HK1061233A1 - Broadspectrum 2-(substituted-amino)- benzothiazol e sulfonamide hiv protease inhibitors - Google Patents
Broadspectrum 2-(substituted-amino)- benzothiazol e sulfonamide hiv protease inhibitorsInfo
- Publication number
- HK1061233A1 HK1061233A1 HK04104020A HK04104020A HK1061233A1 HK 1061233 A1 HK1061233 A1 HK 1061233A1 HK 04104020 A HK04104020 A HK 04104020A HK 04104020 A HK04104020 A HK 04104020A HK 1061233 A1 HK1061233 A1 HK 1061233A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- 4alkyl
- 6alkyl
- substituted
- het2
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01200529 | 2001-02-14 | ||
US28775801P | 2001-05-02 | 2001-05-02 | |
PCT/EP2002/001788 WO2002083657A2 (en) | 2001-02-14 | 2002-02-14 | Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1061233A1 true HK1061233A1 (en) | 2004-09-10 |
Family
ID=26076833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK04104020A HK1061233A1 (en) | 2001-02-14 | 2004-06-03 | Broadspectrum 2-(substituted-amino)- benzothiazol e sulfonamide hiv protease inhibitors |
Country Status (31)
Country | Link |
---|---|
US (1) | US7659404B2 (es) |
EP (1) | EP1370543B1 (es) |
JP (1) | JP4530612B2 (es) |
KR (1) | KR100870184B1 (es) |
CN (2) | CN100369904C (es) |
AP (1) | AP1504A (es) |
AT (1) | ATE343567T1 (es) |
AU (1) | AU2002302363B2 (es) |
BG (1) | BG66301B1 (es) |
BR (1) | BR0207862A (es) |
CA (1) | CA2438304C (es) |
CY (1) | CY1108073T1 (es) |
CZ (1) | CZ304273B6 (es) |
DE (1) | DE60215623T2 (es) |
DK (1) | DK1370543T3 (es) |
EA (1) | EA006096B1 (es) |
EE (1) | EE05385B1 (es) |
ES (1) | ES2275866T3 (es) |
HK (1) | HK1061233A1 (es) |
HR (1) | HRP20030735B1 (es) |
HU (1) | HU229224B1 (es) |
IL (2) | IL157171A0 (es) |
MX (1) | MXPA03007236A (es) |
NO (1) | NO326174B1 (es) |
NZ (1) | NZ527391A (es) |
PL (1) | PL213327B1 (es) |
PT (1) | PT1370543E (es) |
SI (1) | SI1370543T1 (es) |
SK (1) | SK287582B6 (es) |
WO (1) | WO2002083657A2 (es) |
ZA (1) | ZA200306086B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1185712B8 (en) | 1999-05-28 | 2005-10-19 | Virco Bvba | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
MXPA03003476A (es) | 2000-10-20 | 2004-09-10 | Virco Bvba | Nuevos perfiles mutacionales en transcriptasa inversa de vih-1 correlacionan con resistencia fenotipica a farmaco. |
ES2275866T3 (es) | 2001-02-14 | 2007-06-16 | Tibotec Pharmaceuticals Ltd. | 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih. |
US7109230B2 (en) | 2002-01-07 | 2006-09-19 | Sequoia Pharmaceuticals, Inc. | Resistance-repellent retroviral protease inhibitors |
US7157489B2 (en) | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
EP1520247B1 (en) | 2002-07-01 | 2009-05-27 | Tibotec Pharmaceuticals Ltd. | Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance |
WO2004003223A2 (en) | 2002-07-01 | 2004-01-08 | Tibotec Pharmaceuticals Ltd. | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
JP4879484B2 (ja) * | 2002-08-02 | 2012-02-22 | テイボテク・フアーマシユーチカルズ・リミテツド | 広スペクトルの2−アミノ−ベンゾチアゾールスルホンアミドhivプロテアーゼ阻害剤 |
BR0305717A (pt) * | 2002-08-02 | 2004-09-28 | Tibotec Pharm Ltd | Inibidores da protease do hiv 2-amino-benzotiazol sulfonamida de amplo espectro |
CN1860107B (zh) * | 2003-09-30 | 2013-08-21 | 泰博特克药品有限公司 | 苯并*唑磺酰胺化合物的制备方法及其中间体 |
DE10360835A1 (de) * | 2003-12-23 | 2005-07-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Imidazolverbindungen, deren Herstellung und deren Verwendung als Arzneimittel |
JP5073480B2 (ja) * | 2004-05-07 | 2012-11-14 | セコイア、ファーマシューティカルズ、インコーポレイテッド | 耐性防止レトロウイルスプロテアーゼ阻害薬 |
WO2006089942A1 (en) | 2005-02-25 | 2006-08-31 | Tibotec Pharmaceuticals Ltd. | Protease inhibitor precursor synthesis |
AR053845A1 (es) | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450 |
JO2841B1 (en) * | 2006-06-23 | 2014-09-15 | تيبوتيك فارماسيوتيكالز ليمتد | 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV) |
WO2011061590A1 (en) | 2009-11-17 | 2011-05-26 | Hetero Research Foundation | Novel carboxamide derivatives as hiv inhibitors |
JO3090B1 (ar) * | 2009-12-11 | 2017-03-15 | Janssen Sciences Ireland Uc | 5- امينو-4- هيدروكسي-بنتويل اميدات |
US9024038B2 (en) | 2010-12-27 | 2015-05-05 | Purdue Research Foundation | Compunds and methods for treating HIV |
MD20140063A2 (ro) | 2012-04-20 | 2014-12-31 | Gilead Sciences, Inc. | Derivaţi de acid benzotiazol-6-il acetic şi utilizarea acestora pentru tratarea unei infecţii HIV |
CN104000824B (zh) * | 2014-05-28 | 2016-07-06 | 中山大学 | 苯并五元杂环类化合物在制备抗hiv-1病毒药物中的应用 |
US11439608B2 (en) | 2017-09-25 | 2022-09-13 | Qun Lu | Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE141635T1 (de) | 1990-03-09 | 1996-09-15 | Milliken Res Corp | Organische materialien, die sulfonamidogebundene poly(oxyalkylen)gruppen tragen und ihre herstellung |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5843946A (en) * | 1992-08-25 | 1998-12-01 | G.D. Searle & Co. | α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
ES2127938T3 (es) | 1993-08-24 | 1999-05-01 | Searle & Co | Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas. |
PT721331E (pt) | 1993-10-01 | 2002-05-31 | Astrazeneca Ab | Processo i |
ES2303337T3 (es) | 1995-01-20 | 2008-08-01 | G.D. Searle Llc | Inhibidores de la proteasa retroviral de bis-hidroxietilamino sulfonamida. |
US6140505A (en) | 1995-03-10 | 2000-10-31 | G. D. Searle & Co. | Synthesis of benzo fused heterocyclic sulfonyl chlorides |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6143788A (en) * | 1995-03-10 | 2000-11-07 | G.D. Searle & Co. | Bis-amino acid hydroxyethlamino sulfonamide retroviral protease inhibitors |
CZ297676B6 (cs) * | 1995-03-10 | 2007-03-07 | G. D. Searle & Co. | Deriváty hydroxyethylaminosulfonamidu jako inhibitory retrovirové proteázy, farmaceutická kompozice |
US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6861539B1 (en) * | 1995-03-10 | 2005-03-01 | G. D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
AU7722296A (en) | 1995-11-15 | 1997-06-05 | G.D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
CA2240161C (en) | 1996-05-20 | 2005-05-24 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
ID21477A (id) | 1997-03-26 | 1999-06-17 | Janssen Pharmaceutica Nv | Pelet-pelet yang mempunyai inti yang dilapisi dengan suatu anti jamur dan suatu polimer |
AU2012199A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
WO1999033792A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
EP1042280A2 (en) * | 1997-12-24 | 2000-10-11 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
WO1999065870A2 (en) * | 1998-06-19 | 1999-12-23 | Vertex Pharmaceuticals Incorporated | Sulfonamide inhibitors of aspartyl protease |
AU771780B2 (en) | 1998-06-23 | 2004-04-01 | Board Of Trustees Of The University Of Illinois, The | Fitness assay and associated methods |
AU4828199A (en) | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
ES2275866T3 (es) | 2001-02-14 | 2007-06-16 | Tibotec Pharmaceuticals Ltd. | 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih. |
-
2002
- 2002-02-14 ES ES02729930T patent/ES2275866T3/es not_active Expired - Lifetime
- 2002-02-14 AU AU2002302363A patent/AU2002302363B2/en not_active Ceased
- 2002-02-14 PL PL363778A patent/PL213327B1/pl unknown
- 2002-02-14 BR BR0207862-7A patent/BR0207862A/pt not_active IP Right Cessation
- 2002-02-14 AT AT02729930T patent/ATE343567T1/de active
- 2002-02-14 SI SI200230467T patent/SI1370543T1/sl unknown
- 2002-02-14 PT PT02729930T patent/PT1370543E/pt unknown
- 2002-02-14 DE DE60215623T patent/DE60215623T2/de not_active Expired - Lifetime
- 2002-02-14 JP JP2002581413A patent/JP4530612B2/ja not_active Expired - Fee Related
- 2002-02-14 KR KR1020037010506A patent/KR100870184B1/ko not_active IP Right Cessation
- 2002-02-14 CA CA2438304A patent/CA2438304C/en not_active Expired - Fee Related
- 2002-02-14 US US10/467,609 patent/US7659404B2/en not_active Expired - Fee Related
- 2002-02-14 EE EEP200300381A patent/EE05385B1/xx not_active IP Right Cessation
- 2002-02-14 DK DK02729930T patent/DK1370543T3/da active
- 2002-02-14 CZ CZ2003-2415A patent/CZ304273B6/cs not_active IP Right Cessation
- 2002-02-14 HU HU0303257A patent/HU229224B1/hu not_active IP Right Cessation
- 2002-02-14 NZ NZ527391A patent/NZ527391A/xx not_active IP Right Cessation
- 2002-02-14 IL IL15717102A patent/IL157171A0/xx unknown
- 2002-02-14 CN CNB028049829A patent/CN100369904C/zh not_active Expired - Fee Related
- 2002-02-14 CN CN2007101997173A patent/CN101230067B/zh not_active Expired - Fee Related
- 2002-02-14 WO PCT/EP2002/001788 patent/WO2002083657A2/en active IP Right Grant
- 2002-02-14 MX MXPA03007236A patent/MXPA03007236A/es active IP Right Grant
- 2002-02-14 AP APAP/P/2003/002856A patent/AP1504A/en active
- 2002-02-14 EP EP02729930A patent/EP1370543B1/en not_active Expired - Lifetime
- 2002-02-14 EA EA200300891A patent/EA006096B1/ru not_active IP Right Cessation
- 2002-02-14 SK SK1102-2003A patent/SK287582B6/sk not_active IP Right Cessation
-
2003
- 2003-07-30 IL IL157171A patent/IL157171A/en not_active IP Right Cessation
- 2003-08-06 ZA ZA2003/06086A patent/ZA200306086B/en unknown
- 2003-08-13 NO NO20033584A patent/NO326174B1/no not_active IP Right Cessation
- 2003-09-01 BG BG108143A patent/BG66301B1/bg unknown
- 2003-09-12 HR HR20030735A patent/HRP20030735B1/xx not_active IP Right Cessation
-
2004
- 2004-06-03 HK HK04104020A patent/HK1061233A1/xx not_active IP Right Cessation
-
2007
- 2007-01-25 CY CY20071100088T patent/CY1108073T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1061233A1 (en) | Broadspectrum 2-(substituted-amino)- benzothiazol e sulfonamide hiv protease inhibitors | |
CY1109247T1 (el) | Αναστολεις πρωτεασης hiv σουλφοναμιδιου 2-αμινο-βενζοξαζολης ευρεως φασματος | |
MXPA03009179A (es) | 2-(amino sustituido)-benzoxazol sunfonamidas, inhibidores de amplio espectro de la vih proteasa. | |
AR038240A1 (es) | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para su preparacion | |
HUP0402019A2 (hu) | CCR5 antagonistaként alkalmazható piperidinszármazékok és ezeket tartalmazó gyógyszerkészítmények | |
MXPA05011726A (es) | Inhibidores de intregrasa de virus de inmunodeficiencia humana. | |
MY135226A (en) | Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors | |
ES2053525T3 (es) | Acidos hidroxamicos. | |
EA200500350A1 (ru) | Замещенные оксиндолсульфонамидные ингибиторы вич-протеазы широкого спектра действия | |
MXPA04008926A (es) | Inhibidores de entrada a moleculas pequenas. | |
MXPA04008929A (es) | Benzimidazol sulfonamidas sustituidas como inhibidores de amplio espectro de la proteasa del vih. | |
AP1922A (en) | Broadspectrum heterocylclic substituted phenyl containing sulfonamide HIV protease inhibitors. | |
AR045117A1 (es) | Imidazo-pirimidinas y triazolo-pirimidinas:ligandos del receptor de benzodiazepina | |
EA200400756A1 (ru) | Новые соединения бензотиазина и бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат | |
TH85263A (th) | สารยับยั้ง hiv โปรติเอส ที่เป็นเบนซิโซซาโซล ซัลโฟนามีด ที่ถูกแทนที่ สเปกตรัมกว้าง | |
TH85263B (th) | สารยับยั้ง hiv โปรติเอส ที่เป็นเบนซิโซซาโซล ซัลโฟนามีด ที่ถูกแทนที่ สเปกตรัมกว้าง | |
EA200501682A1 (ru) | Ингибиторы вич-интегразы | |
TH54292B (th) | กรรมวิธีสำหรับการเตรียม n-แอริล-แอนธรานิลิคแอซิด และอนุพันธ์ของสารเหล่านั้น | |
ATE508746T1 (de) | Substituiertes indolpyridinium als antiinfektive verbindungen | |
TH80948B (th) | สารประกอบในฐานะ ccr-1 แอนตะโกนิสท์ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20160214 |