BRPI0907247A2 - Métodos para preparar biopterina e para preparar tetraidrobiopterina - Google Patents

Métodos para preparar biopterina e para preparar tetraidrobiopterina

Info

Publication number
BRPI0907247A2
BRPI0907247A2 BRPI0907247-0A BRPI0907247A BRPI0907247A2 BR PI0907247 A2 BRPI0907247 A2 BR PI0907247A2 BR PI0907247 A BRPI0907247 A BR PI0907247A BR PI0907247 A2 BRPI0907247 A2 BR PI0907247A2
Authority
BR
Brazil
Prior art keywords
preparing
biopterin
methods
tetrahydrobiopterin
preparing tetrahydrobiopterin
Prior art date
Application number
BRPI0907247-0A
Other languages
English (en)
Inventor
Mark Henderson
Steven Jungles
Gabriele Roidl
Robert Baffi
Adriano Indolese
Christian Müller
Philipp Schmidt
Stefan Kaiser
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of BRPI0907247A2 publication Critical patent/BRPI0907247A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0907247-0A 2008-01-07 2009-01-06 Métodos para preparar biopterina e para preparar tetraidrobiopterina BRPI0907247A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1952808P 2008-01-07 2008-01-07
US4690908P 2008-04-22 2008-04-22
PCT/US2009/000030 WO2009088979A1 (en) 2008-01-07 2009-01-06 Method of synthesizing tetrahydrobiopterin

Publications (1)

Publication Number Publication Date
BRPI0907247A2 true BRPI0907247A2 (pt) 2015-07-14

Family

ID=40428295

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0907247-0A BRPI0907247A2 (pt) 2008-01-07 2009-01-06 Métodos para preparar biopterina e para preparar tetraidrobiopterina

Country Status (16)

Country Link
US (1) US8178670B2 (pt)
EP (1) EP2240484A1 (pt)
JP (1) JP2011508781A (pt)
KR (1) KR20100101006A (pt)
CN (1) CN101959891A (pt)
AR (1) AR070109A1 (pt)
AU (1) AU2009204476A1 (pt)
BR (1) BRPI0907247A2 (pt)
CA (1) CA2711444C (pt)
CL (2) CL2009000007A1 (pt)
IL (1) IL206845A0 (pt)
MX (1) MX2010007452A (pt)
PE (1) PE20091314A1 (pt)
RU (1) RU2010133160A (pt)
TW (1) TW200942542A (pt)
WO (1) WO2009088979A1 (pt)

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CN102443006B (zh) * 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6r)-四氢生物喋呤盐酸盐的制备方法
TWI481612B (zh) * 2010-10-15 2015-04-21 Innopharmax Inc （６ｒ）－四氫生物喋呤鹽酸鹽的製備方法
KR20140007431A (ko) 2011-02-18 2014-01-17 알렉시온 파마 인터내셔널 에스에이알엘 몰리브도프테린 전구체 z 유도체들의 합성 방법
CN102627644B (zh) 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN102633799B (zh) * 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
JP6994018B2 (ja) 2016-07-26 2022-01-14 バイオマリン ファーマシューティカル インコーポレイテッド 新規アデノ随伴ウイルスキャプシドタンパク質
CN109776540B (zh) * 2017-11-15 2021-07-06 北京启慧生物医药有限公司 一种盐酸沙丙蝶呤的制备方法
US11739345B2 (en) 2018-05-09 2023-08-29 Biomarin Pharmaceutical Inc. Methods of treating phenylketonuria
TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
CN110872293A (zh) * 2018-09-04 2020-03-10 北京启慧生物医药有限公司 一种生物蝶呤的化学合成及纯化方法
AR122409A1 (es) 2020-04-03 2022-09-07 Biomarin Pharm Inc Tratamiento de la fenilcetonuria con aav y formulaciones terapéuticas
CN111505179B (zh) * 2020-04-07 2021-07-13 厦门大学 海洋水体中生物蝶呤的检测方法
CN114814063A (zh) * 2022-04-08 2022-07-29 宁波熙宁检测技术有限公司 一种检测人体内四氢生物蝶呤的方法

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US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
CN1100092A (zh) 1992-12-23 1995-03-15 史密丝克莱恩比彻姆公司 砜的制备方法
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JP2711828B2 (ja) 1996-06-25 1998-02-10 白鳥製薬株式会社 （６ｒ）−テトラヒドローｌ−バイオプテリン塩酸塩の製造法
JP2001302665A (ja) 2000-04-19 2001-10-31 Shiratori Pharmaceutical Co Ltd Ｌ−ビオプテリン又はｄ−ネオプテリンの製造法
US6544994B2 (en) * 2000-06-07 2003-04-08 Eprov Ag Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase
DE60138029D1 (de) 2000-08-31 2009-04-30 Asubio Pharma Co Ltd Verfahren zur herstellung von biopterinen
DE10260263A1 (de) * 2002-12-20 2004-07-15 Biocrates Life Sciences Gmbh Verwendung von Tetrahydrobiopterinderivaten zur Behandlung und Ernährung von Patienten mit Aminosäurestoffwechselstörungen
EP1776364A2 (en) 2003-11-17 2007-04-25 BioMarin Pharmaceutical Inc. Processes for preparing tetrahydrobiopterin, and analogs of tetrahydrobiopterin
WO2005065018A2 (en) * 2003-11-17 2005-07-21 Merck Eprova Ag Crystalline forms of (6r) -l-erythro-tetrahydrobiopterin dihydrochloride
BRPI0416566A (pt) * 2003-11-17 2007-01-23 Biomarin Pharm Inc tratamento de fenilcetonúrias com bh4
US7361759B2 (en) * 2004-12-27 2008-04-22 Shiratori Pharmaceutical Co., Ltd Method for producing L-biopterin
US20060194808A1 (en) * 2005-01-14 2006-08-31 Chronorx Llc, An Alaska Limited Liability Company Clinical applications of tetrahydrobiopterin, lipoic acid and their salts and methods of preparing tetrahydrobiopterin bis-lipoate
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CA2606977C (en) 2005-04-28 2013-05-21 Shiratori Pharmaceutical Co., Ltd. Method for producing hydrazone derivatives
JP2010515747A (ja) 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ

Also Published As

Publication number Publication date
RU2010133160A (ru) 2012-02-20
AU2009204476A1 (en) 2009-07-16
PE20091314A1 (es) 2009-09-03
US8178670B2 (en) 2012-05-15
EP2240484A1 (en) 2010-10-20
KR20100101006A (ko) 2010-09-15
MX2010007452A (es) 2010-08-18
TW200942542A (en) 2009-10-16
US20090198055A1 (en) 2009-08-06
IL206845A0 (en) 2010-12-30
WO2009088979A1 (en) 2009-07-16
CL2009000007A1 (es) 2010-02-19
AR070109A1 (es) 2010-03-17
CA2711444C (en) 2017-12-12
CN101959891A (zh) 2011-01-26
CA2711444A1 (en) 2009-07-16
CL2011000166A1 (es) 2011-07-01
JP2011508781A (ja) 2011-03-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.