HK1158691A1 - 大規模生產病毒的方法 - Google Patents

大規模生產病毒的方法

Info

Publication number
HK1158691A1
HK1158691A1 HK11113237.3A HK11113237A HK1158691A1 HK 1158691 A1 HK1158691 A1 HK 1158691A1 HK 11113237 A HK11113237 A HK 11113237A HK 1158691 A1 HK1158691 A1 HK 1158691A1
Authority
HK
Hong Kong
Prior art keywords
virus
large scale
scale production
cell culture
directed
Prior art date
Application number
HK11113237.3A
Other languages
English (en)
Inventor
Manfred Reiter
Wolfgang Mundt
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21723079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1158691(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of HK1158691A1 publication Critical patent/HK1158691A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
HK11113237.3A 2001-12-10 2011-12-07 大規模生產病毒的方法 HK1158691A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/006,881 US6951752B2 (en) 2001-12-10 2001-12-10 Method for large scale production of virus antigen

Publications (1)

Publication Number Publication Date
HK1158691A1 true HK1158691A1 (zh) 2012-07-20

Family

ID=21723079

Family Applications (2)

Application Number Title Priority Date Filing Date
HK08106127.5A HK1115609A1 (en) 2001-12-10 2008-06-02 Method for large scale production of virus antigen
HK11113237.3A HK1158691A1 (zh) 2001-12-10 2011-12-07 大規模生產病毒的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK08106127.5A HK1115609A1 (en) 2001-12-10 2008-06-02 Method for large scale production of virus antigen

Country Status (18)

Country Link
US (2) US6951752B2 (zh)
EP (3) EP1894998A1 (zh)
JP (2) JP4370511B2 (zh)
CN (2) CN100335619C (zh)
AT (1) ATE447010T2 (zh)
AU (1) AU2002358662B2 (zh)
CA (1) CA2469644C (zh)
DE (2) DE122010000025I1 (zh)
DK (2) DK2330189T3 (zh)
ES (2) ES2335395T5 (zh)
FR (1) FR10C0026I1 (zh)
HK (2) HK1115609A1 (zh)
HU (1) HU225791B1 (zh)
MX (1) MXPA04005644A (zh)
NO (1) NO20042910L (zh)
PL (1) PL208232B1 (zh)
RU (1) RU2314344C2 (zh)
WO (1) WO2003054174A1 (zh)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7445924B2 (en) 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
CA2467099C (en) * 2001-12-20 2013-01-29 Bavarian Nordic A/S Method for the recovery and purification of poxviruses from infected cells
EA009008B1 (ru) 2002-09-05 2007-10-26 Бавариан Нордик А/С Способ амплификации вируса оспы
WO2004058800A2 (en) * 2002-12-23 2004-07-15 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
US20050153419A1 (en) * 2003-12-23 2005-07-14 Schering Corporation Methods for producing cell lines stable in serum-free medium suspension culture
JP2007522814A (ja) 2004-02-23 2007-08-16 クルセル ホランド ベー ヴェー ウイルスの精製方法
WO2005103235A1 (ja) * 2004-04-19 2005-11-03 Denka Seiken Co., Ltd. ウイルスの生産方法
RU2006145303A (ru) * 2004-05-20 2008-06-27 АйДи БАЙОМЕДИКАЛ КОРПОРЕЙШН (CA) Способ получения противогриппозной вакцины
US7344839B2 (en) * 2004-12-23 2008-03-18 Aurx, Inc. Virus preparations and methods
DK2368975T3 (en) * 2004-12-23 2015-01-05 Medimmune Llc Non-tumorigenic MDCK cell line for the propagation of viruses
AU2007245192B2 (en) 2006-03-31 2012-04-12 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
RU2487935C2 (ru) * 2006-09-15 2013-07-20 Медиммун, Ллк. Линии клеток почки собаки майдин-дэрби (mdck), поддерживающие рост вирусов до высоких титров, и способ применения этих клеток в биореакторе
JP5084214B2 (ja) * 2006-09-29 2012-11-28 一般財団法人日本ポリオ研究所 Ｉｐｖワクチン
US8426124B2 (en) * 2007-05-04 2013-04-23 Baxter International Inc. Two-step temperature profile for the propagation of viruses
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
WO2009114693A1 (en) * 2008-03-12 2009-09-17 Wyeth Method for identifying cells suitable for large-scale production of recombinant proteins
CN102170902B (zh) * 2008-08-01 2015-07-15 伽玛疫苗有限公司 流感疫苗
AU2009296628B2 (en) 2008-09-24 2015-01-15 Medimmune, Llc Methods for purification of viruses
AU2009296701B2 (en) 2008-09-24 2015-02-19 Medimmune, Llc Methods for cultivating cells, propagating and purifying viruses
CA3150411C (en) 2009-07-31 2023-09-12 Pnuvax Inc. High yield yellow fever virus strain with increased propagation in cells
JP2013507990A (ja) 2009-10-26 2013-03-07 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス
CA2784741A1 (fr) * 2009-12-23 2011-06-30 Sanofi Pasteur Procede de culture de cellules adherentes
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
SG184833A1 (en) 2010-04-14 2012-11-29 Emd Millipore Corp Methods of producing high titer, high purity virus stocks and methods of use thereof
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
CN101979517B (zh) * 2010-10-15 2011-12-28 普莱柯生物工程股份有限公司 一种利用生物反应器大规模生产流感病毒的方法
AU2012211043B2 (en) 2011-01-27 2017-04-06 Gamma Vaccines Pty Limited Combination vaccines
CN102492659A (zh) * 2011-11-14 2012-06-13 成都康华生物制品有限公司 一种疫苗生产用甲肝病毒的生产方法
EP3022296B1 (en) 2013-07-15 2022-12-28 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
CN103387958B (zh) * 2013-08-16 2016-04-06 北京科兴中维生物技术有限公司 人胚肺成纤维细胞sv-7在病毒培养中的应用
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
JP6783143B2 (ja) 2014-03-25 2020-11-11 テルモ ビーシーティー、インコーポレーテッド 培地の受動的補充
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
CA2969197C (en) 2015-01-26 2020-08-18 Ube Industries, Ltd. Method, device and kit for mass cultivation of cells using polyimide porous membrane
KR101961580B1 (ko) 2015-01-26 2019-03-22 우베 고산 가부시키가이샤 물질의 생산 방법
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
CA3014435C (en) 2016-02-19 2023-04-18 Wisconsin Alumni Research Foundation (Warf) Improved influenza b virus replication for vaccine development
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
KR102307420B1 (ko) 2016-07-25 2021-09-29 우베 고산 가부시키가이샤 세포 배양 모듈
EP3489342B1 (en) 2016-07-25 2022-01-26 UBE Industries, Ltd. Siphon type cultivation method
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
WO2019143291A1 (en) * 2018-01-18 2019-07-25 Yisheng Biopharma (Singapore) Pte. Ltd. Method for adapting influenza viruses to vero cells
EP3749757A4 (en) 2018-02-07 2021-11-24 Bharat Biotech International Limited PROCEDURES FOR ENTEROVIRUS CLEANING AND INACTIVATION AND VACCINE COMPOSITIONS RESULTED FROM THEM
US11241492B2 (en) 2019-01-23 2022-02-08 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to genes in influenza viruses
KR102228267B1 (ko) * 2019-01-25 2021-03-17 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
WO2020153619A1 (ko) * 2019-01-25 2020-07-30 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
WO2020163804A1 (en) 2019-02-08 2020-08-13 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
CA3129932A1 (en) * 2019-02-15 2020-08-20 Ology Bioservices, Inc. Method for virus production
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
TW202122569A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 應用小片多孔膜的細胞培養法
TW202122572A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 胞外體的產生方法
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
CN111850169B (zh) * 2020-07-16 2022-09-27 华农（肇庆）生物产业技术研究院有限公司 一种计算AIV在MDCK-sus细胞中细胞单位均产毒量的方法
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525349A (en) 1981-12-29 1985-06-25 Societe Anonyme Dite: Institut Merueux Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine
US5719051A (en) * 1989-12-22 1998-02-17 Immuno Aktiengesellschaft Perfusion system and a method for the large scale production of virus or virus antigen
AT393356B (de) 1989-12-22 1991-10-10 Immuno Ag Verfahren zur herstellung von fsme-virus-antigen
FR2723740B1 (fr) 1994-08-16 1996-11-08 Pasteur Merieux Serums Vacc Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications
US5824536A (en) * 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
EP1213030B1 (en) 1994-11-10 2009-04-22 Baxter Healthcare SA Method for producing biologicals in protein-free culture
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
GB2319413B (en) * 1996-11-12 2001-06-06 Lsi Logic Corp Driver circuits
US6168944B1 (en) * 1997-01-31 2001-01-02 Schering Corporation Methods for cultivating cells and propagating viruses
DE69835813T2 (de) * 1997-01-31 2007-09-13 Schering Corp. Verfahren zur kultivierung von zellen und zur vermehrung von viren
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US5994134A (en) * 1998-05-04 1999-11-30 Canji, Inc. Viral production process
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
US6855535B2 (en) * 2001-12-10 2005-02-15 Baxter Healthcare S.A. Method of large scale production of Hepatitis A virus

Also Published As

Publication number Publication date
JP4370511B2 (ja) 2009-11-25
PL208232B1 (pl) 2011-04-29
CA2469644A1 (en) 2003-07-03
EP1453956B1 (en) 2009-10-28
FR10C0026I1 (fr) 2011-01-14
DK1453956T3 (da) 2010-01-11
AU2002358662B2 (en) 2008-05-15
EP1894998A1 (en) 2008-03-05
EP2330189A1 (en) 2011-06-08
EP1453956B8 (en) 2010-02-10
AU2002358662A1 (en) 2003-07-09
US20050181495A1 (en) 2005-08-18
RU2004121178A (ru) 2005-10-10
US20030108860A1 (en) 2003-06-12
MXPA04005644A (es) 2005-04-19
CA2469644C (en) 2013-07-23
PL373487A1 (en) 2005-09-05
EP1453956B2 (en) 2017-01-18
HK1115609A1 (en) 2008-12-05
ES2335395T3 (es) 2010-03-26
CN100335619C (zh) 2007-09-05
JP2009261410A (ja) 2009-11-12
JP2005512564A (ja) 2005-05-12
ES2335395T5 (es) 2017-08-31
CN101100657A (zh) 2008-01-09
WO2003054174A1 (en) 2003-07-03
US7524676B2 (en) 2009-04-28
US6951752B2 (en) 2005-10-04
DE122010000025I1 (de) 2010-08-12
NO20042910L (no) 2004-07-09
EP1453956A1 (en) 2004-09-08
JP5021000B2 (ja) 2012-09-05
ES2488818T3 (es) 2014-08-29
DE60234211D1 (de) 2009-12-10
HUP0402415A3 (en) 2005-07-28
HUP0402415A2 (hu) 2005-02-28
ATE447010T2 (de) 2009-11-15
EP2330189B1 (en) 2014-05-21
CN101100657B (zh) 2012-05-30
RU2314344C2 (ru) 2008-01-10
HU225791B1 (en) 2007-09-28
CN1617924A (zh) 2005-05-18
EP1894998A8 (en) 2008-04-23
DK2330189T3 (da) 2014-06-16

Similar Documents

Publication Publication Date Title
HK1158691A1 (zh) 大規模生產病毒的方法
PT1428878E (pt) Processo para a produção e purificação de eritropoietina
DE60043534D1 (de) VERFAHREN UND VORRICHTUNG ZUR HALTUNG UND EXPANSION VON HEMATOPOIETISCHEN STAMMZELLEN UND/ODER VORLäUFERZELLEN
ATE452664T1 (de) Verfahren und vorrichtung zum züchten von zellen
ATE208810T1 (de) Solid-state-fermenter und verfahren zur solid- state-fermentation
ES2150938T3 (es) Produccion mejorada de taxol y taxanos mediante cultivos celulares de especies de taxus.
WO2003067213A3 (en) Modulation of sulfate permease for photosynthetic hydrogen production
HRP20060398A2 (en) Method and fermenter for the anaerobic fermentation of biological waste
AU2002212275A1 (en) Bio-reactor for the cultivation of micro-organisms and method for the production thereof
DE69813042D1 (de) Verfahren zur verbesserung der ausgebeute eines photobioreaktors
HK1093755A1 (en) Method for differentiating mesenchymal stem cell into neural cell
DE60138029D1 (de) Verfahren zur herstellung von biopterinen
ES2076944T3 (es) Procedimiento para el cultivo de bacterias.
DK1495112T3 (da) Cellekulturmedium
WO2000077236A3 (en) Methods for enhancing the production of cytokines in cell cultur e
DE69900936D1 (de) Elektrolysezelle zur Erzeugung von Gas
DE60032791D1 (de) Test für mikroorganismen in zellkulturen
AU2003206926A8 (en) Cultivation method for micro-organisms and bioreactor
WO2003049767A3 (en) Method of large scale production of hepatitis a virus
FR2801900B1 (fr) Methode de production de cellules animales adherentes
ATE521364T1 (de) Zusammensetzung und verfahren zur erhöhung der zelldichte in zellkulturen, die mit dem lentivirus infiziert sind
WO2002062837A3 (en) Cells with enhanced pkr expression for increasing cytokine production

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20221213