MX347804B - Formas solidas de (r)-1(2,2-difluorobenzo[d] [1,3]dioxol-5-il)-n-( 1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il) -1h-indol-5-il) ciclopropanocarboxamida. - Google Patents
Formas solidas de (r)-1(2,2-difluorobenzo[d] [1,3]dioxol-5-il)-n-( 1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il) -1h-indol-5-il) ciclopropanocarboxamida.Info
- Publication number
- MX347804B MX347804B MX2012011062A MX2012011062A MX347804B MX 347804 B MX347804 B MX 347804B MX 2012011062 A MX2012011062 A MX 2012011062A MX 2012011062 A MX2012011062 A MX 2012011062A MX 347804 B MX347804 B MX 347804B
- Authority
- MX
- Mexico
- Prior art keywords
- difluorobenzo
- cyclopropanecarboxamide
- dioxol
- indol
- fluoro
- Prior art date
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- C—CHEMISTRY; METALLURGY
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
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Abstract
La presente invención se relaciona con las formas sólidas de (r)-1-(2,2-difluorobanzo (d) (1,3) dioxol-5il)-N-(1- (2, 3- dihidroxipropil)-6-fluoro-2-(1-hidroxi-2metilpropan-2-il)-1H-indo l-5il) ciclopancarboxamida (compuesto 1) en forma sustancialmente cristalina (Forma A) o forma amorfa, composiciones farmacéuticas de estas, y métodos de tratamiento con estos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31737610P | 2010-03-25 | 2010-03-25 | |
US31995310P | 2010-04-01 | 2010-04-01 | |
US32156110P | 2010-04-07 | 2010-04-07 | |
US32163610P | 2010-04-07 | 2010-04-07 | |
PCT/US2011/030032 WO2011119984A1 (en) | 2010-03-25 | 2011-03-25 | Solid forms of (r)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihyderoxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012011062A MX2012011062A (es) | 2013-01-14 |
MX347804B true MX347804B (es) | 2017-05-15 |
Family
ID=43903962
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012011062A MX347804B (es) | 2010-03-25 | 2011-03-25 | Formas solidas de (r)-1(2,2-difluorobenzo[d] [1,3]dioxol-5-il)-n-( 1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il) -1h-indol-5-il) ciclopropanocarboxamida. |
MX2017001548A MX370904B (es) | 2010-03-25 | 2011-03-25 | Formas solidas de (r)-1(2,2-difluorobenzo[d] [1,3]dioxol-5-il)-n-( 1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il) -1h-indol-5-il)ciclopropanocarboxamida. |
MX2016001939A MX345541B (es) | 2010-03-25 | 2011-03-25 | Formas solidas de (r)-1(2,2-difluorobenzo[d] [1,3]dioxol-5-il)-n-( 1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il) -1h-indol-5-il) ciclopropanocarboxamida. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017001548A MX370904B (es) | 2010-03-25 | 2011-03-25 | Formas solidas de (r)-1(2,2-difluorobenzo[d] [1,3]dioxol-5-il)-n-( 1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il) -1h-indol-5-il)ciclopropanocarboxamida. |
MX2016001939A MX345541B (es) | 2010-03-25 | 2011-03-25 | Formas solidas de (r)-1(2,2-difluorobenzo[d] [1,3]dioxol-5-il)-n-( 1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il) -1h-indol-5-il) ciclopropanocarboxamida. |
Country Status (24)
Country | Link |
---|---|
US (1) | US20110251253A1 (es) |
EP (5) | EP3181561B1 (es) |
JP (5) | JP5734410B2 (es) |
CN (3) | CN109081804B (es) |
AU (3) | AU2011230508B2 (es) |
BR (1) | BR112012024338B1 (es) |
CA (2) | CA2794559C (es) |
CY (2) | CY1123794T1 (es) |
DK (1) | DK2826776T3 (es) |
ES (4) | ES2604105T3 (es) |
FR (1) | FR21C1018I2 (es) |
HR (2) | HRP20230661T1 (es) |
HU (3) | HUE062892T2 (es) |
IL (4) | IL222117B (es) |
LT (2) | LT2826776T (es) |
MX (3) | MX347804B (es) |
NO (1) | NO2021021I1 (es) |
NZ (3) | NZ700556A (es) |
PL (2) | PL3835297T3 (es) |
PT (1) | PT2826776T (es) |
RS (1) | RS61314B1 (es) |
RU (2) | RU2711481C2 (es) |
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