ES2150938T3 - Produccion mejorada de taxol y taxanos mediante cultivos celulares de especies de taxus. - Google Patents

Produccion mejorada de taxol y taxanos mediante cultivos celulares de especies de taxus.

Info

Publication number
ES2150938T3
ES2150938T3 ES93906156T ES93906156T ES2150938T3 ES 2150938 T3 ES2150938 T3 ES 2150938T3 ES 93906156 T ES93906156 T ES 93906156T ES 93906156 T ES93906156 T ES 93906156T ES 2150938 T3 ES2150938 T3 ES 2150938T3
Authority
ES
Spain
Prior art keywords
taxanes
taxol
taxus species
improved production
cell cultivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93906156T
Other languages
English (en)
Inventor
Venkataraman Bringi
Prakash G Kadkade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phyton Inc
Original Assignee
Phyton Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27126086&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2150938(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phyton Inc filed Critical Phyton Inc
Application granted granted Critical
Publication of ES2150938T3 publication Critical patent/ES2150938T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

ESTA INVENCION ESTA DIRIGIDA A METODOS PARA LA PRODUCCION MEJORADA Y RECUPERACION DE TAXOL Y TAXANAS MEDIANTE CULTIVOS DE CELULAS DE ESPECIES TAXUS.
ES93906156T 1992-02-20 1993-02-22 Produccion mejorada de taxol y taxanos mediante cultivos celulares de especies de taxus. Expired - Lifetime ES2150938T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83914492A 1992-02-20 1992-02-20
US07/874,344 US5407816A (en) 1992-02-20 1992-04-24 Enhanced production of taxol and taxanes by cell cultures of taxus species

Publications (1)

Publication Number Publication Date
ES2150938T3 true ES2150938T3 (es) 2000-12-16

Family

ID=27126086

Family Applications (3)

Application Number Title Priority Date Filing Date
ES93906156T Expired - Lifetime ES2150938T3 (es) 1992-02-20 1993-02-22 Produccion mejorada de taxol y taxanos mediante cultivos celulares de especies de taxus.
ES03021426T Expired - Lifetime ES2361150T3 (es) 1992-02-20 1993-02-22 Mejora de la producción de taxol y de texanos mediante cultivos celulares de especies de taxus.
ES99202507T Expired - Lifetime ES2213328T3 (es) 1992-02-20 1993-02-22 Produccion mejorada de taxol y taxanos mediante cultivos celulares de especies de taxus.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES03021426T Expired - Lifetime ES2361150T3 (es) 1992-02-20 1993-02-22 Mejora de la producción de taxol y de texanos mediante cultivos celulares de especies de taxus.
ES99202507T Expired - Lifetime ES2213328T3 (es) 1992-02-20 1993-02-22 Produccion mejorada de taxol y taxanos mediante cultivos celulares de especies de taxus.

Country Status (16)

Country Link
US (1) US5407816A (es)
EP (3) EP1378574B1 (es)
JP (5) JP3513151B2 (es)
KR (6) KR100285788B1 (es)
AT (3) ATE504659T1 (es)
AU (1) AU672194B2 (es)
CA (1) CA2130745C (es)
DE (3) DE69329154T2 (es)
DK (2) DK0960944T3 (es)
ES (3) ES2150938T3 (es)
GR (1) GR3034722T3 (es)
HK (2) HK1024936A1 (es)
NZ (1) NZ249734A (es)
PT (2) PT672162E (es)
SG (1) SG46427A1 (es)
WO (1) WO1993017121A1 (es)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
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US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
US7264951B1 (en) 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
US5850032A (en) * 1992-04-01 1998-12-15 Union Camp Corporation Method for production of plant biological products in precocious neomorphic embryoids
CA2092849C (en) * 1992-04-07 2003-11-18 Paul M. Cino Callus cell induction and the preparation of taxanes
WO1993023555A1 (en) * 1992-05-21 1993-11-25 The Penn State Research Foundation Cultured taxus tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
JP2967532B2 (ja) * 1992-06-11 1999-10-25 日石三菱株式会社 タキサン類化合物の製造方法
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
KR950005081B1 (ko) * 1993-07-06 1995-05-18 산림청임목육종연구소 주목 종자의 씨눈 유래의 체세포배 및 체세포배성세포 혹은 그 배양배지로부터 택솔(Taxol) 및 그 유도체를 생산하는 방법
CN1058054C (zh) * 1993-11-15 2000-11-01 三井化学株式会社 紫杉烷类双萜的生产方法以及获得以高产量产生紫杉烷类双萜的培养细胞的方法
IL113447A (en) * 1994-04-22 1999-01-26 Us Agriculture Attractant for controlling insects and apparatus containing the same
CA2163614C (en) * 1994-11-25 2002-12-31 Yukihito Yukimune Method of producing a taxane-type diterpene
US6248572B1 (en) * 1995-04-27 2001-06-19 Samyang, Genex, Corporation Production of taxol from taxus plant cell culture adding silver nitrate
KR960037826A (ko) * 1995-04-27 1996-11-19 김경환 택서스속 식물세포의 반연속식 배양방법
DE69615499T2 (de) * 1995-04-29 2002-06-06 Samyang Genex Co Massenherstellungsverfahren von taxol aus pflanzen der gattung taxus
WO1996034522A1 (en) * 1995-05-05 1996-11-07 Union Camp Corporation Method for production of plant biological products in precocious neomorphic embryoids
JPH11505422A (ja) * 1995-05-19 1999-05-21 フィテラ インク． 植物細胞培養物および植物組織培養物の処理方法
KR20140062179A (ko) * 1996-05-24 2014-05-22 디에프비 바이오테크 인코포레이티드 탁수스종의 세포 배양에 의한 탁산의 생산 증진 방법
EP2292225B9 (en) 1997-03-31 2012-06-27 Boston Scientific Scimed Limited Dosage form comprising taxol in crystalline form
US5801193A (en) * 1997-04-15 1998-09-01 Immune Modulation, Inc. Compositions and methods for immunosuppressing
KR100287465B1 (ko) 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
KR100266448B1 (ko) * 1997-06-26 2000-09-15 박종헌 식물세포 배양 중의 온도변화에 의한 택솔의 대량생산 방법
ES2178369T3 (es) 1998-01-14 2002-12-16 Bristol Myers Squibb Co Nuevos complejos cristalinos dce baccatina iii con imidazol, 2-metilimidazol o isopropanol.
US6093422A (en) * 1998-01-23 2000-07-25 Zodiac Pool Care, Inc. Biocidal compositions for treating water
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
FR2800740B1 (fr) * 1999-11-08 2002-10-11 Lorraine Inst Nat Polytech Procede de production de metabolites a partir de vegetaux en culture hors sol
EP1301500B1 (en) 2000-06-22 2007-11-21 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
WO2002040633A2 (en) * 2000-11-14 2002-05-23 Regents Of The University Of California Optimized antitrypsin expression in rice cell culture
US6365407B1 (en) * 2001-03-05 2002-04-02 Council Of Scientific & Industrial Research Culture medium composition useful for induction and proliferation of Taxus calli
US20030091659A1 (en) * 2001-11-09 2003-05-15 Avon Products, Inc. Topical composition having undifferentiated plant seed cells and method for using same
US20030124205A1 (en) * 2001-12-28 2003-07-03 Avon Products, Inc. Topical cosmetic composition having a natural plant active ingredient and method of using same
TW200304947A (en) * 2002-02-08 2003-10-16 Bristol Myers Squibb Co Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
CN101421392A (zh) * 2004-02-13 2009-04-29 菲托生物技术公司 茚满酰酰胺在刺激紫杉属次生代谢中的应用
EP1891206B1 (en) 2005-06-03 2013-07-24 Samyang Genexbio Corporation Mass production of secondary metabolites in plant cell culture by use of a saccharide mixture in the culture medium
RU2398874C2 (ru) 2005-10-31 2010-09-10 Юнхва Клеточные клоны камбия, способ их выделения и консервации
US8053238B2 (en) * 2005-10-31 2011-11-08 Unhwa Corporation Isolated population of plant single cells and method of preparing the same
GB0605900D0 (en) * 2006-03-23 2006-05-03 Lipigen As Modulators of nuclear receptors
BRPI0807132A2 (pt) 2007-01-30 2018-12-04 Syngenta Participations Ag enzimas para o tratamento de lignocelulósicos, ácidos nucléicos que codificam as mesmas, e metodos e uso das mesmas
CN101319199B (zh) * 2007-06-08 2010-10-27 中国科学院大连化学物理研究所 一种利用中国红豆杉细胞诱导产生紫杉烷的方法
KR101064518B1 (ko) * 2007-09-21 2011-09-19 주식회사 운화 저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법
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US8713329B2 (en) * 2009-02-26 2014-04-29 Red Hat, Inc. Authenticated secret sharing
BRPI0925040A2 (pt) 2009-04-03 2015-07-21 Dianaplantsciences Inc Produção e extração de procianidinas a partir da cultura celular de plantas
WO2010137879A2 (ko) * 2009-05-26 2010-12-02 주식회사 운화 버드나무과의 형성층 유래 식물줄기세포 및 이의 분리배양방법
WO2010137877A2 (ko) * 2009-05-26 2010-12-02 주식회사 운화 국화과의 형성층 유래 식물줄기세포 및 이의 분리배양방법
JP2012527890A (ja) * 2009-05-28 2012-11-12 株式会社ウンファ 茄子科の形成層由来植物幹細胞及びこれの分離培養方法
CN101671319B (zh) * 2009-09-18 2012-02-29 应成杰 红豆杉无毒提取物的提取工艺
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JP2012217441A (ja) * 2011-04-14 2012-11-12 Housetec Inc タキサン類の生産方法、およびカルス誘導方法
CN102715085B (zh) * 2012-06-19 2014-04-16 湖南农业大学 一种诱导红豆杉种子种胚获得愈伤组织和悬浮细胞的方法
CN102715086B (zh) * 2012-06-19 2014-04-16 湖南农业大学 一种红豆杉试管苗诱导获得愈伤组织和悬浮细胞的方法
CN103058961B (zh) * 2013-01-28 2015-04-29 普洱市红宝生物科技有限公司 从云南红豆杉中提取紫杉醇的方法
CN103570647A (zh) * 2013-11-06 2014-02-12 湖南农业大学 从红豆杉细胞培养液中制备高纯度紫杉醇的方法
KR101603539B1 (ko) * 2014-08-11 2016-03-15 영남대학교 산학협력단 택솔을 생산하는 콜레토트리쿰 데마티움 균주 및 그 용도
KR101786448B1 (ko) 2015-08-24 2017-10-18 영남대학교 산학협력단 택솔을 생산하는 트라이코더마 비리데슨스 tx1 균주 및 이의 용도
CN109022510A (zh) * 2018-08-23 2018-12-18 吉首大学 一种利用南方红豆杉菌根菌与活组织细胞共培养生产紫杉醇及10-dabⅲ的方法
CN110441439B (zh) * 2019-07-01 2022-03-01 杭州师范大学 区分密叶红豆杉和云南红豆杉的代谢标志物及其检测方法
WO2022162101A1 (en) * 2021-01-28 2022-08-04 Phyto-Technics Bv Production of taxol from taxus cuttings

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US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
JPH03216123A (ja) * 1990-01-17 1991-09-24 Nitsusen Kagaku Kogyo Kk 培養植物体の増殖促進方法
WO1992013961A1 (en) * 1991-02-12 1992-08-20 Nippon Steel Corporation Process for producing taxol by cell culture of taxus species
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species

Also Published As

Publication number Publication date
JP2008131955A (ja) 2008-06-12
CA2130745C (en) 2008-01-22
KR20040000390A (ko) 2004-01-03
EP0672162A4 (en) 1995-11-29
KR950700996A (ko) 1995-02-20
EP1378574B1 (en) 2011-04-06
DK0960944T3 (da) 2004-04-05
DK0672162T3 (da) 2000-12-18
KR20090116792A (ko) 2009-11-11
US5407816A (en) 1995-04-18
ES2213328T3 (es) 2004-08-16
ATE195146T1 (de) 2000-08-15
JPH07506721A (ja) 1995-07-27
HK1003718A1 (en) 1998-11-06
JP2004000285A (ja) 2004-01-08
PT672162E (pt) 2001-01-31
EP0960944B1 (en) 2003-12-10
EP0672162B1 (en) 2000-08-02
KR20070104684A (ko) 2007-10-26
AU3729193A (en) 1993-09-13
ATE504659T1 (de) 2011-04-15
DE69333358T2 (de) 2004-08-19
EP0672162A1 (en) 1995-09-20
GR3034722T3 (en) 2001-01-31
CA2130745A1 (en) 1993-09-02
PT960944E (pt) 2004-04-30
KR20110079863A (ko) 2011-07-08
KR100285788B1 (ko) 2001-05-02
ES2361150T3 (es) 2011-06-14
SG46427A1 (en) 1998-02-20
DE69329154T2 (de) 2001-06-07
HK1024936A1 (en) 2000-10-27
DE69329154D1 (de) 2000-09-07
JP2009183305A (ja) 2009-08-20
AU672194B2 (en) 1996-09-26
NZ249734A (en) 1996-08-27
WO1993017121A1 (en) 1993-09-02
DE69334352D1 (de) 2011-05-19
ATE256197T1 (de) 2003-12-15
JP2005348751A (ja) 2005-12-22
JP3513151B2 (ja) 2004-03-31
DE69333358D1 (de) 2004-01-22
EP1378574A1 (en) 2004-01-07
KR100392036B1 (ko) 2003-07-16
EP0960944A1 (en) 1999-12-01

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