HUE062892T2 - (R)-1(2,2-difluorbenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluor-2-(1-hidroxi- 2-metilpropán-2-il)-1H-indol-5-il)ciklopropánkarboxamid elõállítása és köztitermékei - Google Patents

(R)-1(2,2-difluorbenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluor-2-(1-hidroxi- 2-metilpropán-2-il)-1H-indol-5-il)ciklopropánkarboxamid elõállítása és köztitermékei

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Publication number
HUE062892T2
HUE062892T2 HUE20206423A HUE20206423A HUE062892T2 HU E062892 T2 HUE062892 T2 HU E062892T2 HU E20206423 A HUE20206423 A HU E20206423A HU E20206423 A HUE20206423 A HU E20206423A HU E062892 T2 HUE062892 T2 HU E062892T2
Authority
HU
Hungary
Prior art keywords
difluorobenzo
cyclopropanecarboxamide
methylpropan
dioxol
dihydroxypropyl
Prior art date
Application number
HUE20206423A
Other languages
English (en)
Inventor
Ali Keshavarz-Shokri
Beili Zhang
Tim Edward Alcacio
Elaine Chungmin Lee
Yuegang Zhang
Mariusz Krawiec
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of HUE062892T2 publication Critical patent/HUE062892T2/hu

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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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HUE20206423A 2010-03-25 2011-03-25 (R)-1(2,2-difluorbenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluor-2-(1-hidroxi- 2-metilpropán-2-il)-1H-indol-5-il)ciklopropánkarboxamid elõállítása és köztitermékei HUE062892T2 (hu)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31737610P 2010-03-25 2010-03-25
US31995310P 2010-04-01 2010-04-01
US32156110P 2010-04-07 2010-04-07
US32163610P 2010-04-07 2010-04-07

Publications (1)

Publication Number Publication Date
HUE062892T2 true HUE062892T2 (hu) 2023-12-28

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ID=43903962

Family Applications (3)

Application Number Title Priority Date Filing Date
HUE20206423A HUE062892T2 (hu) 2010-03-25 2011-03-25 (R)-1(2,2-difluorbenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluor-2-(1-hidroxi- 2-metilpropán-2-il)-1H-indol-5-il)ciklopropánkarboxamid elõállítása és köztitermékei
HUE14172991A HUE052759T2 (hu) 2010-03-25 2011-03-25 (R)-1(2,2-difluorbenzo(D)(1,3)dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluor-2-(1-hidroxi-2- metilpropán-2-il)-1H-indol-5-il)-ciklo-propánkarboxamid amorf formájának szilárd diszperziója
HUS2100019C HUS2100019I1 (hu) 2010-03-25 2021-05-17 (R)-1(2,2-difluorbenzo(D)(1,3)dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluor-2-(1-hidroxi-2- metilpropán-2-il)-1H-indol-5-il)-ciklo-propánkarboxamid amorf formájának szilárd diszperziója

Family Applications After (2)

Application Number Title Priority Date Filing Date
HUE14172991A HUE052759T2 (hu) 2010-03-25 2011-03-25 (R)-1(2,2-difluorbenzo(D)(1,3)dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluor-2-(1-hidroxi-2- metilpropán-2-il)-1H-indol-5-il)-ciklo-propánkarboxamid amorf formájának szilárd diszperziója
HUS2100019C HUS2100019I1 (hu) 2010-03-25 2021-05-17 (R)-1(2,2-difluorbenzo(D)(1,3)dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluor-2-(1-hidroxi-2- metilpropán-2-il)-1H-indol-5-il)-ciklo-propánkarboxamid amorf formájának szilárd diszperziója

Country Status (25)

Country Link
US (1) US20110251253A1 (hu)
EP (5) EP4253381A3 (hu)
JP (5) JP5734410B2 (hu)
CN (3) CN109081804B (hu)
AU (3) AU2011230508B2 (hu)
BR (1) BR112012024338B1 (hu)
CA (2) CA3016080C (hu)
CY (3) CY1123794T1 (hu)
DK (1) DK2826776T3 (hu)
ES (4) ES2845449T3 (hu)
FR (1) FR21C1018I2 (hu)
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MX2013002035A (es) * 2010-08-23 2013-03-25 Vertex Pharma Composiciones farmaceuticas de (r)-1-(2, 2-difluorobenzo[d] [1, 3]dioxol-5-il)-n-(1-(2, 3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2 -metilpropano-2-il)-1h-indol-5-il) ciclopropanocarboxamida y administracion de las mismas.

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