HK1112479A1 - Disposable bioreactor systems and methods - Google Patents

Disposable bioreactor systems and methods

Info

Publication number
HK1112479A1
HK1112479A1 HK08100627.3A HK08100627A HK1112479A1 HK 1112479 A1 HK1112479 A1 HK 1112479A1 HK 08100627 A HK08100627 A HK 08100627A HK 1112479 A1 HK1112479 A1 HK 1112479A1
Authority
HK
Hong Kong
Prior art keywords
methods
disposable bioreactor
bioreactor systems
systems
disposable
Prior art date
Application number
HK08100627.3A
Other languages
English (en)
Inventor
Geoffrey Hodge
Parrish Galliher
Michael Fisher
Original Assignee
Xcellerex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35197799&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1112479(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xcellerex Inc filed Critical Xcellerex Inc
Publication of HK1112479A1 publication Critical patent/HK1112479A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • B01F35/513Flexible receptacles, e.g. bags supported by rigid containers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • B01F35/53Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B01F35/531Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
    • B01F35/5312Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom with vertical baffles mounted on the walls
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/14Bags
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02Stirrer or mobile mixing elements
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18Flow directing inserts
    • C12M27/20Baffles; Ribs; Ribbons; Auger vanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
HK08100627.3A 2004-06-04 2008-01-17 Disposable bioreactor systems and methods HK1112479A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57714304P 2004-06-04 2004-06-04
US66925205P 2005-04-07 2005-04-07
PCT/US2005/020083 WO2005118771A2 (fr) 2004-06-04 2005-06-06 Systemes de bioreacteurs jetables et procedes associes

Publications (1)

Publication Number Publication Date
HK1112479A1 true HK1112479A1 (en) 2008-09-05

Family

ID=35197799

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08100627.3A HK1112479A1 (en) 2004-06-04 2008-01-17 Disposable bioreactor systems and methods

Country Status (15)

Country Link
US (1) US7629167B2 (fr)
EP (1) EP1773976B2 (fr)
JP (1) JP4680990B2 (fr)
KR (1) KR101021203B1 (fr)
CN (2) CN101001945B (fr)
AU (1) AU2005250500B2 (fr)
BR (1) BRPI0510648B1 (fr)
CA (1) CA2569405C (fr)
CR (1) CR8769A (fr)
DK (1) DK1773976T4 (fr)
ES (1) ES2612212T5 (fr)
HK (1) HK1112479A1 (fr)
MX (1) MXPA06014099A (fr)
NO (1) NO20070069L (fr)
WO (1) WO2005118771A2 (fr)

Families Citing this family (234)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US8182137B2 (en) 2000-10-09 2012-05-22 Atmi Packaging, Inc. Mixing bag or vessel with a fluid-agitating element
US7086778B2 (en) * 2000-10-09 2006-08-08 Levtech, Inc. System using a levitating, rotating pumping or mixing element and related methods
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
EP1534412B1 (fr) 2001-10-03 2010-08-18 Levtech Inc. Recipient de melange possedant un receptacle pour un element agitateur de fluide
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
CA2552717C (fr) 2004-01-07 2011-11-29 Levtech, Inc. Sac melangeur a arroseur integre et receptacle pour detecteur
MXPA06011837A (es) 2004-04-27 2007-01-16 Baxter Int Sistema de reactor de tanque agitado.
JP2008504118A (ja) * 2004-06-23 2008-02-14 リーブテック,インコーポレイテッド 混合用容器心合システム、デバイス及びそれらに関連する方法
US8603805B2 (en) 2005-04-22 2013-12-10 Hyclone Laboratories, Inc. Gas spargers and related container systems
WO2006119622A1 (fr) 2005-05-09 2006-11-16 Saxonia Biotec Gmbh. Appareil pour procurer un milieu a des modules de culture cellulaire
WO2008040567A1 (fr) * 2006-10-03 2008-04-10 Artelis Sac mélangeur souple, dispositif mélangeur et système mélangeur associé
WO2008040568A1 (fr) 2006-10-03 2008-04-10 Artelis Système de mélangeur comprenant un sac souple, sac souple et système de localisation spécifiques destinés à ce système de mélangeur
US7628528B2 (en) * 2005-10-26 2009-12-08 PRS Biotech, Inc. Pneumatic bioreactor
US8790913B2 (en) 2005-10-26 2014-07-29 Pbs Biotech, Inc. Methods of using pneumatic bioreactors
DE102006001623B4 (de) * 2006-01-11 2009-05-07 Sartorius Stedim Biotech Gmbh Behälter und Verfahren zum Mischen von Medien
SE531572C2 (sv) * 2006-04-05 2009-05-26 Millipore Ab Engångsenhet för processa produkter
DE102006018824A1 (de) 2006-04-22 2007-10-25 Bayer Technology Services Gmbh Einweg-Bioreaktor
DE102006022307A1 (de) 2006-05-11 2007-11-15 Respironics Novametrix, LLC, Wallingford Einwegbioreaktor mit Sensoranordnung
WO2007134267A2 (fr) 2006-05-13 2007-11-22 Advanced Technology Materials, Inc. Bioréacteur jetable
JP5145335B2 (ja) 2006-06-16 2013-02-13 エクセレレックス インク. 液体を収容するように形成された容器
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
JP5254226B2 (ja) * 2006-07-14 2013-08-07 エクセレレックス インク. 環境保護用収容システム
US8846382B2 (en) 2006-08-01 2014-09-30 Oliver Muecke Airlift bioreactor
US20080032396A1 (en) * 2006-08-02 2008-02-07 Becton, Dickinson And Company Bioreactor and Method
US11827875B2 (en) 2006-08-02 2023-11-28 Finesse Solutions, Inc. Method for manufacturing a composite sensor
US8008065B2 (en) 2006-08-02 2011-08-30 Finesse Solutions, Llc. Disposable bioreactor vessel port
US9267100B2 (en) 2006-08-02 2016-02-23 Finesse Solutions, Inc. Composite sensor assemblies for single use bioreactors
US10227555B2 (en) 2006-08-02 2019-03-12 Finesse Solutions, Inc. Composite sensor assemblies for single use bioreactors
US20080151683A1 (en) * 2006-11-14 2008-06-26 Charles Meadows Stir-bag system with stand and turbulence member
US10018613B2 (en) 2006-11-16 2018-07-10 General Electric Company Sensing system and method for analyzing a fluid at an industrial site
US9658178B2 (en) 2012-09-28 2017-05-23 General Electric Company Sensor systems for measuring an interface level in a multi-phase fluid composition
US10260388B2 (en) 2006-11-16 2019-04-16 General Electric Company Sensing system and method
US9538657B2 (en) 2012-06-29 2017-01-03 General Electric Company Resonant sensor and an associated sensing method
US9536122B2 (en) 2014-11-04 2017-01-03 General Electric Company Disposable multivariable sensing devices having radio frequency based sensors
US10914698B2 (en) 2006-11-16 2021-02-09 General Electric Company Sensing method and system
US9589686B2 (en) 2006-11-16 2017-03-07 General Electric Company Apparatus for detecting contaminants in a liquid and a system for use thereof
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
US8163886B2 (en) 2006-12-21 2012-04-24 Emd Millipore Corporation Purification of proteins
US20100028990A1 (en) * 2007-02-15 2010-02-04 Broadley-James Corporation Sterile bioreactor bag with integrated drive unit
WO2008101127A2 (fr) * 2007-02-15 2008-08-21 Broadley-James Corporation Gaine de bioréacteur
EP2132534A1 (fr) * 2007-02-28 2009-12-16 Xcellerex, Inc. Mesures de poids de liquides dans des récipients flexibles
US7713730B2 (en) 2007-04-24 2010-05-11 Pbs Biotech, Inc. Pneumatic bioreactor
US9868095B2 (en) 2007-05-02 2018-01-16 Finesse Solutions, Inc. Disposable bioreactor system
US9090398B2 (en) * 2007-05-04 2015-07-28 Emd Millipore Corporation Disposable processing bag with alignment feature
JP2010525833A (ja) * 2007-05-07 2010-07-29 プロタリクス リミテッド 大規模な使い捨て型バイオリアクター
EP2155852B1 (fr) * 2007-06-15 2013-10-09 Cellution Biotech B.V. Bioréacteur flexible amélioré
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
US7832922B2 (en) 2007-11-30 2010-11-16 Levitronix Gmbh Mixing apparatus and container for such
WO2009093995A1 (fr) * 2008-01-25 2009-07-30 Xcellerex, Inc. Système d'élimination de plis de poche, systèmes de détection de fuites, et agitation électromagnétique pour systèmes de confinement de liquides
WO2009093997A1 (fr) * 2008-01-25 2009-07-30 Xcellerex, Inc. Systèmes et procédés d'acquisition et de gestion d'informations dans des systèmes de bioréacteurs et des installations de fabrication
WO2009122310A2 (fr) * 2008-03-19 2009-10-08 Sartorius Stedim Biotech Gmbh Récipient mélangeur jetable
US20090242173A1 (en) * 2008-03-25 2009-10-01 Peter Mitchell Temperature control system
US9340763B2 (en) 2008-03-25 2016-05-17 Ge Healthcare Bio-Sciences Corp. Temperature controlling surfaces and support structures
US10767154B2 (en) 2008-03-25 2020-09-08 Global Life Sciences Solutions Usa Llc Temperature controlling surfaces and support structures
US9534196B2 (en) 2009-03-25 2017-01-03 Ge Healthcare Bio-Sciences Corp. Temperature controlled support surfaces for single use flexible wall systems
US20090269849A1 (en) * 2008-04-25 2009-10-29 Pbs Biotech, Inc. Bioreactor Apparatus
US8381780B2 (en) * 2008-05-22 2013-02-26 Xcellerex, Inc. Lift and support assemblies and methods for collapsible bag containers of vessels and bioreactors
DE102008025507A1 (de) 2008-05-28 2009-12-03 Sartorius Stedim Biotech Gmbh Mischsystem
DE102008025968B4 (de) * 2008-05-30 2014-08-21 Sartorius Stedim Biotech Gmbh Bioreaktor mit Kondensator
EP2130905A1 (fr) 2008-06-04 2009-12-09 Pharmacell B.V. Procédé de culture de cellules eucaryotes
US8999702B2 (en) * 2008-06-11 2015-04-07 Emd Millipore Corporation Stirred tank bioreactor
US8192071B2 (en) 2008-07-16 2012-06-05 Sartorius Stedim Biotech Gmbh Agitator apparatus with collapsible impeller
FR2934371B1 (fr) * 2008-07-25 2012-06-08 Nanotec Solution Dispositif capteur de biomasse a usage unique, procede de realisation de ce dispositif et bioreacteur a usage unique integrant ce capteur
US20110177551A1 (en) * 2008-09-30 2011-07-21 Toray Industries, Inc. Method for producing a chemical product and continuous fermentation apparatus
MX2011004292A (es) 2008-11-03 2011-05-31 Crucell Holland Bv Metodo para la produccion de vectores adenovirales.
GB0820779D0 (en) 2008-11-13 2008-12-17 Artelis S A Cell culture device and method of culturing cells
SG171446A1 (en) 2008-12-16 2011-07-28 Millipore Corp Stirred tank reactor and method
WO2010069321A2 (fr) 2008-12-19 2010-06-24 Stobbe Tech A/S Pompe à diaphragme à commande électronique
DE102009005962A1 (de) 2009-01-23 2010-07-29 Bayer Technology Services Gmbh Begasungssystem
US9687348B2 (en) 2009-03-03 2017-06-27 The Trustees Of Columbia University In The City Of New York Method of making a personalized bone graft
FR2943355B1 (fr) * 2009-03-18 2011-04-08 Sartorius Stedim Biotech Sa Recipient-melangeur avec palier d'arbre en partie superieure
EP2409130B1 (fr) * 2009-03-20 2013-12-04 Pbs Biotech, Inc. Système aseptique automatisable de prélèvement d'échantillons
FR2943560B1 (fr) * 2009-03-24 2011-05-27 Jean Pascal Zambaux Bioreacteur jetable et systeme d'agitation a usage unique
DE102009019697A1 (de) * 2009-05-05 2010-11-18 Bayer Technology Services Gmbh Container
EP2251407B1 (fr) * 2009-05-12 2016-06-29 Eppendorf AG Bioréacteur jetable et son procédé de production
DE102009050448A1 (de) 2009-06-19 2011-12-08 Sartorius Stedim Biotech Gmbh Sensorvorrichtung, aufweisend einen optischen Sensor, einen Behälter und ein Kompartimentierungsmittel
EP2451936B1 (fr) * 2009-07-06 2019-08-28 F.Hoffmann-La Roche Ag Procédé de culture de cellules eucaryotes
US9719705B2 (en) * 2009-09-30 2017-08-01 Ge Healthcare Bio-Sciences Corp. Disposable bioreactor condenser bag and filter heater
WO2011041508A1 (fr) 2009-09-30 2011-04-07 Xcellerex, Inc. Récipient de condenseur de bioréacteur jetable et réchauffeur de filtre
FR2950802B1 (fr) * 2009-10-02 2012-02-03 Sartorius Stedim Biotech Sa Elaboration et/ou conservation d'un produit biopharmaceutique.
DE102009052670B4 (de) * 2009-11-12 2017-10-05 Sartorius Stedim Biotech Gmbh Begasungsvorrichtung für Bioreaktoren
WO2011062621A2 (fr) * 2009-11-17 2011-05-26 Harvard Bioscience, Inc. Bioréacteurs, systèmes, et procédés de production et/ou d'analyse d'organes
CN102656282B (zh) 2009-12-22 2015-09-02 通用电气健康护理生物科学股份公司 用于控制生物反应器中的培养参数的方法
US11773358B2 (en) 2009-12-22 2023-10-03 Cytiva Sweden Ab Method for controlling culture parameters in a bioreactor
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
CA2790819A1 (fr) * 2010-02-25 2011-09-01 Jere Northrop Procede et methode pour optimiser la production d'aliments destines a la consommation humaine et animale
KR101342154B1 (ko) 2010-03-09 2013-12-13 이엠디 밀리포어 코포레이션 센서를 구비한 가공 백 용기
WO2011130617A2 (fr) * 2010-04-15 2011-10-20 Smartflow Technologies, Inc. Bioréacteur intégré et système de séparation et procédés d'utilisation de celui-ci
CN107312062B (zh) 2010-05-17 2021-03-16 Emd密理博公司 用于纯化生物分子的刺激响应性聚合物
US8480292B2 (en) * 2010-06-01 2013-07-09 Boris Dushine Systems, apparatus and methods to reconstitute dehydrated drinks
WO2012005667A1 (fr) * 2010-07-05 2012-01-12 Bioprocess Control Sweden Ab Système de fermentation biologique
DE102010036193A1 (de) * 2010-09-02 2012-03-08 Sartorius Stedim Biotech Gmbh Vorrichtung zur kontaktlosen Übertragung elektrischer Energie für Bioreaktorbauteile
WO2012040574A1 (fr) 2010-09-23 2012-03-29 Xcellerex, Inc. Mise en suspension à usage unique et systèmes de chromatographie
CN102559491A (zh) * 2010-10-14 2012-07-11 杨凯 一种用于百合籽球培养的鼓泡式生物反应器
US8542023B2 (en) 2010-11-09 2013-09-24 General Electric Company Highly selective chemical and biological sensors
CN103391994B (zh) * 2011-01-11 2015-07-22 通用电气医疗集团生物科学公司 可线性缩放规模的单次使用的生物反应器系统
MY148876A (en) * 2011-01-14 2013-06-14 Univ Sains Malaysia A cell culture tank.
EP2484750A1 (fr) * 2011-02-07 2012-08-08 Ecole Polytechnique Fédérale de Lausanne (EPFL) Système de surveillance pour culture cellulaire
WO2012128703A1 (fr) * 2011-03-18 2012-09-27 Ge Healthcare Bio-Sciences Ab Sac flexible pour cultiver des cellules
WO2012130334A1 (fr) 2011-04-01 2012-10-04 Siemens Aktiengesellschaft Bioréacteur à une voie et système de détection pour un bioréacteur
DE102011007013B4 (de) 2011-04-07 2015-08-27 Siemens Aktiengesellschaft Einweg-Bioreaktor
US8668886B2 (en) * 2011-04-24 2014-03-11 Therapeutic Proteins International, LLC Separative bioreactor
US9284841B1 (en) * 2011-07-14 2016-03-15 Julie C. Vickers Disposable heat exchanger assembly for sterile and aseptic biotechnology and pharmaceutical manufacturing applications
CN202786257U (zh) * 2011-08-31 2013-03-13 通用电气健康护理生物科学股份公司 用于生物反应器的排气过滤装置
SI2751255T1 (sl) 2011-09-01 2021-04-30 Gicon Grossmann Ingenieur Consult Gmbh Postopek in naprava za ciljano dovajanje plinov ali plinskih zmesi v tekočino, suspenzijo ali emulzijo v fotobioreaktorju
US8183035B1 (en) * 2011-09-07 2012-05-22 Therapeutic Proteins International, LLC Single container manufacturing of biological product
US9376655B2 (en) 2011-09-29 2016-06-28 Life Technologies Corporation Filter systems for separating microcarriers from cell culture solutions
BR112014007807B1 (pt) 2011-09-30 2020-11-17 Life Technologies Corporation recipiente com pulverizador de película
US10989362B2 (en) 2011-10-07 2021-04-27 Pall Technology Uk Limited Fluid processing control system and related methods
JP6073903B2 (ja) * 2011-10-10 2017-02-01 ダスギプ・インフォメーション・アンド・プロセス・テクノロジー・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングDasgip Information And Process Technology Gmbh バイオリアクタを有するバイオテクノロジー装置、バイオリアクタのための排気ガス温度制御デバイス、およびバイオテクノロジー装置内を流れる排気ガスを処理する方法
SI2773326T1 (sl) 2011-11-04 2019-04-30 Nitto Denko Corporation Metoda za sterilno proizvodnjo delcev lipidno-nukleinske kisline
JP6176674B2 (ja) * 2012-01-13 2017-08-09 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション シングルユース可撓性壁システムのための温度制御支持表面
SG11201405443YA (en) * 2012-03-07 2014-10-30 Ge Healthcare Bio Sciences Disposable valve and flexible containers for pressurized bioreactors
US9339764B2 (en) * 2012-03-12 2016-05-17 Uchicago Argonne, Llc Internal gas and liquid distributor for electrodeionization device
US9284521B2 (en) * 2012-03-24 2016-03-15 Therapeutic Proteins International, LLC Pivoting pressurized single-use bioreactor
US9339026B2 (en) 2012-06-14 2016-05-17 Therapeutic Proteins International, LLC Pneumatically agitated and aerated single-use bioreactor
WO2014031749A1 (fr) 2012-08-22 2014-02-27 General Electric Company Système sans fil et procédé d'évaluation d'un état de fonctionnement d'une machine
US10598650B2 (en) 2012-08-22 2020-03-24 General Electric Company System and method for measuring an operative condition of a machine
US10684268B2 (en) 2012-09-28 2020-06-16 Bl Technologies, Inc. Sensor systems for measuring an interface level in a multi-phase fluid composition
KR101247515B1 (ko) * 2012-10-15 2013-03-26 김창수 버섯종균 배양장치
EP2926076B1 (fr) * 2012-12-03 2020-06-03 Global Life Sciences Solutions USA LLC Surfaces de régulation de température et structures de support
CN103028336A (zh) * 2012-12-29 2013-04-10 上海乐纯生物技术有限公司 配液袋子
CN105377874A (zh) 2013-03-08 2016-03-02 建新公司 治疗性蛋白药物物质的整合连续制造
WO2014172047A1 (fr) * 2013-04-19 2014-10-23 Emd Millipore Corporation Déflecteur de film souple dans un bioréacteur à usage unique
EP3004319B1 (fr) 2013-06-05 2018-12-19 GE Healthcare Bio-Sciences AB Récipient jetable et système de mélangeage comprenant le récipient
US10076753B2 (en) 2013-06-12 2018-09-18 Ge Healthcare Bio-Sciences Corp. Disposable container and mixing system comprising the container
KR102270616B1 (ko) * 2013-06-17 2021-06-30 씨티바 스웨덴 에이비 온도 센서를 갖는 생물반응기 시스템
US11944946B2 (en) 2013-06-28 2024-04-02 Saint-Gobain Performance Plastics Corporation Mixing assemblies including magnetic impellers
BR112015031637B1 (pt) * 2013-06-28 2022-01-18 Saint-Gobain Performance Plastics Corporation Conjuntos de mistura incluindo impelidores magnéticos
WO2015034416A1 (fr) 2013-09-06 2015-03-12 Ge Healthcare Bio-Sciences Ab Poche pour culture cellulaire à membrane de dialyse interne
CN110172406B (zh) * 2013-09-16 2023-08-08 豪夫迈·罗氏有限公司 具有多个或可调节位置的搅拌器设计的生物反应器
EP3031901B1 (fr) * 2013-10-11 2017-09-27 Panasonic Healthcare Holdings Co., Ltd. Appareil de culture
WO2015056267A1 (fr) * 2013-10-14 2015-04-23 Algalo Industries Ltd. Système et procédé de croissance d'algues
EP3825394B1 (fr) 2013-12-10 2023-10-25 Abec, Inc. Conteneur pour usage unique ayant un dispositif d' étanchéité et son usage
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
DE102014101839B4 (de) * 2014-02-13 2018-03-15 Sartorius Stedim Biotech Gmbh Verpackung für einen flexiblen Behälter und Transporteinheit
EP3119504B1 (fr) 2014-03-21 2020-10-14 Life Technologies Corporation Systèmes de filtration de gaz pour systèmes de traitement de fluide
US10005005B2 (en) 2014-03-21 2018-06-26 Life Technologies Corporation Condenser systems for fluid processing systems
JP6020513B2 (ja) * 2014-05-29 2016-11-02 横河電機株式会社 細胞培養バッグおよび細胞培養バッグの製造方法
US9079690B1 (en) 2014-06-26 2015-07-14 Advanced Scientifics, Inc. Freezer bag, storage system, and method of freezing
US9587215B2 (en) 2014-08-07 2017-03-07 General Electric Company Devices, systems and methods for automated transfer of a sample
US9457306B2 (en) 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
DE102014117658B4 (de) 2014-12-02 2023-02-16 Sartorius Stedim Biotech Gmbh Mischvorrichtung mit Strömungsbrecher
BR112017021509A2 (pt) * 2015-04-13 2018-07-03 Rosemount Analytical Inc ?vaso de biorreator, e, método para fabricação de um vaso de reação de uso único?.
US11052165B2 (en) 2015-04-20 2021-07-06 Global Life Sciences Solutions Usa Llc Method for virus clearance
EP3286295A1 (fr) * 2015-04-20 2018-02-28 GE Healthcare Bio-Sciences Corp. Désactivation de virus
DE102015007061B4 (de) * 2015-06-02 2023-12-14 Sartorius Stedim Biotech Gmbh System, Vorrichtung und Verfahren zum Aufnehmen eines Einwegbeutels
DE102015110894B3 (de) * 2015-07-06 2016-09-01 Sartorius Stedim Biotech Gmbh Verfahren zum Messen einer Mehrzahl von Zustandsparametern eines in einem Behälter enthaltenen Fluids
JP6764221B2 (ja) * 2015-07-22 2020-09-30 株式会社日立製作所 攪拌装置
US10323494B2 (en) 2015-07-23 2019-06-18 General Electric Company Hydrocarbon production system and an associated method thereof
US10077646B2 (en) 2015-07-23 2018-09-18 General Electric Company Closed loop hydrocarbon extraction system and a method for operating the same
US10047596B2 (en) 2015-07-23 2018-08-14 General Electric Company System and method for disposal of water produced from a plurality of wells of a well-pad
US9920292B2 (en) 2015-08-31 2018-03-20 General Electric Company System and method for initiating a cell culture
EP3356509B1 (fr) * 2015-10-01 2019-07-31 GE Healthcare Bio-Sciences AB Dispositif de fixation d'un filtre
US10836989B2 (en) * 2015-10-16 2020-11-17 Global Life Sciences Solutions Usa Llc Disposable container, mixing system and packaging
KR20180074775A (ko) 2015-10-26 2018-07-03 론자 리미티드 생물약제의 생산을 위한 제조 설비
WO2017081288A1 (fr) 2015-11-11 2017-05-18 Lonza Ltd Protéines associées à crispr (cas) à immunogénicité réduite
US10576393B2 (en) * 2015-12-18 2020-03-03 General Electric Company System and method for condensing moisture in a bioreactor gas stream
CN105413554B (zh) * 2015-12-25 2018-09-18 奥星制药设备(石家庄)有限公司 基于一次性无菌袋的配液平台及其搅拌配制和转运方法
CN108778515B (zh) 2015-12-29 2020-11-17 生命科技股份有限公司 具有部分分割分隔区的柔性生物处理容器
WO2017123788A2 (fr) * 2016-01-12 2017-07-20 Sarfaraz Niazi Bioréacteur polyvalent
IL261411B2 (en) 2016-03-02 2024-03-01 Lonza Ag Improved fermentation process
US10689873B2 (en) 2016-03-10 2020-06-23 Lonza Ltd Customizable facility
CA3017165A1 (fr) 2016-03-10 2017-09-14 Lonza Ltd Installation personnalisable
WO2017207822A1 (fr) 2016-06-03 2017-12-07 Lonza Limited Bioréacteur à usage unique
US20180010082A1 (en) * 2016-06-03 2018-01-11 Lonza Ltd Bioreactor With Higher Agitation Rates
US10975409B2 (en) 2016-06-10 2021-04-13 Lonza Ltd Method for stabilizing proteins
JP7364334B2 (ja) 2016-06-24 2023-10-18 ロンザ リミテッド 直径可変型バイオリアクタ
US11359176B2 (en) 2016-07-12 2022-06-14 Global Life Sciences Solutions Usa Llc Microfluidic device for cell culture monitoring
WO2018026577A1 (fr) 2016-08-02 2018-02-08 Lonza Ltd Établissement adaptable
CN109891244A (zh) 2016-08-12 2019-06-14 隆扎有限公司 对宿主细胞蛋白质的蛋白质组分析
US10808216B2 (en) 2016-10-05 2020-10-20 Lonza Ltd Reactor surface finish remediation
CN110072602A (zh) 2016-11-17 2019-07-30 龙沙有限公司 具有过滤器锁定设计的过滤器组件
CN110087750A (zh) 2016-11-17 2019-08-02 龙沙有限公司 过滤器移动装置
CN110177864B (zh) 2016-12-01 2022-11-08 生命科技股份有限公司 微载体过滤袋总成和使用方法
WO2018107099A1 (fr) 2016-12-09 2018-06-14 Lonza Ltd Procédé de réduction du titre viral dans des médicaments
WO2018107067A1 (fr) 2016-12-09 2018-06-14 Lonza Ltd Disques de rupture pour bioréacteurs et leurs procédés d'utilisation
WO2018122247A1 (fr) 2016-12-29 2018-07-05 Ge Healthcare Bio-Sciences Ab Boîtier destiné à contenir un sac de biotraitement souple
KR20190105067A (ko) 2017-01-18 2019-09-11 론자 리미티드 모노클론성 평가 방법
WO2018144794A1 (fr) 2017-02-03 2018-08-09 Lonza Ltd Procédés d'analyse de pluralités de cellules et de détection de variants de séquences protéiques dans la fabrication de produits biologiques
US11559811B2 (en) 2017-02-10 2023-01-24 Lonza Ltd. Cell culture system and method
JP7467119B2 (ja) 2017-02-17 2024-04-15 ロンザ リミテッド 発現困難タンパク質のための多部位ssi細胞
WO2018151819A1 (fr) 2017-02-17 2018-08-23 Lonza Ltd Procédé de production de variants de produits biologiques
EP3583205A1 (fr) 2017-02-17 2019-12-25 Lonza Ltd Cellules de mammifère pour produire des virus adéno-associés
US10244406B2 (en) 2017-03-07 2019-03-26 Lonza Ltd. Wireless sensor information monitoring
ES2684630B2 (es) * 2017-03-30 2019-07-02 Inversiones Hiki6 S L Método, programa informático y planta multifuncional, modular y móvil de mezcla y envasado
KR102447734B1 (ko) 2017-04-07 2022-09-28 에피본, 인크. 접종 및 배양용 시스템 및 방법
US11054362B2 (en) * 2017-04-10 2021-07-06 David Robert Howland System and method for bacterial detection using film formation promotion with enhanced corrosion imbalance
US20200208171A1 (en) 2017-06-16 2020-07-02 Lonza Ltd Universal self-regulating mammalian cell line platform for the production of biologics
EP3684905A1 (fr) * 2017-09-19 2020-07-29 Life Technologies Corporation Systèmes et méthodes pour une chambre souple avec élément de mélange pliable
CN111433342A (zh) 2017-09-29 2020-07-17 龙沙有限公司 用于生物反应器系统的灌注装置
SG11202003030RA (en) 2017-10-03 2020-04-29 Abec Inc Reactor systems
KR20200068697A (ko) 2017-10-06 2020-06-15 론자 리미티드 라만 분광법을 사용하는 세포 배양의 자동 제어
WO2019077623A1 (fr) * 2017-10-17 2019-04-25 Shree Biocare Solutions Pvt. Ltd. Bioréacteur jetable amélioré
CN111630148A (zh) 2017-11-20 2020-09-04 隆萨有限公司 在防止乳酸积累的同时繁殖细胞培养物的过程和系统
JP2021509007A (ja) 2017-12-05 2021-03-18 ロンザ リミテッドLonza Limited トロポロンをアッセイする方法
US20200318051A1 (en) * 2017-12-28 2020-10-08 Locus Ip Company, Llc Reactors and Submerged Fermentation Methods for Producing Microbe-Based Products
JP7108036B2 (ja) 2018-02-02 2022-07-27 ロンザ リミテッド 細胞選択方法及び細胞代謝改変方法
US20210024864A1 (en) 2018-04-20 2021-01-28 Global Life Sciences Solutions Usa Llc Multiport plate for a bioprocess bag
WO2019209805A1 (fr) 2018-04-27 2019-10-31 Baxter International Inc. Procédé de mélange d'une solution pharmaceutique et système de mélange
US11447730B2 (en) 2018-05-30 2022-09-20 Global Life Sciences Solutions Usa Llc Bioreactor system and method of bioprocessing
US20210230531A1 (en) * 2018-06-05 2021-07-29 Vbc Holdings Llc Automated and dynamically adjustable gas mixer for bioreactor system
JP2021530225A (ja) 2018-07-13 2021-11-11 ロンザ リミテッドLonza Limited 内因性タンパク質のレベルを低下させることによって生物学的産物の産生を改善する方法
WO2020028616A1 (fr) 2018-08-02 2020-02-06 Lonza Ltd Procédés de fabrication d'une protéine de recombinaison comprenant une liaison disulfure
US10220361B1 (en) 2018-08-03 2019-03-05 Boris Dushine Magnetic stirring system for the automated and optimized reconstitution of powdered infant formulations and methods of using same
US10350561B1 (en) 2018-08-03 2019-07-16 Boris Dushine Magnetic stirring system for wine aeration and method of using same
WO2020041454A1 (fr) 2018-08-21 2020-02-27 Lonza Ltd Procédé de création de données de référence pour prédire les concentrations d'attributs de qualité
SG11202101860UA (en) 2018-08-31 2021-03-30 Genzyme Corp Sterile chromatography resin and use thereof in manufacturing processes
EP3844288A1 (fr) 2018-10-01 2021-07-07 Lonza Ltd. Cellules ssi à expression transgénique prévisible et stable et procédés de formation
GB201816897D0 (en) * 2018-10-17 2018-11-28 Ge Healthcare Bio Sciences Corp A Bioreactor System
KR102076363B1 (ko) * 2018-10-29 2020-02-11 바이오퍼스글로벌(주) 일회용 생물 발효기
US11065589B2 (en) 2018-12-10 2021-07-20 Pall Corporation Radially driven agitator
GB201900741D0 (en) 2019-01-18 2019-03-06 Synpromics Ltd Liver-specifc inducible prometers and methods of use thereof
SG11202108273UA (en) * 2019-02-01 2021-08-30 Abec Inc Reactor systems
US20200255791A1 (en) * 2019-02-08 2020-08-13 Georgia Tech Research Corporation Sensing Systems
ES2922351T3 (es) 2019-02-11 2022-09-13 Lonza Ag Método y sistema de formulación de tampones
DE102019110061B4 (de) * 2019-04-16 2023-11-30 Sartorius Stedim Biotech Gmbh Bioprozessbeutel für eine bioprozesstechnische Anlage
US20210016287A1 (en) 2019-07-16 2021-01-21 Ge Healthcare Bio-Sciences Corp. Reinforced bioreactor component structure system for cell cultivation
KR20220097910A (ko) 2019-11-14 2022-07-08 론자 리미티드 세포 선택 방법
US11535421B2 (en) * 2019-12-30 2022-12-27 Global Life Sciences Solutions Usa Llc System and method for packaging a bioprocessing bag and associated components, and packaging for a bioprocessing bag
JP2023509585A (ja) 2020-01-10 2023-03-09 ロンザ ウォーカーズヴィル,インコーポレーテッド 生物学的プロセスおよび細胞集団を精製するためのフィルター装置および方法
CA3171636A1 (fr) 2020-03-26 2021-09-30 Graham WHYTESIDE Promoteurs inductibles par forskoline et promoteurs inductibles par hypoxie
WO2021209743A1 (fr) 2020-04-15 2021-10-21 Synpromics Limited Promoteurs inductibles par forskoline et promoteurs inductibles par hypoxie
WO2022133105A1 (fr) 2020-12-18 2022-06-23 Lonza Biologics Inc. Déconnexion stérile de systèmes de bioprocédé et son procédé d'utilisation
NL2027815B1 (en) 2021-03-23 2022-10-07 Academisch Ziekenhuis Leiden Genomic integration
US11752509B2 (en) 2021-06-17 2023-09-12 Upside Foods, Inc. Fluid dispenser for recovering material from a surface
CA3231495A1 (fr) 2021-09-15 2023-03-23 Sanisure, Inc. Systeme de melange magnetique a faible volume
WO2024006236A1 (fr) 2022-06-28 2024-01-04 Amgen Inc. Configurations d'installation adaptatives pour la fabrication de produits thérapeutiques
DE102022117005A1 (de) * 2022-07-07 2024-01-18 Bausch + Ströbel SE + Co. KG Pumpvorrichtung und Pumpanordnung mit mindestens einer Pumpvorrichtung
CN116948817A (zh) * 2023-05-06 2023-10-27 四川大学 一次性生物安全型生物反应器以及监测方法

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE200792C (fr) 1907-09-28
US2793166A (en) * 1952-10-18 1957-05-21 Bristol Lab Inc Stirring device for laboratory fermenters
US2956739A (en) * 1957-02-13 1960-10-18 Tothill Gordon Roy Variable pitch impellers and closure seals therefor
US2958517A (en) * 1958-04-28 1960-11-01 Bellco Glass Inc Vessel for tissue culture and the like comprising a magnetic stirrer
US4162855A (en) * 1974-11-18 1979-07-31 Spectroderm International, Inc. Magnetic stirrer apparatus
SE397637B (sv) 1976-03-09 1977-11-14 Wik G Magnetomrorare
FR2376898A1 (fr) 1977-01-10 1978-08-04 Schick Josef Procede et installation pour la production microbiologique de proteines d'unicellulaires a partir d'ethanol
JPH0634698B2 (ja) * 1984-02-04 1994-05-11 オリンパス光学工業株式会社 反応分析装置
FR2569994B1 (fr) 1984-09-13 1986-11-21 Technicatome Dispositif de melange mobile
JPS6350311Y2 (fr) 1984-11-16 1988-12-23
US4620794A (en) 1984-11-20 1986-11-04 Jule Inc. Gradient formers
DE3577578D1 (de) * 1985-02-01 1990-06-13 Maerkl Herbert Folienfermenter.
US4668632A (en) 1985-02-06 1987-05-26 Vxr, Inc. Sparger and apparatus for and method of growing cells
US4724149A (en) * 1985-05-29 1988-02-09 Gul Valentin E Method for preservation of fish
US4882062A (en) 1986-08-29 1989-11-21 Rainin Instrument Co., Inc. Solvent mixing chamber for a liquid chromatography system
US4830511A (en) 1986-10-29 1989-05-16 The Coca-Cola Company Postmix juice dispensing system
EP0363441B1 (fr) 1987-03-02 1992-09-09 Ionode Pty. Ltd. Appareil et procede de melange
GB2202549A (en) 1987-03-20 1988-09-28 Philip John Whitney Foldable fermenter
JPS63233773A (ja) * 1987-03-23 1988-09-29 Reika Kogyo Kk 培養装置
JPS63278539A (ja) 1987-05-11 1988-11-16 Tosoh Corp 液分注装置
US4808348A (en) 1987-05-14 1989-02-28 The Coca-Cola Company Microgravity carbonator
JPS63283570A (ja) * 1987-05-15 1988-11-21 Daido Sanso Kk 発酵槽
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
IL86442A (en) 1988-05-19 1992-02-16 Plant Biotec Ltd Air lift fermenter formed from flexible plastic sheets
US5075234A (en) * 1988-11-02 1991-12-24 Josefino Tunac Fermentor/bioreactor systems having high aeration capacity
US5028142A (en) 1989-04-06 1991-07-02 Biotrack, Inc. Reciprocal mixer
JPH03160983A (ja) * 1989-11-21 1991-07-10 Toshiba Corp 培養装置
EP0487741A4 (en) 1990-06-14 1993-04-28 Kiichi Hirata Device for making emulsion and combustion system thereof
US5156701A (en) 1990-08-20 1992-10-20 Denco Inc. Total containment welding of plastic tubes
US5401212A (en) 1990-08-29 1995-03-28 Intelligent Enclosures Corporation Environmental control system
US5205783A (en) 1991-08-22 1993-04-27 Accu*Aire Systems, Inc. Air flow control equipment in chemical laboratory buildings
US5183336A (en) * 1992-01-21 1993-02-02 Kontes Glass Company Stirring assembly
US5664938A (en) 1992-03-05 1997-09-09 Yang; Frank Jiann-Fu Mixing apparatus for microflow gradient pumping
IT1258959B (it) 1992-06-09 1996-03-11 Impianto a moduli mobili per lo sviluppo e la produzione di prodotti biotecnologici su scala pilota
US5227138A (en) 1992-09-09 1993-07-13 Virginia Mason Clinic Blood transport apparatus
US5240322A (en) 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with rotatable vaned internal magnetic mixing element
US5352036A (en) 1992-09-23 1994-10-04 Habley Medical Technology Corporation Method for mixing and dispensing a liquid pharmaceutical with a miscible component
US5261742A (en) 1993-02-23 1993-11-16 Eastman Kodak Company Air-powered apparatus and method for mixing a liquefied sample and weighing the sample
US5368390A (en) 1993-03-01 1994-11-29 General Signal Corporation Mixer systems
JP2663327B2 (ja) * 1993-05-20 1997-10-15 哲夫 西田 培養処理槽及びこれを併設した水処理施設
US5342781A (en) 1993-07-15 1994-08-30 Su Wei Wen W External-loop perfusion air-lift bioreactor
IL110456A0 (en) 1993-07-30 1994-10-21 Du Pont Apparatus for multiphase liquid separation
US5591344A (en) 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
US6500343B2 (en) 1995-02-21 2002-12-31 Iqbal W. Siddiqi Method for mixing and separation employing magnetic particles
WO1996026011A1 (fr) 1995-02-21 1996-08-29 Siddiqi Iqbal W Appareil et procede de melange et de separation a l'aide de particules magnetiques
US5478149A (en) 1995-04-24 1995-12-26 Magnetic Mixers, Inc. Magnetic mixer
JPH09141079A (ja) 1995-11-15 1997-06-03 Shiseido Co Ltd 水溶性両親媒性高分子電解質からなる乳化剤、これを配合した乳化組成物及び乳化化粧料
IL119310A (en) 1996-09-26 1999-07-14 Metabogal Ltd Cell/tissue culturing device and method
US5779359A (en) 1996-12-05 1998-07-14 General Signal Corporation Mixer having exposed clean-in-place bearing assemblies
US5758965A (en) 1996-12-05 1998-06-02 General Signal Corporation Mixer system
JP3705461B2 (ja) 1996-12-26 2005-10-12 富士写真フイルム株式会社 ハロゲン化銀乳剤の製造方法及びハロゲン化銀写真乳剤
DE69841409D1 (de) 1997-05-20 2010-02-04 Zymequest Inc Gerät zum selektiven Exprimieren von ein oder mehreren flüssigen Materialien aus einem Behälter
KR100234283B1 (ko) 1997-08-27 1999-12-15 윤종용 습식현상기의 현상액 공급 시스템
US5939313A (en) * 1997-09-12 1999-08-17 Praxair Technology, Inc. Stationary vortex system for direct injection of supplemental reactor oxygen
CN1064403C (zh) * 1997-12-31 2001-04-11 华南理工大学 管道气升式磁处理光生物反应器微藻生产系统及监控方法
US6247840B1 (en) 1998-01-15 2001-06-19 Shaik A. Gaffar Dialysis container with sample saver
AU6021699A (en) 1998-09-01 2000-03-21 Penn State Research Foundation Method and apparatus for aseptic growth or processing of biomass
US6086243A (en) 1998-10-01 2000-07-11 Sandia Corporation Electrokinetic micro-fluid mixer
US8026096B1 (en) 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US6379625B1 (en) 1999-12-23 2002-04-30 Peter Zuk, Jr. Apparatus comprising a disposable device and reusable instrument for synthesizing chemical compounds, and for testing chemical compounds for solubility
US6416215B1 (en) 1999-12-14 2002-07-09 University Of Kentucky Research Foundation Pumping or mixing system using a levitating magnetic element
US6432698B1 (en) 1999-01-06 2002-08-13 Rutgers, The State University Disposable bioreactor for culturing microorganisms and cells
US6391698B1 (en) 1999-02-26 2002-05-21 United Microelectronics Corp. Forming complementary metal-oxide semiconductor with gradient doped source/drain
US6132309A (en) 1999-03-10 2000-10-17 Panelli; Paul Giulo Modular clean room plenum
DE19917398C2 (de) 1999-04-16 2002-06-20 Accoris Gmbh Modulares chemisches Mikrosystem
IL129564A (en) 1999-04-23 2004-06-20 Atlantium Lasers Ltd A method for disinfecting and purifying liquids and gases and a device for its use
US6357907B1 (en) 1999-06-15 2002-03-19 V & P Scientific, Inc. Magnetic levitation stirring devices and machines for mixing in vessels
ATE411110T1 (de) 1999-07-19 2008-10-15 Biomerieux Bv Verfahren zum mengen von magnetteilchen mit einer flüssigkeit
FR2799138B1 (fr) * 1999-10-05 2002-02-08 Opifex Reacteur pour la realisation de cultures cellulaires ou de micro-organismes ou pour la mise en solution ou en suspension de poudre dans un milieu liquide
US6758593B1 (en) 2000-10-09 2004-07-06 Levtech, Inc. Pumping or mixing system using a levitating magnetic element, related system components, and related methods
US6402367B1 (en) 2000-06-01 2002-06-11 Aemp Corporation Method and apparatus for magnetically stirring a thixotropic metal slurry
US6837613B2 (en) 2001-04-10 2005-01-04 Levtech, Inc. Sterile fluid pumping or mixing system and related method
AU783125B2 (en) 2000-10-31 2005-09-29 Dsm Ip Assets B.V. Optimisation of fermentation processes
US6544788B2 (en) * 2001-02-15 2003-04-08 Vijay Singh Disposable perfusion bioreactor for cell culture
US6467946B1 (en) 2001-04-24 2002-10-22 Dade Microscan Inc. Method and apparatus for mixing liquid samples in a container using rotating magnetic fields
JP2002350500A (ja) * 2001-05-24 2002-12-04 Mitsubishi Electric Corp 半導体集積回路装置
US6670171B2 (en) * 2001-07-09 2003-12-30 Wheaton Usa, Inc. Disposable vessel
AU2002325755A1 (en) 2001-09-18 2003-04-01 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
EP1534412B1 (fr) 2001-10-03 2010-08-18 Levtech Inc. Recipient de melange possedant un receptacle pour un element agitateur de fluide
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US6736906B2 (en) 2002-04-10 2004-05-18 International Business Machines Corporation Turbine part mount for supercritical fluid processor
US20030198128A1 (en) 2002-04-19 2003-10-23 Carlson Roger W. Mixing system having non-contacting bearings
US6837610B2 (en) * 2002-09-27 2005-01-04 Ilc Dover Lpp Bioprocess container, bioprocess container mixing device and method of use thereof
US6673598B1 (en) 2002-10-29 2004-01-06 Synthecon, Inc. Disposable culture bag
US7144727B2 (en) 2003-04-14 2006-12-05 Synthecon, Inc. Interlinked culture chamber for biologicals
US20040229335A1 (en) 2003-05-15 2004-11-18 Introgen Therapeutics, Inc. Methods and compositions for the production of adenoviral vectors
US7168848B2 (en) 2003-07-02 2007-01-30 Spx Corporation Axial-pumping impeller apparatus and method for magnetically-coupled mixer
US20050076076A1 (en) 2003-08-08 2005-04-07 Liberty Logistics Inc. Collaborative logistics information exchange method and apparatus
CA2552717C (fr) * 2004-01-07 2011-11-29 Levtech, Inc. Sac melangeur a arroseur integre et receptacle pour detecteur
MXPA06011837A (es) * 2004-04-27 2007-01-16 Baxter Int Sistema de reactor de tanque agitado.

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ES2612212T3 (es) 2017-05-12
MXPA06014099A (es) 2007-05-09
JP4680990B2 (ja) 2011-05-11
EP1773976A2 (fr) 2007-04-18
US20050272146A1 (en) 2005-12-08
EP1773976B2 (fr) 2020-01-01
CA2569405A1 (fr) 2005-12-15
NO20070069L (no) 2007-03-05
AU2005250500B2 (en) 2011-06-23
CN101001945A (zh) 2007-07-18
CN102492607B (zh) 2014-12-10
AU2005250500A1 (en) 2005-12-15
BRPI0510648A (pt) 2007-11-20
US7629167B2 (en) 2009-12-08
EP1773976B1 (fr) 2016-12-07
DK1773976T3 (en) 2017-01-30
CA2569405C (fr) 2011-05-03
ES2612212T5 (es) 2020-06-25
CN101001945B (zh) 2012-02-08
CN102492607A (zh) 2012-06-13
CR8769A (es) 2007-08-28
WO2005118771A2 (fr) 2005-12-15
BRPI0510648B1 (pt) 2016-04-26
KR20070053200A (ko) 2007-05-23
KR101021203B1 (ko) 2011-03-11
JP2008501347A (ja) 2008-01-24
WO2005118771A3 (fr) 2006-02-02
DK1773976T4 (da) 2020-02-10

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