HK1048479A1 - 包含烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂 - Google Patents

包含烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂 Download PDF

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Publication number
HK1048479A1
HK1048479A1 HK03100478.8A HK03100478A HK1048479A1 HK 1048479 A1 HK1048479 A1 HK 1048479A1 HK 03100478 A HK03100478 A HK 03100478A HK 1048479 A1 HK1048479 A1 HK 1048479A1
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HK
Hong Kong
Prior art keywords
macrocyclic
hepatitis
moieties
virus
alkyl
Prior art date
Application number
HK03100478.8A
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English (en)
Chinese (zh)
Inventor
Venkatraman Srikanth
X. Chen Kevin
Arasappan Ashok
George Njoroge F.
M. Girijavallabhan Viyyoor
Chan Tin-Yau
A. Mckittrick Brian
J. Prongay Andrew
S. Madison Vincent
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Schering Corporation
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Publication of HK1048479A1 publication Critical patent/HK1048479A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK03100478.8A 2000-04-19 2001-04-17 包含烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂 HK1048479A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19820400P 2000-04-19 2000-04-19
US60/198,204 2000-04-19
PCT/US2001/012530 WO2001081325A2 (en) 2000-04-19 2001-04-17 Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising alkyl and aryl alanine p2 moieties

Publications (1)

Publication Number Publication Date
HK1048479A1 true HK1048479A1 (zh) 2003-04-04

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HK03100478.8A HK1048479A1 (zh) 2000-04-19 2001-04-17 包含烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂

Country Status (22)

Country Link
US (1) US6914122B2 (enExample)
EP (1) EP1274724A2 (enExample)
JP (1) JP4748912B2 (enExample)
KR (1) KR20020097220A (enExample)
CN (3) CN1432022A (enExample)
AR (1) AR030558A1 (enExample)
AU (1) AU2001253621A1 (enExample)
BR (1) BR0110104A (enExample)
CA (1) CA2406532A1 (enExample)
CZ (1) CZ20023473A3 (enExample)
HK (1) HK1048479A1 (enExample)
HU (1) HUP0302957A2 (enExample)
IL (1) IL151935A0 (enExample)
MX (1) MXPA02010375A (enExample)
NO (1) NO20025030L (enExample)
NZ (1) NZ521456A (enExample)
PE (1) PE20011288A1 (enExample)
PL (1) PL358591A1 (enExample)
RU (1) RU2002131163A (enExample)
SK (1) SK14952002A3 (enExample)
WO (1) WO2001081325A2 (enExample)
ZA (1) ZA200208014B (enExample)

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