HK1002234A1 - 5'-indolinyl-5beta-amidomethyloxazolidin-2-ones, 3-(fused-ring substituted)phenyl-5beta-amidomethy-loxazolidin-2-ones and 3-(nitrogen substituted)phenyl-5beta-amidomethyloxazolidin-2-ones - Google Patents

5'-indolinyl-5beta-amidomethyloxazolidin-2-ones, 3-(fused-ring substituted)phenyl-5beta-amidomethy-loxazolidin-2-ones and 3-(nitrogen substituted)phenyl-5beta-amidomethyloxazolidin-2-ones Download PDF

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Publication number
HK1002234A1
HK1002234A1 HK98101252A HK98101252A HK1002234A1 HK 1002234 A1 HK1002234 A1 HK 1002234A1 HK 98101252 A HK98101252 A HK 98101252A HK 98101252 A HK98101252 A HK 98101252A HK 1002234 A1 HK1002234 A1 HK 1002234A1
Authority
HK
Hong Kong
Prior art keywords
alkyl
oxazolidin
acetamidomethyl
defined above
optionally substituted
Prior art date
Application number
HK98101252A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1002234B (en
Inventor
L. Brickner Steven.
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Publication of HK1002234B publication Critical patent/HK1002234B/en
Publication of HK1002234A1 publication Critical patent/HK1002234A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK98101252A 1988-09-15 1998-02-18 5'-indolinyl-5beta-amidomethyloxazolidin-2-ones, 3-(fused-ring substituted)phenyl-5beta-amidomethy-loxazolidin-2-ones and 3-(nitrogen substituted)phenyl-5beta-amidomethyloxazolidin-2-ones HK1002234A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24498888A 1988-09-15 1988-09-15
US244988 1988-09-15
US25385088A 1988-10-05 1988-10-05
US253850 1988-10-05
US32494289A 1989-03-17 1989-03-17
US324942 1989-03-17

Publications (2)

Publication Number Publication Date
HK1002234B HK1002234B (en) 1998-08-07
HK1002234A1 true HK1002234A1 (en) 1998-08-07

Family

ID=27399816

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98101252A HK1002234A1 (en) 1988-09-15 1998-02-18 5'-indolinyl-5beta-amidomethyloxazolidin-2-ones, 3-(fused-ring substituted)phenyl-5beta-amidomethy-loxazolidin-2-ones and 3-(nitrogen substituted)phenyl-5beta-amidomethyloxazolidin-2-ones

Country Status (14)

Country Link
EP (3) EP0359418B1 (https=)
JP (2) JP2865211B2 (https=)
KR (1) KR0138262B1 (https=)
AT (2) ATE201870T1 (https=)
AU (1) AU617871B2 (https=)
CA (1) CA1335103C (https=)
DE (2) DE68929303T2 (https=)
DK (2) DK175696B1 (https=)
ES (1) ES2157934T3 (https=)
GR (1) GR3036491T3 (https=)
HK (1) HK1002234A1 (https=)
LV (1) LV12888B (https=)
TW (1) TW219936B (https=)
WO (1) WO1990002744A1 (https=)

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US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
PT97888B (pt) * 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
JPH06510285A (ja) * 1991-08-14 1994-11-17 プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド 抗不整脈及び抗細動剤として有用な環状ウレタン類
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
KR950702417A (ko) * 1992-07-08 1995-07-29 로렌스 티. 웰츠 마이코박테륨 투베르쿨로시스에 대해 유용한 5′-인돌리닐 옥사졸리디논(5′-indolinyl oxazolidinones useful against mycobacterium tuberculosis)
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
JP3933198B2 (ja) * 1994-10-26 2007-06-20 ファルマシア・アンド・アップジョン・カンパニー フェニルオキサゾリジノン抗菌剤
BR9509673A (pt) * 1994-11-15 1997-09-30 Upjohn Co Compostos e uso dos mesmos
DK0807112T3 (da) * 1995-02-03 2001-12-17 Upjohn Co Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
NZ306310A (en) * 1995-05-11 2001-05-25 Upjohn Co Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601627A1 (de) * 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
CN1138765C (zh) 1997-05-30 2004-02-18 法玛西雅厄普约翰美国公司 带有硫代羰基功能基的噁唑烷酮抗菌剂
DE19730847A1 (de) * 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
BR9813985A (pt) * 1997-11-12 2000-09-26 Upjohn Co Derivados de oxazolidinona e composições farmacêuticas
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
DE19802239A1 (de) * 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
KR20010015910A (ko) * 1998-01-23 2001-02-26 로렌스 티. 마이젠헬더 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법
ES2203473T3 (es) * 1999-05-27 2004-04-16 PHARMACIA & UPJOHN COMPANY Oxazolidinonas biciclicas como agentes antibacterianos.
US6441005B1 (en) 1999-07-28 2002-08-27 Pharmacia & Upjohn Company Oxazolidinone compounds and compositions, and methods of using the same
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
BR0112826A (pt) 2000-07-17 2003-06-24 Ranbaxy Lab Ltd Derivados da oxazolidinona como antimicrobianos
JP4269144B2 (ja) 2000-10-02 2009-05-27 エモリー ユニバーシティ 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ
PE20020689A1 (es) * 2000-11-17 2002-08-03 Upjohn Co Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
GB0118407D0 (en) * 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
MX2007001526A (es) * 2004-08-06 2007-03-27 Pharmacia & Upjohn Co Llc Oxazolidinonas que contienen oxindoles como agentes antibacterianos.
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
MX2007011873A (es) * 2005-04-06 2007-11-07 Pharmacia & Upjohn Co Llc Una oxindoloxazolidinona como agente antibacteriano.
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
AU2008339607B2 (en) * 2007-12-24 2012-08-02 Cipla Limited Process for the synthesis of propargylated aminoindan derivatives
CA2794153C (en) 2010-03-25 2018-01-02 Glaxosmithkline Llc Substituted indoline derivatives as perk inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
AU617871B2 (en) 1991-12-05
CA1335103C (en) 1995-04-04
DE68918792D1 (de) 1994-11-17
DK200401246A (da) 2004-08-18
LV12888B (en) 2002-12-20
ATE201870T1 (de) 2001-06-15
WO1990002744A1 (en) 1990-03-22
EP0434714A1 (en) 1991-07-03
ATE112773T1 (de) 1994-10-15
DE68929303T2 (de) 2002-05-02
EP0609905A1 (en) 1994-08-10
ES2157934T3 (es) 2001-09-01
JPH1180139A (ja) 1999-03-26
DE68918792T2 (de) 1995-03-30
DE68929303D1 (de) 2001-07-12
EP0609905B1 (en) 2001-06-06
GR3036491T3 (en) 2001-11-30
JP3188418B2 (ja) 2001-07-16
KR900701780A (ko) 1990-12-04
KR0138262B1 (ko) 1998-05-15
JPH04500665A (ja) 1992-02-06
TW219936B (https=) 1994-02-01
DK175696B1 (da) 2005-01-24
EP0359418B1 (en) 1994-10-12
DK45591D0 (da) 1991-03-13
DK175940B1 (da) 2005-08-01
EP0359418A1 (en) 1990-03-21
AU4195789A (en) 1990-04-02
JP2865211B2 (ja) 1999-03-08
DK45591A (da) 1991-03-13

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060822