HRP20020481B1 - Condensed azepines as vasopressin agonists - Google Patents

Condensed azepines as vasopressin agonists

Info

Publication number
HRP20020481B1
HRP20020481B1 HR20020481A HRP20020481A HRP20020481B1 HR P20020481 B1 HRP20020481 B1 HR P20020481B1 HR 20020481 A HR20020481 A HR 20020481A HR P20020481 A HRP20020481 A HR P20020481A HR P20020481 B1 HRP20020481 B1 HR P20020481B1
Authority
HR
Croatia
Prior art keywords
independently selected
lower alkyl
ome
acyl
vasopressin agonists
Prior art date
Application number
HR20020481A
Other languages
English (en)
Croatian (hr)
Inventor
Doreen Ashworth Mary
William Gary Pitt Robert
Hudson Peter
Christopher Yea Martyn
Richard Franklin Jeremy
Original Assignee
Vantia Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vantia Limited filed Critical Vantia Limited
Publication of HRP20020481A2 publication Critical patent/HRP20020481A2/hr
Publication of HRP20020481B1 publication Critical patent/HRP20020481B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20020481A 2000-01-05 2002-05-31 Condensed azepines as vasopressin agonists HRP20020481B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0000079.4A GB0000079D0 (en) 2000-01-05 2000-01-05 Novel antidiuretic agents
PCT/GB2001/000023 WO2001049682A1 (en) 2000-01-05 2001-01-04 Condensed azepines as vasopressin agonists

Publications (2)

Publication Number Publication Date
HRP20020481A2 HRP20020481A2 (en) 2004-08-31
HRP20020481B1 true HRP20020481B1 (en) 2009-03-31

Family

ID=9883168

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020481A HRP20020481B1 (en) 2000-01-05 2002-05-31 Condensed azepines as vasopressin agonists

Country Status (34)

Country Link
US (3) US7074781B2 (sv)
EP (1) EP1248784B1 (sv)
JP (2) JP3869723B2 (sv)
KR (1) KR100605466B1 (sv)
CN (1) CN1183129C (sv)
AR (1) AR035327A1 (sv)
AT (1) ATE366730T1 (sv)
AU (1) AU777538B2 (sv)
BR (1) BR0107414B1 (sv)
CA (1) CA2396277C (sv)
CY (1) CY1108034T1 (sv)
CZ (1) CZ303444B6 (sv)
DE (1) DE60129298T2 (sv)
DK (1) DK1248784T3 (sv)
EE (1) EE200200367A (sv)
ES (1) ES2288923T3 (sv)
GB (1) GB0000079D0 (sv)
HK (1) HK1046910B (sv)
HR (1) HRP20020481B1 (sv)
HU (1) HU229937B1 (sv)
IL (1) IL149528A0 (sv)
MX (1) MXPA02006546A (sv)
MY (1) MY140467A (sv)
NO (1) NO322571B1 (sv)
NZ (1) NZ518803A (sv)
PL (1) PL211341B1 (sv)
PT (1) PT1248784E (sv)
RU (1) RU2259367C2 (sv)
SI (1) SI1248784T1 (sv)
SK (1) SK287005B6 (sv)
UA (1) UA73152C2 (sv)
UY (1) UY26521A1 (sv)
WO (1) WO2001049682A1 (sv)
ZA (1) ZA200205180B (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138393B2 (en) 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
EP1268418B1 (en) * 2000-03-27 2006-06-14 Applied Research Systems ARS Holding N.V. Pharmaceutically active pyrrolidine derivatives as bax inhibitors
AU5620901A (en) * 2000-03-27 2001-10-08 Applied Research Systems Pharmaceutically active pyrrolidine derivatives as bax inhibitors
GB0015601D0 (en) * 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
AU2004234258B2 (en) * 2003-04-28 2009-04-09 Tacurion 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or salt thereof
PT1530967E (pt) * 2003-11-13 2006-09-29 Ferring Bv Embalagem blister e uma forma de dosagem solida que compreende desmopressina.
EP1813603A1 (en) * 2004-11-17 2007-08-01 Kissei Pharmaceutical Co., Ltd. Aromatic amide derivatives, medicinal compositions containing the same, medical uses of both
EP1867639A1 (en) * 2005-03-25 2007-12-19 Kissei Pharmaceutical Co., Ltd. Urea derivative, medicinal composition containing the same, and medicinal use of these
WO2007052517A1 (ja) * 2005-10-31 2007-05-10 Sumitomo Chemical Company, Limited ヒドロキシ－２－ピロリジンカルボキシアミド化合物の製法
TW200820976A (en) * 2006-09-25 2008-05-16 Kissei Pharmaceutical 1,4-benzodiazepine derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes
MX2009011923A (es) * 2007-05-10 2009-11-18 Amr Technology Inc Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina.
JP5451613B2 (ja) 2007-08-06 2014-03-26 アラーガン、インコーポレイテッド デスモプレシン薬物送達のための方法及びデバイス
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
ES2710454T3 (es) * 2008-05-21 2019-04-25 Ferring Bv Desmopresina bucodispersable para aumentar el periodo inicial de sueño ininterrumpido por nocturia
GB201005623D0 (en) * 2010-04-01 2010-05-19 Vantia Ltd New polymorph
GB201105537D0 (en) 2011-03-31 2011-05-18 Vantia Ltd New process
WO2020154581A1 (en) 2019-01-24 2020-07-30 Assia Chemical Industries Ltd Solid state forms of fedovapagon-salicyclic acid co-crystal

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514667A1 (en) * 1991-04-19 1992-11-25 Otsuka Pharmaceutical Co., Ltd. Benzazepin derivatives as vasopressin antagonists
WO1994012476A1 (en) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Benzanilide derivative
WO1994020473A1 (en) * 1993-03-11 1994-09-15 Yamanouchi Pharmaceutical Co., Ltd. Compound with vasopressin antagonism
US5753644A (en) * 1992-10-16 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Vasopressin antagonist and oxytocin antagonist
WO1999006409A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists
WO1999006403A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960886A (en) 1968-07-03 1976-06-01 Sterling Drug Inc. Substituted N-arylanilines
CA1047490A (en) 1973-04-18 1979-01-30 Friedrich Karrer Ethers
CH599752A5 (sv) 1973-04-18 1978-05-31 Ciba Geigy Ag
DE2355454A1 (de) 1973-11-07 1976-10-07 Paul Geisslinger Lochmaschine
CA1265798A (en) 1984-12-10 1990-02-13 Motoo Mutsukado 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it
US5753677A (en) 1989-10-20 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
WO1991005549A1 (en) 1989-10-20 1991-05-02 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
JPH05320135A (ja) * 1992-05-19 1993-12-03 Yamanouchi Pharmaceut Co Ltd テトラヒドロベンズアゼピン誘導体
EP0612319A1 (en) 1992-08-20 1994-08-31 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
GB9307527D0 (en) 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US5516774A (en) 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5968930A (en) 1993-07-29 1999-10-19 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5843952A (en) 1993-07-29 1998-12-01 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5760031A (en) 1993-07-29 1998-06-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
FI1215U1 (fi) * 1993-12-03 1994-02-21 Valmet Paper Machinery Inc Anlaeggning i samband med styrningen av en vira
CA2166556A1 (en) * 1994-05-06 1995-11-16 Leo Kool Microwave transmission system
CN100384825C (zh) 1994-06-15 2008-04-30 大塚制药株式会社 苯并杂环衍生物
JP2926335B2 (ja) * 1997-06-13 1999-07-28 大塚製薬株式会社 医薬組成物
WO2000021959A1 (en) 1998-10-09 2000-04-20 Janssen Pharmaceutica N.V. 4,5-dihydro-isoxazole derivatives and their pharmaceutical use
GB2355454A (en) 1999-10-20 2001-04-25 Ferring Bv Antidiuretic agents
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
DE10033337A1 (de) 2000-07-08 2002-01-17 Boehringer Ingelheim Pharma Biphenylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
GB0120051D0 (en) 2001-08-16 2001-10-10 Ferring Bv Oxytocin agonists
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
EP1449844A1 (en) 2003-02-14 2004-08-25 Ferring B.V. benzamide derivatives as oxytocin agonists and vasopressin antagonists
EP1627876A1 (en) 2004-08-20 2006-02-22 Ferring B.V. Heterocyclic condensed compounds useful as antidiuretic agents
US7341963B2 (en) * 2005-05-17 2008-03-11 Milliken & Company Non-woven material with barrier skin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514667A1 (en) * 1991-04-19 1992-11-25 Otsuka Pharmaceutical Co., Ltd. Benzazepin derivatives as vasopressin antagonists
US5753644A (en) * 1992-10-16 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Vasopressin antagonist and oxytocin antagonist
WO1994012476A1 (en) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Benzanilide derivative
WO1994020473A1 (en) * 1993-03-11 1994-09-15 Yamanouchi Pharmaceutical Co., Ltd. Compound with vasopressin antagonism
WO1999006409A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists
WO1999006403A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists

Also Published As

Publication number Publication date
ATE366730T1 (de) 2007-08-15
BR0107414A (pt) 2002-10-08
NO322571B1 (no) 2006-10-30
US20060154916A1 (en) 2006-07-13
PL355808A1 (en) 2004-05-17
AR035327A1 (es) 2004-05-12
MXPA02006546A (es) 2002-12-09
CA2396277C (en) 2012-03-20
SI1248784T1 (sl) 2007-12-31
JP2003519228A (ja) 2003-06-17
IL149528A0 (en) 2002-11-10
SK9112002A3 (en) 2003-01-09
BR0107414B1 (pt) 2014-09-16
CZ303444B6 (cs) 2012-09-19
JP3869723B2 (ja) 2007-01-17
NZ518803A (en) 2003-03-28
JP3813629B2 (ja) 2006-08-23
HK1046910B (zh) 2007-08-31
JP2006137767A (ja) 2006-06-01
SK287005B6 (sk) 2009-09-07
PL211341B1 (pl) 2012-05-31
AU777538B2 (en) 2004-10-21
KR100605466B1 (ko) 2006-07-28
RU2002120798A (ru) 2004-01-10
UA73152C2 (en) 2005-06-15
MY140467A (en) 2009-12-31
US7560454B2 (en) 2009-07-14
RU2259367C2 (ru) 2005-08-27
UY26521A1 (es) 2001-03-16
CN1392875A (zh) 2003-01-22
KR20020063191A (ko) 2002-08-01
DK1248784T3 (da) 2007-10-29
CA2396277A1 (en) 2001-07-12
CY1108034T1 (el) 2013-09-04
PT1248784E (pt) 2007-10-02
US7074781B2 (en) 2006-07-11
EP1248784B1 (en) 2007-07-11
HUP0203917A3 (en) 2004-07-28
DE60129298T2 (de) 2008-01-03
HK1046910A1 (en) 2003-01-30
EE200200367A (et) 2003-12-15
GB0000079D0 (en) 2000-02-23
CN1183129C (zh) 2005-01-05
ES2288923T3 (es) 2008-02-01
AU2384601A (en) 2001-07-16
WO2001049682A1 (en) 2001-07-12
US20080261951A1 (en) 2008-10-23
US20030087892A1 (en) 2003-05-08
HRP20020481A2 (en) 2004-08-31
NO20023137D0 (no) 2002-06-27
EP1248784A1 (en) 2002-10-16
ZA200205180B (en) 2004-02-05
HU229937B1 (hu) 2015-01-28
DE60129298D1 (de) 2007-08-23
HUP0203917A2 (hu) 2003-03-28
NO20023137L (no) 2002-06-27
CZ20022305A3 (cs) 2002-10-16

Similar Documents

Publication Publication Date Title
HRP20020481B1 (en) Condensed azepines as vasopressin agonists
AR003453A1 (es) Inhibidores de agregado de plaquetas, su uso en la fabricacion de medicamentos, composicion farmaceutica que los contiene y procedimiento para la preparacion de dichos inhibidores
UY26750A1 (es) Derivados de tiofeno útiles como agentes anticancerosos
MY132073A (en) Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
IL96486A0 (en) Tricyclic compounds,their preparation and pharmaceutical compositions containing them
UY29312A1 (es) Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones
TW200611687A (en) Pharmaceutical compositions used for immunosuppressant
IL94768A0 (en) Pharmaceutical compositions containing aryl-substituted amine derivatives,certain such novel compounds and their preparation
BRPI0518068A (pt) composto ou um éster ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, inibidor seletivo de aurora a, agente anti-tumor, e, preparação combinada
IT1254373B (it) Eteroprostanoidi, procedimento per la loro preparazione e loro impiegoterapeutico.
TNSN08518A1 (en) 18-methyl-19-nor-androst -4-en-17, 17 -spiroether (18-methyl-19-nor-20- spirox-4¬en-3-0ne) and pharmaceutical preparations containing the same
IL154964A0 (en) Benzsulfonamide derivatives, their preparation and pharmaceutical compositions containing them
EA200000792A3 (ru) Новые пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции
HUP0203471A2 (hu) Trombózisellenes hatású vegyületek, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
DE68926981D1 (de) Cephemverbindungen und Verfahren zu ihrer Herstellung
PT874841E (pt) Derivados da 1-benzenossulfonilpirrolidina como antagonistas do receptor da bradiquinina
DK1228052T3 (da) Derivater af 1-cyklisk aminoalkylcyclohexan, farmaceutiske sammensætninger indeholdende disse og anvendelse af disse som antikonvulsivum
ATE136031T1 (de) Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ATE225787T1 (de) Arylsubstituierte heterocyclische verbindungen
AR030262A1 (es) Derivados de acido 15-hidroxieicosatetraenoico modificados de cadena omega , composiciones que lo comprenden y el uso de los mismos para la manufactura de un medicamento para su utilizacion en el tratamiento del ojo seco
ZA979331B (en) Pharmaceutical compounds.
RU97116496A (ru) Аналоги аргинина, ингибирующие no-синтазу
IL106080A (en) Pharmaceutical compositions containing amidinoalkane-1, 1-bisphosphonic acids and some such novel compounds
ATE240295T1 (de) Stickstoffenthaltende tetracyclische verbindungen
DE69011235D1 (de) Derivate von N-(Vincristinyl-23) und N-(Noranhydro-5-vinblastinyl-23) von Amino-1-methylphosphonsäure, ihre Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: VANTIA LIMITED, GB

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20181231

Year of fee payment: 19

PBON Lapse due to non-payment of renewal fee

Effective date: 20200104