GB9713730D0 - Organic compounds - Google Patents

Organic compounds

Info

Publication number
GB9713730D0
GB9713730D0 GBGB9713730.1A GB9713730A GB9713730D0 GB 9713730 D0 GB9713730 D0 GB 9713730D0 GB 9713730 A GB9713730 A GB 9713730A GB 9713730 D0 GB9713730 D0 GB 9713730D0
Authority
GB
United Kingdom
Prior art keywords
formula
compound
organic compounds
conditions
forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9713730.1A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10815103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB9713730(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Priority to GBGB9713730.1A priority Critical patent/GB9713730D0/en
Publication of GB9713730D0 publication Critical patent/GB9713730D0/en
Priority to CO98036359A priority patent/CO4940463A1/es
Priority to PCT/EP1998/003929 priority patent/WO1999001458A1/en
Priority to PL336719A priority patent/PL192761B1/pl
Priority to CNB988064677A priority patent/CN1139595C/zh
Priority to DK98936392T priority patent/DK0994880T3/da
Priority to AT98936392T priority patent/ATE287410T1/de
Priority to RU2000101826/04A priority patent/RU2219181C2/ru
Priority to HU0003053A priority patent/HU227755B1/hu
Priority to SI9830759T priority patent/SI0994880T1/xx
Priority to IL13276198A priority patent/IL132761A0/xx
Priority to AU85409/98A priority patent/AU739211B2/en
Priority to EP98936392A priority patent/EP0994880B1/en
Priority to SK1866-99A priority patent/SK285665B6/sk
Priority to DE69828692T priority patent/DE69828692T2/de
Priority to KR10-1999-7010048A priority patent/KR100399765B1/ko
Priority to PE1998000568A priority patent/PE97699A1/es
Priority to ARP980103094A priority patent/AR017754A1/es
Priority to ES98936392T priority patent/ES2236922T3/es
Priority to JP50628799A priority patent/JP3880634B2/ja
Priority to NZ500994A priority patent/NZ500994A/en
Priority to CZ0474099A priority patent/CZ297244B6/cs
Priority to IDW991682A priority patent/ID24897A/id
Priority to PT98936392T priority patent/PT994880E/pt
Priority to HK00106806.1A priority patent/HK1028597B/en
Priority to CA002290412A priority patent/CA2290412C/en
Priority to BR9810956-1A priority patent/BR9810956A/pt
Priority to TR1999/03189T priority patent/TR199903189T2/xx
Priority to MYPI98002955A priority patent/MY118718A/en
Priority to ZA985655A priority patent/ZA985655B/xx
Priority to TW087111867A priority patent/TW552264B/zh
Priority to NO19995909A priority patent/NO312765B1/no
Priority to US09/690,404 priority patent/US6423722B1/en
Priority to JP2006055107A priority patent/JP4504323B2/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB9713730.1A 1997-06-30 1997-06-30 Organic compounds Pending GB9713730D0 (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
GBGB9713730.1A GB9713730D0 (en) 1997-06-30 1997-06-30 Organic compounds
CO98036359A CO4940463A1 (es) 1997-06-30 1998-06-25 Macrolidas cristalinas
BR9810956-1A BR9810956A (pt) 1997-06-30 1998-06-26 "macrolidas cristalinas e processo para sua preparação"
TR1999/03189T TR199903189T2 (xx) 1997-06-30 1998-06-26 Kristalin makrolidler ve haz�rlanmalar�na y�nelik i�lem.
KR10-1999-7010048A KR100399765B1 (ko) 1997-06-30 1998-06-26 결정형 마크로리드 및 이들의 제조방법
JP50628799A JP3880634B2 (ja) 1997-06-30 1998-06-26 結晶性マクロライドおよびその調製方法
CNB988064677A CN1139595C (zh) 1997-06-30 1998-06-26 结晶性大环内酯及其制备方法
DK98936392T DK0994880T3 (da) 1997-06-30 1998-06-26 Krystallinske makrolider samt fremgangsmåde til deres fremstilling
AT98936392T ATE287410T1 (de) 1997-06-30 1998-06-26 Kristalline macrolide und verfahren zu ihrer herstellung
RU2000101826/04A RU2219181C2 (ru) 1997-06-30 1998-06-26 Кристаллические макролиды, способы их получения и фармацевтическая композиция на их основе
HU0003053A HU227755B1 (en) 1997-06-30 1998-06-26 Crystalline forms of 33-epichloro-33-desoxyascomycin, process for their preparation and pharmaceutical compositions containing them
SI9830759T SI0994880T1 (https=) 1997-06-30 1998-06-26
IL13276198A IL132761A0 (en) 1997-06-30 1998-06-26 Crystalline macrolides and process for their preparation
AU85409/98A AU739211B2 (en) 1997-06-30 1998-06-26 Crystalline macrolides and process for their preparation
EP98936392A EP0994880B1 (en) 1997-06-30 1998-06-26 Crystalline macrolides and process for their preparation
SK1866-99A SK285665B6 (sk) 1997-06-30 1998-06-26 Kryštalické makrolidy, spôsob ich prípravy, farmaceutický prostriedok a ich použitie
DE69828692T DE69828692T2 (de) 1997-06-30 1998-06-26 Kristalline macrolide und verfahren zu ihrer herstellung
PCT/EP1998/003929 WO1999001458A1 (en) 1997-06-30 1998-06-26 Crystalline macrolides and process for their preparation
PE1998000568A PE97699A1 (es) 1997-06-30 1998-06-26 Macrolidas cristalinas
ARP980103094A AR017754A1 (es) 1997-06-30 1998-06-26 Macrolidas cristalinas, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
ES98936392T ES2236922T3 (es) 1997-06-30 1998-06-26 Macrolidos cristalinos y procedimiento para su preparacion.
PL336719A PL192761B1 (pl) 1997-06-30 1998-06-26 Makrolid krystaliczny, sposób jego wytwarzania, kompozycja farmaceutyczna zawierająca ten makrolid oraz jego zastosowanie
NZ500994A NZ500994A (en) 1997-06-30 1998-06-26 Crystalline macrolides ( 33-epichloro-33-desoxyascomycin or 33-epichloro-33-desoxy-FR520 )
CZ0474099A CZ297244B6 (cs) 1997-06-30 1998-06-26 Krystalické formy 33-epichlor-33-desoxyaskomycinu, zpusob jejich prípravy a farmaceutické prostredky s jejich obsahem
IDW991682A ID24897A (id) 1997-06-30 1998-06-26 Makrolida kristalin
PT98936392T PT994880E (pt) 1997-06-30 1998-06-26 Macrolidos cristalinos e processos para a sua preparacao
HK00106806.1A HK1028597B (en) 1997-06-30 1998-06-26 Crystalline macrolides and process for their preparation
CA002290412A CA2290412C (en) 1997-06-30 1998-06-26 Crystalline macrolides and process for their preparation
ZA985655A ZA985655B (en) 1997-06-30 1998-06-29 Crystalline macrolides
MYPI98002955A MY118718A (en) 1997-06-30 1998-06-29 Crystalline macrolides and process for their preparation
TW087111867A TW552264B (en) 1997-06-30 1998-07-21 Macrolide crystallines, process for preparation thereof and pharmaceutical composition comprising same
NO19995909A NO312765B1 (no) 1997-06-30 1999-12-02 Krystallinske makrolider, fremgangsmåte for deres fremstilling, farmasöytiske sammensetninger inneholdende disse oganvendelsen av makrolidene
US09/690,404 US6423722B1 (en) 1997-06-30 2000-10-17 Crystalline macrolides and process for their preparation
JP2006055107A JP4504323B2 (ja) 1997-06-30 2006-03-01 結晶性マクロライドおよびその調製方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9713730.1A GB9713730D0 (en) 1997-06-30 1997-06-30 Organic compounds

Publications (1)

Publication Number Publication Date
GB9713730D0 true GB9713730D0 (en) 1997-09-03

Family

ID=10815103

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9713730.1A Pending GB9713730D0 (en) 1997-06-30 1997-06-30 Organic compounds

Country Status (31)

Country Link
US (1) US6423722B1 (https=)
EP (1) EP0994880B1 (https=)
JP (2) JP3880634B2 (https=)
KR (1) KR100399765B1 (https=)
CN (1) CN1139595C (https=)
AR (1) AR017754A1 (https=)
AT (1) ATE287410T1 (https=)
AU (1) AU739211B2 (https=)
BR (1) BR9810956A (https=)
CA (1) CA2290412C (https=)
CO (1) CO4940463A1 (https=)
CZ (1) CZ297244B6 (https=)
DE (1) DE69828692T2 (https=)
DK (1) DK0994880T3 (https=)
ES (1) ES2236922T3 (https=)
GB (1) GB9713730D0 (https=)
HU (1) HU227755B1 (https=)
ID (1) ID24897A (https=)
IL (1) IL132761A0 (https=)
MY (1) MY118718A (https=)
NO (1) NO312765B1 (https=)
NZ (1) NZ500994A (https=)
PE (1) PE97699A1 (https=)
PL (1) PL192761B1 (https=)
PT (1) PT994880E (https=)
RU (1) RU2219181C2 (https=)
SK (1) SK285665B6 (https=)
TR (1) TR199903189T2 (https=)
TW (1) TW552264B (https=)
WO (1) WO1999001458A1 (https=)
ZA (1) ZA985655B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
EP1663220B1 (en) * 2003-09-03 2009-12-02 Glaxo Group Limited Novel process for the preparation of pleuromutilin derivatives
PT1734927E (pt) * 2004-04-08 2012-09-05 Meda Pharma S A R L Composição em espuma de pimecrolimus contendo hexilenoglicol, opcionalmente álcool oleílico, dimetilisossorbida e/ou triglicéridos de cadeia média
CA2584430A1 (en) * 2004-12-01 2006-06-08 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods for preparing pimecrolimus
TW200837067A (en) * 2006-11-06 2008-09-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
JP2010512333A (ja) * 2006-12-07 2010-04-22 ヘルシン ヘルスケア ソシエテ アノニム 塩酸パロノセトロンの結晶及び非晶質形
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
EP2944332B1 (en) 2009-07-10 2016-08-17 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2453938B1 (en) 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8669360B2 (en) * 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
WO2014145780A1 (en) 2013-03-15 2014-09-18 Biosensors International Group, Ltd. Purification of rapamycin derivatives
EP3178824A1 (en) 2015-12-08 2017-06-14 Medichem, S.A. Process for preparing pimecrolimus
ES2906158T3 (es) * 2017-05-01 2022-04-13 Meda Pharma Gmbh & Co Kg Proceso para convertir ascomicina bruta en pimecrolimus purificado
EP3741367A1 (en) 2019-05-21 2020-11-25 Premark Pharma GmbH Treatment of ocular disease
WO2024209038A1 (en) 2023-04-06 2024-10-10 Premark Pharma Gmbh Use of pimecrolimus for the treatment of dry eye in patients characterized by a corneal staining score of 4 or 5 on the oxford grading scale

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118816A (en) * 1975-04-08 1976-10-19 Meiji Seika Kaisha Ltd A process for stabilizing non-crystalloidal solid
US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
CY1306A (en) 1980-10-01 1985-12-06 Glaxo Group Ltd Aminoalkyl furan derivative
JP2728482B2 (ja) * 1989-01-26 1998-03-18 協和醗酵工業株式会社 マクロライド系抗生物質の精製法
JPH089630B2 (ja) 1989-07-10 1996-01-31 ヘマ・ソシエダード・アノニマ 有機化合物の、または関連する改善
DK0427680T3 (da) * 1989-11-09 1995-12-18 Sandoz Ltd Heteroatom-holdige cykliske forbindelser
EP0594600A1 (en) * 1990-03-13 1994-05-04 FISONS plc Immunosuppressive macrocyclic compounds
EP0480623A1 (en) * 1990-10-11 1992-04-15 Merck & Co. Inc. New halomacrolides and derivatives having immunosuppressive activity
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
ES2100291T3 (es) 1991-07-30 1997-06-16 Ajinomoto Kk Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos.
US5247076A (en) 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5221740A (en) 1992-01-16 1993-06-22 American Home Products Corporation Oxepane isomers of rapamycin useful as immunosuppressive agents
UA41884C2 (uk) * 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
JP3808500B2 (ja) * 1994-02-22 2006-08-09 キューレータズ オブ ディ ユニバーシティ オブ ミズーリ 分離剤としての大環状抗生物質
CA2229718A1 (en) * 1995-08-24 1997-03-06 David J. Mathre Process for the preparation of imidazolyl macrolide immunosuppressants
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds

Also Published As

Publication number Publication date
SK186699A3 (en) 2000-05-16
CA2290412A1 (en) 1999-01-14
HU227755B1 (en) 2012-02-28
AR017754A1 (es) 2001-10-24
EP0994880B1 (en) 2005-01-19
US6423722B1 (en) 2002-07-23
IL132761A0 (en) 2001-03-19
PT994880E (pt) 2005-06-30
HK1028597A1 (en) 2001-02-23
CN1261365A (zh) 2000-07-26
TW552264B (en) 2003-09-11
CO4940463A1 (es) 2000-07-24
CZ297244B6 (cs) 2006-10-11
HUP0003053A2 (hu) 2001-02-28
JP3880634B2 (ja) 2007-02-14
CN1139595C (zh) 2004-02-25
JP2001506279A (ja) 2001-05-15
ID24897A (id) 2000-08-31
WO1999001458A1 (en) 1999-01-14
MY118718A (en) 2005-01-31
KR20010020423A (ko) 2001-03-15
NO995909L (no) 1999-12-02
PE97699A1 (es) 1999-10-29
ZA985655B (en) 1998-12-30
ATE287410T1 (de) 2005-02-15
AU739211B2 (en) 2001-10-04
TR199903189T2 (xx) 2000-06-21
PL192761B1 (pl) 2006-12-29
JP2006151999A (ja) 2006-06-15
SK285665B6 (sk) 2007-05-03
NO995909D0 (no) 1999-12-02
KR100399765B1 (ko) 2003-09-29
NZ500994A (en) 2001-08-31
DE69828692T2 (de) 2006-01-12
DK0994880T3 (da) 2005-05-30
JP4504323B2 (ja) 2010-07-14
PL336719A1 (en) 2000-07-03
NO312765B1 (no) 2002-07-01
DE69828692D1 (de) 2005-02-24
EP0994880A1 (en) 2000-04-26
HUP0003053A3 (en) 2003-03-28
ES2236922T3 (es) 2005-07-16
CZ474099A3 (cs) 2000-04-12
AU8540998A (en) 1999-01-25
RU2219181C2 (ru) 2003-12-20
CA2290412C (en) 2009-11-10
BR9810956A (pt) 2000-09-26

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