JO3090B1 - 5- امينو-4- هيدروكسي-بنتويل اميدات - Google Patents

5- امينو-4- هيدروكسي-بنتويل اميدات

Info

Publication number
JO3090B1
JO3090B1 JOP/2010/0423A JOP20100423A JO3090B1 JO 3090 B1 JO3090 B1 JO 3090B1 JO P20100423 A JOP20100423 A JO P20100423A JO 3090 B1 JO3090 B1 JO 3090B1
Authority
JO
Jordan
Prior art keywords
4alkyl
4alkoxy
pentoyl
amides
hydroxy
Prior art date
Application number
JOP/2010/0423A
Other languages
English (en)
Inventor
Kevin Parkes
Johannes Wilhelmus J Thuring
Bengt Bertil Samuelsson
Wim Bert Griet Schepens
Genadiy Kalayanov
Bart Rudolf Romanie Kesteleyn
Jörg Kurt Wegner
Hans Kristian Wallberg
Original Assignee
Janssen Sciences Ireland Uc
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc, Medivir Ab filed Critical Janssen Sciences Ireland Uc
Application granted granted Critical
Publication of JO3090B1 publication Critical patent/JO3090B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

مثبطات HIV لها الصيغة : حيث R1 هي هالو ، الكوكسي 1-4 ذرات كربون ، ثالث فلورو ميثوكسي ; R2 هي: R3 هي: R4 :هي N هي صفر أو 1 ، A هي CH أو N ،R5 و R6 هما هيدروجين ، الكيل 1-4 ذرات كربون ، هالو ، R7 و R8 هما الكيل 1-4 ذرات كربون أو الكوكسي الكيل 1-4 ذرات كربون ، R9 هي الكيل 1-4 ذرات الكربون ، بروبيل حلقي ، ثالث فلورو ميثيل ، الوكسي 1-4 ذرات كربون أو ثاني ميثيل امينو ، R10 هو هيدروجين ، الكيل 1-4 ذرات الكربون ، بروبيل حلقي ، ثالث فلورو ميثيل ، الوكسي 1-4 ذرات كربون أو ثاني ميثيل امينو ، و أملاح الاضافة و المائيات المقبولة صيدلانيا ، التركيبات الصيدلانية المحتوية لهذه المركبات بصفتها محتويات فعالة و عمليات لتحضير المركبات الذكورة .
JOP/2010/0423A 2009-12-11 2010-11-30 5- امينو-4- هيدروكسي-بنتويل اميدات JO3090B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09178979 2009-12-11
EP10162370 2010-05-10

Publications (1)

Publication Number Publication Date
JO3090B1 true JO3090B1 (ar) 2017-03-15

Family

ID=43534084

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2010/0423A JO3090B1 (ar) 2009-12-11 2010-11-30 5- امينو-4- هيدروكسي-بنتويل اميدات

Country Status (24)

Country Link
US (1) US8592429B2 (ar)
EP (1) EP2509950B1 (ar)
JP (1) JP5797662B2 (ar)
KR (1) KR101771698B1 (ar)
CN (1) CN102770413B (ar)
AP (1) AP3217A (ar)
AR (1) AR079354A1 (ar)
AU (1) AU2010329867B2 (ar)
BR (1) BR112012013493B1 (ar)
CA (1) CA2783929C (ar)
DK (1) DK2509950T3 (ar)
EA (1) EA020758B1 (ar)
ES (1) ES2536774T3 (ar)
HK (1) HK1177454A1 (ar)
IL (1) IL219272A (ar)
JO (1) JO3090B1 (ar)
MX (1) MX2012006613A (ar)
NZ (1) NZ599916A (ar)
PL (1) PL2509950T3 (ar)
PT (1) PT2509950E (ar)
SG (1) SG181609A1 (ar)
TW (1) TWI485149B (ar)
UY (1) UY33098A (ar)
WO (1) WO2011070131A1 (ar)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3575301A4 (en) 2017-03-16 2020-08-05 Jiangsu Hengrui Medicine Co., Ltd. HETEROARYL [4,3-C] PYRIMIDINE-5-AMINE DERIVATIVE, PROCESS FOR PREPARATION AND MEDICAL USES

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
EP0534511A1 (en) * 1991-08-16 1993-03-31 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
CN1089269A (zh) * 1993-01-04 1994-07-13 希巴-盖吉股份公司 新颖的作为治疗剂的5-氨基-4-羟基己酸衍生物
US5733882A (en) * 1994-01-17 1998-03-31 Smithkline Beecham Corporation Retroviral protease inhibitors
PT708085E (pt) * 1994-10-19 2002-11-29 Novartis Ag Eteres antivirais de isosteros de substrato de aspartato protease
BR0207862A (pt) * 2001-02-14 2004-06-22 Tibotec Pharm Ltd Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro
TWI286476B (en) * 2001-12-12 2007-09-11 Tibotec Pharm Ltd Combination of cytochrome P450 dependent protease inhibitors
US7834043B2 (en) * 2003-12-11 2010-11-16 Abbott Laboratories HIV protease inhibiting compounds
CN101115713A (zh) * 2005-02-10 2008-01-30 美迪维尔公司 人类免疫缺陷性病毒蛋白酶抑制剂
CA2594395A1 (en) * 2005-02-10 2006-08-17 Medivir Ab Hiv protease inhibitors
WO2007048557A1 (en) * 2005-10-25 2007-05-03 Medivir Ab Protease inhibitors
JO2841B1 (ar) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2- (مستبدلة- امينو )- بنزوثيازول سلفوناميد بصفتها مثبطات بروتييز اتش اي في (فيروس نقص المناعة البشرية )
ES2574831T3 (es) * 2006-07-21 2016-06-22 Gilead Sciences, Inc. Inhibidores de la proteasa antivirales

Also Published As

Publication number Publication date
BR112012013493A8 (pt) 2017-12-26
ES2536774T3 (es) 2015-05-28
KR20120107104A (ko) 2012-09-28
IL219272A0 (en) 2012-06-28
AP3217A (en) 2015-04-30
TWI485149B (zh) 2015-05-21
IL219272A (en) 2014-09-30
CA2783929A1 (en) 2011-06-16
EA020758B1 (ru) 2015-01-30
CN102770413B (zh) 2015-08-26
CA2783929C (en) 2020-04-07
CN102770413A (zh) 2012-11-07
EP2509950B1 (en) 2015-02-25
US20120295920A1 (en) 2012-11-22
DK2509950T3 (en) 2015-05-18
WO2011070131A1 (en) 2011-06-16
KR101771698B1 (ko) 2017-08-25
PT2509950E (pt) 2015-06-08
NZ599916A (en) 2013-10-25
MX2012006613A (es) 2012-07-10
BR112012013493A2 (pt) 2016-05-31
PL2509950T3 (pl) 2015-10-30
JP2013513576A (ja) 2013-04-22
JP5797662B2 (ja) 2015-10-21
US8592429B2 (en) 2013-11-26
BR112012013493B1 (pt) 2020-12-08
UY33098A (es) 2011-06-30
TW201130823A (en) 2011-09-16
AU2010329867A1 (en) 2012-05-24
EA201290487A1 (ru) 2012-11-30
SG181609A1 (en) 2012-07-30
EP2509950A1 (en) 2012-10-17
HK1177454A1 (en) 2013-08-23
AP2012006228A0 (en) 2012-04-30
AR079354A1 (es) 2012-01-18
AU2010329867B2 (en) 2016-01-28

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