HK1002810A1 - Dtpa-complexes derivatives, pharmaceutical compositions containing them, their use and process for their preparation - Google Patents

Dtpa-complexes derivatives, pharmaceutical compositions containing them, their use and process for their preparation Download PDF

Info

Publication number
HK1002810A1
HK1002810A1 HK98101936A HK98101936A HK1002810A1 HK 1002810 A1 HK1002810 A1 HK 1002810A1 HK 98101936 A HK98101936 A HK 98101936A HK 98101936 A HK98101936 A HK 98101936A HK 1002810 A1 HK1002810 A1 HK 1002810A1
Authority
HK
Hong Kong
Prior art keywords
represent
tris
carboxymethyl
hydrogen atom
complex
Prior art date
Application number
HK98101936A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1002810B (en
Inventor
Schmitt-Willich Heribert
Platzek Johannes
Gries Heinz
Schuhmann-Giampieri Gabriele
Vogler Hubert
Weinmann Hanns-Joachim
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6384290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1002810(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of HK1002810B publication Critical patent/HK1002810B/xx
Publication of HK1002810A1 publication Critical patent/HK1002810A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/94—Bismuth compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HK98101936A 1989-06-30 1998-03-10 Dtpa-complexes derivatives, pharmaceutical compositions containing them, their use and process for their preparation HK1002810A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3922005A DE3922005A1 (de) 1989-06-30 1989-06-30 Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
DE3922005 1989-06-30

Publications (2)

Publication Number Publication Date
HK1002810B HK1002810B (en) 1998-09-18
HK1002810A1 true HK1002810A1 (en) 1998-09-18

Family

ID=6384290

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98101936A HK1002810A1 (en) 1989-06-30 1998-03-10 Dtpa-complexes derivatives, pharmaceutical compositions containing them, their use and process for their preparation

Country Status (24)

Country Link
EP (1) EP0405704B1 (cs)
JP (1) JP2603357B2 (cs)
KR (1) KR100190808B1 (cs)
AT (1) ATE115546T1 (cs)
AU (1) AU637111B2 (cs)
CA (1) CA2020142C (cs)
CZ (1) CZ277926B6 (cs)
DD (1) DD296276B5 (cs)
DE (3) DE3922005A1 (cs)
DK (1) DK0405704T3 (cs)
ES (1) ES2066113T3 (cs)
FI (1) FI102168B (cs)
HK (1) HK1002810A1 (cs)
HU (1) HU210208B (cs)
IE (1) IE65676B1 (cs)
IL (1) IL94818A (cs)
NL (1) NL300182I2 (cs)
NO (2) NO179203C (cs)
NZ (1) NZ234295A (cs)
PT (1) PT94541B (cs)
RU (1) RU2086554C1 (cs)
TW (1) TW219356B (cs)
UA (1) UA27275C2 (cs)
ZA (1) ZA905129B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
DE4302289A1 (de) * 1993-01-25 1994-07-28 Schering Ag Verfahren zur Herstellung C-substituierter Diethylentriamine
DE4302287A1 (de) * 1993-01-25 1994-07-28 Schering Ag Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
DE4341724A1 (de) * 1993-12-03 1995-06-08 Schering Ag Halogenaryl-substituierte Metallkomplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
SK68897A3 (en) * 1994-11-30 1998-10-07 Schering Ag Use of chelate compounds as diagnostic agents in the x-ray examination of liver and bile ducts
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
TW319763B (cs) 1995-02-01 1997-11-11 Epix Medical Inc
CA2212162A1 (en) * 1995-02-09 1996-08-15 Schering Aktiengesellschaft Liposomes that contain contrast media for the visualization of intravascular space
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
JP2759627B2 (ja) * 1995-07-21 1998-05-28 東北大学長 非エステル結合性ｄｔｐａ誘導体およびその製造方法
DE19641197C2 (de) * 1996-09-24 1999-02-18 Schering Ag Ionenpaare und ihre Verwendung als Kontrastmittel
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
DE19712012A1 (de) * 1997-03-13 1998-09-24 Schering Ag Verfahren zur Herstellung kristalliner 3,6,9-Triaza-3,6-9-tris(carboxymethyl)-4-(4- ethoxybenzyl)-undecandisäure
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
US6534040B2 (en) * 1999-12-23 2003-03-18 Health Research, Inc. Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
KR100749087B1 (ko) * 2006-06-02 2007-08-14 경북대학교 산학협력단 신규한 ｄｔｐａ-비스-아미드 리간드들 및 이들이 결합된가돌리늄 착물
SE533165C2 (sv) * 2008-06-13 2010-07-13 Chemseq Internat Ab Kemikalie och förfarande för komplexbindning av metalljoner, som är minst tvåvärda
EP2338874A1 (en) * 2009-12-16 2011-06-29 Bracco Imaging S.p.A Process for the preparation of chelated compounds
DE102010023890A1 (de) 2010-06-11 2011-12-15 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung kristalliner 3,6,9-Triaza-3,6,9-tris(carboxymethyl)-4-(ethoxybenzyl)-undecandinsäure und die Verwendung zur Herstellung von Primovist
JP2013531643A (ja) 2010-06-11 2013-08-08 バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー 結晶質３，６，９−トリアザ−３，６，９−トリス（カルボキシメチル）−４−（４−エトキシベンジル）ウンデカン二酸を調製する方法及びプリモビスト（Ｐｒｉｍｏｖｉｓｔ）（登録商標）を製造するための方法
CN104761461A (zh) * 2014-09-09 2015-07-08 山东富创医药科技有限公司 一种新的钆塞酸二钠中间体的制备方法
WO2017208258A1 (en) * 2016-05-30 2017-12-07 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of gadolinium complex of (4s)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9- triazaundecanedioic acid disodium (gadoxetate disodium)
JP6867639B2 (ja) * 2016-10-11 2021-05-12 学校法人 聖マリアンナ医科大学 非イオン性ヨード造影剤の結合体
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
HU208947B (en) * 1987-07-16 1994-02-28 Nycomed As Diagnostical compositions and process for producing aminopolycarboxylic acids, their derivatives and metal-kelates
AU617338B2 (en) * 1987-07-16 1991-11-28 Nycomed As Aminopolycarboxylic acids and derivatives thereof
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
IL94818A0 (en) 1991-04-15
FI102168B1 (fi) 1998-10-30
DE122004000051I1 (de) 2005-04-21
EP0405704A2 (de) 1991-01-02
IL94818A (en) 1996-05-14
EP0405704A3 (en) 1991-03-27
DE3922005A1 (de) 1991-01-10
DE122004000051I2 (de) 2011-12-29
NO902925D0 (no) 1990-06-29
PT94541B (pt) 1997-02-28
CS9003174A2 (en) 1991-11-12
UA27275C2 (uk) 2000-09-15
HUT54622A (en) 1991-03-28
JPH03215457A (ja) 1991-09-20
FI102168B (fi) 1998-10-30
HU904040D0 (en) 1990-12-28
IE902299L (en) 1990-12-30
NZ234295A (en) 1993-02-25
RU2086554C1 (ru) 1997-08-10
ATE115546T1 (de) 1994-12-15
NO179203C (no) 1996-08-28
EP0405704B1 (de) 1994-12-14
AU5802490A (en) 1991-01-03
HU210208B (en) 1995-02-28
CZ277926B6 (en) 1993-06-16
NO179203B (no) 1996-05-20
DE59007987D1 (de) 1995-02-02
IE902299A1 (en) 1991-01-16
CA2020142A1 (en) 1990-12-31
KR100190808B1 (ko) 1999-06-01
NO2005013I2 (no) 2006-06-19
CA2020142C (en) 2001-04-17
DK0405704T3 (da) 1995-02-20
PT94541A (pt) 1991-02-08
ES2066113T3 (es) 1995-03-01
NL300182I2 (nl) 2005-08-01
NO902925L (no) 1991-01-02
AU637111B2 (en) 1993-05-20
JP2603357B2 (ja) 1997-04-23
FI903295A0 (fi) 1990-06-29
TW219356B (cs) 1994-01-21
KR910000134A (ko) 1991-01-29
NL300182I1 (nl) 2005-06-01
ZA905129B (en) 1991-04-24
IE65676B1 (en) 1995-11-15
DD296276B5 (de) 1995-11-02

Similar Documents

Publication Publication Date Title
HK1002810A1 (en) Dtpa-complexes derivatives, pharmaceutical compositions containing them, their use and process for their preparation
HK1002810B (en) Dtpa-complexes derivatives, pharmaceutical compositions containing them, their use and process for their preparation
US6039931A (en) Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
AU644639B2 (en) DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production
EP0485045B1 (de) Mono-N-substituierte 1,4,7,10-Tetraazacyclododecan-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
EP0230893B1 (en) Paramagnetic chelates
US5362475A (en) Gadolinium chelates for magnetic resonance imaging
US5798092A (en) Derivatized DTPA complexes pharmaceutical agents containing these compounds, their use, and processes for their production
LU85177A1 (de) Diagnostische mittel
US5648063A (en) Sterile composition comprising a chelate complex for magnetic resonance imaging
US5733522A (en) Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use and process for their production
US5843399A (en) DTPA monoamides for MRI
SK277828B6 (en) Complex dipa derivatives, pharmaceutical agents containing this compounds, their using and method of their production
DD296276A5 (de) Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltendepharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20100626