PE20091314A1 - Metodo para sintetizar tetrahidrobiopterina - Google Patents
Metodo para sintetizar tetrahidrobiopterinaInfo
- Publication number
- PE20091314A1 PE20091314A1 PE2009000007A PE2009000007A PE20091314A1 PE 20091314 A1 PE20091314 A1 PE 20091314A1 PE 2009000007 A PE2009000007 A PE 2009000007A PE 2009000007 A PE2009000007 A PE 2009000007A PE 20091314 A1 PE20091314 A1 PE 20091314A1
- Authority
- PE
- Peru
- Prior art keywords
- biopterin
- hydroxylase
- water
- organic phase
- approximately
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
REFERIDA A UN PROCEDIMIENTO QUE COMPRENDE A) HIDROLIZAR DIACETILBIOPTERINA A BIOPTERINA EN PRESENCIA DE DIETILAMINA EN UNA MEZCLA BIFASICA QUE COMPRENDE UNA FASE ACUOSA QUE CONTIENE AGUA Y UNA FASE ORGANICA QUE CONTIENE UN SOLVENTE ORGANICO INMISCIBLE AL AGUA SELECCIONADO DE ALCOHOL, I-BUTANOL. LA HIDROLISIS SE LLEVA A CABO A APROXIMADAMENTE 50C; B) EXTAER LA FASE ORGANICA SEPARADA UNA O MAS VECES CON AGUA PARA RECUPERAR LA BIOPTERINA REMANENTE EN LA FASE ORGANICA Y RECOLECTAR LA FASE ACUOSA; C) AGREGAR TRIETILAMINA PARA ELEVAR EL PH HASTA APROXIMADAMENTE 11; D) HIDROGENAR LA BIOPTERINA EN LA MEZCLA ACUOSA A TETRAHIDROPTERINA EN PRESENCIA DE UN CATALIZADOR METALICO (NEGRO DE PLATINO) BAJO UNA PRESION DE HIDROGENO DESDE 14bar-50 bar. LA TETRAHIDROPTETINA FUNCIONA COMO COFACTOR PARA UN NUMERO DE DIFERENTES ENZIMAS, INCLUYENDO FENILALANINA HIDROXILASA (PHA), TIROSINA 3-HIDROXILASA, TRIPTOFAN-5-HIDROXILASA Y TODAS LAS TRES ISOFORMAS DE OXIDO NITRICO SINTASA (NOS)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1952808P | 2008-01-07 | 2008-01-07 | |
| US4690908P | 2008-04-22 | 2008-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091314A1 true PE20091314A1 (es) | 2009-09-03 |
Family
ID=40428295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000007A PE20091314A1 (es) | 2008-01-07 | 2009-01-06 | Metodo para sintetizar tetrahidrobiopterina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8178670B2 (es) |
| EP (1) | EP2240484A1 (es) |
| JP (1) | JP2011508781A (es) |
| KR (1) | KR20100101006A (es) |
| CN (1) | CN101959891A (es) |
| AR (1) | AR070109A1 (es) |
| AU (1) | AU2009204476A1 (es) |
| BR (1) | BRPI0907247A2 (es) |
| CA (1) | CA2711444C (es) |
| CL (2) | CL2009000007A1 (es) |
| IL (1) | IL206845A0 (es) |
| MX (1) | MX2010007452A (es) |
| PE (1) | PE20091314A1 (es) |
| RU (1) | RU2010133160A (es) |
| TW (1) | TW200942542A (es) |
| WO (1) | WO2009088979A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102443006B (zh) * | 2010-10-13 | 2016-02-24 | 因华生技制药股份有限公司 | (6r)-四氢生物喋呤盐酸盐的制备方法 |
| TWI481612B (zh) * | 2010-10-15 | 2015-04-21 | Innopharmax Inc | （６ｒ）－四氫生物喋呤鹽酸鹽的製備方法 |
| SG192826A1 (en) | 2011-02-18 | 2013-09-30 | Alexion Pharma Internat Sarl | Methods for synthesizing molybdopterin precursor z derivatives |
| CN102633799B (zh) | 2012-04-10 | 2014-06-25 | 凯莱英医药集团（天津）股份有限公司 | 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法 |
| CN102627644B (zh) * | 2012-04-10 | 2014-04-16 | 凯莱英医药集团（天津）股份有限公司 | 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法 |
| WO2016189542A1 (en) | 2015-05-28 | 2016-12-01 | Natco Pharma Ltd | Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin |
| CN109715650B (zh) | 2016-07-26 | 2024-03-08 | 生物马林药物股份有限公司 | 新颖腺相关病毒衣壳蛋白 |
| CN109776540B (zh) * | 2017-11-15 | 2021-07-06 | 北京启慧生物医药有限公司 | 一种盐酸沙丙蝶呤的制备方法 |
| SG11202010830WA (en) | 2018-05-09 | 2020-11-27 | Biomarin Pharm Inc | Methods of treating phenylketonuria |
| TW202005978A (zh) | 2018-05-14 | 2020-02-01 | 美商拜奧馬林製藥公司 | 新穎肝靶向腺相關病毒載體 |
| CN110872293A (zh) * | 2018-09-04 | 2020-03-10 | 北京启慧生物医药有限公司 | 一种生物蝶呤的化学合成及纯化方法 |
| AR122409A1 (es) | 2020-04-03 | 2022-09-07 | Biomarin Pharm Inc | Tratamiento de la fenilcetonuria con aav y formulaciones terapéuticas |
| CN111505179B (zh) * | 2020-04-07 | 2021-07-13 | 厦门大学 | 海洋水体中生物蝶呤的检测方法 |
| CN114814063A (zh) * | 2022-04-08 | 2022-07-29 | 宁波熙宁检测技术有限公司 | 一种检测人体内四氢生物蝶呤的方法 |
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| CH500999A (de) | 1967-04-07 | 1970-12-31 | Ciba Geigy Ag | Verfahren zur Herstellung von Pterinderivaten |
| US3505329A (en) | 1968-02-06 | 1970-04-07 | Smithkline Corp | Process for the synthesis of biopterin |
| JPS5883691A (ja) | 1981-11-13 | 1983-05-19 | Kanegafuchi Chem Ind Co Ltd | １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法 |
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| GB8318833D0 (en) | 1983-07-12 | 1983-08-10 | Wellcome Found | Chemical compounds |
| JPS5976086A (ja) | 1982-09-20 | 1984-04-28 | ザ ウエルカム フアウンデ−シヨン リミテツド | プテリジン化合物 |
| JPS59112987A (ja) | 1982-12-20 | 1984-06-29 | Kanegafuchi Chem Ind Co Ltd | １′，２′―ジアシル―（６ｒ，ｓ）―５，６，７，８―テトラヒドロ―ｌ―ビオプテリンおよびその製法 |
| US5196533A (en) | 1983-04-11 | 1993-03-23 | South Alabama Medical Science Foundation, Usa | Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines |
| US4587340A (en) | 1983-09-19 | 1986-05-06 | Burroughs Wellcome Co. | Biopterin analogs |
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| JPS59186986A (ja) | 1984-03-17 | 1984-10-23 | Kanegafuchi Chem Ind Co Ltd | １′，２′−ジアシル−ｌ−ビオプテリンの製造法 |
| JPS60199889A (ja) | 1984-03-24 | 1985-10-09 | Kanegafuchi Chem Ind Co Ltd | ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法 |
| US4550109A (en) | 1984-05-31 | 1985-10-29 | The Board Of Regents, The University Of Texas System | Lipoidal biopterin compounds |
| JPS617287A (ja) | 1984-06-21 | 1986-01-13 | Kanegafuchi Chem Ind Co Ltd | ５‐デオキシ‐ｌ‐アラビノースの製造法 |
| CA1262347A (en) | 1985-01-28 | 1989-10-17 | Suntory Limited | Preparation process of (6r)-tetrahydro-l-biopterin |
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| CA1334654C (en) | 1987-11-30 | 1995-03-07 | Masayasu Kurono | Intermediates for synthesizing bh _and its derivatives |
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| JP2711828B2 (ja) | 1996-06-25 | 1998-02-10 | 白鳥製薬株式会社 | （６ｒ）−テトラヒドローｌ−バイオプテリン塩酸塩の製造法 |
| JP2001302665A (ja) | 2000-04-19 | 2001-10-31 | Shiratori Pharmaceutical Co Ltd | Ｌ−ビオプテリン又はｄ−ネオプテリンの製造法 |
| US6544994B2 (en) | 2000-06-07 | 2003-04-08 | Eprov Ag | Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase |
| CN1247778C (zh) | 2000-08-31 | 2006-03-29 | 第一阿斯比奥制药株式会社 | 生物蝶呤的生产方法 |
| DE10260263A1 (de) | 2002-12-20 | 2004-07-15 | Biocrates Life Sciences Gmbh | Verwendung von Tetrahydrobiopterinderivaten zur Behandlung und Ernährung von Patienten mit Aminosäurestoffwechselstörungen |
| RU2434870C2 (ru) | 2003-11-17 | 2011-11-27 | Мерк Эпрова Аг | Кристаллические формы дигидрохлорида (6r)-l-эритро-тетрагидробиоптерина |
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-
2009
- 2009-01-06 CA CA2711444A patent/CA2711444C/en active Active
- 2009-01-06 BR BRPI0907247-0A patent/BRPI0907247A2/pt not_active IP Right Cessation
- 2009-01-06 CN CN2009801079643A patent/CN101959891A/zh active Pending
- 2009-01-06 CL CL2009000007A patent/CL2009000007A1/es unknown
- 2009-01-06 PE PE2009000007A patent/PE20091314A1/es not_active Application Discontinuation
- 2009-01-06 WO PCT/US2009/000030 patent/WO2009088979A1/en active Application Filing
- 2009-01-06 JP JP2010541558A patent/JP2011508781A/ja active Pending
- 2009-01-06 AU AU2009204476A patent/AU2009204476A1/en not_active Abandoned
- 2009-01-06 RU RU2010133160/04A patent/RU2010133160A/ru not_active Application Discontinuation
- 2009-01-06 KR KR1020107017494A patent/KR20100101006A/ko not_active Application Discontinuation
- 2009-01-06 AR ARP090100026A patent/AR070109A1/es not_active Application Discontinuation
- 2009-01-06 EP EP09700703A patent/EP2240484A1/en not_active Withdrawn
- 2009-01-06 TW TW098100222A patent/TW200942542A/zh unknown
- 2009-01-06 MX MX2010007452A patent/MX2010007452A/es active IP Right Grant
- 2009-01-06 US US12/349,479 patent/US8178670B2/en active Active
-
2010
- 2010-07-06 IL IL206845A patent/IL206845A0/en unknown
-
2011
- 2011-01-27 CL CL2011000166A patent/CL2011000166A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090198055A1 (en) | 2009-08-06 |
| EP2240484A1 (en) | 2010-10-20 |
| KR20100101006A (ko) | 2010-09-15 |
| US8178670B2 (en) | 2012-05-15 |
| CA2711444A1 (en) | 2009-07-16 |
| CL2011000166A1 (es) | 2011-07-01 |
| WO2009088979A1 (en) | 2009-07-16 |
| MX2010007452A (es) | 2010-08-18 |
| TW200942542A (en) | 2009-10-16 |
| CA2711444C (en) | 2017-12-12 |
| AR070109A1 (es) | 2010-03-17 |
| RU2010133160A (ru) | 2012-02-20 |
| AU2009204476A1 (en) | 2009-07-16 |
| IL206845A0 (en) | 2010-12-30 |
| JP2011508781A (ja) | 2011-03-17 |
| CN101959891A (zh) | 2011-01-26 |
| CL2009000007A1 (es) | 2010-02-19 |
| BRPI0907247A2 (pt) | 2015-07-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |