AR017754A1 - Macrolidas cristalinas, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento - Google Patents
Macrolidas cristalinas, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamentoInfo
- Publication number
- AR017754A1 AR017754A1 ARP980103094A ARP980103094A AR017754A1 AR 017754 A1 AR017754 A1 AR 017754A1 AR P980103094 A ARP980103094 A AR P980103094A AR P980103094 A ARP980103094 A AR P980103094A AR 017754 A1 AR017754 A1 AR 017754A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- compound
- formula
- macrolidas
- cristalinas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Macrolidas, que comprenden el compuesto de la formula (I) o una forma tautomérica o solvatada del mismo, en forma cristalina. su preparacion involucraconvertir apropiadamente el compuesto amorfo de la formula (I), o el compuesto de la formula (I) enuna forma diferente de la Forma A, o el compuesto de laformula (I) en una forma diferente de la Forma B, respectivamente, a partir de una solucion del mismo, bajo condiciones que induzcan cristalizacion, o bajocondiciones que induzcan cristalizacionpreferencial de la Forma A o B respectivamente. Estos cristales se indican particularmente para utilizarse en lapreparacion de formas galénicas locales del compuesto para uso farmacéutico, por ejemplo cremas, emulsiones, y unguentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9713730.1A GB9713730D0 (en) | 1997-06-30 | 1997-06-30 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR017754A1 true AR017754A1 (es) | 2001-10-24 |
Family
ID=10815103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980103094A AR017754A1 (es) | 1997-06-30 | 1998-06-26 | Macrolidas cristalinas, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6423722B1 (es) |
| EP (1) | EP0994880B1 (es) |
| JP (2) | JP3880634B2 (es) |
| KR (1) | KR100399765B1 (es) |
| CN (1) | CN1139595C (es) |
| AR (1) | AR017754A1 (es) |
| AT (1) | ATE287410T1 (es) |
| AU (1) | AU739211B2 (es) |
| BR (1) | BR9810956A (es) |
| CA (1) | CA2290412C (es) |
| CO (1) | CO4940463A1 (es) |
| CZ (1) | CZ297244B6 (es) |
| DE (1) | DE69828692T2 (es) |
| DK (1) | DK0994880T3 (es) |
| ES (1) | ES2236922T3 (es) |
| GB (1) | GB9713730D0 (es) |
| HK (1) | HK1028597A1 (es) |
| HU (1) | HU227755B1 (es) |
| ID (1) | ID24897A (es) |
| IL (1) | IL132761A0 (es) |
| MY (1) | MY118718A (es) |
| NO (1) | NO312765B1 (es) |
| NZ (1) | NZ500994A (es) |
| PE (1) | PE97699A1 (es) |
| PL (1) | PL192761B1 (es) |
| PT (1) | PT994880E (es) |
| RU (1) | RU2219181C2 (es) |
| SK (1) | SK285665B6 (es) |
| TR (1) | TR199903189T2 (es) |
| TW (1) | TW552264B (es) |
| WO (1) | WO1999001458A1 (es) |
| ZA (1) | ZA985655B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9713730D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| GB0125443D0 (en) * | 2001-10-23 | 2001-12-12 | Novartis Ag | Organic Compounds |
| DE602004024417D1 (de) * | 2003-09-03 | 2010-01-14 | Glaxo Group Ltd | Neues verfahren zur herstellung von pleuromutilinderivaten |
| KR20070060144A (ko) * | 2004-12-01 | 2007-06-12 | 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 | 결정체 마크로라이드의 제조 방법 |
| WO2008057511A2 (en) * | 2006-11-06 | 2008-05-15 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
| US20100105724A1 (en) * | 2006-12-07 | 2010-04-29 | Helsinn Healthcare Sa | Crystalline and amorphous forms of palonosetron hydrochloride |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| JP2012532670A (ja) | 2009-07-10 | 2012-12-20 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 薬剤搬送バルーンのためのナノ結晶の使用 |
| EP2453938B1 (en) | 2009-07-17 | 2015-08-19 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
| WO2012031236A1 (en) | 2010-09-02 | 2012-03-08 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| WO2013022458A1 (en) * | 2011-08-05 | 2013-02-14 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| CN105102967B (zh) | 2013-03-15 | 2018-10-12 | 生物传感器国际集团有限公司 | 雷帕霉素衍生物的纯化 |
| EP3178824A1 (en) | 2015-12-08 | 2017-06-14 | Medichem, S.A. | Process for preparing pimecrolimus |
| EP3619215B1 (en) * | 2017-05-01 | 2021-11-17 | MEDA Pharma GmbH & Co. KG | Process to convert crude ascomycin into purified pimecrolimus |
| EP3741367A1 (en) | 2019-05-21 | 2020-11-25 | Premark Pharma GmbH | Treatment of ocular disease |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51118816A (en) * | 1975-04-08 | 1976-10-19 | Meiji Seika Kaisha Ltd | A process for stabilizing non-crystalloidal solid |
| US4127647A (en) * | 1975-04-08 | 1978-11-28 | Meiji Seika Kaisha, Ltd. | Process for preparation of stable amorphous macrolide antibiotic solids |
| CY1306A (en) | 1980-10-01 | 1985-12-06 | Glaxo Group Ltd | Aminoalkyl furan derivative |
| JP2728482B2 (ja) * | 1989-01-26 | 1998-03-18 | 協和醗酵工業株式会社 | マクロライド系抗生物質の精製法 |
| EP0433428B1 (en) | 1989-07-10 | 1994-10-12 | Chemferm V.O.F. | A stable form of cephradine, process for its production and intermediates used therein |
| AU640963B2 (en) * | 1989-11-09 | 1993-09-09 | MEDA Pharma S.a.r.l | Heteroatoms-containing tricyclic compounds |
| IE910847A1 (en) * | 1990-03-13 | 1991-09-25 | Fisons Plc | Immunosuppressive macrocyclic compounds |
| EP0480623A1 (en) * | 1990-10-11 | 1992-04-15 | Merck & Co. Inc. | New halomacrolides and derivatives having immunosuppressive activity |
| US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
| DE69217762T2 (de) | 1991-07-30 | 1997-10-09 | Ajinomoto Kk | Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung |
| US5247076A (en) | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
| US5221740A (en) | 1992-01-16 | 1993-06-22 | American Home Products Corporation | Oxepane isomers of rapamycin useful as immunosuppressive agents |
| UA41884C2 (uk) * | 1993-11-05 | 2001-10-15 | Амерікан Хоум Продактс Корпорейшн | Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів |
| JP3808500B2 (ja) * | 1994-02-22 | 2006-08-09 | キューレータズ オブ ディ ユニバーシティ オブ ミズーリ | 分離剤としての大環状抗生物質 |
| JPH11512096A (ja) * | 1995-08-24 | 1999-10-19 | メルク エンド カンパニー インコーポレーテッド | イミダゾリルマクロライド免疫抑制剤の製造方法 |
| GB9713730D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
-
1997
- 1997-06-30 GB GBGB9713730.1A patent/GB9713730D0/en active Pending
-
1998
- 1998-06-25 CO CO98036359A patent/CO4940463A1/es unknown
- 1998-06-26 IL IL13276198A patent/IL132761A0/xx not_active IP Right Cessation
- 1998-06-26 SK SK1866-99A patent/SK285665B6/sk not_active IP Right Cessation
- 1998-06-26 CZ CZ0474099A patent/CZ297244B6/cs not_active IP Right Cessation
- 1998-06-26 HU HU0003053A patent/HU227755B1/hu unknown
- 1998-06-26 PT PT98936392T patent/PT994880E/pt unknown
- 1998-06-26 NZ NZ500994A patent/NZ500994A/en not_active IP Right Cessation
- 1998-06-26 BR BR9810956-1A patent/BR9810956A/pt not_active Application Discontinuation
- 1998-06-26 TR TR1999/03189T patent/TR199903189T2/xx unknown
- 1998-06-26 RU RU2000101826/04A patent/RU2219181C2/ru active
- 1998-06-26 WO PCT/EP1998/003929 patent/WO1999001458A1/en active IP Right Grant
- 1998-06-26 CN CNB988064677A patent/CN1139595C/zh not_active Expired - Lifetime
- 1998-06-26 AR ARP980103094A patent/AR017754A1/es active IP Right Grant
- 1998-06-26 KR KR10-1999-7010048A patent/KR100399765B1/ko not_active IP Right Cessation
- 1998-06-26 AU AU85409/98A patent/AU739211B2/en not_active Expired
- 1998-06-26 ES ES98936392T patent/ES2236922T3/es not_active Expired - Lifetime
- 1998-06-26 ID IDW991682A patent/ID24897A/id unknown
- 1998-06-26 PE PE1998000568A patent/PE97699A1/es not_active IP Right Cessation
- 1998-06-26 DK DK98936392T patent/DK0994880T3/da active
- 1998-06-26 JP JP50628799A patent/JP3880634B2/ja not_active Expired - Lifetime
- 1998-06-26 AT AT98936392T patent/ATE287410T1/de active
- 1998-06-26 DE DE69828692T patent/DE69828692T2/de not_active Expired - Lifetime
- 1998-06-26 CA CA002290412A patent/CA2290412C/en not_active Expired - Lifetime
- 1998-06-26 PL PL336719A patent/PL192761B1/pl unknown
- 1998-06-26 EP EP98936392A patent/EP0994880B1/en not_active Expired - Lifetime
- 1998-06-29 ZA ZA985655A patent/ZA985655B/xx unknown
- 1998-06-29 MY MYPI98002955A patent/MY118718A/en unknown
- 1998-07-21 TW TW087111867A patent/TW552264B/zh not_active IP Right Cessation
-
1999
- 1999-12-02 NO NO19995909A patent/NO312765B1/no not_active IP Right Cessation
-
2000
- 2000-10-17 US US09/690,404 patent/US6423722B1/en not_active Expired - Lifetime
- 2000-10-25 HK HK00106806A patent/HK1028597A1/xx not_active IP Right Cessation
-
2006
- 2006-03-01 JP JP2006055107A patent/JP4504323B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR017754A1 (es) | Macrolidas cristalinas, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento | |
| ES2157254T3 (es) | Ceftiofur (acido libre) cristalino. | |
| BR9915420A (pt) | Composto, composição farmacêutica, métodos de tratar um distúrbio mediado por tnf e por p38 cinase, inflamação e artrite e processo de preparar pirazóis | |
| CO5310550A1 (es) | Nuevo derivado de androstano antiinflamatorio, su polimorfo, sus formas cristalinas solvatadas, composiciones farmaceutias, proceso para prepararlo, intermediario | |
| AR005009A1 (es) | Monohidrato del cdch, procedimiento para su produccion , composiciones antibacteriales que lo contienen, uso del monohidrato del cdch para la manufactura de medicamentos. | |
| AR005703A1 (es) | Oxazolidinonas sustituidas, procedimiento para su preparacion, uso de las mismas para preparar medicamentos y medicamentos que las contienen | |
| AR025052A1 (es) | Derivados de 2-dialquilaminoalquilbifenilo sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de estoscompuestos para la preparacion de medicamentos. | |
| BR9202002A (pt) | Composto quimico de acido carboxilico,composicao farmaceutica,processo para preparacao de um composto,e,uso deste composto | |
| BR0017013A (pt) | Composições de antibiótico azalìdeo | |
| HUT46847A (en) | Process for producing retarde pharmaceutical compositions of oral application | |
| AR077416A2 (es) | Compuesto polimorfo estable de flibanserina , procedimiento industrial para su preparacion y uso del mismo para preparar medicamentos | |
| MX9203396A (es) | Monohidrato de furoato de mometasona, proceso para producirlo y composiciones farmaceuticas. | |
| ECSP003792A (es) | Cristal de 4-carboxamino-1,2,3,4-tetrahidroquinolina 2-sustituida | |
| BR0008011A (pt) | Agente embranquecedor fluorescente, suapreparação e uso | |
| UY27410A1 (es) | Formas novedosas crudas cristalinas | |
| CL43546B (es) | Compuesto derivado de tetrahidroquinolina con actividad moduladora del receptor fsh; composicion farmaceutica que contiene al compuesto; y uso del compuesto en la preparacion de medicamentos para la regulacion de la fertilidad. | |
| ES2178214T3 (es) | Preparacion de zeolita l. | |
| RU2000101826A (ru) | Кристаллические макролиды и способ их получения | |
| MY126071A (en) | Crystalline form ii of cabergoline. | |
| AR035553A1 (es) | Formas cristalinas de melagatran, proceso para su produccion, formulacion farmaceutica, y uso de este compuesto en la elaboracion de medicamentos. | |
| MX9400165A (es) | Derivados de ter-butilergolina, proceso para su produccion y composiciones farmaceuticas que los contienen. | |
| ECSP982561A (es) | Macrolidas cristalinas | |
| BR0005392A (pt) | Composição de dhea e processo | |
| AU2003267551A1 (en) | Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone | |
| BR9902347A (pt) | Azabiciclos como inibidores de rotomase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |