HK1163661A1 - 作為 調節劑的雜芳基衍生物 - Google Patents

作為 調節劑的雜芳基衍生物

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Publication number
HK1163661A1
HK1163661A1 HK12103803.7A HK12103803A HK1163661A1 HK 1163661 A1 HK1163661 A1 HK 1163661A1 HK 12103803 A HK12103803 A HK 12103803A HK 1163661 A1 HK1163661 A1 HK 1163661A1
Authority
HK
Hong Kong
Prior art keywords
cftr
modulators
heteroaryl derivatives
heteroaryl
derivatives
Prior art date
Application number
HK12103803.7A
Other languages
English (en)
Inventor
．哈蒂達-魯哈
．米勒
周競蘭
．貝爾
Original Assignee
沃泰克斯藥物股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 沃泰克斯藥物股份有限公司 filed Critical 沃泰克斯藥物股份有限公司
Publication of HK1163661A1 publication Critical patent/HK1163661A1/zh

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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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