MXPA05011726A - Inhibidores de intregrasa de virus de inmunodeficiencia humana. - Google Patents

Inhibidores de intregrasa de virus de inmunodeficiencia humana.

Info

Publication number
MXPA05011726A
MXPA05011726A MXPA05011726A MXPA05011726A MXPA05011726A MX PA05011726 A MXPA05011726 A MX PA05011726A MX PA05011726 A MXPA05011726 A MX PA05011726A MX PA05011726 A MXPA05011726 A MX PA05011726A MX PA05011726 A MXPA05011726 A MX PA05011726A
Authority
MX
Mexico
Prior art keywords
optionally polysubstituted
polysubstituted
hiv integrase
integrase inhibitors
optionally
Prior art date
Application number
MXPA05011726A
Other languages
English (en)
Inventor
Inge Dierynck
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of MXPA05011726A publication Critical patent/MXPA05011726A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a los compuestos que tienen la formula (I) (ver formula (I)), y sus N-oxidos, sales, formas estereoisomericas, mezclas racemicas, profarmacos, esteres y metabolitos de los mismos, en los cuales X es (ver formula) A, conjuntamente con los carbonos del anillo fenilo al cual estan unidos forman un arilo monociclico o un Het2 monociclico; R1 es hidrogeno, halo, nitro, ciano, sultam, sultim, cicloalquilo de C3-7, C(=O)-R5, S(=O)y-R6, OR7, NR8R9, C(=NR8)-R5, alquilo de C1-6 opcionalmente polisustituido, alquenilo de C2-6 opcionalmente polisustituido o alquinilo de C2-6 opcionalmente polisustituido; R2 es hidrogeno, cicloalquilo de C3-7, arilo, Het1, Het2, C(=O)-R5, S(=O)y-R6, OR7, NR8R9, C(=NR8)-R5, o alquilo de C1-6 opcionalmente polisustituido, alquenilo de C2-6 opcionalmente polisustituido o alquinilo de C2-6 opcionalmente polisustituido; ademas se refiere a su uso como inhibidores de integrasa de VIH, los procedimientos para su preparacion asi como tambien las composiciones farmaceuticas y a los equipos de diagnostico que los comprenden; se refiere tambien a las combinaciones de los mismos con otros agentes antirretrovirales, y a su uso en los ensayos como compuestos o como reactivos de referencia.
MXPA05011726A 2003-04-28 2004-04-27 Inhibidores de intregrasa de virus de inmunodeficiencia humana. MXPA05011726A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46598703P 2003-04-28 2003-04-28
EP03101164 2003-04-28
PCT/EP2004/050621 WO2004096807A2 (en) 2003-04-28 2004-04-27 Hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
MXPA05011726A true MXPA05011726A (es) 2006-01-23

Family

ID=33420586

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011726A MXPA05011726A (es) 2003-04-28 2004-04-27 Inhibidores de intregrasa de virus de inmunodeficiencia humana.

Country Status (13)

Country Link
US (1) US20060211724A1 (es)
EP (1) EP1625130A2 (es)
KR (1) KR20060006047A (es)
CN (1) CN1812992A (es)
AP (1) AP2005003451A0 (es)
AR (1) AR044518A1 (es)
AU (1) AU2004234087A1 (es)
BR (1) BRPI0409873A (es)
CA (1) CA2522990A1 (es)
MX (1) MXPA05011726A (es)
NO (1) NO20055230L (es)
TW (1) TW200507848A (es)
WO (1) WO2004096807A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200716632A (en) * 2005-05-16 2007-05-01 Gilead Sciences Inc Integrase inhibitor compounds
EP1885722B1 (en) 2005-05-19 2011-11-16 Merck Canada Inc. Quinoline derivatives as ep4 antagonists
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
CA2616314A1 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of hiv
US20080039487A1 (en) * 2005-12-21 2008-02-14 Gilead Sciences, Llc Processes and intermediates useful for preparing integrase inhibitor compounds
US20090306054A1 (en) * 2006-05-16 2009-12-10 Gilead Sciences ,Inc. Integrase inhibitors
EP1916249A1 (en) * 2006-10-10 2008-04-30 LEK Pharmaceuticals D.D. 3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(thio)oxo-2-(thio)oxo-azolidin-5-ylidene derivatives as antibacterial agents
DK2124562T3 (en) 2007-03-09 2016-08-01 Second Genome Inc BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof
US20090291921A1 (en) * 2007-11-20 2009-11-26 Gilead Sciences, Inc. Integrase inhibitors
JP5562255B2 (ja) 2008-01-25 2014-07-30 キメリクス，インコーポレイテッド ウイルス感染を治療する方法
US8822500B2 (en) 2008-03-19 2014-09-02 Chembridge Corporation Tyrosine kinase inhibitors
US9249147B2 (en) 2008-03-19 2016-02-02 Chembridge Corporation Tyrosine kinase inhibitors
MX2010010272A (es) 2008-03-19 2011-05-25 Chembridge Corp Nuevos inhibidores de tirosina quinasa.
KR20120034592A (ko) * 2009-04-09 2012-04-12 베링거 인겔하임 인터내셔날 게엠베하 Ｈｉｖ 복제의 저해제
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
EP3830093A1 (en) 2018-07-27 2021-06-09 Biotheryx, Inc. Bifunctional compounds as cdk modulators
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6841558B2 (en) * 2000-10-12 2005-01-11 Merck & Co., Inc. Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors
AU2003301439A1 (en) * 2002-10-16 2004-05-04 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US7442773B2 (en) * 2004-01-23 2008-10-28 The Board Of Trustees Of The University Of Illinois Universal peptide-binding scaffolds and protein chips

Also Published As

Publication number Publication date
EP1625130A2 (en) 2006-02-15
KR20060006047A (ko) 2006-01-18
AR044518A1 (es) 2005-09-14
WO2004096807A8 (en) 2005-09-22
TW200507848A (en) 2005-03-01
WO2004096807A2 (en) 2004-11-11
WO2004096807A3 (en) 2005-01-06
AU2004234087A1 (en) 2004-11-11
NO20055230L (no) 2005-11-07
US20060211724A1 (en) 2006-09-21
BRPI0409873A (pt) 2006-05-16
CA2522990A1 (en) 2004-11-11
CN1812992A (zh) 2006-08-02
AP2005003451A0 (en) 2005-12-31

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