DE60138029D1 - Verfahren zur herstellung von biopterinen - Google Patents

Verfahren zur herstellung von biopterinen

Info

Publication number
DE60138029D1
DE60138029D1 DE60138029T DE60138029T DE60138029D1 DE 60138029 D1 DE60138029 D1 DE 60138029D1 DE 60138029 T DE60138029 T DE 60138029T DE 60138029 T DE60138029 T DE 60138029T DE 60138029 D1 DE60138029 D1 DE 60138029D1
Authority
DE
Germany
Prior art keywords
production
present
biopterines
transformed
biopterin compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60138029T
Other languages
English (en)
Inventor
Masayuki Yabuta
Kazuaki Furukawa
Nobue Miyamoto
Katsuhiko Yamamoto
Kazuhiro Ohsuye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asubio Pharma Co Ltd
Original Assignee
Asubio Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asubio Pharma Co Ltd filed Critical Asubio Pharma Co Ltd
Application granted granted Critical
Publication of DE60138029D1 publication Critical patent/DE60138029D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
DE60138029T 2000-08-31 2001-08-28 Verfahren zur herstellung von biopterinen Expired - Lifetime DE60138029D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000262973 2000-08-31
PCT/JP2001/007395 WO2002018587A1 (fr) 2000-08-31 2001-08-28 Procede de production de biopterines

Publications (1)

Publication Number Publication Date
DE60138029D1 true DE60138029D1 (de) 2009-04-30

Family

ID=18750574

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60138029T Expired - Lifetime DE60138029D1 (de) 2000-08-31 2001-08-28 Verfahren zur herstellung von biopterinen

Country Status (13)

Country Link
US (2) US20040014167A1 (de)
EP (1) EP1314782B1 (de)
JP (1) JP4817590B2 (de)
KR (1) KR100916163B1 (de)
CN (1) CN1247778C (de)
AT (1) ATE426021T1 (de)
AU (1) AU2001280215B9 (de)
BR (1) BR0113411A (de)
CA (1) CA2420374A1 (de)
DE (1) DE60138029D1 (de)
ES (1) ES2320531T3 (de)
IL (2) IL154530A0 (de)
WO (1) WO2002018587A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
DK3138566T3 (da) 2003-11-17 2022-01-31 Biomarin Pharm Inc Behandling af phenylketonuri med bh4
EP1845952A2 (de) * 2004-11-17 2007-10-24 Biomarin Pharmaceutical Inc. Stabile tablettenformulierung von tetrahydrobiopterin
JPWO2006085535A1 (ja) * 2005-02-09 2008-06-26 株式会社カネカ テトラヒドロビオプテリン生合成酵素を用いたビオプテリン類の製造方法
JP2010523708A (ja) 2007-04-11 2010-07-15 バイオマリン ファーマシューティカル インコーポレイテッド テトラヒドロビオプテリンを投与する方法、関連する組成物および測定方法
JP5084481B2 (ja) * 2007-12-10 2012-11-28 花王株式会社 血圧調節剤のスクリーニング方法及び評価方法
RU2470642C2 (ru) 2008-01-03 2012-12-27 Байомарин Фармасьютикл Инк. Аналоги птерина для лечения состояния, чувствительного к вн4
BRPI0907247A2 (pt) 2008-01-07 2015-07-14 Biomarin Pharm Inc Métodos para preparar biopterina e para preparar tetraidrobiopterina
WO2012135389A2 (en) * 2011-03-28 2012-10-04 The Regents Of The University Of California Host cells and methods for oxidizing aromatic amino acids
KR101229912B1 (ko) * 2011-04-06 2013-02-05 강원대학교산학협력단 재조합 대장균을 이용한 세피아프테린의 제조방법
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102516246B (zh) * 2011-11-30 2014-08-06 安徽农业大学 一种从蚕体中提取纯化高纯度墨蝶呤的方法
US20150037849A1 (en) * 2012-02-29 2015-02-05 Danmarks Tekniske Universitet Microorganisms for the production of 5-hydroxytryptophan
EP2820121A1 (de) * 2012-02-29 2015-01-07 Danmarks Tekniske Universitet Mikroorganismen zur herstellung von melatonin
CN102925476B (zh) * 2012-11-15 2014-12-03 中国科学院上海巴斯德研究所 酵母中自组装的具有免疫原性的肠道病毒病毒样颗粒的制备方法及其应用
CN103215216B (zh) * 2013-04-16 2015-05-20 中国人民解放军军事医学科学院基础医学研究所 黑色素瘤治疗性质粒DNA疫苗pSVK-CAVA的制备方法及其专用工程菌及发酵培养基
US20160230200A1 (en) * 2013-09-05 2016-08-11 Danmarks Tekniske Universitet Microorganisms for efficient production of melatonin and related compounds
EP3143153A4 (de) * 2014-05-16 2018-01-03 The University Of Georgia Research Foundation, Inc. Mikrobieller ansatz zur herstellung von 5-hydroxytryptophan
WO2016109769A1 (en) * 2015-01-02 2016-07-07 Georgia Tech Research Corporation Pterin-dependent biocatalysts and uses thereof
US10851365B2 (en) 2016-03-31 2020-12-01 Danmarks Tekniske Universitet Optimized microbial cells for production of melatonin and other compounds
EP3436595B1 (de) 2016-03-31 2024-02-28 Danmarks Tekniske Universitet Optimierte mikrobielle zellen zur herstellung von melatonin und anderen verbindungen
US10883127B2 (en) 2016-05-24 2021-01-05 Danmarks Tekniske Universitet Variants of acetylserotonin O-methyltransferase and uses thereof
ES2963672T3 (es) 2016-12-13 2024-04-01 Univ Danmarks Tekniske Arilalquilamina N-acetiltransferasa y usos de la misma
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer
JP2020068734A (ja) * 2018-11-01 2020-05-07 国立大学法人東京工業大学 Ｓｐｒをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物
US20220145340A1 (en) 2019-03-15 2022-05-12 Danmarks Tekniske Universitet Engineered cells for production of indole-derivatives
CN111073884A (zh) * 2020-02-14 2020-04-28 昆明理工大学 提高非编码区域距离＜50bp的SNP中具有功能效应的SNP位点检测准确率的方法
CN111505179B (zh) * 2020-04-07 2021-07-13 厦门大学 海洋水体中生物蝶呤的检测方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS619296A (ja) * 1984-06-22 1986-01-16 Kanegafuchi Chem Ind Co Ltd 微生物によるｌ−エリスロ−ビオプテリンの製造法
JPS6152296A (ja) * 1984-08-21 1986-03-14 Kanegafuchi Chem Ind Co Ltd 微生物によるｌ−エリスロ−ビオプテリンの製造法
JP2674707B2 (ja) * 1988-06-22 1997-11-12 株式会社ビタミン研究所 Ｌ‐ビオプテリンの製法
DE3853711T2 (de) * 1987-11-30 1996-01-11 Vitamin Kenkyusho Kk Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.
JP2575781B2 (ja) * 1988-02-29 1997-01-29 日清製粉株式会社 ２，３−ジアシルオキシ−４−ヒドロキシ−トペンタナールおよびその製造方法
JP3137333B2 (ja) * 1990-07-21 2001-02-19 サントリー株式会社 テトラヒドロビオプテリンの製法およびそれに用いる酵素
JP2754959B2 (ja) 1991-07-24 1998-05-20 三菱電機株式会社 空気調和機のセンサ識別装置
KR100456062B1 (ko) * 2001-06-18 2004-11-08 박영식 재조합 대장균에 의한 테리딘 화합물의 제조방법

Also Published As

Publication number Publication date
CN1247778C (zh) 2006-03-29
US20040014167A1 (en) 2004-01-22
ATE426021T1 (de) 2009-04-15
CN1449442A (zh) 2003-10-15
EP1314782A1 (de) 2003-05-28
KR20030033042A (ko) 2003-04-26
ES2320531T3 (es) 2009-05-25
US7807421B2 (en) 2010-10-05
JP4817590B2 (ja) 2011-11-16
IL154530A0 (en) 2003-09-17
AU8021501A (en) 2002-03-13
EP1314782A4 (de) 2005-01-12
CA2420374A1 (en) 2003-02-24
AU2001280215B9 (en) 2007-03-22
US20060008869A1 (en) 2006-01-12
BR0113411A (pt) 2004-01-06
KR100916163B1 (ko) 2009-09-08
IL154530A (en) 2011-02-28
EP1314782B1 (de) 2009-03-18
AU2001280215B2 (en) 2006-08-03
WO2002018587A1 (fr) 2002-03-07
JPWO2002018587A1 (ja) 2004-01-15

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