KR900013950A - (7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온 화합물 및 약학적 담체를 함유한 약학적 조성물 - Google Patents

(7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온 화합물 및 약학적 담체를 함유한 약학적 조성물 Download PDF

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Publication number
KR900013950A
KR900013950A KR1019900003574A KR900003574A KR900013950A KR 900013950 A KR900013950 A KR 900013950A KR 1019900003574 A KR1019900003574 A KR 1019900003574A KR 900003574 A KR900003574 A KR 900003574A KR 900013950 A KR900013950 A KR 900013950A
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South Korea
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compound
pharmaceutical composition
hydroxy
methyl
animal
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KR1019900003574A
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English (en)
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KR0183401B1 (ko
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제랄드 아노우드 조제프 마리아 테레시아 사스
도르늄 에밀 마틴 반
Original Assignee
에프.쥐.엠 헤르만츠, 에.쥐.제이 베르미렌
악조 엔·브이
에.쥐.제이 베르미렌
악조 엔.브이
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Application filed by 에프.쥐.엠 헤르만츠, 에.쥐.제이 베르미렌, 악조 엔·브이, 에.쥐.제이 베르미렌, 악조 엔.브이 filed Critical 에프.쥐.엠 헤르만츠, 에.쥐.제이 베르미렌
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Abstract

내용 없음

Description

(7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온 화합물 및 약학적 담체를 함유한 약학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 제I형 화합물의 분말 X-선 회절 스펙트럼이고,
제2도는 제II형 화합물의 분말 X-선 회절 스펙트럼이며,
제3도는 제I형 및 제II형의 분말 X-선 회절 스펙트럼으로 부터 벗어난 다형 화합물(I)의 스펙트럼이다.

Claims (9)

  1. 순수한 결정질이고 기타 다른 결정질 형태를 거의 완전히 함유하지 않는 (7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온-구조의 화합물 및 약학적으로 적합한 담체를 함유한 약학적 조성물.
  2. 제1항에 있어서, 순수한 결정질 화합물은 제1도에 주어지는 바의 스펙트럼에 대응하는 분말 X-선 회절 스펙트럼에 의해 규정되는 화합물인 것을 특징으로 하는 약학적 조성물.
  3. 제1항에 있어서, 순수한 결정질 화합물은 제2도에 주어지는 바의 스펙트럼에 대응하는 분말 X-선 회절 스펙트럼에 의해 규정되는 화합물인 것을 특징으로 하는 약학적 조성물.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, 상기 화합물의 결정 순도는 95%이상인 것을 특징으로 하는 약학적 조성물.
  5. 제2항에 따른 약학적 조성물에 사용되는 순수한 결정질 화합물을 제조하는 방법에 있어서, 다형성 화합물은 극성 용매로 부터 결정되는 방법.
  6. 제3항에 따른 약학적 조성물에 사용되는 순수한 결정질 화합물을 제조하는 방법에 있어서, 다형성 화합물은 무슥성 용매로 부터 결정되는 방법.
  7. 제1도 또는 제2도에 주어진 스펙트럼에 대응하는 분말 X-선 회절 스펙트럼에 의해 규정된 (7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-온의 치료학적 충분량을 폐경기 증상을 지닌 동물에 투여하는 것을 포함하는 폐경기 증상을 지닌 동물의 치료 방법.
  8. 제1도 또는 제2도에 주어진 스펙트럼에 대응하는 분말 X-선 회절 스펙트럼에 의해 규정된 (7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온의 치료학적 충분량을 면역 결핍 동물에 투여하는 것을 포함하는 면역 결핍 동물의 치료 방법.
  9. 제1도 또는 제2도에 주어진 스펙트럼에 대응하는 분말 X-선 회절 스펙트럼에 의해 규정된 (7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온의 치료학적 충분량을 골다공증 동물에게 투여하는 것을 포함하는 골다공증 동물의 치료 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900003574A 1989-03-18 1990-03-17 (7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온 구조의 화합물 및 약학적 허용 담체를 함유한 약학적 조성물 KR0183401B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8900673 1989-03-18
NL8900673 1989-03-18

Publications (2)

Publication Number Publication Date
KR900013950A true KR900013950A (ko) 1990-10-22
KR0183401B1 KR0183401B1 (ko) 1999-05-01

Family

ID=19854317

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KR1019900003574A KR0183401B1 (ko) 1989-03-18 1990-03-17 (7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온 구조의 화합물 및 약학적 허용 담체를 함유한 약학적 조성물

Country Status (17)

Country Link
US (1) US5037817A (ko)
EP (1) EP0389035B1 (ko)
JP (2) JP3139709B2 (ko)
KR (1) KR0183401B1 (ko)
AT (1) ATE98490T1 (ko)
AU (1) AU625083B2 (ko)
CA (1) CA2011452C (ko)
DE (1) DE69005165T2 (ko)
DK (1) DK0389035T3 (ko)
ES (1) ES2062292T3 (ko)
FI (1) FI94865C (ko)
HK (1) HK1002019A1 (ko)
IE (1) IE63051B1 (ko)
MX (1) MX9203787A (ko)
NZ (1) NZ232946A (ko)
PT (1) PT93488B (ko)
ZA (1) ZA901674B (ko)

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ES2134313T3 (es) * 1993-03-05 1999-10-01 Akzo Nobel Nv Utilizacion de derivados de pregnano para el tratamiento de tumores.
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
IL123984A (en) * 1997-04-22 2004-09-27 Akzo Nobel Nv Pharmacological dosage units containing tibolone and carrier pharmacy are acceptable
CN100378116C (zh) 1998-10-16 2008-04-02 欧加农股份有限公司 包含(7α,17α)-17-羟基-7-甲基-19-去甲-17-孕-5(10)-烯-20-炔-3-酮的高纯度组合物
CA2332767A1 (en) * 1999-03-18 2000-09-21 Genelabs Technologies, Inc. Dhea composition and method
US7045513B1 (en) 1999-03-18 2006-05-16 Genelabs Technologies, Inc. DHEA composition and method
TWI265167B (en) 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
US20040229854A1 (en) * 2000-11-28 2004-11-18 Pieter Haan De Immediate release dosage form for HRT
EP1444247B1 (en) * 2001-10-18 2007-06-13 Norton Healthcare Limited Tibolone formulations
GB0125061D0 (en) * 2001-10-18 2001-12-12 Norton Healthcare Ltd Pharmaceutical composition
JP2005518412A (ja) * 2002-01-22 2005-06-23 アクゾ・ノベル・エヌ・ベー 内因性エストロゲンの合成を阻害する薬物の投与に伴う愁訴の治療におけるチボロン
GB0304927D0 (en) 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
CN1324041C (zh) * 2003-04-01 2007-07-04 上海迪赛诺医药科技开发有限公司 替勃龙晶型i的制备方法
WO2004103378A1 (en) * 2003-05-23 2004-12-02 Akzo Nobel N.V. Immediate-release pharmaceutical dosage form comprising polymorphous tibolone
WO2006125453A1 (en) * 2005-05-23 2006-11-30 Newchem S.P.A. Process for the preparation of pure crystalline tibolone
EP1821571A1 (en) * 2006-02-15 2007-08-22 Oticon A/S Loop antenna for in the ear audio device
ITMI20130120A1 (it) * 2013-01-25 2014-07-26 Ind Chimica Srl Processo per la preparazione in forma cristallina di tibolone, (7alfa,17alfa)-17-idrossi-7-metil-19-norpregn-5(10)-en-20-in-3-one
PL3452019T3 (pl) 2016-05-04 2021-12-20 Novalon S.A. Zastosowanie alkoholi cukrowych w kompozycjach tybolonu

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BE665514A (ko) * 1964-06-16
US4933168A (en) * 1975-05-27 1990-06-12 Syntex Pharmaceuticals International Limited Stable, crystalline flunisolide
US4273710A (en) * 1979-05-21 1981-06-16 Syntex Corporation Process for preparing flunisolide
US4447426A (en) * 1982-01-18 1984-05-08 E. R. Squibb & Sons, Inc. Steroid monohydrates, formulations containing same and method
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US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators

Also Published As

Publication number Publication date
JPH0347195A (ja) 1991-02-28
ES2062292T3 (es) 1994-12-16
FI901328A0 (fi) 1990-03-16
DE69005165D1 (de) 1994-01-27
IE63051B1 (en) 1995-03-22
US5037817A (en) 1991-08-06
CA2011452A1 (en) 1990-09-18
KR0183401B1 (ko) 1999-05-01
NZ232946A (en) 1991-08-27
EP0389035A1 (en) 1990-09-26
PT93488A (pt) 1990-11-07
FI94865C (fi) 1995-11-10
HK1002019A1 (en) 1998-07-24
AU5139490A (en) 1990-09-20
EP0389035B1 (en) 1993-12-15
MX9203787A (es) 1992-07-01
CA2011452C (en) 1999-05-25
DE69005165T2 (de) 1994-05-05
DK0389035T3 (da) 1994-02-14
JP3139709B2 (ja) 2001-03-05
AU625083B2 (en) 1992-07-02
FI94865B (fi) 1995-07-31
JP2001139473A (ja) 2001-05-22
IE900709L (en) 1990-09-18
PT93488B (pt) 1996-02-29
ATE98490T1 (de) 1994-01-15
ZA901674B (en) 1990-12-28

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