HK1145874A1 - Systems and methods for particle focusing in microchannels - Google Patents

Systems and methods for particle focusing in microchannels

Info

Publication number
HK1145874A1
HK1145874A1 HK10112212.5A HK10112212A HK1145874A1 HK 1145874 A1 HK1145874 A1 HK 1145874A1 HK 10112212 A HK10112212 A HK 10112212A HK 1145874 A1 HK1145874 A1 HK 1145874A1
Authority
HK
Hong Kong
Prior art keywords
microchannels
systems
methods
particle focusing
focusing
Prior art date
Application number
HK10112212.5A
Other languages
English (en)
Inventor
Mehmet Toner
Dino Dicarlo
John Edd
Daniel Irimia
Aman Russom
Sunitha Nagrath
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of HK1145874A1 publication Critical patent/HK1145874A1/xx

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/0087—Settling tanks provided with means for ensuring a special flow pattern, e.g. even inflow or outflow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/265—Separation of sediment aided by centrifugal force or centripetal force by using a vortex inducer or vortex guide, e.g. coil
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D45/00—Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces
    • B01D45/04—Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by utilising inertia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D45/00—Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces
    • B01D45/12—Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
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    • C—CHEMISTRY; METALLURGY
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    • C12M47/04—Cell isolation or sorting
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L41/00—Branching pipes; Joining pipes to walls
    • F16L41/02—Branch units, e.g. made in one piece, welded, riveted
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17D—PIPE-LINE SYSTEMS; PIPE-LINES
    • F17D1/00—Pipe-line systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2400/04—Moving fluids with specific forces or mechanical means
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    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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    • B33Y80/00—Products made by additive manufacturing
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    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
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    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N15/10—Investigating individual particles
    • G01N2015/1028—Sorting particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/85938—Non-valved flow dividers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/85978—With pump
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
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    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Fluid Mechanics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
HK10112212.5A 2007-04-16 2010-12-29 Systems and methods for particle focusing in microchannels HK1145874A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92360907P 2007-04-16 2007-04-16
US92383707P 2007-04-17 2007-04-17
US99913107P 2007-10-16 2007-10-16
PCT/US2008/060440 WO2008130977A2 (en) 2007-04-16 2008-04-16 Systems and methods for particle focusing in microchannels

Publications (1)

Publication Number Publication Date
HK1145874A1 true HK1145874A1 (en) 2011-05-06

Family

ID=39619134

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10112212.5A HK1145874A1 (en) 2007-04-16 2010-12-29 Systems and methods for particle focusing in microchannels
HK14108201.2A HK1194817A1 (zh) 2007-04-16 2014-08-11 使粒子在微通道中聚集的系統和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK14108201.2A HK1194817A1 (zh) 2007-04-16 2014-08-11 使粒子在微通道中聚集的系統和方法

Country Status (6)

Country Link
US (8) US8186913B2 (zh)
EP (3) EP2562531A3 (zh)
JP (2) JP5172946B2 (zh)
CN (2) CN101765762B (zh)
HK (2) HK1145874A1 (zh)
WO (1) WO2008130977A2 (zh)

Families Citing this family (334)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US8276760B2 (en) * 2006-11-30 2012-10-02 Palo Alto Research Center Incorporated Serpentine structures for continuous flow particle separations
US9433880B2 (en) * 2006-11-30 2016-09-06 Palo Alto Research Center Incorporated Particle separation and concentration system
US8931644B2 (en) * 2006-11-30 2015-01-13 Palo Alto Research Center Incorporated Method and apparatus for splitting fluid flow in a membraneless particle separation system
US9862624B2 (en) * 2007-11-07 2018-01-09 Palo Alto Research Center Incorporated Device and method for dynamic processing in water purification
US10052571B2 (en) * 2007-11-07 2018-08-21 Palo Alto Research Center Incorporated Fluidic device and method for separation of neutrally buoyant particles
US9486812B2 (en) * 2006-11-30 2016-11-08 Palo Alto Research Center Incorporated Fluidic structures for membraneless particle separation
EP2562531A3 (en) 2007-04-16 2013-03-06 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
US8642288B2 (en) * 2007-06-07 2014-02-04 Technion Research & Development Foundation Ltd. Methods for viscoelastic focusing of particles
NO327688B1 (no) * 2007-09-07 2009-09-14 Abb As Fremgangsmåte og system for forutsigelse i et olje-/gassproduksjonssystem
US8120770B2 (en) * 2007-09-10 2012-02-21 The Penn State Research Foundation Three-dimensional (3D) hydrodynamic focusing using a microfluidic device
US8941826B2 (en) 2007-09-10 2015-01-27 The Penn State Research Foundation Three-dimensional (3D) hydrodynamic focusing using a microfluidic device
JP5098650B2 (ja) * 2008-01-08 2012-12-12 ソニー株式会社 微小粒子の送流方法及び分析方法、並びに微小粒子分析用基板
WO2009140326A2 (en) 2008-05-16 2009-11-19 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids
FR2931080B1 (fr) * 2008-05-13 2010-07-30 Commissariat Energie Atomique Procede et dispositif d'extraction d'une phase liquide d'une suspension
US9068181B2 (en) 2008-05-23 2015-06-30 The General Hospital Corporation Microfluidic droplet encapsulation
US9132394B2 (en) * 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8865003B2 (en) * 2008-09-26 2014-10-21 Abbott Laboratories Apparatus and method for separation of particles suspended in a liquid from the liquid in which they are suspended
US8312763B2 (en) * 2008-10-15 2012-11-20 Massachusetts Institute Of Technology Method and apparatus for trapping single particles in microfluidic channels
KR101041870B1 (ko) 2008-11-25 2011-06-16 한국전자통신연구원 Ｐｄｍｓ 미세입자의 제조 방법
FR2941866B1 (fr) 2009-02-09 2011-05-13 Maco Pharma Sa Procede pour modifier les proprietes d'un fluide par irradiation et systeme pour sa mise en oeuvre
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8331751B2 (en) 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US20120028272A1 (en) * 2009-04-01 2012-02-02 University Of Louisville Research Foundation, Inc. Device and methods for isolating cells
CN102460154B (zh) * 2009-04-13 2015-10-07 华盛顿大学 整体决策液份分级
US20110070581A1 (en) * 2009-04-27 2011-03-24 Amit Gupta Separation of Leukocytes
EP2425226B1 (en) * 2009-04-27 2020-10-07 El Spectra, LLC Pipette instrument
JP5459471B2 (ja) * 2009-07-16 2014-04-02 富士ゼロックス株式会社 送液方法及び分級方法
US9625454B2 (en) * 2009-09-04 2017-04-18 The Research Foundation For The State University Of New York Rapid and continuous analyte processing in droplet microfluidic devices
EP2309266A1 (en) * 2009-09-21 2011-04-13 F. Hoffmann-La Roche AG Method for carrying out reactions in an analytical device
US8208138B2 (en) * 2009-09-24 2012-06-26 University Of Cincinnati Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems
DE102009043426B4 (de) * 2009-09-29 2012-05-24 Siemens Aktiengesellschaft Vorrichtung und Verfahren zur Gewinnung, zum Nachweis und zur Analyse von Zellen in einem mikrofluidischen System
DE102009047802B4 (de) 2009-09-30 2012-07-05 Siemens Aktiengesellschaft Vorrichtung zum Filtern eines oder mehrerer nachzuweisender Partikel aus einem Fluid
US9034658B2 (en) 2009-11-23 2015-05-19 The General Hospital Corporation Microfluidic devices for the capture of biological sample components
JP5807004B2 (ja) * 2010-02-24 2015-11-10 公益財団法人神奈川科学技術アカデミー 細胞分析装置
KR20130000396A (ko) * 2010-03-04 2013-01-02 메사추세츠 인스티튜트 오브 테크놀로지 세포 검출 및 단리를 위한 마이크로유체 선별기
JP2011196846A (ja) * 2010-03-19 2011-10-06 Soka Univ 検出容器およびそれを使用する微粒子状試料を検出する方法
US9963739B2 (en) 2010-05-21 2018-05-08 Hewlett-Packard Development Company, L.P. Polymerase chain reaction systems
US10132303B2 (en) * 2010-05-21 2018-11-20 Hewlett-Packard Development Company, L.P. Generating fluid flow in a fluidic network
WO2011146069A1 (en) 2010-05-21 2011-11-24 Hewlett-Packard Development Company, L.P. Fluid ejection device including recirculation system
US9395050B2 (en) 2010-05-21 2016-07-19 Hewlett-Packard Development Company, L.P. Microfluidic systems and networks
EP2603793A4 (en) * 2010-08-15 2014-03-19 Gpb Scientific Llc MICROFLUIDIC CELL SEPARATION IN A BLOOD ASSAY
US8361415B2 (en) 2010-09-13 2013-01-29 The Regents Of The University Of California Inertial particle focusing system
US8693762B2 (en) 2010-09-14 2014-04-08 The Regents Of The University Of California Inertial particle focusing flow cytometer
CA2809877C (en) 2010-09-14 2021-11-23 The Regents Of The University Of California Method and device for isolating cells from heterogeneous solution using microfluidic trapping vortices
WO2012037369A1 (en) 2010-09-15 2012-03-22 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
WO2012040067A2 (en) * 2010-09-22 2012-03-29 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
WO2012040493A2 (en) * 2010-09-22 2012-03-29 California Institute Of Technology A lateral flow microfluidic assaying device and related method
JP6049621B2 (ja) * 2010-09-26 2016-12-21 ダ・ユー・エンタープライジズ、エルエルシー 分析物の分離
KR20120032255A (ko) * 2010-09-28 2012-04-05 삼성전자주식회사 자기력을 이용한 세포 분리 장치 및 분리 방법
JP5641213B2 (ja) * 2010-10-01 2014-12-17 国立大学法人 千葉大学 連続的２次元粒子分離装置および粒子分離方法
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
US8797741B2 (en) * 2010-10-21 2014-08-05 Raytheon Company Maintaining thermal uniformity in micro-channel cold plates with two-phase flows
US8460607B2 (en) 2010-10-22 2013-06-11 Abbott Laboratories Microfluidic device having a flow channel
CN102451653B (zh) * 2010-10-27 2014-04-16 中国科学院大连化学物理研究所 一种可实现酸性气体高效吸收的微反应方法
AU2011320908A1 (en) * 2010-10-28 2013-05-23 Yale University Microfluidic processing of target species in ferrofluids
US9090865B2 (en) 2010-10-29 2015-07-28 The Regents Of The University Of California Systems and methods for particle classification and sorting
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
EP2641094B1 (en) * 2010-11-18 2019-03-06 The Regents of The University of California Method for high-throughput solution exchange for cell and particle suspensions
WO2012068003A2 (en) 2010-11-18 2012-05-24 The Regents Of The University Of California Particle focusing systems and methods
US9815060B2 (en) 2010-11-18 2017-11-14 The Regents Of The University Of California Method and device for high-throughput solution exchange for cell and particle suspensions
US8980106B2 (en) 2010-12-15 2015-03-17 Abbott Laboratories Apparatus and method for separation of whole blood into plasma or serum and cells
PE20141524A1 (es) * 2011-02-01 2014-10-31 Basf Se Aparato para ahorro de energia y separacion continua de constituyentes magneticos y limpieza eficiente de la fraccion magnetica
WO2012128742A1 (en) * 2011-03-18 2012-09-27 Empire Technology Development Llc Method of separating particulate matter from water using inertial forces
KR20120113533A (ko) * 2011-04-05 2012-10-15 삼성전자주식회사 타겟 분자 분리 장치 및 이를 이용한 타겟 분자 분리 방법
EP2701517B1 (en) 2011-04-29 2017-06-07 Converge Biotech Inc. Conformal coating of cells for immunoisolation
CN110763842A (zh) 2011-06-29 2020-02-07 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
CN103998394B (zh) 2011-08-01 2016-08-17 德诺弗科学公司 细胞捕获系统和使用方法
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
CA2850335A1 (en) * 2011-09-30 2013-06-20 The Regents Of The University Of California Devices and methods for shape-based particle separation
EP2587248A1 (en) * 2011-10-25 2013-05-01 Koninklijke Philips Electronics N.V. Filtering particles from blood or other media
WO2013085797A1 (en) * 2011-12-06 2013-06-13 Focus Biomedical, Llc Method of washing cells using passive separation of a lysed blood sample with clean buffer using inertial microfluidic separation and focusing in spiral microchannels
WO2013086183A1 (en) 2011-12-07 2013-06-13 Huang Lotien R Method and device for sample processing
US9987632B2 (en) * 2012-02-03 2018-06-05 University Of Cincinnati Microfluidic methods for passive separation of cells and particles
US10180398B2 (en) 2012-02-29 2019-01-15 National Technology & Engineering Solutions Of Sandia, Llc Trajectory-based triggering system for hyperspectral imaging flow cytometer
US9797836B1 (en) * 2012-02-29 2017-10-24 National Technology & Engineering Solutions Of Sandia, Llc Hyperspectral imaging flow cytometer
US9517474B2 (en) 2012-05-18 2016-12-13 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
CN102680673B (zh) * 2012-05-29 2014-06-25 西安金磁纳米生物技术有限公司 一种用于净化黄曲霉毒素样本的免疫磁性微粒及其制备和应用方法
US10748278B2 (en) 2012-06-18 2020-08-18 Sobru Solutions, Inc. Organism evaluation system and method of use
CN104520436B (zh) * 2012-06-18 2017-07-28 索布鲁解决方案公司 微生物评价系统
US11446660B2 (en) 2012-06-18 2022-09-20 Scanlogx, Inc Organism evaluation system and method of use
US10509976B2 (en) 2012-06-22 2019-12-17 Malvern Panalytical Limited Heterogeneous fluid sample characterization
US20150362421A1 (en) * 2012-06-22 2015-12-17 Malvern Instruments Limited Particle characterization
EP2864051B1 (en) 2012-06-25 2020-09-23 The General Hospital Corporation Sorting particles using high gradient magnetic fields
CA2894459C (en) 2012-07-27 2020-07-07 Engender Technologies Limited Method and system for microfluidic particle orientation and/or sorting
US9372144B2 (en) 2013-10-01 2016-06-21 Owl biomedical, Inc. Particle manipulation system with out-of-plane channel
US11898954B2 (en) 2012-08-01 2024-02-13 Owl biomedical, Inc. Particle manipulation system with camera/classifier confirmation and deep learning algorithm
US9194786B2 (en) 2012-08-01 2015-11-24 Owl biomedical, Inc. Particle manipulation system with cytometric capability
TWI471260B (zh) * 2012-08-20 2015-02-01 Nat Univ Tsing Hua 製備奈米粒子之連續反應裝置及製備奈米粒子之方法
US10048201B2 (en) * 2012-09-10 2018-08-14 The Trustees Of Princeton University Fluid channels for computational imaging in optofluidic microscopes
KR20150061643A (ko) 2012-09-21 2015-06-04 메사추세츠 인스티튜트 오브 테크놀로지 미소 유체 장치 및 그의 용도
DE102012217487A1 (de) * 2012-09-26 2014-04-17 Agilent Technologies, Inc. - A Delaware Corporation - Fluidschnittstelle zwischen Fluidleitungen unterschiedlicher Querschnitte
US9804068B2 (en) 2012-09-28 2017-10-31 University Of Maryland Particle separation and concentration using spiral inertial filtration
JP6396305B2 (ja) 2012-10-24 2018-09-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 粒子の変形及び分析システム及び方法
US9739714B2 (en) 2012-10-29 2017-08-22 Mbio Diagnostics, Inc. Particle identification system, cartridge and associated methods
KR101356933B1 (ko) * 2012-12-28 2014-01-29 고려대학교 산학협력단 표면탄성파를 이용한 미세유동 크로마토 그래피 기반 미세입자 분리 장치 및 방법
US10040018B2 (en) 2013-01-09 2018-08-07 Imagine Tf, Llc Fluid filters and methods of use
US9752181B2 (en) 2013-01-26 2017-09-05 Denovo Sciences, Inc. System and method for capturing and analyzing cells
US11110458B2 (en) 2013-02-01 2021-09-07 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
WO2014133451A1 (en) * 2013-02-28 2014-09-04 Acousort Ab System and method to analyze non-spherical cells
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
CA3028416C (en) 2013-03-11 2022-05-17 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
US10371622B2 (en) 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
US9757726B2 (en) 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
US10345199B2 (en) * 2013-03-14 2019-07-09 Sobru Solutions, Inc. Sample acquisition system and method of use
US10662408B2 (en) 2013-03-14 2020-05-26 Inguran, Llc Methods for high throughput sperm sorting
US10077462B2 (en) 2013-03-15 2018-09-18 The Broad Institute, Inc. Microfluidic microbe detection and isolation
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
EP2971287B1 (en) 2013-03-15 2019-08-14 GPB Scientific, LLC On-chip microfluidic processing of particles
CN105247042B (zh) 2013-03-15 2021-06-11 普林斯顿大学理事会 用于高通量纯化的方法和设备
ES2678244T3 (es) 2013-03-28 2018-08-09 National Research Council Of Canada Separador de microfluidos de bomba peristáltica
FR3004540B1 (fr) * 2013-04-15 2016-02-26 Oreal Systeme microfluidique d'evaluation de l'efficacite d'un produit anti-transpirant et procede associe
CN103301799B (zh) * 2013-04-18 2014-12-31 万华化学集团股份有限公司 一种制备异佛尔酮腈的反应器及采用该反应器连续制备异佛尔酮腈的方法
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
TWI655963B (zh) * 2013-06-14 2019-04-11 帕洛阿爾托研究中心公司 流體動力分離裝置及流體動力分離方法
US9580678B2 (en) * 2013-06-21 2017-02-28 The Regents Of The University Of California Microfluidic tumor tissue dissociation device
WO2015002975A1 (en) 2013-07-05 2015-01-08 University Of Washington Through Its Center For Commercialization Methods, compositions and systems for microfluidic assays
CN103343090B (zh) * 2013-07-12 2014-09-17 湖南工程学院 一种集成化多功能可控细胞操纵及分析微流控芯片及应用
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
CN103464229B (zh) * 2013-09-10 2015-07-15 东南大学 一种稀有细胞多级分选微流控器件
US9863865B2 (en) 2013-10-01 2018-01-09 Owl biomedical, Inc. Cell sorting system using electromagnetic solenoid
US9604214B2 (en) 2013-10-01 2017-03-28 Owl biomedical, Inc. Cell sorting system using microfabricated components
US9404838B2 (en) 2013-10-01 2016-08-02 Owl biomedical, Inc. Particle manipulation system with out-of-plane channel and focusing element
US20150126828A1 (en) * 2013-10-15 2015-05-07 Ibis Biosciences, Inc. Blood sampling
KR20160075568A (ko) * 2013-10-16 2016-06-29 클리어브릿지 바이오메딕스 피티이 엘티디 세포 검출 및 분리를 위한 마이크로유체 분류기
US9589383B2 (en) 2013-10-18 2017-03-07 Nvidia Corporation Unified position based solver for visual effects
EP3058316B1 (en) 2013-10-18 2019-03-13 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
US9613449B2 (en) * 2013-10-18 2017-04-04 Nvidia Corporation Method and apparatus for simulating stiff stacks
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
WO2015066635A1 (en) 2013-11-01 2015-05-07 Daniel Irimia Cell sorting
GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
CN103642671B (zh) * 2013-11-21 2014-11-05 西安交通大学 一种用于细胞富集与提取的微流体生物芯片
CN103614283B (zh) * 2013-11-21 2014-12-10 西安交通大学 一种用于细胞三维富集的微流控芯片
CN103642672B (zh) * 2013-11-21 2014-11-05 西安交通大学 一种用于细胞高效分离的生物芯片
AU2014352822B2 (en) 2013-11-22 2019-06-20 The General Hospital Corporation Microfluidic methods and systems for isolating particle clusters
US10359354B2 (en) * 2013-12-18 2019-07-23 Azure Biosystems, Inc. Chip assembly, flow cell and flow cytometer for characterizing particles
US9752175B2 (en) 2014-01-06 2017-09-05 The Trustees Of Princeton University Systems and methods to detect biofilm streamer growth and their uses
WO2015116068A1 (en) 2014-01-29 2015-08-06 Hewlett-Packard Development Company, L.P. Microfluidic valve
US10307760B2 (en) * 2014-01-30 2019-06-04 The General Hospital Corporation Inertio-elastic focusing of particles in microchannels
EP3107995B1 (en) 2014-02-18 2019-10-30 Massachusetts Institute Of Technology Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs)
CN103864173B (zh) * 2014-02-26 2015-10-28 南京航空航天大学 一种在多个位置上同时聚集微/纳颗粒的方法及其装置
EP2918263B1 (en) * 2014-03-13 2017-05-03 Sabanci Üniversitesi Pharmaceutical drug delivery system
WO2015153816A2 (en) 2014-04-01 2015-10-08 Academia Sinica Methods and systems for cancer diagnosis and prognosis
CN103923825B (zh) * 2014-04-17 2016-01-13 东南大学 一种集成细胞分选及检测的微流控芯片系统
US20170045521A1 (en) * 2014-04-22 2017-02-16 The General Hospital Corporation System and method for determination of ligand-target binding by multi-photon fluorescence anisotropy microscopy
US9861920B1 (en) 2015-05-01 2018-01-09 Imagine Tf, Llc Three dimensional nanometer filters and methods of use
US10391705B2 (en) * 2014-05-09 2019-08-27 Nike, Inc. System and method for forming three-dimensional structures
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
US10232373B2 (en) 2014-06-16 2019-03-19 Bio-Rad Laboratories, Inc. Size alternating injection into drops to facilitate sorting
US10730047B2 (en) 2014-06-24 2020-08-04 Imagine Tf, Llc Micro-channel fluid filters and methods of use
WO2015200857A1 (en) 2014-06-27 2015-12-30 The Regents Of The University Of California Apparatus and method for label-free analysis of rare cells from bodily fluids
WO2016004101A1 (en) * 2014-07-02 2016-01-07 The Regents Of The University Of California Devices for separating constituents in a sample and methods for use thereof
WO2016023008A1 (en) 2014-08-07 2016-02-11 The General Hospital Corporation Platelet-targeted microfluidic isolation of cells
CN104162337B (zh) * 2014-08-22 2016-03-30 成都代代吉前瞻科技股份有限公司 一种简易高效的dep空气净化系统
CN105381824B (zh) * 2014-08-26 2019-04-23 中央研究院 收集器架构布局设计
US10124275B2 (en) 2014-09-05 2018-11-13 Imagine Tf, Llc Microstructure separation filters
CN107250341A (zh) * 2014-09-17 2017-10-13 麻省理工学院 用于灌注生物反应器细胞保留的方法及微流体系统
WO2016044555A1 (en) * 2014-09-17 2016-03-24 Massachusetts Institute Of Technology System and method for inertial focusing microfiltration for intra-operative blood salvage autotransfusion
JP6832848B2 (ja) 2014-10-20 2021-02-24 ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション 組織試料処理システム及びそれに関連する方法
US11143548B2 (en) 2014-10-28 2021-10-12 Massachusetts Institute Of Technology Simultaneous oscillation and frequency tracking of multiple resonances via digitally implemented phase-locked loop array
JP6757723B2 (ja) 2014-11-03 2020-09-23 ザ ジェネラル ホスピタル コーポレイション ミクロ流体装置における粒子の濃縮
KR101662808B1 (ko) 2014-11-28 2016-10-14 한국과학기술연구원 나선형 분지채널을 이용한 미세유체칩 여과 장치 및 방법
CN106170301A (zh) * 2014-12-03 2016-11-30 士捷医疗设备(武汉)有限公司 一种模拟细胞体内环境的微流体器件及其应用
CN104562630A (zh) * 2015-02-09 2015-04-29 黄惠民 牛角瓜纤维及牛角瓜纤维导入液化纳米颗粒材料的方法
WO2016133929A1 (en) 2015-02-18 2016-08-25 Imagine Tf, Llc Three dimensional filter devices and apparatuses
EP3271273A4 (en) * 2015-03-19 2018-12-05 IPEG, Inc. Pressure differential proofing method for pneumatic conveying
CN107407625B (zh) * 2015-03-25 2021-06-29 斯泰特皮尔股份公司 用于测量小颗粒、特别是纳米管的暴露量的装置
US11919229B2 (en) 2015-04-16 2024-03-05 Lawrence Livermore National Security, Llc Large area projection micro stereolithography
WO2016210348A2 (en) 2015-06-26 2016-12-29 Ancera, Inc. Background defocusing and clearing in ferrofluid-based capture assays
WO2017003380A1 (en) * 2015-07-02 2017-01-05 Nanyang Technological University Leukocyte and microparticles fractionation using microfluidics
US10118842B2 (en) 2015-07-09 2018-11-06 Imagine Tf, Llc Deionizing fluid filter devices and methods of use
BR122020004273B1 (pt) 2015-07-17 2022-11-29 Cue Health Inc Cartucho de análise de amostras
US10676719B2 (en) 2015-07-31 2020-06-09 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
CN105241940B (zh) * 2015-08-05 2018-04-27 深圳大学 一种基于介电泳力场的药效检测方法及其系统
US10479046B2 (en) 2015-08-19 2019-11-19 Imagine Tf, Llc Absorbent microstructure arrays and methods of use
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
US20170059459A1 (en) * 2015-08-27 2017-03-02 Ativa Medical Corporation Fluid processing micro-feature devices and methods
AU2016314375A1 (en) 2015-09-03 2018-04-26 Aqua Hd Separation & Filtration Systems Ltd A duct for use in a system for separating particles suspended in a fluid, and a method of designing such duct
CN108603827A (zh) * 2015-09-11 2018-09-28 莱布尼茨光电技术研究所 用于个体化的患者血液分析的装置
WO2017046178A1 (en) 2015-09-14 2017-03-23 Medisieve Ltd Magnetic filter apparatus and method
CA3000389A1 (en) * 2015-10-01 2017-04-06 The Regents Of The University Of Michigan Assay plate and uses thereof
US10730044B2 (en) 2015-10-01 2020-08-04 The Regents Of The University Of Michigan Assay plate and uses thereof
US20170113222A1 (en) * 2015-10-22 2017-04-27 Owl biomedical, Inc. Particle manipulation system with spiral focusing channel
DK3374083T3 (da) 2015-11-10 2021-01-18 Illumina Inc Inerti dråbe generering og partikelindkapsling
US10690593B2 (en) * 2015-11-13 2020-06-23 Horiba, Ltd. Sample analyzer and recording medium recording sample analysis program
US11009464B2 (en) * 2015-12-11 2021-05-18 International Business Machines Corporation Smartphone compatible on-chip biodetection using integrated optical component and microfluidic channel with nanopillar array
KR101855490B1 (ko) * 2016-01-22 2018-05-08 한국과학기술원 점탄성유체와 점성유체의 병행층류를 이용한 미소 입자 분리 및 세정 방법
WO2017127120A1 (en) 2016-01-22 2017-07-27 Hewlett-Packard Development Company, L.P. Fluid sensing with control of particle aggregation in sensing zone
EP3408217B1 (en) * 2016-01-28 2020-12-23 Biolidics Limited Multi-stage target cell enrichment using a microfluidic device
US10722540B1 (en) 2016-02-01 2020-07-28 The Regents Of The University Of California Microfluidic device and method for shear stress-induced transformation of cells
CN105647799B (zh) * 2016-02-24 2018-08-10 西安交通大学 一种组合式场流分离的循环肿瘤细胞分离装置
JP6739739B2 (ja) * 2016-03-08 2020-08-12 東京都公立大学法人 粒子分別方法及びそれを実施するための粒子分別装置
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
JP2017177083A (ja) * 2016-03-31 2017-10-05 東ソー株式会社 粒子分離装置
WO2017181186A1 (en) * 2016-04-15 2017-10-19 Vortex Biosciences, Inc. Microfluidic chips and cartridges and systems utilizing microfluidic chips and cartridges
WO2017201495A1 (en) 2016-05-19 2017-11-23 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for automated single cell cytological classification in flow
WO2017201546A1 (en) * 2016-05-20 2017-11-23 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for automated single cell cytological classification in flow
CN105944775B (zh) * 2016-06-22 2018-04-10 苏州汶颢芯片科技有限公司 单细胞分离微流控芯片
CN109416314A (zh) * 2016-07-01 2019-03-01 生命技术公司 用于浓缩颗粒的方法、系统和装置
US20190275521A1 (en) * 2016-07-21 2019-09-12 Agency For Science, Technology And Research Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof
CN109414710B (zh) 2016-07-28 2021-02-05 医疗过滤有限公司 磁力混合器及方法
US10717086B2 (en) 2016-08-29 2020-07-21 The Regents Of The University Of California Integrated system for isolation and emulsification of particles and cells
CN109996596B (zh) * 2016-09-06 2022-10-21 普林斯顿大学理事会 通过气体溶解来连续流动分离颗粒的装置和方法
US10558204B2 (en) * 2016-09-19 2020-02-11 Palo Alto Research Center Incorporated System and method for scalable real-time micro-object position control with the aid of a digital computer
US10010883B2 (en) 2016-09-20 2018-07-03 International Business Machines Corporation Deterministic lateral displacement arrays
WO2018067614A1 (en) * 2016-10-04 2018-04-12 Massachusetts Institute Of Technology Fiber microfluidics
CN106483059B (zh) * 2016-10-13 2019-03-19 中国人民解放军第三军医大学第一附属医院 用于单个或少量活细胞无标记检测的太赫兹流式细胞传感器及其检测方法
US9770717B1 (en) * 2016-11-03 2017-09-26 International Business Machines Corporation Microfluidic chip with bead integration system
JP6923181B2 (ja) * 2016-11-30 2021-08-18 国立大学法人東京工業大学 微粒子分離デバイスおよび微粒子の分離方法
DE102016124097B4 (de) 2016-12-12 2022-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zum Nachweis von Teilchen
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
US10272431B2 (en) 2017-02-18 2019-04-30 Owl biomedical, Inc. Microfabricated cell sorter using pressure pulse
IL251036A0 (en) 2017-03-08 2017-06-29 Aqua Hd Separation And Filtration Systems Ltd System and method for separating particles suspended in a liquid
DE112018001435T5 (de) 2017-03-17 2019-12-05 Istanbul Teknik Universitesi Mikrokanal mit aus asymmetrischen Windungen aufgebauter spiralförmiger Geometrie zur kontinuierlichen Abtrennung von Krebszellen aus Blut und Anreicherung derselben im Kreislaufsystem
CN106841151A (zh) * 2017-03-20 2017-06-13 广东顺德工业设计研究院(广东顺德创新设计研究院) 微流控芯片及其微流道结构和液态微滴的检测方法
EP3601522A4 (en) 2017-03-31 2021-04-28 Massachusetts Institute of Technology SYSTEMS, ARTICLES AND PROCEDURES FOR FLOW PARTICLES
GB2561587B (en) 2017-04-19 2021-05-19 The Technology Partnership Plc Apparatus and method for sorting microfluidic particles
JP6710850B1 (ja) * 2017-04-20 2020-06-17 バイオフルイディカ、インコーポレイテッド 液体サンプルからバイオマーカーを単離するための流体密封性フローシステム
CN113967036B (zh) * 2017-04-28 2024-08-30 深圳迈瑞生物医疗电子股份有限公司 超声成像设备及利用超声检测血管壁剪切指数的方法
EP4435113A1 (en) 2017-05-18 2024-09-25 10x Genomics, Inc. Methods and systems for sorting droplets and beads
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
KR101955640B1 (ko) * 2017-05-31 2019-03-07 주식회사 엔아이티코리아 집진 장치용 압력 조절 모듈 및 이를 가진 지하 터널용 집진 장치
US11474023B2 (en) 2017-06-02 2022-10-18 The General Hospital Corporation Oscillatory focusing of particles in channels
WO2018236708A1 (en) 2017-06-19 2018-12-27 Massachusetts Institute Of Technology SYSTEMS AND METHODS FOR MEASURING PARTICLE PROPERTIES
EP3645167A4 (en) 2017-06-28 2021-02-24 Bio-rad Laboratories, Inc. DROPLET DETECTION SYSTEM AND METHOD
KR102184789B1 (ko) 2017-07-19 2020-11-30 윌리엄 매스턴 주니어 제임스 저에너지 동적 정수시스템 및 정수방법
CN107488582B (zh) * 2017-08-08 2021-09-10 上海交通大学 稀有细胞和颗粒富集分离柔性微流控芯片
US10821442B2 (en) 2017-08-22 2020-11-03 10X Genomics, Inc. Devices, systems, and kits for forming droplets
AU2018323449B2 (en) 2017-08-29 2020-09-03 Bio-Rad Laboratories, Inc. System and method for isolating and analyzing cells
JPWO2019044610A1 (ja) * 2017-08-30 2020-09-24 京セラ株式会社 粒子分離デバイスおよびそれを用いた粒子分離装置
JP7393328B2 (ja) 2017-09-01 2023-12-06 ジーピービー・サイエンティフィック・インコーポレイテッド マイクロ流体を使用した治療的に活性な細胞を調製する方法
JP7332586B2 (ja) * 2017-09-19 2023-08-23 ハイファイバイオ エスアエス マイクロ流体システムにおける粒子選別
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
US11517900B2 (en) 2017-10-27 2022-12-06 University Of Utah Research Foundation Microfluidic system for sperm separation and enrichment from various types of sperm samples
WO2019089979A1 (en) 2017-11-01 2019-05-09 Bio-Rad Laboratories, Inc. Microfluidic system and method for arranging objects
JP2019086340A (ja) * 2017-11-02 2019-06-06 シスメックス株式会社 細胞検出方法および細胞検出システム
US11041185B2 (en) * 2017-11-10 2021-06-22 Reliant Immune Diagnostics, Inc. Modular parallel/serial dual microfluidic chip
US10930381B2 (en) 2017-11-10 2021-02-23 Reliant Immune Diagnostics, Inc. Microfluidic testing system for mobile veterinary applications
US11527324B2 (en) 2017-11-10 2022-12-13 Reliant Immune Diagnostics, Inc. Artificial intelligence response system based on testing with parallel/serial dual microfluidic chip
US11200986B2 (en) 2017-11-10 2021-12-14 Reliant Immune Diagnostics, Inc. Database and machine learning in response to parallel serial dual microfluidic chip
US10930380B2 (en) 2017-11-10 2021-02-23 Reliant Immune Diagnostics, Inc. Communication loop and record loop system for parallel/serial dual microfluidic chip
US11124821B2 (en) 2017-11-10 2021-09-21 Reliant Immune Diagnostics, Inc. Microfluidic testing system with cell capture/analysis regions for processing in a parallel and serial manner
CN109772480B (zh) * 2017-11-15 2020-11-10 中国科学院青岛生物能源与过程研究所 单个微粒包裹液滴在微流控芯片中形成并分别导出的方法
EP3723906A4 (en) * 2017-12-15 2021-08-25 Singapore University of Technology and Design FOCUSING AND SORTING INERT CELLS
CN112088023B (zh) 2018-01-05 2024-05-14 帕斯艾克斯公司 用于捕获和去除流体中的疾病物质的装置
WO2019147228A1 (en) 2018-01-24 2019-08-01 Hewlett-Packard Development Company, L.P. Object focusing
WO2019153032A1 (en) * 2018-02-07 2019-08-15 University Of South Australia Pre-natal cell isolation
KR102224918B1 (ko) * 2018-03-20 2021-03-09 (주)인벤티지랩 도네페질 및 메만틴을 포함하는 인지 장애 관련 질병의 예방 또는 치료용 약학적 복합 조성물 및 이의 제조 방법
US11229912B2 (en) 2018-03-27 2022-01-25 Hewlett-Packard Development Company, L.P. Particle separation
MX2019003718A (es) * 2018-03-28 2019-09-30 Ipeg Inc Sistema y metodo que utiliza telemetria para caracterizar, mantener y analizar sistemas de transporte neumatico.
CA3038323A1 (en) * 2018-03-28 2019-09-28 Ipeg, Inc. System and method using telemetry to configure control systems for pneumatic conveying systems
WO2019204333A1 (en) * 2018-04-17 2019-10-24 The Regents Of The University Of California A particle-sorting device for the separation, isolation and enrichment of particles at ultra-low concentration
CN108318394B (zh) * 2018-05-09 2024-04-16 南京安控易创计算机科技有限公司 一种微流控分选测量可吸入颗粒物的方法及装置
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
DE102018112722A1 (de) * 2018-05-28 2019-11-28 Rolls-Royce Deutschland Ltd & Co Kg Messvorrichtung mit mindestens einem Fluidkanal für die Führung eines Messfluids
US11253804B2 (en) * 2018-06-01 2022-02-22 Mobiair Pte. Ltd. Apparatus and method to clean particle loaded fluid using low energy multi-flow splitter technology requiring no filter media
EP3814775A4 (en) 2018-06-29 2021-09-01 The General Hospital Corporation ISOLATION AND ANALYSIS OF CELLS AND RARE PARTICLES DERIVED FROM THE BRAIN
US11192110B2 (en) 2018-07-06 2021-12-07 Liu Lian Methods and systems for cell-based non-invasive prenatal testing
US10611995B2 (en) * 2018-08-15 2020-04-07 Deepcell, Inc. Systems and methods for particle analysis
CN108872047B (zh) * 2018-08-15 2021-02-26 军事科学院系统工程研究院卫勤保障技术研究所 一种微流控电阻抗检测区分微小粒子形状的系统及方法
US11815507B2 (en) 2018-08-15 2023-11-14 Deepcell, Inc. Systems and methods for particle analysis
CN109011213A (zh) * 2018-08-17 2018-12-18 江苏莱福医疗器械科技有限公司 一种放射性粒子自动排序装置
US11028359B2 (en) 2018-09-11 2021-06-08 Global Life Sciences Solutions Usa Llc Separation devices, associated methods, and systems
IT201800009526A1 (it) * 2018-10-17 2020-04-17 Alessandro Capodicasa Metodo per la preparazione di nuovi materiali antiossidanti e antimicrobici per il settore dei preparati per uso cosmetico, dermo-cosmetico e dei complementi alimentari
CN111073791A (zh) * 2018-10-19 2020-04-28 深圳华大生命科学研究院 粒子聚焦芯片、单细胞制备系统及单细胞制备方法
US11162143B2 (en) 2018-10-21 2021-11-02 The University Of Kansas Methods for generating therapeutic delivery platforms
US11440002B2 (en) * 2018-10-23 2022-09-13 International Business Machines Corporation Microfluidic chips with one or more vias filled with sacrificial plugs
JP2020082047A (ja) * 2018-11-30 2020-06-04 シスメックス株式会社 分離成否判定方法、粒子検出方法および粒子分離装置
IL263582A (en) * 2018-12-09 2020-06-30 Vbact Ltd A system for photographing and monitoring flows
WO2020122876A1 (en) * 2018-12-11 2020-06-18 Hewlett-Packard Development Company, L.P. Part packing based on agent usage
EP3670667A1 (en) 2018-12-19 2020-06-24 Paris Sciences et Lettres - Quartier Latin Identification of cognate pairs of ligands and receptors
CN109684717B (zh) * 2018-12-23 2023-04-07 贵州大学 基于量纲分析的油炒烹饪中表面换热系数的预测方法
CN111375245A (zh) * 2018-12-31 2020-07-07 中国石油化工股份有限公司 一种连接气液旋流分离器与下游气相管道的管式组件
CA3126148A1 (en) 2019-01-10 2020-07-16 Travera LLC Calibration of a functional biomarker instrument
CN109655447B (zh) * 2019-01-28 2022-04-08 广东海天创新技术有限公司 用于微生物计数的检测系统和方法
CN113874114A (zh) * 2019-04-08 2021-12-31 技术研究及发展基金有限公司 纳升液滴阵列设备的多路复用阵列
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
EP4245140A3 (en) 2019-04-18 2024-01-17 ABS Global, Inc. System and process for continuous addition of cryoprotectant
CN109939488B (zh) * 2019-04-29 2023-07-11 上海柏中观澈智能科技有限公司 一种用于分离流体中颗粒物的流体系统及用途
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
CN114072490A (zh) 2019-05-07 2022-02-18 伯乐实验室有限公司 用于自动化的单细胞加工的系统和方法
CN110174332B (zh) * 2019-05-28 2021-11-09 中国工程物理研究院激光聚变研究中心 一种测试乳粒聚并难易程度的方法
CN112076808B (zh) * 2019-06-13 2024-06-28 安行生物技术有限公司 利用超高频声波控制溶液中的微粒移动的方法及设备
SG11202112898WA (en) 2019-06-14 2021-12-30 Bio Rad Laboratories System and method for automated single cell processing and analyses
EP4003596A4 (en) 2019-07-31 2023-08-16 Cytovale Inc. SYSTEM AND METHOD FOR DETERMINING IMMUNE ACTIVITY
DE102019212316A1 (de) * 2019-08-16 2021-02-18 varyCELL GmbH Aufbereitungseinrichtung zur Aufbereitung einer Zellsuspension für ein Analyseverfahren, Verfahren zur Aufbereitung einer Zellsuspension für ein Analyseverfahren, Reaktorgehäuse und Verteilergehäuse
AU2020380721B2 (en) * 2019-11-06 2023-11-09 Korea University Research And Business Foundation Droplet deformation-based method of transferring material into cells and chip for same
US12059679B2 (en) 2019-11-19 2024-08-13 10X Genomics, Inc. Methods and devices for sorting droplets and particles
KR20220101731A (ko) * 2019-11-29 2022-07-19 도날드슨 컴파니, 인코포레이티드 유체 중의 입자를 분리시키기 위한 시스템 및 방법
DE102019219659A1 (de) 2019-12-16 2021-08-19 Robert Bosch Gmbh Kartusche mit einem mikrofluidischen System für die Durchführung einer Analyse einer Probe
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
CN113614509B (zh) * 2020-01-23 2023-12-19 京东方科技集团股份有限公司 微流体通道背板及其制备方法、微流控检测芯片
DE102020102389A1 (de) 2020-01-31 2021-08-05 Albert-Ludwigs-Universität Freiburg Verfahren und system zur isolation von molekülfraktionen
US20210237064A1 (en) * 2020-01-31 2021-08-05 Astrin Biosciences, Inc. Biological Fluid Filtration System
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
US11365071B2 (en) * 2020-04-28 2022-06-21 IPEG, Inc Automatic tuning system for pneumatic material conveying systems
CN111585673B (zh) * 2020-04-30 2021-09-07 电子科技大学 一种分子通信中的信道切换方法
EP4164795A4 (en) 2020-06-12 2024-01-24 BioFluidica, Inc. DUAL-DEPTH THERMOPLASTIC MICROFLUIDIC DEVICE AND ASSOCIATED SYSTEMS AND METHODS
CA3183029A1 (en) 2020-06-24 2021-12-30 Hifibio (Hk) Limited Methods for identification of cognate pairs of ligands and receptors
EP3957976A1 (en) * 2020-08-20 2022-02-23 Cellular Highways Ltd. Particle standards for reflected light scatter measurements from degenerate particle foci
WO2022045980A1 (en) * 2020-08-25 2022-03-03 Singapore University Of Technology And Design Device and method for determining a mechanical property of a particle
TWI769507B (zh) * 2020-08-26 2022-07-01 國立陽明交通大學 具有階差之級聯設計微流體結構
CN112044179B (zh) * 2020-09-02 2021-12-21 江苏鸿捷环保设备有限公司 一种磁摆动式废气中大颗粒杂质拦截设备
CN112275336B (zh) * 2020-10-20 2021-11-19 大连理工大学 一种多通道集成微流控芯片及其高通量制备单分散凝胶微球的方法
CN112354573B (zh) 2020-10-26 2022-01-04 深圳亘流科技有限公司 阶跃式惯性聚焦微流控芯片
CN112452364A (zh) * 2020-11-18 2021-03-09 江南大学 一种用于快速分选的微流控芯片及制造方法
CN112691625A (zh) * 2020-12-02 2021-04-23 中国科学院大连化学物理研究所 一种纳米药物的超声微反应器制备方法
CN112557379A (zh) * 2020-12-08 2021-03-26 深圳先进技术研究院 基于液滴注入的生化发光检测系统
CN114806799A (zh) * 2021-01-29 2022-07-29 广州万孚生物技术股份有限公司 体外分析诊断仪、循环肿瘤细胞分选富集的微流控芯片及方法
WO2022173345A1 (en) * 2021-02-09 2022-08-18 Amniotics Ab An amniotic cell separating apparatus
WO2022232053A1 (en) * 2021-04-26 2022-11-03 Volumetric Biotechnologies, Inc. Systems and methods for performing optically calibrated large-area microstereolithography
US20220395768A1 (en) * 2021-06-02 2022-12-15 Donaldson Company, Inc. Maintenance of hydrodynamic separators
CN113333040B (zh) * 2021-06-03 2022-09-30 大连理工大学 一种利用振荡流的高集成度微纳颗粒汇聚微流控装置
CN113769797B (zh) * 2021-09-02 2023-03-14 浙江理工大学 一种流固两相输运中的微尺度颗粒直径测定的方法
EP4395933A1 (en) 2021-09-03 2024-07-10 Elegen Corporation Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources
CN113856891B (zh) * 2021-09-16 2022-07-05 江南大学 一种高效干法与湿法组合的粉体微颗粒分级装置及方法
CN114100706B (zh) * 2021-10-18 2022-08-19 吉林大学 一种基于粒子漂移的粒子分选方法及系统
US11548003B1 (en) 2022-01-13 2023-01-10 CytoVale Inc. System and method for determining an immune activation state
US11592371B1 (en) 2022-01-13 2023-02-28 CytoVale Inc. System and method for determining an immune activation state
US11964281B2 (en) 2022-02-03 2024-04-23 CytoVale Inc. System and method for correcting patient index
CN114534652B (zh) * 2022-02-08 2024-07-19 上海天泽云泰生物医药有限公司 波形微结构混合单元及其用途
WO2023177528A1 (en) * 2022-03-15 2023-09-21 The Board Of Trustees Of The University Of Illinois Microfluidic system and method
CN114632564B (zh) * 2022-04-20 2024-03-08 香港城市大学深圳研究院 一种集成微流控芯片及原代循环肿瘤细胞体外处理方法
EP4279575A1 (en) * 2022-05-20 2023-11-22 Albert-Ludwigs-Universität Freiburg Device and method for particle isolation
US20230390769A1 (en) * 2022-06-01 2023-12-07 Donaldson Company, Inc. Hydrodynamic separator with tapered microfluidic channel
GB2625107A (en) * 2022-12-06 2024-06-12 Univ Of Northumbria At Newcastle Particle sorter
CN116037236B (zh) * 2023-03-31 2023-06-20 北京百力格生物科技有限公司 微流控芯片、微流控芯片组件及递送纳米颗粒制备方法

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3693792A (en) * 1971-05-05 1972-09-26 John F Sylvester Electrodynamic particle separator
US4290011A (en) * 1978-05-18 1981-09-15 Particle Data, Inc. Particle length and volume comeasurement with controlled orientation
US4446015A (en) * 1981-11-30 1984-05-01 E. I. Du Pont De Nemours And Company Field flow fractionation channel
JP2965688B2 (ja) * 1990-11-30 1999-10-18 シスメックス株式会社 粒子検出装置
US5412466A (en) * 1991-07-26 1995-05-02 Toa Medical Electronics Co., Ltd. Apparatus for forming flattened sample flow for analyzing particles
US5314529A (en) * 1993-09-13 1994-05-24 Tilton Donald E Entrained droplet separator
GB9410558D0 (en) * 1994-05-26 1994-07-13 The Technology Partnership Ltd Method of transferring matter from a bulk medium
JPH0864169A (ja) * 1994-08-24 1996-03-08 Shimadzu Corp 粒子分離装置
US6454945B1 (en) * 1995-06-16 2002-09-24 University Of Washington Microfabricated devices and methods
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5626758A (en) * 1995-08-08 1997-05-06 Rensselaer Polytechnic Institute Coiled membrane filtration system
DE19634450A1 (de) * 1996-08-26 1998-03-05 Basf Ag Vorrichtung zur kontinuierlichen Durchführung chemischer Reaktionen
DK0925494T3 (da) * 1996-09-04 2002-07-01 Scandinavian Micro Biodevices Mikrostrømningssystem til partikelseparation og analyse
US6221654B1 (en) * 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5968820A (en) 1997-02-26 1999-10-19 The Cleveland Clinic Foundation Method for magnetically separating cells into fractionated flow streams
US6003678A (en) * 1997-08-21 1999-12-21 University Of Washington Particle separating apparatus and method
US5819948A (en) * 1997-08-21 1998-10-13 Van Den Engh; Gerrit J. Particle separating apparatus and method
AU747940B2 (en) * 1997-11-12 2002-05-30 Applera Corporation Serpentine electrophoresis channel with self-correcting bends
US6540896B1 (en) * 1998-08-05 2003-04-01 Caliper Technologies Corp. Open-Field serial to parallel converter
US6169394B1 (en) * 1998-09-18 2001-01-02 University Of The Utah Research Foundation Electrical detector for micro-analysis systems
EP1179087B1 (en) 1999-05-17 2019-03-27 Caliper Life Sciences, Inc. Focusing of microparticles in microfluidic systems
FR2801809B1 (fr) * 1999-12-03 2002-02-22 Degremont Procede de filtration membranaire de liquides et dispositif de mise en oeuvre dudit procede
US7242474B2 (en) 2004-07-27 2007-07-10 Cox James A Cytometer having fluid core stream position control
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US20020172622A1 (en) 2001-04-03 2002-11-21 Weigl Bernhard H. Microfluidic device for concentrating particles in a concentrating solution
AU2002320507A1 (en) * 2001-07-13 2003-01-29 Caliper Technologies Corp. Microfluidic devices and systems for separating components of a mixture
WO2003066191A1 (en) * 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US20030175980A1 (en) 2002-03-14 2003-09-18 Hayenga Jon W. Ribbon flow cytometry and cell sorting
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US7157274B2 (en) * 2002-06-24 2007-01-02 Cytonome, Inc. Method and apparatus for sorting particles
US6808075B2 (en) * 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
EP2278338B1 (en) * 2002-05-09 2020-08-26 The University of Chicago Device and method for pressure-driven plug transport and reaction
JP2006501449A (ja) * 2002-09-27 2006-01-12 ザ ジェネラル ホスピタル コーポレーション 細胞分離のためのマイクロ流体デバイスおよびその使用
US7079244B2 (en) * 2002-11-18 2006-07-18 International Remote Imaging Systems, Inc. Particle analyzer with specimen tube in-line mixer
DE10304653B4 (de) 2003-02-05 2005-01-27 Evotec Technologies Gmbh Mehrparametrige Detektion in einem fluidischen Mikrosystem
JP3741108B2 (ja) 2003-03-18 2006-02-01 ソニー株式会社 レーザー発光モジュール
JP2004330008A (ja) * 2003-05-01 2004-11-25 Rikogaku Shinkokai マイクロチャンネル装置
JP4533382B2 (ja) * 2003-08-28 2010-09-01 セルラ・インコーポレイテッド マイクロ流体分析およびソーティング用の一体化された構造物
WO2005042137A2 (en) * 2003-10-30 2005-05-12 Cytonome, Inc. Multilayer hydrodynamic sheath flow structure
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
JP4461900B2 (ja) * 2004-05-10 2010-05-12 富士ゼロックス株式会社 微粒子分散液の送液方法、及び微粒子分散液の送液装置
JP4461941B2 (ja) * 2004-07-21 2010-05-12 富士ゼロックス株式会社 微粒子分散液の送液方法、及び微粒子分散液の送液装置
US7008304B1 (en) * 2004-08-17 2006-03-07 Media Blast & Abrasives, Inc. Abrasive and dust separator
JP4462058B2 (ja) * 2004-09-22 2010-05-12 富士ゼロックス株式会社 微粒子の分級方法、及び微粒子の分級装置
US7333197B2 (en) * 2004-11-17 2008-02-19 Honeywell International Inc. Raman detection based flow cytometer
WO2006056219A1 (en) * 2004-11-24 2006-06-01 Preventor Utbc Gmbh Process for separation of dispersions and an apparatus
EP1846163A2 (en) * 2005-01-13 2007-10-24 Micronics, Inc. Microfluidic rare cell detection device
US20060177940A1 (en) * 2005-02-07 2006-08-10 Furst Eric M Optical trap separations in microfluidic flows
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8343756B2 (en) * 2005-10-07 2013-01-01 The General Hospital Corporation Devices and methods for cell manipulation
US7964078B2 (en) * 2005-11-07 2011-06-21 The Regents Of The University Of California Microfluidic device for cell and particle separation
WO2008016414A2 (en) * 2006-06-01 2008-02-07 The Trustees Of Princeton University Apparatus and method for continuous particle separation
KR100747909B1 (ko) 2006-07-10 2007-08-08 현대자동차주식회사 조수석 에어백 하우징 구조
US8656949B2 (en) * 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
US7807454B2 (en) * 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
US8276760B2 (en) * 2006-11-30 2012-10-02 Palo Alto Research Center Incorporated Serpentine structures for continuous flow particle separations
US10052571B2 (en) * 2007-11-07 2018-08-21 Palo Alto Research Center Incorporated Fluidic device and method for separation of neutrally buoyant particles
US9486812B2 (en) * 2006-11-30 2016-11-08 Palo Alto Research Center Incorporated Fluidic structures for membraneless particle separation
US9433880B2 (en) * 2006-11-30 2016-09-06 Palo Alto Research Center Incorporated Particle separation and concentration system
ATE538377T1 (de) * 2007-04-02 2012-01-15 Acoustic Cytometry Systems Inc Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln
EP2562531A3 (en) 2007-04-16 2013-03-06 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
US7858372B2 (en) * 2007-04-25 2010-12-28 Sierra Sensors Gmbh Flow cell facilitating precise delivery of reagent to a detection surface using evacuation ports and guided laminar flows, and methods of use
US7691636B2 (en) * 2007-05-23 2010-04-06 Beckman Coulter, Inc. Method and apparatus for compensating for variations in particle trajectories in electrostatic sorter for flowcell cytometer
US8941826B2 (en) * 2007-09-10 2015-01-27 The Penn State Research Foundation Three-dimensional (3D) hydrodynamic focusing using a microfluidic device
US8120770B2 (en) 2007-09-10 2012-02-21 The Penn State Research Foundation Three-dimensional (3D) hydrodynamic focusing using a microfluidic device
WO2009126352A2 (en) * 2008-01-24 2009-10-15 Sandia National Laboratories Novel micropores and methods of making and using thereof
US9068181B2 (en) * 2008-05-23 2015-06-30 The General Hospital Corporation Microfluidic droplet encapsulation
US20110167932A1 (en) * 2008-09-17 2011-07-14 Research Triangle Institute Coarse particle exposure monitor
US9492797B2 (en) * 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
JP4674625B2 (ja) * 2008-09-25 2011-04-20 富士ゼロックス株式会社 分級装置及び分級方法
US8318439B2 (en) 2008-10-03 2012-11-27 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
JP5309918B2 (ja) * 2008-11-18 2013-10-09 富士ゼロックス株式会社 着色樹脂粒子、着色樹脂粒子の製造方法、及び、静電荷像現像用トナー
US8162149B1 (en) * 2009-01-21 2012-04-24 Sandia Corporation Particle sorter comprising a fluid displacer in a closed-loop fluid circuit
US8034629B2 (en) 2009-06-26 2011-10-11 Massachusetts Institute Of Technology High precision scanning of encoded hydrogel microparticles
US8460269B2 (en) * 2009-09-14 2013-06-11 University of Pittsburgh—of the Commonwealth System of Higher Education Directed cell-based therapy using microbubble tagged cells
US8208138B2 (en) 2009-09-24 2012-06-26 University Of Cincinnati Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems
US9470617B2 (en) * 2010-04-07 2016-10-18 Sony Corporation Flow cytometry apparatus
US9395050B2 (en) 2010-05-21 2016-07-19 Hewlett-Packard Development Company, L.P. Microfluidic systems and networks
US8361415B2 (en) 2010-09-13 2013-01-29 The Regents Of The University Of California Inertial particle focusing system
US8693762B2 (en) * 2010-09-14 2014-04-08 The Regents Of The University Of California Inertial particle focusing flow cytometer
US9090865B2 (en) * 2010-10-29 2015-07-28 The Regents Of The University Of California Systems and methods for particle classification and sorting
WO2012075358A2 (en) * 2010-12-02 2012-06-07 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Tubular array for fluidic focusing with integrated optical access region
US8980106B2 (en) * 2010-12-15 2015-03-17 Abbott Laboratories Apparatus and method for separation of whole blood into plasma or serum and cells
US9821310B2 (en) * 2011-03-31 2017-11-21 The University Of Akron Two-stage microfluidic device for acoustic particle manipulation and methods of separation
US9797836B1 (en) 2012-02-29 2017-10-24 National Technology & Engineering Solutions Of Sandia, Llc Hyperspectral imaging flow cytometer
CA2894459C (en) 2012-07-27 2020-07-07 Engender Technologies Limited Method and system for microfluidic particle orientation and/or sorting
US9194786B2 (en) * 2012-08-01 2015-11-24 Owl biomedical, Inc. Particle manipulation system with cytometric capability
JP6025982B2 (ja) * 2012-08-01 2016-11-16 ザ・ペン・ステート・リサーチ・ファンデーション 粒子および細胞の高効率分離およびマニピュレーション
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US9604214B2 (en) * 2013-10-01 2017-03-28 Owl biomedical, Inc. Cell sorting system using microfabricated components
JP6757723B2 (ja) * 2014-11-03 2020-09-23 ザ ジェネラル ホスピタル コーポレイション ミクロ流体装置における粒子の濃縮
US10976232B2 (en) * 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
DK3374083T3 (da) * 2015-11-10 2021-01-18 Illumina Inc Inerti dråbe generering og partikelindkapsling
JP7332586B2 (ja) * 2017-09-19 2023-08-23 ハイファイバイオ エスアエス マイクロ流体システムにおける粒子選別

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