HK1036405A1 - A stable oxaliplatin solution formulation and the preparation process thereof. - Google Patents

A stable oxaliplatin solution formulation and the preparation process thereof.

Info

Publication number
HK1036405A1
HK1036405A1 HK01107235A HK01107235A HK1036405A1 HK 1036405 A1 HK1036405 A1 HK 1036405A1 HK 01107235 A HK01107235 A HK 01107235A HK 01107235 A HK01107235 A HK 01107235A HK 1036405 A1 HK1036405 A1 HK 1036405A1
Authority
HK
Hong Kong
Prior art keywords
preparation process
solution formulation
oxaliplatin solution
stable oxaliplatin
stable
Prior art date
Application number
HK01107235A
Other languages
English (en)
Inventor
Nicholas H Anderson
Stephen Brown
David A England
Ross Blundell
Martin R Gray
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10827600&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1036405(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of HK1036405A1 publication Critical patent/HK1036405A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK01107235A 1998-02-25 2001-10-16 A stable oxaliplatin solution formulation and the preparation process thereof. HK1036405A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9804013.2A GB9804013D0 (en) 1998-02-25 1998-02-25 Formulations
PCT/GB1999/000572 WO1999043355A2 (en) 1998-02-25 1999-02-25 Formulations containing oxaliplatin

Publications (1)

Publication Number Publication Date
HK1036405A1 true HK1036405A1 (en) 2002-01-04

Family

ID=10827600

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01107235A HK1036405A1 (en) 1998-02-25 2001-10-16 A stable oxaliplatin solution formulation and the preparation process thereof.

Country Status (28)

Country Link
US (1) US6306902B1 (xx)
EP (1) EP0943331B1 (xx)
JP (1) JP4430229B2 (xx)
KR (1) KR20010041182A (xx)
CN (1) CN1152718C (xx)
AR (1) AR015524A1 (xx)
AT (1) ATE202472T1 (xx)
AU (1) AU757101B2 (xx)
BR (1) BR9908273A (xx)
CA (1) CA2261500C (xx)
CZ (1) CZ302196B6 (xx)
DE (1) DE69900162T2 (xx)
DK (1) DK0943331T3 (xx)
ES (1) ES2161085T3 (xx)
GB (1) GB9804013D0 (xx)
GR (1) GR3036646T3 (xx)
GT (1) GT199900019A (xx)
HK (1) HK1036405A1 (xx)
HU (1) HU224611B1 (xx)
IL (1) IL137772A (xx)
MX (1) MXPA00008195A (xx)
NO (1) NO329900B1 (xx)
PL (1) PL197948B1 (xx)
PT (1) PT943331E (xx)
RU (1) RU2207857C2 (xx)
UA (1) UA70316C2 (xx)
WO (1) WO1999043355A2 (xx)
ZA (1) ZA991489B (xx)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9804013D0 (en) 1998-02-25 1998-04-22 Sanofi Sa Formulations
JP4884587B2 (ja) * 1998-10-14 2012-02-29 デビオファーム・ソシエテ・アノニム オキサリ白金調製物の容器包装
RU2252022C2 (ru) * 1999-08-30 2005-05-20 Дебиофарм С.А. Стабильный фармацевтический препарат оксалиплатины для парентерального введения
US7070796B1 (en) 1999-08-30 2006-07-04 Debiopharm S.A. Pharmaceutically stable oxaliplatinum preparation for parenteral administration
WO2002047725A2 (fr) * 2000-12-12 2002-06-20 Debiopharm S.A. Preparation pharmaceutique d'oxaliplatine pour administration par voie parenterale et procede d'obtention de ladite preparation
ATE365037T1 (de) 2001-03-02 2007-07-15 Debiopharm Sa Verwendung eines eine oxaliplatinlösung beinhaltenden fläschchens
WO2003004505A1 (en) * 2001-07-02 2003-01-16 Debiopharm S.A. Oxaliplatin active substance with a very low content of oxalic acid
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
CA2388352A1 (en) * 2002-05-31 2003-11-30 Voiceage Corporation A method and device for frequency-selective pitch enhancement of synthesized speed
DE10314377A1 (de) * 2003-03-28 2004-10-07 Stada Arzneimittel Ag Gebrauchsfertige Oxaliplatin-Lösungen
US20050020556A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes
GB2441445B (en) * 2003-08-28 2008-04-23 Mayne Pharma Ltd Acid containing oxaliplatin formulation
EP2243480A1 (en) * 2003-08-28 2010-10-27 Mayne Pharma Pty Ltd Pharmaceutical formulations comprising oxaliplatin and an acid.
JP2007504177A (ja) * 2003-09-02 2007-03-01 プリヴァ−ラケマ，エー．エス． 医薬組成物、その製造方法及び治療上の使用
CZ300795B6 (cs) * 2003-09-02 2009-08-12 Pliva-Lachema A. S. Farmaceutická kompozice a zpusob její výroby
EP1704156A1 (en) 2003-11-25 2006-09-27 Platco Technologies (Proprietary) Limited Platinum(ii) complexes, preparation and use
CN100471493C (zh) * 2003-12-17 2009-03-25 梅比欧法姆股份有限公司 含有奥沙利铂的脂质体制剂
WO2005102312A1 (en) * 2004-04-27 2005-11-03 Mayne Pharma Limited Concentrated oxaliplatin solutions
US7589225B2 (en) 2004-09-01 2009-09-15 Platco Technologies (Proprietary) Limited Preparation of platinum(II) complexes
US20060063833A1 (en) * 2004-09-22 2006-03-23 Edgar Schridde Ready-to-use oxaliplatin solutions
US20060063720A1 (en) * 2004-09-22 2006-03-23 Edgar Schridde Oxaliplatin solution concentrate
DE102004052877B4 (de) * 2004-11-02 2008-06-19 Ebewe Pharma Ges.M.B.H. Nfg.Kg Stabile wässrige Formulierungen eines Platin-Derivats
DE102004063764A1 (de) * 2004-12-29 2006-07-13 Hexal Ag Kunststoff-Flasche für Oxaliplatin
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
WO2006103691A1 (en) * 2005-03-28 2006-10-05 Dabur Pharma Ltd. Stable pharmaceutical compositions of platinum (ii) antitumour agents
EP1874290A1 (en) * 2005-04-09 2008-01-09 Vuab Pharma A. S. A process for the preparation of an oxaliplatin preparation
DE102005038347A1 (de) * 2005-08-11 2007-02-15 Hexal Ag Herstellung einer Oxaliplatin-Lösung und Behälter sowie Behälter-Set mit der Lösung
WO2007029268A2 (en) * 2005-09-05 2007-03-15 Dabur Pharma Limited Stable oxaliplatin formulation
RU2008135369A (ru) 2006-01-30 2010-03-10 Платко Текнолоджис (Проприэтэри) Лимитед (Za) Получение комплексов платины(ii)
KR100913063B1 (ko) 2006-09-13 2009-08-21 주식회사유한양행 옥살리플라틴-함유 주사용 용액
KR20090102844A (ko) * 2007-01-22 2009-09-30 플리바-라케마 에이. 에스. 알콜 당-계 완충액을 함유한 옥살리플라틴 약제학적 조성물
EP2152239A1 (en) * 2007-11-12 2010-02-17 Intas Pharmaceuticals Limited Stable oxaliplatin composition for parenteral administration
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
US9023834B2 (en) * 2008-11-13 2015-05-05 Taigen Biotechnology Co., Ltd. Lyophilization formulation
CN101461801B (zh) * 2008-12-26 2013-05-15 辰欣药业股份有限公司 一种奥沙利铂药物组合物及其制备方法
WO2011034394A2 (ko) 2009-09-21 2011-03-24 주식회사 중외제약 옥살리플라틴의 나노 입자 및 이를 제조하는 방법
CN102274171A (zh) * 2011-08-04 2011-12-14 上海希迪制药有限公司 一种奥沙利铂注射剂
CN104523674B (zh) * 2014-12-11 2017-10-24 广州市上为医药科技有限公司 一种以奥沙利铂为主药成分的注射用组合物
KR101683635B1 (ko) * 2014-12-29 2016-12-09 가천대학교 산학협력단 락테이트 금속염을 포함하는 암 치료용 약학 조성물
CN104829653B (zh) * 2015-05-06 2016-03-23 山东罗欣药业集团股份有限公司 一种奥沙利铂水合物晶体及其冻干粉针剂
KR20200099172A (ko) 2018-01-12 2020-08-21 (주) 메티메디제약 만성 염증성 질환의 치료 방법

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041077B2 (ja) * 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
PT93772A (pt) 1989-04-17 1991-01-08 Searle & Co Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer
US5214174A (en) 1989-12-15 1993-05-25 Tsumura & Co. Platinum complex and anti-tumor agent comprising said complex as active ingredient
JPH04185601A (ja) * 1990-11-20 1992-07-02 Unitika Ltd 白金抗癌剤徐放性製剤
NZ245112A (en) * 1991-11-15 1995-07-26 Smithkline Beecham Corp Pharmaceutical composition comprising a camptothecin analog and a platinum coordination compound
JPH0776230B2 (ja) * 1992-01-13 1995-08-16 田中貴金属工業株式会社 白金化合物の製造方法
JPH05238936A (ja) 1992-02-27 1993-09-17 Dainippon Pharmaceut Co Ltd カルシトリオールの水性液剤
JPH06287021A (ja) * 1992-04-22 1994-10-11 Tanaka Kikinzoku Kogyo Kk 光学活性な白金錯化合物の光学的分割方法
JP2673331B2 (ja) * 1993-01-12 1997-11-05 田中貴金属工業 株式会社 光学的に高純度なシス―オキザラート（トランス―１―１，２―シクロヘキサンジアミン）白金（▲ｉｉ▼）
AU5416394A (en) * 1992-11-24 1994-06-22 Debiopharm S.A. Cisplatinum/oxaliplatinum combination
JP3025602B2 (ja) * 1993-05-21 2000-03-27 デビオファーム エス．アー． 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法
US5455270A (en) * 1993-08-11 1995-10-03 Bristol-Myers Squibb Co. Stabilized solutions of platinum(II) antitumor agents
KR100365171B1 (ko) 1994-08-08 2003-02-19 드바이오팜 에스.아. 약학적으로안정한옥살리플라티늄제제
ES2206478T3 (es) * 1994-11-11 2004-05-16 Debiopharm S.A. Composiciones carcinostaticas que contienen cis-oxaliplatino y otra u otras sustancias carcinostaticas compatibles.
FR2740686B1 (fr) * 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
EP0801070B1 (en) 1996-04-10 2003-04-16 Debiopharm S.A. Process of preparing platinum compound
JPH09294809A (ja) 1996-05-07 1997-11-18 Terumo Corp 薬液注入器具
GB9804013D0 (en) 1998-02-25 1998-04-22 Sanofi Sa Formulations

Also Published As

Publication number Publication date
BR9908273A (pt) 2000-10-24
AR015524A1 (es) 2001-05-02
ES2161085T3 (es) 2001-11-16
PL343021A1 (en) 2001-07-30
GT199900019A (es) 2000-08-04
ZA991489B (en) 1999-09-30
NO329900B1 (no) 2011-01-24
JP4430229B2 (ja) 2010-03-10
DE69900162D1 (de) 2001-08-02
ATE202472T1 (de) 2001-07-15
JP2002504524A (ja) 2002-02-12
KR20010041182A (ko) 2001-05-15
HUP0103707A3 (en) 2004-07-28
AU757101B2 (en) 2003-01-30
WO1999043355A2 (en) 1999-09-02
EP0943331B1 (en) 2001-06-27
UA70316C2 (uk) 2004-10-15
PT943331E (pt) 2001-12-28
CN1152718C (zh) 2004-06-09
GR3036646T3 (en) 2001-12-31
GB9804013D0 (en) 1998-04-22
NO20004240L (no) 2000-10-18
CZ20003089A3 (cs) 2000-12-13
WO1999043355A3 (en) 1999-11-04
AU2632499A (en) 1999-09-15
CZ302196B6 (cs) 2010-12-15
IL137772A (en) 2006-04-10
DK0943331T3 (da) 2001-10-15
NO20004240D0 (no) 2000-08-24
CN1291886A (zh) 2001-04-18
HU224611B1 (hu) 2005-11-28
PL197948B1 (pl) 2008-05-30
CA2261500C (en) 2001-07-17
EP0943331A3 (en) 1999-11-03
RU2207857C2 (ru) 2003-07-10
EP0943331A2 (en) 1999-09-22
HUP0103707A2 (hu) 2002-02-28
MXPA00008195A (es) 2004-11-22
CA2261500A1 (en) 1999-08-25
US6306902B1 (en) 2001-10-23
DE69900162T2 (de) 2002-04-18

Similar Documents

Publication Publication Date Title
HK1036405A1 (en) A stable oxaliplatin solution formulation and the preparation process thereof.
HK1042653A1 (en) External preparation.
ZA989061B (en) Medicaments.
MXPA01005543A (es) Formulacion de liberacion controlada que consta de gnrh-ii.
ZA99454B (en) Novel dosage form.
ZA964711B (en) Novel compounds, the preparation and use thereof.
AU7773001A (en) Acylacetonitriles, process for preparation thereof and miticides containing the same
PL343512A1 (en) Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
IL138609A0 (en) Antipicornaviral compounds, their preparation and use
HUP0102215A3 (en) Benzoylpyridazines, pharmaceutical compositions containing the same and process for their preparation
HUP0001923A3 (en) Pesticidal 1-aryl-3-iminopyrazoles, process for their preparation, their use
HUP0104033A3 (en) 1-benzoyl-tetrahydropyridazine derivatives, process for their preparation, their use and medicaments containing the compounds
ZA200007636B (en) N-Phenyl-N'-Phenylpropylpiperazine derivatives and process for the preparation thereof.
ZA9810625B (en) Benzylidenepyrazolones, their preparation and use.
GB9925151D0 (en) Ammonium 3,5-diaminopicrate
HK1038363A1 (en) Phosphinous and phosphonic acid derivatives used as medicaments.
IL128238A0 (en) 11-Acetyl-12, 13-dioxabicyclo [8.2.1]-tridecenone derivatives processes for the preparation thereof and medicaments containing these compounds
HK1042406A1 (en) Liquid formulation.
ZA9810673B (en) 1-methyl-5-alkysulfonyl-, 1-methyl-5-alkylsulfinyl- and 1-methyl-5-alkylthio-substituted pyrazolylpyrazoles, process for their preparation and their use as herbicides
ZA994697B (en) Pharmaceutical formulation.
EP1157700A4 (en) ANTI-HIV AGENT
HK1052176A1 (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and the use thereof as medicaments.
ZA99918B (en) Pharmaceutical formulation.
MD956F1 (en) N-carboxyaryl-N',N'-dimethylthiouûreas preparation process
AU6825098A (en) Stable arenediazonium salts, a process for the preparation thereof and the uses thereof

Legal Events

Date Code Title Description
CHPA Change of a particular in the register (except of change of ownership)