of treating ischemia perefusion injury using adenosine receptor antagonists |
US20040067955A1 (en) | 2002-09-06 | 2004-04-08 | Fujisawa Pharmaceutical Co. Ltd. | Pyridazinone compound and pharmaceutical use thereof |
WO2004030635A2 (en) | 2002-10-03 | 2004-04-15 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
KR101312736B1 (ko) | 2003-02-27 | 2013-09-27 | 팔라우 파르마 에스에이 | 피라졸로피리딘 유도체 |
AU2003249604B2 (en) | 2003-05-06 | 2011-06-30 | Gilead Sciences, Inc. | A2B adenosine receptor antagonists |
NZ545715A (en) | 2003-08-25 | 2009-02-28 | Adenosine Therapeutics Llc | Substituted 8-heteroaryl xanthines |
ES2229928B1 (es) * | 2003-10-02 | 2006-07-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirimidin-2-amina. |
GB0323138D0 (en) | 2003-10-03 | 2003-11-05 | Chang Lisa C W | Pyrimidines substituted in the 2,4,6 positions and their different uses |
WO2005040151A1 (en) * | 2003-10-27 | 2005-05-06 | Astellas Pharma Inc. | Pyrazine derivatives and pharmaceutical use thereof |
BRPI0415888A (pt) | 2003-10-31 | 2007-01-09 | Cv Therapeutics Inc | antagonistas do receptor de adenosina a2b |
GB0401336D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
ES2241496B1 (es) * | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
ES2274712B1 (es) * | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
ES2303776B1 (es) | 2006-12-29 | 2009-08-07 | Laboratorios Almirall S.A. | Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b. |
-
2005
- 2005-07-29 ES ES200501876A patent/ES2270715B1/es not_active Expired - Fee Related
-
2006
- 2006-07-13 UY UY29672A patent/UY29672A1/es unknown
- 2006-07-25 CA CA002616428A patent/CA2616428A1/en not_active Abandoned
- 2006-07-25 CN CNA2006800340045A patent/CN101268064A/zh active Pending
- 2006-07-25 MX MX2008001035A patent/MX2008001035A/es not_active Application Discontinuation
- 2006-07-25 PE PE2006000899A patent/PE20070407A1/es not_active Application Discontinuation
- 2006-07-25 UA UAA200802498A patent/UA93883C2/ru unknown
- 2006-07-25 AU AU2006278875A patent/AU2006278875A1/en not_active Abandoned
- 2006-07-25 US US11/997,048 patent/US7790728B2/en not_active Expired - Fee Related
- 2006-07-25 SG SG201004274-5A patent/SG162805A1/en unknown
- 2006-07-25 WO PCT/EP2006/007318 patent/WO2007017096A1/en active Application Filing
- 2006-07-25 KR KR1020087002157A patent/KR20080040681A/ko not_active Application Discontinuation
- 2006-07-25 EP EP06762807A patent/EP1922313A1/en not_active Withdrawn
- 2006-07-25 NZ NZ565150A patent/NZ565150A/en unknown
- 2006-07-25 JP JP2008523220A patent/JP2009502837A/ja active Pending
- 2006-07-25 RU RU2008107264/04A patent/RU2417994C2/ru not_active IP Right Cessation
- 2006-07-28 AR ARP060103279A patent/AR056008A1/es not_active Application Discontinuation
- 2006-07-28 TW TW095127615A patent/TW200728299A/zh unknown
-
2008
- 2008-01-10 IL IL188725A patent/IL188725A0/en unknown
- 2008-01-11 ZA ZA200800353A patent/ZA200800353B/xx unknown
- 2008-01-17 EC EC2008008113A patent/ECSP088113A/es unknown
- 2008-01-24 NO NO20080451A patent/NO20080451L/no not_active Application Discontinuation
-
2010
- 2010-06-04 US US12/794,059 patent/US20100273757A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ565150A (en) | 2011-02-25 |
CN101268064A (zh) | 2008-09-17 |
US7790728B2 (en) | 2010-09-07 |
RU2417994C2 (ru) | 2011-05-10 |
ECSP088113A (es) | 2008-02-20 |
RU2008107264A (ru) | 2009-09-10 |
KR20080040681A (ko) | 2008-05-08 |
US20100273757A1 (en) | 2010-10-28 |
EP1922313A1 (en) | 2008-05-21 |
TW200728299A (en) | 2007-08-01 |
ES2270715B1 (es) | 2008-04-01 |
JP2009502837A (ja) | 2009-01-29 |
US20090042891A1 (en) | 2009-02-12 |
IL188725A0 (en) | 2008-08-07 |
CA2616428A1 (en) | 2007-02-15 |
AR056008A1 (es) | 2007-09-12 |
PE20070407A1 (es) | 2007-05-12 |
SG162805A1 (en) | 2010-07-29 |
MX2008001035A (es) | 2008-03-14 |
ZA200800353B (en) | 2008-12-31 |
AU2006278875A1 (en) | 2007-02-15 |
WO2007017096A1 (en) | 2007-02-15 |
UY29672A1 (es) | 2007-01-31 |
ES2270715A1 (es) | 2007-04-01 |
NO20080451L (no) | 2008-02-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA93883C2 (ru) | Производные пиразина, полезные kak антагонисты аденозинового рецептора | |
TW200728277A (en) | Bicyclic derivatives as P38 inhibitors | |
MX2007001289A (es) | Piridinas condensadas como inhibidores de cinasa. | |
TN2010000101A1 (en) | Fungicidal 2-alkylthio-2-quinolinyloxy -acetamide derivatives | |
MX2009010595A (es) | Derivados de pirrolopirimidina. | |
TN2010000064A1 (en) | Novel herbicides | |
TN2010000102A1 (en) | Novel fungicides | |
MX2009007713A (es) | Derivados de piridazina, procedimientos para su preparacion y su uso como fungicidas. | |
TW200611907A (en) | Fused heterocyclic compound | |
GB0508318D0 (en) | Organic compounds | |
MX2010001364A (es) | Derivados de ciclopentandiona puenteados triciclicos como herbicidas. | |
GB0508314D0 (en) | Organic compounds | |
MX2009007302A (es) | Derivados de purina. | |
MX2010003156A (es) | Derivados de aril amida substituida con tetrazol y usos de los mismos. | |
TW200638930A (en) | Acetylene derivatives | |
SG153811A1 (en) | Quinazolinone derivatives useful as vanilloid antagonists | |
TW200740814A (en) | Compounds | |
UA103625C2 (en) | 5-hetrocyclylalkyl-3-hydroxy-2-phenylcyclopent-2-enons as herbicides | |
UA101963C2 (en) | 4-amino-pyrimidine derivatives | |
WO2006136837A3 (en) | Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators | |
WO2007000340A8 (en) | Bicyclic derivatives as p38 kinase inhibitors | |
WO2009007115A8 (en) | Tropane derivatives useful as pesticides | |
MX2010006787A (es) | Análogos halogenados de agentes anti-fibroticos. | |
HK1115500A1 (en) | Isoquinolines as igf-1r inhibitors | |
MY149973A (en) | 3-carboxypropyl-aminotetralin derivatives as mu opioid receptor antagonists |