HK1209055A1 - Auris formulations for treating otic diseases and conditions - Google Patents

Auris formulations for treating otic diseases and conditions

Info

Publication number
HK1209055A1
HK1209055A1 HK15109820.0A HK15109820A HK1209055A1 HK 1209055 A1 HK1209055 A1 HK 1209055A1 HK 15109820 A HK15109820 A HK 15109820A HK 1209055 A1 HK1209055 A1 HK 1209055A1
Authority
HK
Hong Kong
Prior art keywords
conditions
auris formulations
otic diseases
treating otic
treating
Prior art date
Application number
HK15109820.0A
Other languages
English (en)
Chinese (zh)
Inventor
杰伊.利希特爾
貝內迪克特.福爾拉特
安德魯.
.特拉梅爾
塞爾希奧.
.杜龍
法布里斯.皮烏
路易斯.
.德拉瑪麗
葉强
卡爾.勒貝爾
邁克爾.克里斯托弗.斯凱夫
杰弗里.
.哈里斯
Original Assignee
Otonomy Inc
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otonomy Inc, Univ California filed Critical Otonomy Inc
Publication of HK1209055A1 publication Critical patent/HK1209055A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0046Ear
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/325Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1808Epidermal growth factor [EGF] urogastrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/185Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1858Platelet-derived growth factor [PDGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1883Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK15109820.0A 2008-04-21 2015-10-08 Auris formulations for treating otic diseases and conditions HK1209055A1 (en)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US4654308P 2008-04-21 2008-04-21
US4887808P 2008-04-29 2008-04-29
US12771308P 2008-05-14 2008-05-14
US5562508P 2008-05-23 2008-05-23
US6042508P 2008-06-10 2008-06-10
US7371608P 2008-06-18 2008-06-18
US7458308P 2008-06-20 2008-06-20
US7657608P 2008-06-27 2008-06-27
US7656708P 2008-06-27 2008-06-27
US8245008P 2008-07-21 2008-07-21
US8383008P 2008-07-25 2008-07-25
US8387108P 2008-07-25 2008-07-25
US8609408P 2008-08-04 2008-08-04
US8610508P 2008-08-04 2008-08-04
US8795108P 2008-08-11 2008-08-11
US8790508P 2008-08-11 2008-08-11
US8827508P 2008-08-12 2008-08-12
US9438408P 2008-09-04 2008-09-04
US10111208P 2008-09-29 2008-09-29
US14003308P 2008-12-22 2008-12-22
US16023309P 2009-03-13 2009-03-13

Publications (1)

Publication Number Publication Date
HK1209055A1 true HK1209055A1 (en) 2016-03-24

Family

ID=41217397

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15109820.0A HK1209055A1 (en) 2008-04-21 2015-10-08 Auris formulations for treating otic diseases and conditions

Country Status (13)

Country Link
US (7) US9132087B2 (fr)
EP (1) EP2278999A4 (fr)
JP (6) JP2011518195A (fr)
KR (6) KR101449785B1 (fr)
CN (2) CN104491864A (fr)
AU (1) AU2009239429B2 (fr)
BR (1) BRPI0910850B1 (fr)
CA (1) CA2721927C (fr)
HK (1) HK1209055A1 (fr)
IL (2) IL208549A (fr)
MX (1) MX2010011545A (fr)
RU (1) RU2499592C2 (fr)
WO (1) WO2009132050A2 (fr)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2094836B1 (fr) 2006-11-15 2016-06-08 Massachusetts Eye & Ear Infirmary Génération de cellules de l'oreille interne
US9994585B2 (en) 2007-12-31 2018-06-12 Aphios Corporation Transplantation therapies
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
CA2721927C (fr) 2008-04-21 2014-01-28 Otonomy, Inc. Preparations auriculaires de traitement de maladies et etats otiques
CA2723458C (fr) 2008-05-14 2014-01-28 Otonomy, Inc. Compositions de corticosteroides a liberation controlee et procedes pour le traitement de troubles otiques
US8846770B2 (en) 2008-06-18 2014-09-30 Otonomy, Inc. Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders
WO2010011466A2 (fr) 2008-06-27 2010-01-28 Otonomy, Inc. Compositions de modulation du snc à libération contrôlée et procédés de traitement des troubles otiques
GB2461962B (en) * 2008-07-25 2011-02-16 Otonomy Inc Slow release NMDA receptor antagonist for otic disorders
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US20110207689A1 (en) * 2008-08-11 2011-08-25 Auckland Uniservices Limited The treatment of hearing loss
CA2751761A1 (fr) 2008-10-22 2010-04-29 House Ear Institute Traitement therapeutique et/ou prophylactique de pathologies de l'oreille interne par la modulation du recepteur metabotropique du glutamate
US8987328B2 (en) * 2008-10-30 2015-03-24 Trinity Laboratories, Inc. Esters of capsaicinoids as dietary supplements
JP5809061B2 (ja) 2008-11-24 2015-11-10 マサチューセッツ・アイ・アンド・イア・インファーマリー 有毛細胞を産生するための経路
JP6013736B2 (ja) * 2008-12-22 2016-10-25 オトノミ—,インク. 耳の障害の処置のための耳感覚細胞モジュレータ組成物の制御放出及びその方法
MX2011012875A (es) 2009-06-05 2012-02-28 13Therapeutics Inc Peptidos inmunoreguladores y metodos de uso.
EP2470015B1 (fr) * 2009-08-24 2016-01-13 Hough Ear Institute Nitrone derivés pour le traitement de la surdité neurosensorielle
US8877746B2 (en) * 2009-08-25 2014-11-04 Cardioklne, Inc Compositions for delivery of insoluble agents
US20140076336A1 (en) * 2009-09-17 2014-03-20 Ascentia Health, Inc. Ear insert for relief of tmj discomfort and headaches
WO2011049958A2 (fr) * 2009-10-21 2011-04-28 Otonomy, Inc. Modulation de la température de gélification de formulations contenant des poloxamères
CN102008470B (zh) * 2010-05-24 2012-08-29 中国人民解放军第二军医大学 复方制剂及其预防和治疗噪声性听力损伤的用途
WO2011150859A1 (fr) * 2010-06-04 2011-12-08 Comprehensive Drug Enterprises Ltd Formulations aqueuses orales de méclizine comprenant un agent aromatisant
WO2011156631A2 (fr) * 2010-06-09 2011-12-15 Joule Unlimited Technologies, Inc. Procédés et compositions pour extraire, dans des cellules hôtes, des produits carbonés
DE102010030053A1 (de) * 2010-06-14 2011-12-15 Awd.Pharma Gmbh & Co.Kg Injizierbare Darreichungsform von Flupirtin
CN102858321A (zh) * 2010-06-18 2013-01-02 莫茨药物股份两合公司 用于局部使用1-氨基-烷基环己烷衍生物的凝胶制剂
KR101134622B1 (ko) * 2010-08-12 2012-04-09 한국원자력연구원 암포테리신 b의 서방성 수화겔 및 이의 제조방법
NZ608239A (en) 2010-09-13 2015-05-29 Bev Rx Inc Aqueous drug delivery system comprising off - flavor masking agent
EP2675409A4 (fr) * 2011-02-18 2015-04-08 Otonomy Inc Prévention de l'ototoxicité induite par un médicament et rétablissement après ototoxicité induite par un médicament
EP2678004A1 (fr) 2011-02-25 2014-01-01 Eydo Pharma Nanoencapsulation d'huiles essentielles pour la prévention et la guérison des maladies infectieuses seules ou associées à un antibiotique
US8580748B2 (en) * 2011-04-06 2013-11-12 13Therapeutics, Inc. Peptides for the treatment of hearing
CN102805896A (zh) * 2011-05-30 2012-12-05 惠觅宙 经皮给药方法、制剂和系统
CN103596943B (zh) * 2011-06-07 2016-10-12 奥蒂福尼疗法有限公司 用作kv3抑制剂的乙内酰脲衍生物
US9901616B2 (en) 2011-08-31 2018-02-27 University Of Georgia Research Foundation, Inc. Apoptosis-targeting nanoparticles
RU2480214C1 (ru) 2011-09-22 2013-04-27 Валентина Ивановна Ахапкина Состав, обладающий модуляторной активностью с соразмерным влиянием, фармацевтическая субстанция (варианты), применение фармацевтической субстанции, фармацевтическая и парафармацевтическая композиция (варианты), способ получения фармацевтических составов
US20140341940A1 (en) * 2011-11-09 2014-11-20 Iseu da Silva Nunes Immunomodulator for the treatment of cancerous tumors in the epithelial tissue lining surfaces inside or outside body organs
EP4035683A1 (fr) * 2011-12-12 2022-08-03 Adare Pharmaceuticals USA, Inc. Formulations de particules à libération prolongée
US9034347B2 (en) * 2011-12-19 2015-05-19 Arphios Corporation Drug delivery system and method for the treatment of neuro-degenerative disease
WO2013123298A1 (fr) 2012-02-17 2013-08-22 University Of Georgia Research Foundation, Inc. Nanoparticules de trafic mitochondrial d'agents
JP2015511242A (ja) * 2012-02-23 2015-04-16 インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラリシェルシェ メディカル) 病変性前庭障害の治療に使用するカルシニューリン阻害剤
EP2819741B1 (fr) * 2012-02-27 2018-03-28 O-Ray Pharma, Inc. Implants de médicaments solides pour l'administration intracochléaire d'agents thérapeutiques pour le traitement de troubles otiques
US20130288981A1 (en) * 2012-04-02 2013-10-31 Buck Institute For Research On Aging Targeting senescent cells and cancer cells by interference with jnk and/or foxo4
JP6289460B2 (ja) * 2012-07-16 2018-03-07 コーネル ユニヴァーシティー 難聴を治療するためのニコチンアミドリボシド
JP2015527398A (ja) 2012-09-07 2015-09-17 マサチューセッツ アイ アンド イヤー インファーマリー 聴覚喪失治療
CN105228614A (zh) 2012-11-28 2016-01-06 阿菲欧斯公司 用于治疗神经退化疾病和其它疾病的组合治疗剂和方法
PT2970890T (pt) 2013-03-14 2020-04-24 Massachusetts Inst Technology Composições e métodos para expansão e cultura de células estaminais epiteliais
JP2016517883A (ja) 2013-05-03 2016-06-20 オレゴン ヘルス アンド サイエンス ユニバーシティー X連鎖副腎白質ジストロフィーの処置におけるソベチロムの使用
WO2014205127A2 (fr) 2013-06-18 2014-12-24 New York University Facteurs cellulaires impliqués dans la cytotoxicité des leucocidines de staphylococcus aureus : cibles thérapeutiques inédites
WO2015031393A1 (fr) 2013-08-27 2015-03-05 Otonomy, Inc. Méthodes pour le traitement de troubles otiques chez les enfants
EP2853533A1 (fr) * 2013-09-29 2015-04-01 Audiocure Pharma GmbH 6-fluor-9-méthyl-ß-carboline
RU2551359C9 (ru) * 2013-11-28 2021-08-20 Общество с ограниченной ответственностью "Мамонт Фарм" Наноразмерная слабо закристаллизованная модификация 4-метил-N-[3-(4-метилимидазол-1-ил)-5-(трифторметил)фенил]-3-[(4-пиридин-3-илпиримидин-2-ил)амино]бензамида гидрохлорида моногидрата, способ ее получения и фармацевтическая композиция на ее основе
US10441616B2 (en) * 2014-02-20 2019-10-15 Ajou University Industry-Academic Cooperation Foundation Pharmaceutical composition for treating or preventing sensorineural hearing loss, containing cysteinyl leukotriene receptor antagonist and ginkgo leaf extract
US10398663B2 (en) 2014-03-14 2019-09-03 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
WO2015164580A1 (fr) * 2014-04-23 2015-10-29 Auris Medical Ag Méthodes et compositions pour le traitement et la prévention de l'acouphène
US10010585B2 (en) * 2014-06-16 2018-07-03 Massachusetts Eye And Ear Infirmary Methods of treating vestibular schwannoma and reducing hearing or neurite loss caused by vestibular schwannoma
WO2016022776A2 (fr) 2014-08-06 2016-02-11 Massachusetts Eye And Ear Infirmary Augmentation de la durée de vie d'atoh1 pour diriger la différenciation des cellules ciliées neurosensorielles
KR20230019500A (ko) * 2014-09-03 2023-02-08 더 브리검 앤드 우먼즈 하스피털, 인크. 청력 손실의 치료를 위해 내이 털세포를 생성하기 위한 조성물, 시스템, 및 방법
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
CA2961660A1 (fr) * 2014-10-01 2016-04-07 Als Mountain Llc Composition pharmaceutique comprenant de l'aspirine, de la metformine et de la serotonine avec un agent tensioactif non ionique
KR102436976B1 (ko) * 2015-02-09 2022-08-25 슬링샷 바이오사이언시즈 인코포레이티드 튜닝가능한 광 특성을 갖는 하이드로겔 입자 및 이를 사용하기 위한 방법
US9701650B2 (en) 2015-02-20 2017-07-11 Oregon Health & Science University Derivatives of sobetirome
KR101636733B1 (ko) * 2015-02-24 2016-07-07 인제대학교 산학협력단 에키노크롬 a를 유효성분으로 함유하는 운동능력 증진용 건강식품 및 이를 이용한 운동능력 증진방법
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
EP3328898B8 (fr) * 2015-07-28 2024-04-10 6452728 Canada Corp. Compositions d'agoniste trkb ou trkc et méthodes de traitement de troubles otiques
ES2956666T3 (es) * 2015-10-27 2023-12-26 Purdue Research Foundation Productos terapéuticos a base de polímeros para el pardeamiento inductivo de grasa
US20170128424A1 (en) * 2015-11-11 2017-05-11 Qrono, Inc. Sustained release pharmaceutical compositions and methods of use
CA3004849C (fr) 2015-11-16 2024-06-11 Georges Gaudriault Procede de morcellement et/ou de ciblage de principes pharmaceutiquement actifs vers un tissu synovial
WO2017096233A1 (fr) 2015-12-04 2017-06-08 Massachusetts Eye And Ear Infirmary Traitement de perte auditive par inhibition de la caséine kinase 1
JP2019506153A (ja) 2016-01-08 2019-03-07 マサチューセッツ インスティテュート オブ テクノロジー 分化した腸内分泌細胞およびインスリン産生細胞の作製
CA3013038A1 (fr) 2016-01-29 2017-08-03 Massachusetts Eye And Ear Infirmary Expansion et differenciation des cellules de support de l'oreille interne, et methodes d'utilisation de ces dernieres
WO2017147221A1 (fr) * 2016-02-26 2017-08-31 Med-El Elektromedizinische Geraete Gmbh Détection de réflexe stapédien évoqué électriquement
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
KR101785455B1 (ko) * 2016-03-16 2017-11-20 전남대학교산학협력단 귀리 추출물을 유효성분으로 포함하는 난청의 예방 또는 치료용 약제학적 조성물
BR112018071560A2 (pt) 2016-04-21 2019-02-12 Astrocyte Pharmaceuticals, Inc. compostos e métodos para tratar condições neurológicas e cardiovasculares
JP7033789B2 (ja) * 2016-06-29 2022-03-11 オトノミー,インク. トリグリセリド耳用製剤とその使用
WO2018017834A1 (fr) * 2016-07-21 2018-01-25 The Regents Of The University Of California Procédés pour l'induction de stéréocils sur les cellules ciliées
EP3512513A4 (fr) 2016-09-16 2020-04-15 Otonomy, Inc. Formulations de gel otique pour le traitement de l'otite externe
US10707531B1 (en) 2016-09-27 2020-07-07 New Dominion Enterprises Inc. All-inorganic solvents for electrolytes
JP2019537582A (ja) * 2016-10-31 2019-12-26 ハフ イアー インスティテュート シナプス形成および神経突起形成を増強するための方法
US11253193B2 (en) * 2016-11-08 2022-02-22 Cochlear Limited Utilization of vocal acoustic biomarkers for assistive listening device utilization
US20190321493A1 (en) * 2016-11-18 2019-10-24 Mayo Foundation For Medical Education And Research Materials and methods for treating regional pain
WO2018111908A1 (fr) * 2016-12-13 2018-06-21 The Regents Of The University Of California Système de culture sans xénobiotique pour faire croître des cellules souches limbiques humaines
RU2630129C1 (ru) * 2016-12-19 2017-09-05 Государственное бюджетное учреждение здравоохранения города Москвы "Научно-исследовательский клинический институт оториноларингологии им. Л.И. Свержевского" Департамента здравоохранения города Москвы Способ определения степени эндолимфатического гидропса при болезни меньера, выбор тактики лечения и оценка ее эффективности
CA3048220A1 (fr) 2016-12-30 2018-07-05 Frequency Therapeutics, Inc. Composes 1h-pyrrole-2,5-dione et leurs procedes d'utilisation pour induire un auto-renouvellement de cellules de support souches/progenitrices
LT3698791T (lt) * 2017-02-02 2024-02-12 Otolanum Ag Intranazalinė kompozicija, apimanti betahistiną
US20200085764A1 (en) * 2017-04-19 2020-03-19 Phio Pharmaceuticals Corp. Topical delivery of nucleic acid compounds
JP6443783B2 (ja) 2017-06-07 2018-12-26 株式会社エコ・プランナー 熱交換装置の制御方法及び熱交換装置並びに水冷式ヒートポンプ冷暖房装置
US12076415B2 (en) * 2017-08-18 2024-09-03 King Fahd University Of Petroleum And Minerals Use of nano-sized clay crystallites to restore adhesion among tumor and aging stem cells
EP3691618A1 (fr) 2017-10-06 2020-08-12 Foundry Therapeutics, Inc. Dépôts implantabes pour la libération contrôlée d'agents thérapeutiques
WO2019118330A1 (fr) * 2017-12-12 2019-06-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Hydrogel thermosensible contenant des microparticules de polymère pour administration contrôlée de médicament à l'oreille
WO2019126783A1 (fr) * 2017-12-22 2019-06-27 Otonomy, Inc. Formulations otiques à base de triglycérides et leurs utilisations
KR20200108873A (ko) * 2018-01-09 2020-09-21 오토노미, 인코포레이티드 성장 인자 귀 제제
US20210361820A1 (en) * 2018-01-31 2021-11-25 Systagenix Wound Management, Limited Antimicrobial composition, dressing, dressing components, and method
CN112020359A (zh) 2018-02-09 2020-12-01 分贝治疗公司 含有抗铂化学保护剂的高渗药物组合物
EP3749322A4 (fr) 2018-02-09 2021-11-17 Astrocyte Pharmaceuticals, Inc. Composés et méthodes de traitement d'une dépendance et de troubles associés
JP6383133B1 (ja) * 2018-02-21 2018-08-29 国立大学法人信州大学 液体塞栓剤組成物
CA3096745A1 (fr) * 2018-04-04 2019-10-10 Alivio Therapeutics, Inc. Gels auto-assembles pour l'administration controlee de produits biologiques et leurs procedes de fabrication
AU2019321641A1 (en) 2018-08-17 2021-04-15 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating Jag-1
WO2020037326A1 (fr) 2018-08-17 2020-02-20 Frequency Therapeutics, Inc. Compositions et méthodes pour produire des cellules ciliées par la régulation à la baisse de foxo
EP3856741A4 (fr) 2018-09-26 2022-06-22 Astrocyte Pharmaceuticals, Inc. Composés polymorphes et leurs utilisations
AU2019397068A1 (en) * 2018-12-12 2021-06-24 Curelator, Inc. System and method for detecting auditory biomarkers
US11827596B2 (en) 2018-12-12 2023-11-28 Autobahn Therapeutics, Inc. Thyromimetics
US10561736B1 (en) 2019-01-09 2020-02-18 Spiral Therapeutics, Inc. Apoptosis inhibitor formulations for prevention of hearing loss
WO2020180624A1 (fr) 2019-03-01 2020-09-10 Autobahn Therapeutics, Inc. Nouveaux thyromimétiques
US11197820B2 (en) * 2019-04-30 2021-12-14 The Medical College Of Wisconsin, Inc. Trans-tympanic membrane delivery platform and uses thereof
CN110101871B (zh) * 2019-05-30 2022-03-25 广东工业大学 一种包埋白藜芦醇的制备方法
EP3977092A1 (fr) * 2019-05-30 2022-04-06 Beckman Coulter, Inc. Procédés et systèmes d'immobilisation d'un échantillon biologique pour une imagerie microscopique
US10813947B1 (en) 2019-05-31 2020-10-27 Decibel Therapeutics, Inc. Methods of otoprotection against platinum-based antineoplastic agents
WO2020254249A1 (fr) * 2019-06-21 2020-12-24 Proqr Therapeutics Ii B.V. Administration d'acides nucléiques pour le traitement de troubles auditifs
US12007368B2 (en) * 2019-09-24 2024-06-11 Halliburton Energy Services, Inc. Fragile and normal viscoelastic components of drilling fluid gels
RU2749857C1 (ru) * 2019-12-23 2021-06-17 Псарева Нелли Александровна Способ борьбы со средним и наружным отитом
KR102530724B1 (ko) * 2020-01-13 2023-05-09 아스트로메디컬 바이오테크놀로지, 리미티드 악액질의 치료에서의 케타민의 용도
EP4093387A4 (fr) * 2020-01-24 2024-04-24 Dompé farmaceutici S.p.A. Formulation de facteur de croissance pour un état associé à un événement otique
EP3854385A1 (fr) * 2020-01-27 2021-07-28 ROS Therapeutics ApS Forme posologique de méthotrexate
AU2021235058A1 (en) * 2020-03-11 2022-09-01 Iterum Therapeutics International Limited Combinations of beta-lactam compounds, probenecid, and valproic acid and uses thereof
JP2023526244A (ja) * 2020-05-13 2023-06-21 スパイラル・セラピューティクス・インコーポレイテッド 化合物を内耳に投与するためのゲル化溶液
RU2741252C1 (ru) * 2020-06-01 2021-01-22 федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се Способ выбора метода хирургического лечения пациентов с болезнью меньера
WO2023048748A1 (fr) * 2020-08-10 2023-03-30 Ziropa, Inc. Compositions et procédés d'administration topique
US20240245602A1 (en) * 2020-08-28 2024-07-25 President And Fellows Of Harvard College Drug combination kits and methods of drug delivery
RU2751697C1 (ru) * 2020-09-09 2021-07-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Донской государственный аграрный университет" Средство для лечения отитов наружного слухового прохода у собак
CN112618571B (zh) * 2020-09-30 2023-04-07 杭州贤石生物科技有限公司 治疗骨科疾病的可注射水凝胶微球及其制备方法与应用
CN112125969A (zh) * 2020-09-30 2020-12-25 东南大学 生物因子rimbp2在维持内耳毛细胞特性上的应用
EP4251127A1 (fr) 2020-11-26 2023-10-04 Alain Moussy Composition pharmaceutique pour le traitement de troubles de l'oreille interne par administration locale dans la zone tympanique
CN112557158B (zh) * 2021-02-28 2021-05-28 中国工程物理研究院核物理与化学研究所 一种用于空气样品中氙的分离纯化收集装置
CN113425852B (zh) * 2021-05-24 2022-06-03 北京大学 一种可穿过血迷路屏障的偶联物及其制备方法
CN113456580B (zh) * 2021-07-21 2024-03-22 沈阳化工大学 一种白藜芦醇原位凝胶制备及其表征方法
KR102675908B1 (ko) 2021-09-03 2024-06-14 충남대학교산학협력단 내이 질환 치료를 위한 국소 약물전달용 나노입자 함유 하이드로겔 조성물 및 이의 제조방법
CA3241657A1 (fr) * 2021-12-23 2023-06-29 Celia Belline Derives de 4-phenyl-tetrahydropyridine pour le traitement de troubles auditifs
WO2023154770A1 (fr) * 2022-02-09 2023-08-17 9 Meters Biopharma, Inc. Compositions et méthodes d'inhibition de la kinase rho
WO2023230430A1 (fr) * 2022-05-21 2023-11-30 Neuvision Development Llc Administration oculaire topique d'ambroxol contre la douleur oculaire
EP4299059A1 (fr) 2022-07-01 2024-01-03 Labelic Analysis, S.L. Composition pour le traitement de l'acouphène
EP4316462A1 (fr) * 2022-08-05 2024-02-07 Dompé farmaceutici S.p.a. Administration intranasale de bdnf pour le traitement de la perte auditive neurosensorielle
CN115317446A (zh) * 2022-09-01 2022-11-11 黑龙江迪龙制药有限公司 一种含有天麻素的复方制剂及其制备方法
WO2024148287A2 (fr) * 2023-01-06 2024-07-11 Gateway Biotechnology, Inc. Polythérapies pour le traitement de troubles auditifs
CN116019818B (zh) * 2023-01-18 2024-03-19 上海交通大学医学院附属第九人民医院 一种用于预防、改善和/或治疗耳蜗突触损伤的组合物及其应用
CN117448350B (zh) * 2023-10-18 2024-05-10 哈尔滨学院 一种利用桑黄Pb-bHLH9基因提高酿酒酵母多重胁迫抗性的应用

Family Cites Families (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2010115A1 (de) 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrogranulaten
US4188373A (en) 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4474572A (en) 1981-09-29 1984-10-02 Syntex (U.S.A.) Inc. Implanting device and implant magazine
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4968507A (en) * 1984-06-20 1990-11-06 Merck & Co., Inc. Controlled porosity osmotic pump
US4758435A (en) 1986-08-11 1988-07-19 American Cyanamid Company Estradiol implant composition and method for preparation
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US4900552A (en) 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US6436425B1 (en) 1988-11-16 2002-08-20 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
JPH05503512A (ja) 1989-11-29 1993-06-10 ブリガム・アンド・ウイメンズ・ホスピタル 白血球接着阻害因子としての[ala il―8]↓7↓7
US5292516A (en) 1990-05-01 1994-03-08 Mediventures, Inc. Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
IT1251151B (it) 1991-08-05 1995-05-04 Fidia Spa Materiale spugnoso essenzialmente costituito da acido ialuronico,o suoi derivati
EP0551626A1 (fr) 1991-12-19 1993-07-21 LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. Gel thermoréversible utile comme excipient pharmaceutique pour une formation galénique
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US6083354A (en) 1992-07-24 2000-07-04 Matsushita Electric Industrial Co., Ltd. Treatment method for diamonds
ES2113094T3 (es) 1993-03-09 1998-04-16 Epic Therapeutics Inc Las microparticulas macromoleculares y metodos de obtencion.
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
WO1995004533A2 (fr) * 1993-08-04 1995-02-16 Andrulis Pharmaceuticals Corporation Traitement de la polyarthrite rhumatoide par le thalidomide seul ou associe a d'autres anti-inflammatoires
US5421818A (en) 1993-10-18 1995-06-06 Inner Ear Medical Delivery Systems, Inc. Multi-functional inner ear treatment and diagnostic system
PT754032E (pt) 1994-04-08 2002-05-31 Atrix Lab Inc Composicoes liquidas para difusao
TW438601B (en) 1994-05-18 2001-06-07 Janssen Pharmaceutica Nv New mucoadhesive emulsion compositions and a process for the preparation thereof
JPH10503179A (ja) 1994-06-24 1998-03-24 イミュネックス・コーポレーション 放出制御性ポリペプチド組成物および炎症性腸疾患の治療方法
GB9505032D0 (en) 1995-03-13 1995-05-03 Westminster Lab Ltd Improvements in or relating to organic compositions
IL112834A (en) 1995-03-01 2000-12-06 Yeda Res & Dev Pharmaceutical compositions for controlled release of soluble receptors
JPH11510837A (ja) * 1995-07-28 1999-09-21 フォーカル,インコーポレイテッド 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
FR2742357B1 (fr) 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa Nanoparticules stabilisees et filtrables dans des conditions steriles
FR2742750B1 (fr) 1995-12-22 1998-01-30 Oreal Nouveaux derives de l'acide l-2-oxothiazolidine 4-carboxylique et leur utilisation pour le soin de la peau
US6225282B1 (en) * 1996-01-05 2001-05-01 Genentech, Inc. Treatment of hearing impairments
WO1997031008A1 (fr) 1996-02-23 1997-08-28 Industrial Research Limited Procede de detection/dosage d'enzymes et substrats associes
US5929041A (en) 1996-02-23 1999-07-27 Amgen Inc. Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
US5837681A (en) * 1996-02-23 1998-11-17 Amgen Inc. Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product
WO1997038698A1 (fr) 1996-04-18 1997-10-23 University Technology Corporation Procedes pour le traitement de troubles de l'oreille interne et moyenne
US5861174A (en) 1996-07-12 1999-01-19 University Technology Corporation Temperature sensitive gel for sustained delivery of protein drugs
US6156728A (en) * 1996-11-01 2000-12-05 Genentech, Inc. Treatment of inner ear hair cells
US5945126A (en) 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
US5939421A (en) 1997-07-01 1999-08-17 Signal Pharmaceuticals, Inc. Quinazoline analogs and related compounds and methods for treating inflammatory conditions
US6043221A (en) 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
DK1021204T3 (da) 1997-09-26 2006-05-08 Noven Pharma Bioadhæsive præparater og fremgangsmåder til topisk administration af aktive midler
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6117949A (en) 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6004573A (en) 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
JP2001520188A (ja) 1997-10-22 2001-10-30 ポニカウ,ジェンス 粘膜組織の炎症を治療および予防するための方法ならびに物質
DE19748763A1 (de) 1997-11-05 1999-05-06 Hans Peter Zenner Verwendung von Vasopressin-Antagonisten
SE9704186D0 (sv) 1997-11-14 1997-11-14 Astra Ab New composition of matter
US6649621B2 (en) 1997-12-16 2003-11-18 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms
US6177434B1 (en) 1997-12-16 2001-01-23 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms
GB9812426D0 (en) 1998-06-10 1998-08-05 Reckitt & Colmann Prod Ltd Improvements in or relating to organic compositions
EP1109563A4 (fr) 1998-08-04 2009-07-22 Madash Llp Hydrogels sensibles a la chaleur a terminaison modifiee
US6319513B1 (en) 1998-08-24 2001-11-20 The Procter & Gamble Company Oral liquid mucoadhesive compounds
US20020009478A1 (en) 1998-08-24 2002-01-24 Douglas Joseph Dobrozsi Oral liquid mucoadhesive compositions
IL141688A0 (en) * 1998-09-04 2002-03-10 Scios Inc Hydrogel compositions for the controlled release administration of growth factors
US6740664B2 (en) 1998-09-30 2004-05-25 Alcon, Inc. Methods for treating otic and ophthalmic infections
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US8197461B1 (en) 1998-12-04 2012-06-12 Durect Corporation Controlled release system for delivering therapeutic agents into the inner ear
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
JP3572570B2 (ja) 1999-02-01 2004-10-06 オーテックス株式会社 カチオン重合性有機物質用の重合開始剤
JP4430247B2 (ja) 1999-04-08 2010-03-10 インダストリアル リサーチ リミテッド ヌクレオシド代謝インヒビターの製造方法
US6287588B1 (en) 1999-04-29 2001-09-11 Macromed, Inc. Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
DK1180159T3 (da) 1999-05-28 2008-11-17 Targeted Genetics Corp Fremgangsmåder og sammensætninger til at sænke niveauet af Tumor-Nekrose-Faktor (TNF) i TNF-associerede lidelser
EP1194425B1 (fr) 1999-06-23 2005-08-10 Aventis Pharma Deutschland GmbH Benzimidazoles substitues
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US6458387B1 (en) 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
DE19951360A1 (de) 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
US7151191B2 (en) 2000-01-13 2006-12-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
GB0003154D0 (en) 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
WO2001068648A1 (fr) 2000-03-15 2001-09-20 Aventis Pharma Deutschland Gmbh Beta-carbolines substituees ayant une activite inhibitrice de l'ikb-kinase
AU2001251011A1 (en) * 2000-03-27 2001-10-08 The General Hospital Corporation Treatments for immune-mediated ear disorders
US7758888B2 (en) 2000-04-21 2010-07-20 Sol-Gel Technologies Ltd. Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
US6589549B2 (en) 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
US7018645B1 (en) 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
US20020013331A1 (en) 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
US7289110B2 (en) * 2000-07-17 2007-10-30 Human Messaging Ab Method and arrangement for identifying and processing commands in digital images, where the user marks the command, for example by encircling it
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
WO2002018371A1 (fr) 2000-08-29 2002-03-07 Industrial Research Limited Inhibiteurs du metabolisme des nucleosides
JP4272338B2 (ja) 2000-09-22 2009-06-03 バイエル アクチェンゲゼルシャフト ピリジン誘導体
IL145584A0 (en) 2000-10-02 2002-06-30 Pfizer Prod Inc Nmda nr2b antagonists for treatment
AU2002211662A1 (en) 2000-10-12 2002-04-22 Smith Kline Beecham Corporation Nf-kappab inhibitors
EP1324759A4 (fr) 2000-10-12 2004-05-12 Smithkline Beecham Corp Inhibiteurs du nf-g(k)b
ES2305125T3 (es) 2000-10-26 2008-11-01 Amgen Inc. Agentes anti-inflamatorios.
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
JP2002193938A (ja) 2000-12-01 2002-07-10 Bayer Ag 4−アリールピリジン誘導体
US7122544B2 (en) 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
WO2002059084A2 (fr) 2001-01-04 2002-08-01 Albert Einstein College Of Medicine Of Yeshiva University Inhibiteurs des adp-ribosyl transferases, cyclases, et hydrolases, et utilisations de ceux-ci
SE0100158D0 (sv) 2001-01-19 2001-01-19 Synphora Ab Novel method and composition for local treatment of Meniere´s disease and tinnitus
CA2436770A1 (fr) 2001-02-01 2002-08-08 James R. Burke Methodes de traitement de maladies inflammatoires et immunitaires a l'aide d'inhibiteurs ikb kinase (ikk)
US20060269602A1 (en) 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
WO2002094265A1 (fr) 2001-05-24 2002-11-28 Leo Pharma A/S Procede de modulation de l'activite de nf-kb
US20030045515A1 (en) 2001-05-24 2003-03-06 Lise Binderup Combination medicament for treatment of neoplastic diseases
SE0102617D0 (sv) 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
AR035293A1 (es) 2001-08-23 2004-05-05 Novartis Ag Composicion oftalmica.
JP2005506983A (ja) 2001-09-19 2005-03-10 ファルマシア・コーポレーション 炎症の治療のための置換ピラゾリル化合物
DE60220422T2 (de) 2001-09-19 2008-02-07 Pharmacia Corp. Substituierte pyrazol-verbindungen zur behandlung von entzündungen
JP2005506334A (ja) 2001-10-04 2005-03-03 スミスクライン・ビーチャム・コーポレイション NF−κB阻害剤
WO2003045907A2 (fr) 2001-11-21 2003-06-05 Albert Einstein College Of Medecine Of Yeshiva University Produits et activites de sir2
US7001615B1 (en) 2001-12-07 2006-02-21 Alcon, Inc. Sustained release ophthalmic, otic and nasal suspension
MXPA04005427A (es) 2001-12-10 2005-04-19 Amgen Inc Ligandos de receptor vainilloide y su uso en tratamientos.
MXPA04006882A (es) 2002-01-17 2004-12-06 Neurogen Corp Analogos substituidos de quinazolin-4-ilamina como moduladores de receptores de capsaicina.
US20030229333A1 (en) 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
JP2003277383A (ja) 2002-03-14 2003-10-02 Bayer Ag 光学活性ピリジン誘導体およびそれを含む医薬
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
ES2355472T3 (es) 2002-05-22 2011-03-28 Amgen Inc. Derivados de aminopirimidina para su uso como ligandos del receptor vaniloide para el tratamiento del dolor.
US7022680B2 (en) 2002-05-30 2006-04-04 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
TW200410945A (en) 2002-08-08 2004-07-01 Amgen Inc Vanilloid receptor ligands and their use in treatments"
US7589110B2 (en) 2002-09-06 2009-09-15 Durect Corporation Delivery of modulators of glutamate-mediated neurotransmission to the inner ear
AU2003286792A1 (en) 2002-10-29 2004-05-25 Oregon Health And Science University Fludrocortisone treatment for hearing loss
US7220431B2 (en) * 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
US7582635B2 (en) 2002-12-24 2009-09-01 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
US8802116B2 (en) * 2003-02-27 2014-08-12 Novasel Australia Pty. Ltd. Poloxamer emulsion preparations
AU2003900887A0 (en) * 2003-02-27 2003-03-13 Novasel Australia Pty Ltd Poloxamer emulsion preparations
US20040185047A1 (en) 2003-03-21 2004-09-23 Jill Giles-Komar Anti- TNF antibodies, compositions, methods and uses
DE602004025460D1 (de) 2003-04-21 2010-03-25 Lilly Co Eli Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
DK1477166T3 (da) 2003-04-28 2006-12-11 Biofrontera Bioscience Gmbh Anvendelse af riluzoler kombineret med egnede hjælpe- og tilsætningsstoffer til behandling af sygdomme, som er kendetegnet ved en hyperproliferation af keratinocytter, navnlig neurodermitis og psoriasis
US20040247575A1 (en) 2003-06-03 2004-12-09 Caplice Noel M. Smooth muscle progenitor cells
US7329664B2 (en) 2003-07-16 2008-02-12 Neurogen Corporation Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues
NZ545506A (en) 2003-07-24 2009-11-27 Euro Celtique Sa Therapeutic agents useful for treating pain
WO2005033105A2 (fr) 2003-09-30 2005-04-14 Amgen Inc. Ligands de recepteur vanilloide et leur utilisation dans certains traitements
WO2005046438A2 (fr) 2003-11-06 2005-05-26 Pluromed, Inc. Pince interne pour procedures chirurgicales
US20050137122A1 (en) 2003-12-17 2005-06-23 Alcon, Inc. Use of agents that prevent generation of amyloid and amyloid-like lipoproteins, and/or use of agents that promote sequestration and/or degradation of, and/or prevent neurotoxicity of such proteins in the treatment of hearing loss and improving body balance
US7312330B2 (en) 2003-12-24 2007-12-25 Renovis, Inc. Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
TW200530235A (en) 2003-12-24 2005-09-16 Renovis Inc Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
JP2005220070A (ja) 2004-02-05 2005-08-18 Medgel Corp 神経再生および保護のための生体吸収性高分子ハイドロゲル製剤
US20060063802A1 (en) 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US8268866B2 (en) 2004-03-29 2012-09-18 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
BRPI0511029A (pt) 2004-05-12 2007-11-27 Aventis Pharma Inc ácido 2-{[2-(2-metil amino-pirimidin-4-il)-1h-indol-5-carbonil]-amino}-3-(feni l piridin-2-il-amino)-propiÈnico substancialmente puro como um inibidor da i capa b quinase
CA2568028A1 (fr) 2004-05-24 2005-12-08 Auris Medical, Llc. Combine aspirateur otique et distributeur de medicament
US20060034889A1 (en) 2004-08-16 2006-02-16 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
US20060046970A1 (en) 2004-08-31 2006-03-02 Insite Vision Incorporated Topical otic compositions and methods of topical treatment of prevention of otic infections
AU2005291075A1 (en) 2004-10-05 2006-04-13 Merz Pharma Gmbh & Co. Kgaa Novel cyclic and acyclic propenones for treating CNS disorders
US8498681B2 (en) 2004-10-05 2013-07-30 Tomophase Corporation Cross-sectional mapping of spectral absorbance features
US20060105967A1 (en) 2004-11-18 2006-05-18 Advanced Gene Technology, Corp. Flavone derivatives as TNFalpha inhibitors or antagonists
WO2006076318A1 (fr) 2005-01-12 2006-07-20 Aventis Pharmaceuticals Inc. Sel monopotassique d'un inhibiteur de i$g(k)b kinase
US20060276393A1 (en) 2005-01-13 2006-12-07 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
US20080085901A1 (en) 2005-01-14 2008-04-10 Neurogen Corporation Heteroaryl Substituted Quinolin-4-Ylamine Analogues
EP1861161A4 (fr) 2005-01-24 2012-05-16 Neurosystec Corp Appareil et methode permettant de distribuer des agents therapeutiques et/ou autres a l'oreille interne et a d'autres tissus
CN101232885A (zh) 2005-01-25 2008-07-30 神经能质公司 经取代的哒嗪基喹啉-4-基胺和嘧啶基喹啉-4-基胺类似物
US20060221197A1 (en) 2005-03-30 2006-10-05 Jung Edward K Image transformation estimator of an imaging device
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2006095263A1 (fr) 2005-03-10 2006-09-14 Pfizer Japan Inc. Composes a base de n-sulfonylaminophenylethyl-2-phenoxy acetamide substitues
US8476319B2 (en) 2005-03-10 2013-07-02 3M Innovative Properties Company Methods of treating ear infections
EP1863757A4 (fr) 2005-03-14 2012-02-22 Evotec Ag Derives d'amide utilises comme ligands des canaux ioniques et compositions pharmaceutiques et procedes d'utilisation de ceux-ci
CN101160285A (zh) 2005-03-17 2008-04-09 辉瑞大药厂 适用于治疗疼痛的n-(n-磺酰氨基甲基)环丙烷甲酰胺衍生物
WO2006102964A2 (fr) 2005-03-29 2006-10-05 Evonik Röhm Gmbh Forme pharmaceutique multiparticulaire constituee de pellets renfermant une substance ayant un effet modulaire sur la liberation de l'ingredient actif
WO2006129164A1 (fr) 2005-05-31 2006-12-07 Pfizer Japan Inc. Composes aryloxy-n-bicyclomethyl acetamide substitues en tant qu'agonistes vr1
WO2007012064A2 (fr) * 2005-07-20 2007-01-25 Cypress Bioscience, Inc. Prevention et traitement de troubles auditifs
WO2007031098A1 (fr) 2005-09-12 2007-03-22 Xigen S.A. Inhibiteurs peptidiques permeables aux cellules de la voie de transduction de signal jnk
AU2006295236A1 (en) 2005-09-26 2007-04-05 Piedmont Pharmaceuticals Llc Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery into the middle ear
CA2622002A1 (fr) 2005-09-26 2007-04-05 Piedmont Pharmaceuticals Llc Procedes de traitement et de prevention de l'otite moyenne par le biais de tensioactifs non ioniques pour faciliter la delivrance de medicament transmembranaire dans l'oreille moyenne
NZ566062A (en) 2005-09-28 2009-08-28 Auris Medical Ag Pharmaceutical compositions for the treatment of inner ear disorders comprising an arylcycloalkylamine such as ketamine and a biocompatible polymer
EP1957475A1 (fr) 2005-10-21 2008-08-20 Merz Pharma GmbH & Co.KGaA Chromenones et leur utilisation en tant que modulateurs des recepteurs metabotropes au glutamate
US7785834B2 (en) 2005-11-10 2010-08-31 Ercole Biotech, Inc. Soluble TNF receptors and their use in treatment of disease
US20070110788A1 (en) 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US20070178051A1 (en) 2006-01-27 2007-08-02 Elan Pharma International, Ltd. Sterilized nanoparticulate glucocorticosteroid formulations
JP4273235B2 (ja) * 2006-06-01 2009-06-03 国立大学法人 新潟大学 アクアポリン4阻害薬
AR061571A1 (es) 2006-06-23 2008-09-03 Smithkline Beecham Corp Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un
TW200819458A (en) 2006-06-23 2008-05-01 Merz Pharma Gmbh & Co Kgaa Metabotropic glutamate receptor modulators
US8377898B2 (en) 2006-10-12 2013-02-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
WO2008049196A1 (fr) 2006-10-27 2008-05-02 Iomedix Development International Srl Compositions destinées à améliorer les niveaux de cholestérol dans le sang
EP2094836B1 (fr) 2006-11-15 2016-06-08 Massachusetts Eye & Ear Infirmary Génération de cellules de l'oreille interne
EP2150244A1 (fr) 2007-04-23 2010-02-10 House Ear Institute Traitement et/ou prévention de la presbyacousie par la modulation du récepteur métabotropique du glutamate de type 7
CA2721927C (fr) 2008-04-21 2014-01-28 Otonomy, Inc. Preparations auriculaires de traitement de maladies et etats otiques
CA2723458C (fr) 2008-05-14 2014-01-28 Otonomy, Inc. Compositions de corticosteroides a liberation controlee et procedes pour le traitement de troubles otiques
US8822410B2 (en) 2008-05-19 2014-09-02 Children's Medical Center Corporation Tympanic membrane permeating ear drops and uses thereof
US8648119B2 (en) 2008-05-23 2014-02-11 Otonomy, Inc. Controlled release immunomodulator compositions and methods for the treatment of otic disorders
CN101288643B (zh) * 2008-06-17 2012-11-14 杨喜鸿 含有他克莫司的凝胶剂组合物及其制备方法和药物应用
US8846770B2 (en) 2008-06-18 2014-09-30 Otonomy, Inc. Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders
US8349353B2 (en) 2008-06-27 2013-01-08 Otonomy, Inc. Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders
WO2010011466A2 (fr) 2008-06-27 2010-01-28 Otonomy, Inc. Compositions de modulation du snc à libération contrôlée et procédés de traitement des troubles otiques
MX2011000545A (es) 2008-07-14 2011-02-24 Otonomy Inc Composiciones de liberacion controlada para la modulacion de apoptosis y metodos para el tratamiento de trastornos oticos.
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US20100016450A1 (en) 2008-07-21 2010-01-21 Otonomy, Inc. Controlled release delivery devices for the treatment of otic disorders
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US10092580B2 (en) 2008-07-21 2018-10-09 Otonomy, Inc. Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
US8399018B2 (en) 2008-07-21 2013-03-19 Otonomy, Inc. Controlled release ion channel modulator compositions and methods for the treatment of otic disorders
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
CA2751761A1 (fr) 2008-10-22 2010-04-29 House Ear Institute Traitement therapeutique et/ou prophylactique de pathologies de l'oreille interne par la modulation du recepteur metabotropique du glutamate
JP5376987B2 (ja) 2009-02-18 2013-12-25 キヤノン株式会社 レチクルの製造方法、および面形状計測装置
JP6395687B2 (ja) * 2015-10-16 2018-09-26 株式会社カプコン 映像生成方法、映像生成プログラムおよび映像生成装置

Also Published As

Publication number Publication date
JP6147653B2 (ja) 2017-06-14
EP2278999A4 (fr) 2015-04-22
CA2721927C (fr) 2014-01-28
JP2011518195A (ja) 2011-06-23
US20190307678A1 (en) 2019-10-10
US20220040096A1 (en) 2022-02-10
US20160095902A1 (en) 2016-04-07
WO2009132050A9 (fr) 2011-02-03
US9132087B2 (en) 2015-09-15
RU2499592C2 (ru) 2013-11-27
JP2014058557A (ja) 2014-04-03
KR102340754B1 (ko) 2021-12-16
US20160243028A1 (en) 2016-08-25
MX2010011545A (es) 2011-04-11
RU2010147298A (ru) 2012-05-27
BRPI0910850A2 (pt) 2020-08-25
KR101449785B1 (ko) 2014-10-14
CN104491864A (zh) 2015-04-08
AU2009239429B2 (en) 2013-08-29
CN102014957A (zh) 2011-04-13
US20090306225A1 (en) 2009-12-10
US20200230051A1 (en) 2020-07-23
US11123285B2 (en) 2021-09-21
CA2721927A1 (fr) 2009-10-29
JP2017119723A (ja) 2017-07-06
WO2009132050A2 (fr) 2009-10-29
WO2009132050A3 (fr) 2010-01-14
JP2020147610A (ja) 2020-09-17
US20160228357A1 (en) 2016-08-11
EP2278999A2 (fr) 2011-02-02
US10751281B2 (en) 2020-08-25
IL208549A0 (en) 2010-12-30
KR20160029870A (ko) 2016-03-15
US10272034B2 (en) 2019-04-30
KR20200035508A (ko) 2020-04-03
US11123286B2 (en) 2021-09-21
KR20100135299A (ko) 2010-12-24
IL208549A (en) 2017-04-30
KR20210107137A (ko) 2021-08-31
IL251768A0 (en) 2017-06-29
KR20130097813A (ko) 2013-09-03
IL251768B (en) 2022-02-01
JP6296565B2 (ja) 2018-03-20
BRPI0910850B1 (pt) 2022-06-14
JP2016026218A (ja) 2016-02-12
KR20190026056A (ko) 2019-03-12
AU2009239429A1 (en) 2009-10-29
JP6544535B2 (ja) 2019-07-17
JP2019085423A (ja) 2019-06-06
CN102014957B (zh) 2014-12-10

Similar Documents

Publication Publication Date Title
IL251768A0 (en) Oris compositions for the treatment of ear diseases and conditions
EP2176283A4 (fr) Methodes et compositions de traitement des maladies cerebrales
HK1145339A1 (zh) 用於定向整合的方法和組合物
ZA200908711B (en) Methods and compositions for treating allergic diseases
EP2655334A4 (fr) Compositions et méthodes utilisables en vue du traitement de maladies
EP2521724A4 (fr) Agents et méthodes de traitement de maladies ischémiques et d'autres maladies
IL202015A0 (en) Methods and compositions for treating skin conditions
EP2262474A4 (fr) Procédés et compositions pour la cicatrisation
IL208458A0 (en) Compositions and methods for skin care
EP2497482A4 (fr) Fig. 2:composition destinée à prévenir et à traiter des maladies induites par le virus de la grippe
IL209216A (en) Preparations for the prevention and treatment of neurodegenerative diseases
PL2349231T3 (pl) Kompozycje i metody leczenia chorób kopyta
HK1162366A1 (en) Devices and methods for treating and or preventing diseases
ZA200907492B (en) Compositions for targeted imaging and therapy
EP2326200A4 (fr) Applicateurs de flux d'air et procédés de traitement apparentés
IL210097A0 (en) Compositions and methods for treating unfluenza
IL209336A0 (en) Compositions for treating hyperproliferative diseases and uses thereof
EP2268281A4 (fr) Thiénopyrroles et pyrrolothiazoles utilisés comme nouveaux agents thérapeutiques
EP2429584A4 (fr) Procédés et compositions de traitement
IL204728A0 (en) Methods and compounds for treating retinol-related diseases
HK1149545A1 (en) Compositions and methods for treating ophthalmic diseases
ZA201108079B (en) Composition and method for controlling pests
IL209947A0 (en) Compositions and methods for treating corneal inflammation
EP2237777A4 (fr) Compositions et procédés pour traiter des maladies neurodégénératives
EP2462131A4 (fr) Compositions et procédés pour traiter des maladies associées au bêta-amyloïde