EP1324759A4 - Inhibiteurs du nf-g(k)b - Google Patents
Inhibiteurs du nf-g(k)bInfo
- Publication number
- EP1324759A4 EP1324759A4 EP01979731A EP01979731A EP1324759A4 EP 1324759 A4 EP1324759 A4 EP 1324759A4 EP 01979731 A EP01979731 A EP 01979731A EP 01979731 A EP01979731 A EP 01979731A EP 1324759 A4 EP1324759 A4 EP 1324759A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23975900P | 2000-10-12 | 2000-10-12 | |
US239759P | 2000-10-12 | ||
PCT/US2001/031866 WO2002030353A2 (fr) | 2000-10-12 | 2001-10-12 | INHIBITEURS DU NF-λB |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1324759A2 EP1324759A2 (fr) | 2003-07-09 |
EP1324759A4 true EP1324759A4 (fr) | 2004-05-12 |
Family
ID=22903601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01979731A Withdrawn EP1324759A4 (fr) | 2000-10-12 | 2001-10-12 | Inhibiteurs du nf-g(k)b |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1324759A4 (fr) |
JP (1) | JP2004523476A (fr) |
AU (1) | AU2002211663A1 (fr) |
WO (1) | WO2002030353A2 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0003154D0 (en) * | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
CA2427284A1 (fr) | 2000-10-26 | 2002-05-30 | Tularik Inc. | Agents anti-inflammatoires |
SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102617D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
US7166639B2 (en) | 2001-10-04 | 2007-01-23 | Smithkline Beecham Corporation | NF-κB inhibitors |
WO2003037886A2 (fr) * | 2001-10-30 | 2003-05-08 | Pharmacia Corporation | Derives de carboxamide heteroaromatique destines au traitement des inflammations |
AU2002365611A1 (en) | 2001-12-05 | 2003-06-17 | F. Hoffmann - La Roche Ag | Inflammation modulators |
AU2003249683A1 (en) * | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Nf-:b inhibitors |
ES2285125T3 (es) | 2002-06-06 | 2007-11-16 | Smithkline Beecham Corporation | Inhibidores de nf-kb. |
WO2004041285A1 (fr) | 2002-10-31 | 2004-05-21 | Amgen Inc. | Agents anti-inflammatoires |
JP2006510676A (ja) * | 2002-12-06 | 2006-03-30 | スミスクライン・ビーチャム・コーポレイション | NF−κB阻害剤 |
SE0300092D0 (sv) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300091D0 (sv) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
ATE412645T1 (de) | 2003-08-15 | 2008-11-15 | Astrazeneca Ab | Substituierte thiophene und deren verwendungen |
MXPA06007054A (es) * | 2003-12-19 | 2007-04-17 | Elixir Pharmaceuticals Inc | Metodos para tratar una enfermedad. |
EP2305671A1 (fr) * | 2004-01-05 | 2011-04-06 | AstraZeneca AB | Dérivés de thiophène et thiazole comme inhibiteurs de CHK 1 |
TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
PE20060748A1 (es) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
PE20070173A1 (es) | 2005-06-30 | 2007-03-14 | Smithkline Beecham Corp | Compuestos de indol carboxamidas como inhibidores de ikk2 |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
JP5478488B2 (ja) | 2007-06-20 | 2014-04-23 | メルク・シャープ・アンド・ドーム・コーポレーション | Janusキナーゼの阻害剤 |
US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
KR102340754B1 (ko) | 2008-04-21 | 2021-12-16 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
WO2010005841A1 (fr) * | 2008-07-09 | 2010-01-14 | Merck & Co., Inc. | Inhibiteurs des kinases janus |
EP2406249A1 (fr) | 2009-03-10 | 2012-01-18 | Glaxo Group Limited | Dérivés d'indole comme inhibiteurs de ikk2 |
WO2012046793A1 (fr) * | 2010-10-07 | 2012-04-12 | 参天製薬株式会社 | Nouvel inhibiteur de jak3 contenant, à titre de principe actif, un dérivé de thiophène portant un groupe uréido et un groupe aminocarbonyle à titre de substituants |
EP2520292A1 (fr) | 2011-05-06 | 2012-11-07 | Helmholtz-Zentrum für Infektionsforschung GmbH | Utilisation de spirangiens pour le traitement ou la prévention des troubles liés à IL-8 ou IL-6 |
CA3029281A1 (fr) | 2016-06-29 | 2018-01-04 | Otonomy, Inc. | Formulations otiques a base de triglycerides et leurs utilisations |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0853083A1 (fr) * | 1997-01-06 | 1998-07-15 | Pfizer Inc. | Dérivés de pyridylfuran et pyridylthiphène et leur utilisation pharmaceutique |
WO2001058890A1 (fr) * | 2000-02-12 | 2001-08-16 | Astrazeneca Ab | Derives de carboxamides heteroaromatiques et leur utilisation comme inhibiteurs de l'enzyme ikk-2 |
WO2001098290A2 (fr) * | 2000-06-19 | 2001-12-27 | Pharmacia Italia S.P.A. | Derives de thiophene actifs en tant qu'inhibiteurs de kinase, leur procede de preparation, et compositions pharmaceutiques les contenant |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1468012A (en) * | 1973-08-09 | 1977-03-23 | Beecham Group Ltd | 2-amino-3-carboxy-thiophene derivatives |
JP3236683B2 (ja) * | 1992-11-06 | 2001-12-10 | 大日本印刷株式会社 | 熱転写用染料及び熱転写シート |
JPH06143838A (ja) * | 1992-11-06 | 1994-05-24 | Sankyo Kagaku Kk | 感熱転写記録用色素 |
-
2001
- 2001-10-12 EP EP01979731A patent/EP1324759A4/fr not_active Withdrawn
- 2001-10-12 WO PCT/US2001/031866 patent/WO2002030353A2/fr not_active Application Discontinuation
- 2001-10-12 JP JP2002533800A patent/JP2004523476A/ja active Pending
- 2001-10-12 AU AU2002211663A patent/AU2002211663A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0853083A1 (fr) * | 1997-01-06 | 1998-07-15 | Pfizer Inc. | Dérivés de pyridylfuran et pyridylthiphène et leur utilisation pharmaceutique |
WO2001058890A1 (fr) * | 2000-02-12 | 2001-08-16 | Astrazeneca Ab | Derives de carboxamides heteroaromatiques et leur utilisation comme inhibiteurs de l'enzyme ikk-2 |
WO2001098290A2 (fr) * | 2000-06-19 | 2001-12-27 | Pharmacia Italia S.P.A. | Derives de thiophene actifs en tant qu'inhibiteurs de kinase, leur procede de preparation, et compositions pharmaceutiques les contenant |
Also Published As
Publication number | Publication date |
---|---|
AU2002211663A1 (en) | 2002-04-22 |
WO2002030353A3 (fr) | 2002-06-27 |
JP2004523476A (ja) | 2004-08-05 |
WO2002030353A2 (fr) | 2002-04-18 |
EP1324759A2 (fr) | 2003-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030411 |
|
AK | Designated contracting states |
Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040329 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 31/4409 B Ipc: 7A 61K 31/4406 B Ipc: 7A 61K 31/381 A |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060419 |