CZ302196B6 - Stabilní prípravek na bázi roztoku oxaliplatiny, použití oxaliplatiny pri získávání tohoto prípravku, zpusob stabilizace vodného roztoku oxaliplatiny, zpusob získání tohoto prípravku, a balený farmaceutický produkt - Google Patents
Stabilní prípravek na bázi roztoku oxaliplatiny, použití oxaliplatiny pri získávání tohoto prípravku, zpusob stabilizace vodného roztoku oxaliplatiny, zpusob získání tohoto prípravku, a balený farmaceutický produkt Download PDFInfo
- Publication number
- CZ302196B6 CZ302196B6 CZ20003089A CZ20003089A CZ302196B6 CZ 302196 B6 CZ302196 B6 CZ 302196B6 CZ 20003089 A CZ20003089 A CZ 20003089A CZ 20003089 A CZ20003089 A CZ 20003089A CZ 302196 B6 CZ302196 B6 CZ 302196B6
- Authority
- CZ
- Czechia
- Prior art keywords
- oxaliplatin
- buffer
- formulation
- solution
- oxalic acid
- Prior art date
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- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 title claims abstract description 109
- 229960001756 oxaliplatin Drugs 0.000 title claims abstract description 108
- 239000000203 mixture Substances 0.000 title claims abstract description 99
- 238000009472 formulation Methods 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 30
- 230000000087 stabilizing effect Effects 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 11
- 239000000243 solution Substances 0.000 title abstract description 81
- 239000007864 aqueous solution Substances 0.000 title abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 title description 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims abstract description 147
- 235000006408 oxalic acid Nutrition 0.000 claims abstract description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 38
- 238000002360 preparation method Methods 0.000 claims abstract description 27
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 16
- 239000003937 drug carrier Substances 0.000 claims abstract description 16
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 13
- -1 alkali metal salt Chemical class 0.000 claims abstract description 13
- 201000011510 cancer Diseases 0.000 claims abstract description 4
- 239000000872 buffer Substances 0.000 claims description 35
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 claims description 23
- 229940039790 sodium oxalate Drugs 0.000 claims description 23
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 8
- 229940127557 pharmaceutical product Drugs 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 239000012298 atmosphere Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
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- 238000001802 infusion Methods 0.000 claims description 4
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 239000003708 ampul Substances 0.000 claims description 3
- 239000006172 buffering agent Substances 0.000 abstract description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 36
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 32
- 229910052757 nitrogen Inorganic materials 0.000 description 24
- 239000012535 impurity Substances 0.000 description 21
- 229910052697 platinum Inorganic materials 0.000 description 20
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- 150000003058 platinum compounds Chemical class 0.000 description 12
- 229940045985 antineoplastic platinum compound Drugs 0.000 description 7
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- 238000010438 heat treatment Methods 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
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- 239000000126 substance Substances 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical class NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 description 5
- 239000012299 nitrogen atmosphere Substances 0.000 description 5
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
- 102100028735 Dachshund homolog 1 Human genes 0.000 description 3
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- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 description 2
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- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 2
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- MUTQTHUBSRXFQO-UHFFFAOYSA-L oxalate;platinum(2+) Chemical compound [Pt+2].[O-]C(=O)C([O-])=O MUTQTHUBSRXFQO-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Rešení se týká stabilního prípravku na bázi roztoku oxaliplatiny, který obsahuje oxaliplatinu, úcinné stabilizující množství pufru, kterým je kyselina štavelová nebo sul kyseliny štavelové a alkalického kovu, a farmaceuticky prijatelný nosic, kterým je voda. Do rozsahu tohoto rešení rovnež náleží použití oxaliplatiny pri získávání tohoto prípravku pro lécbu rakoviny, zpusob stabilizace vodného roztoku oxaliplatiny pridáním úcinného stabilizujícího množství kyseliny štavelové nebo soli alkalického kovu této kyseliny do tohoto roztoku a zpusob získání uvedeného prípravku.
Claims (21)
- PATENTOVÉ NÁROKY1. Stabilní přípravek na bázi roztoku oxaliplatiny, vyznačující se tím, že obsahuje oxaliplatinu, účinné stabilizující množství pufru, kterým je kyselina šťavelová nebo sůl kyseliny šťavelové a alkalického kovu, a farmaceuticky přijatelný nosič, kterým je voda, přičemž toto účinné stabilizující množství pufru se pri vyjádření v molámí koncentraci pohybuje v rozmezí od 1 x ΚΓ4 M do 5 x ΙΟ*4 M a přípravek je stabilní po dobu alespoň 15 měsíců.
- 2. Přípravek podle nároku 1, vyznačující se tím, že tímto pufrem je kyselina šťavelová nebo oxalát sodný.
- 3. Přípravek podle nároku 2, vyznačující se tím, že tímto pufrem je kyselina Šťavelová.
- 4. Přípravek podle nároku kteréhokoliv z nároků 1 až 3, vyznačující se tím, že množství pufru pri vyjádření v molámí koncentraci činí 2 x 101 M.-26CZ 302196 B6
- 5. Přípravek podle kteréhokoliv z nároků 1 až 3, vyznačující se tím, pufru při vyjádření v molámí koncentraci činí 4 x ΙΟ4 M.
- 6. Přípravek podle kteréhokoli z nároků 1 až 5, vyznačující se tím, oxaliplatiny se pohybuje v rozmezí od 1 mg/ml do 7 mg/ml.
- 7. Přípravek podle kteréhokoli z nároků laž5, vyznačující se tím, oxaliplatiny se pohybuje v rozmezí od 1 mg/ml do 5 mg/ml.
- 8. Přípravek podle kteréhokoli z nároků 1 až 5, vyznačující se tím, oxaliplatiny se pohybuje v rozmezí od 2 mg/ml do 5 mg/ml.
- 9. Přípravek podle kteréhokoli z nároků 1 až 5, vyznačující se tím, oxaliplatiny činí 5 mg/ml.že množství že množství že množství že množství že množství
- 10. Přípravek podle nároku 3, vyznačující se tím, že množství oxaliplatiny činí 5 mg/ml a množství pufru pri vyjádření v molámí koncentraci činí 2 x ΚΓ4 M.
- 11. Přípravek podle nároku 3, vyznačující se tím, že množství oxaliplatiny činí 5 mg/ml a množství pufru pri vyjádření v molámí koncentraci činí 4 x ΚΓ4 M.
- 12. Přípravek podle kteréhokoli z nároků 1 až 11 pro použití v oblasti medicíny.
- 13. Použití oxaliplatiny pro výrobu přípravku podle kteréhokoli z nároků 1 až 11 pro léčbu rakoviny.
- 14. Použití oxaliplatiny pro výrobu přípravku podle kteréhokoli z nároků 1 až 11 pro léčbu pevného tumoru.
- 15. Způsob výroby přípravku definovaného v kterémkoli z nároků lažll, vyznačující setím, že zahrnuje smíchání farmaceuticky přijatelného nosiče, kterým je voda, pufru, kterým je kyselina šťavelová nebo sůl alkalického kovu této kyseliny, a oxaliplatiny.
- 16. Způsob výroby přípravku definovaného v kterémkoli z nároků lažll, vyznačující setím, že zahrnuje kroky:smíchání farmaceuticky přijatelného nosiče, kterým je voda, a pufru, kterým je kyselina šťavelová nebo sůl alkalického kovu této kyseliny; rozpuštění oxaliplatiny v této směsi;ochlazení směsi vytvořené v kroku (b) a doplnění na konečný objem s pomocí farmaceuticky přijatelného nosiče;zfiltrování roztoku vytvořeného v kroku (c); a případná sterilizace produktu vytvořeného v kroku (d).
- 17. Způsob podle nároku 16, vyznačující se tím, že tento způsob je realizován v inertní atmosféře.
- 18. Způsob podle nároku 16, vyznačující se tím, že produkt vytvořený v rámci kroku (d) je sterilizován vystavením účinku tepla.
- 19. Balený farmaceutický produkt, vyznačující se tím, že zahrnuje přípravek podle kteréhokoli z nároků 1 až 11 v utěsnitelné nádobě.
- 20. Balený farmaceutický produkt podle nároku 19, vyznačující se tím, že touto nádobou je ampulka, lékovka, infúzní vak nebo injekční stříkačka.-27CZ 302196 B6
- 21. Balený farmaceutický produkt podle nároku 20, vyznačující se tím, nádobou je dělená injekční stříkačka.
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| GBGB9804013.2A GB9804013D0 (en) | 1998-02-25 | 1998-02-25 | Formulations |
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| CZ20003089A3 CZ20003089A3 (cs) | 2000-12-13 |
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| CZ20003089A CZ302196B6 (cs) | 1998-02-25 | 1999-02-25 | Stabilní prípravek na bázi roztoku oxaliplatiny, použití oxaliplatiny pri získávání tohoto prípravku, zpusob stabilizace vodného roztoku oxaliplatiny, zpusob získání tohoto prípravku, a balený farmaceutický produkt |
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| EP (1) | EP0943331B1 (cs) |
| JP (1) | JP4430229B2 (cs) |
| KR (1) | KR20010041182A (cs) |
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| AT (1) | ATE202472T1 (cs) |
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| BR (1) | BR9908273A (cs) |
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| HU (1) | HU224611B1 (cs) |
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Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9804013D0 (en) | 1998-02-25 | 1998-04-22 | Sanofi Sa | Formulations |
| MXPA01003799A (es) * | 1998-10-14 | 2003-06-09 | Debiopharm Sa | Empaque para preparacion de oxaliplatino. |
| KR100688217B1 (ko) * | 1999-08-30 | 2007-02-28 | 데비오 팜 소시에떼 아노님 | 비경구 투여용의 약학적으로 안정된 옥살리백금 약학제제 및 그 조제방법 |
| US7070796B1 (en) | 1999-08-30 | 2006-07-04 | Debiopharm S.A. | Pharmaceutically stable oxaliplatinum preparation for parenteral administration |
| EP1341555A2 (fr) * | 2000-12-12 | 2003-09-10 | Debiopharm S.A. | Preparation pharmaceutique d'oxaliplatine pour administration par voie parenterale et procede d'obtention de ladite preparation |
| ES2287238T3 (es) | 2001-03-02 | 2007-12-16 | Debiopharm S.A. | Utilizacion de un vial que contiene una solucion de oxaliplatino. |
| US20040186172A1 (en) * | 2001-07-02 | 2004-09-23 | Houssam Ibrahim | Oxaliplatin active substance with a very low content of oxalic acid |
| US6476068B1 (en) * | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
| CA2388352A1 (en) * | 2002-05-31 | 2003-11-30 | Voiceage Corporation | A method and device for frequency-selective pitch enhancement of synthesized speed |
| DE10314377A1 (de) * | 2003-03-28 | 2004-10-07 | Stada Arzneimittel Ag | Gebrauchsfertige Oxaliplatin-Lösungen |
| US20050020556A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes |
| GB2441445B (en) * | 2003-08-28 | 2008-04-23 | Mayne Pharma Ltd | Acid containing oxaliplatin formulation |
| EP1680103A4 (en) * | 2003-08-28 | 2009-03-25 | Mayne Pharma Ltd | OXALIPLATINE FORMULATIONS CONTAINING ACID |
| JP2007504177A (ja) * | 2003-09-02 | 2007-03-01 | プリヴァ−ラケマ，エー．エス． | 医薬組成物、その製造方法及び治療上の使用 |
| CZ300795B6 (cs) * | 2003-09-02 | 2009-08-12 | Pliva-Lachema A. S. | Farmaceutická kompozice a zpusob její výroby |
| EP2330110A1 (en) | 2003-11-25 | 2011-06-08 | Platco Technologies (Proprietary) Limited | Platinum(II) complexes, preparation and use |
| AU2004297126B2 (en) * | 2003-12-10 | 2010-11-25 | Toudai Tlo, Ltd. | Coordination complex of diaminocyclohexaneplatinum(II) with block copolymer containing poly(carboxylic acid) segment and antitumor agent comprising the same |
| CN100471493C (zh) * | 2003-12-17 | 2009-03-25 | 梅比欧法姆股份有限公司 | 含有奥沙利铂的脂质体制剂 |
| WO2005102312A1 (en) * | 2004-04-27 | 2005-11-03 | Mayne Pharma Limited | Concentrated oxaliplatin solutions |
| SI1789427T1 (sl) | 2004-09-01 | 2009-10-31 | Platco Technologies Proprietar | Priprava kompleksov platine(II) |
| US20060063720A1 (en) * | 2004-09-22 | 2006-03-23 | Edgar Schridde | Oxaliplatin solution concentrate |
| US20060063833A1 (en) * | 2004-09-22 | 2006-03-23 | Edgar Schridde | Ready-to-use oxaliplatin solutions |
| DE102004052877B4 (de) * | 2004-11-02 | 2008-06-19 | Ebewe Pharma Ges.M.B.H. Nfg.Kg | Stabile wässrige Formulierungen eines Platin-Derivats |
| DE102004063764A1 (de) * | 2004-12-29 | 2006-07-13 | Hexal Ag | Kunststoff-Flasche für Oxaliplatin |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| DE602005014393D1 (de) * | 2005-03-28 | 2009-06-18 | Dabur Pharma Ltd | Stabile pharmazeutische zusammensetzungen aus antitumoralen platin-(ii)-mitteln |
| WO2006108428A1 (en) * | 2005-04-09 | 2006-10-19 | Vuab Pharma A.S. | A process for the preparation of an oxaliplatin preparation |
| RU2292210C1 (ru) * | 2005-05-03 | 2007-01-27 | Институт химии и химической технологии СО РАН (ИХХТ СО РАН) | Способ получения стерилизованной микрокристаллической цис-дихлородиамминплатины (ii) |
| DE102005038347A1 (de) * | 2005-08-11 | 2007-02-15 | Hexal Ag | Herstellung einer Oxaliplatin-Lösung und Behälter sowie Behälter-Set mit der Lösung |
| WO2007029268A2 (en) * | 2005-09-05 | 2007-03-15 | Dabur Pharma Limited | Stable oxaliplatin formulation |
| WO2007085957A1 (en) | 2006-01-30 | 2007-08-02 | Platco Technologies (Proprietary) Limited | Preparation of platinum (ll) complexes |
| KR100913063B1 (ko) | 2006-09-13 | 2009-08-21 | 주식회사유한양행 | 옥살리플라틴-함유 주사용 용액 |
| US20100093849A1 (en) * | 2007-01-22 | 2010-04-15 | Borek Zaludek | Oxaliplatin pharmaceutical composition with alcoholic sugar-based buffer |
| RU2340347C2 (ru) * | 2007-01-24 | 2008-12-10 | Институт химии и химической технологии СО РАН (ИХХТ СО РАН) | Способ получения стерилизованной микрокристаллической соли цис-дихлороамминизопропиламинплатины (ii) |
| EP2152239A1 (en) * | 2007-11-12 | 2010-02-17 | Intas Pharmaceuticals Limited | Stable oxaliplatin composition for parenteral administration |
| US20090130017A1 (en) * | 2007-11-19 | 2009-05-21 | Searete Llc | Targeted short-lived drug delivery |
| US9023834B2 (en) * | 2008-11-13 | 2015-05-05 | Taigen Biotechnology Co., Ltd. | Lyophilization formulation |
| CN101461801B (zh) * | 2008-12-26 | 2013-05-15 | 辰欣药业股份有限公司 | 一种奥沙利铂药物组合物及其制备方法 |
| AU2010296180B2 (en) | 2009-09-21 | 2016-05-05 | Bio-Synectics, Inc | Oxaliplatin nanoparticles and method for preparing same |
| CN102274171A (zh) * | 2011-08-04 | 2011-12-14 | 上海希迪制药有限公司 | 一种奥沙利铂注射剂 |
| CN104523674B (zh) * | 2014-12-11 | 2017-10-24 | 广州市上为医药科技有限公司 | 一种以奥沙利铂为主药成分的注射用组合物 |
| KR101683635B1 (ko) | 2014-12-29 | 2016-12-09 | 가천대학교 산학협력단 | 락테이트 금속염을 포함하는 암 치료용 약학 조성물 |
| CN104829653B (zh) * | 2015-05-06 | 2016-03-23 | 山东罗欣药业集团股份有限公司 | 一种奥沙利铂水合物晶体及其冻干粉针剂 |
| MX2020007462A (es) | 2018-01-12 | 2020-09-14 | Metimedi Pharmaceuticals Co Ltd | Metodos de tratamiento de enfermedades inflamatorias cronicas. |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0464210A1 (en) * | 1989-12-15 | 1992-01-08 | TSUMURA & CO. | Novel platinum complex and antitumor drug containing the same as active ingredient |
| WO1994012193A1 (fr) * | 1992-11-24 | 1994-06-09 | Debiopharm S.A. | Combinaison de cisplatine avec l'oxaliplatine |
| EP0642792A1 (en) * | 1993-08-11 | 1995-03-15 | Bristol-Myers Squibb Company | Stabilized solutions of platinum (II) antitumor agents |
| CZ286714B6 (en) * | 1994-08-08 | 2000-06-14 | Debiopharm Sa | Pharmaceutically stable preparation based on oxaliplatinum |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041077B2 (ja) * | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体 |
| PT93772A (pt) | 1989-04-17 | 1991-01-08 | Searle & Co | Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer |
| JPH04185601A (ja) * | 1990-11-20 | 1992-07-02 | Unitika Ltd | 白金抗癌剤徐放性製剤 |
| EP1393729A3 (en) * | 1991-11-15 | 2004-03-17 | Smithkline Beecham Corporation | Combination chemotherapy involving topotecan and a platinum coordination compound |
| JPH0776230B2 (ja) * | 1992-01-13 | 1995-08-16 | 田中貴金属工業株式会社 | 白金化合物の製造方法 |
| JPH05238936A (ja) | 1992-02-27 | 1993-09-17 | Dainippon Pharmaceut Co Ltd | カルシトリオールの水性液剤 |
| JP2673331B2 (ja) * | 1993-01-12 | 1997-11-05 | 田中貴金属工業 株式会社 | 光学的に高純度なシス―オキザラート（トランス―１―１，２―シクロヘキサンジアミン）白金（▲ｉｉ▼） |
| JPH06287021A (ja) * | 1992-04-22 | 1994-10-11 | Tanaka Kikinzoku Kogyo Kk | 光学活性な白金錯化合物の光学的分割方法 |
| JP3025602B2 (ja) * | 1993-05-21 | 2000-03-27 | デビオファーム エス．アー． | 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法 |
| ES2206478T3 (es) * | 1994-11-11 | 2004-05-16 | Debiopharm S.A. | Composiciones carcinostaticas que contienen cis-oxaliplatino y otra u otras sustancias carcinostaticas compatibles. |
| FR2740686B1 (fr) * | 1995-11-03 | 1998-01-16 | Sanofi Sa | Formulation pharmaceutique lyophilisee stable |
| DK1308454T3 (da) | 1996-04-10 | 2005-08-01 | Debiopharm Sa | Fremgangsmåde til fremstilling af platinforbindelse |
| JPH09294809A (ja) | 1996-05-07 | 1997-11-18 | Terumo Corp | 薬液注入器具 |
| GB9804013D0 (en) | 1998-02-25 | 1998-04-22 | Sanofi Sa | Formulations |
-
1998
- 1998-02-25 GB GBGB9804013.2A patent/GB9804013D0/en not_active Ceased
-
1999
- 1999-02-11 CA CA002261500A patent/CA2261500C/en not_active Expired - Lifetime
- 1999-02-11 GT GT199900019A patent/GT199900019A/es unknown
- 1999-02-22 US US09/255,087 patent/US6306902B1/en not_active Expired - Lifetime
- 1999-02-24 AR ARP990100774A patent/AR015524A1/es active IP Right Grant
- 1999-02-24 ZA ZA9901489A patent/ZA991489B/xx unknown
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- 1999-02-25 JP JP2000533150A patent/JP4430229B2/ja not_active Expired - Lifetime
- 1999-02-25 AU AU26324/99A patent/AU757101B2/en not_active Expired
- 1999-02-25 ES ES99301412T patent/ES2161085T3/es not_active Expired - Lifetime
- 1999-02-25 DE DE69900162T patent/DE69900162T2/de not_active Ceased
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- 1999-02-25 MX MXPA00008195A patent/MXPA00008195A/es active IP Right Grant
- 1999-02-25 PL PL343021A patent/PL197948B1/pl unknown
- 1999-02-25 BR BR9908273-0A patent/BR9908273A/pt not_active Application Discontinuation
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- 1999-02-25 CN CNB99803276XA patent/CN1152718C/zh not_active Expired - Lifetime
- 1999-02-25 HU HU0103707A patent/HU224611B1/hu active IP Right Grant
- 1999-02-25 AT AT99301412T patent/ATE202472T1/de active
- 1999-02-25 KR KR1020007009239A patent/KR20010041182A/ko not_active Ceased
- 1999-02-25 WO PCT/GB1999/000572 patent/WO1999043355A2/en not_active Application Discontinuation
- 1999-02-25 PT PT99301412T patent/PT943331E/pt unknown
- 1999-02-25 EP EP99301412A patent/EP0943331B1/en not_active Expired - Lifetime
- 1999-02-25 UA UA2000095450A patent/UA70316C2/uk unknown
-
2000
- 2000-08-09 IL IL137772A patent/IL137772A/en not_active IP Right Cessation
- 2000-08-24 NO NO20004240A patent/NO329900B1/no not_active IP Right Cessation
-
2001
- 2001-09-18 GR GR20010401504T patent/GR3036646T3/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0464210A1 (en) * | 1989-12-15 | 1992-01-08 | TSUMURA & CO. | Novel platinum complex and antitumor drug containing the same as active ingredient |
| WO1994012193A1 (fr) * | 1992-11-24 | 1994-06-09 | Debiopharm S.A. | Combinaison de cisplatine avec l'oxaliplatine |
| EP0642792A1 (en) * | 1993-08-11 | 1995-03-15 | Bristol-Myers Squibb Company | Stabilized solutions of platinum (II) antitumor agents |
| CZ286714B6 (en) * | 1994-08-08 | 2000-06-14 | Debiopharm Sa | Pharmaceutically stable preparation based on oxaliplatinum |
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