DE69828692D1 - Kristalline macrolide und verfahren zu ihrer herstellung - Google Patents

Kristalline macrolide und verfahren zu ihrer herstellung

Info

Publication number
DE69828692D1
DE69828692D1 DE69828692T DE69828692T DE69828692D1 DE 69828692 D1 DE69828692 D1 DE 69828692D1 DE 69828692 T DE69828692 T DE 69828692T DE 69828692 T DE69828692 T DE 69828692T DE 69828692 D1 DE69828692 D1 DE 69828692D1
Authority
DE
Germany
Prior art keywords
preparing
macrolides
crystalline
crystalline macrolides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69828692T
Other languages
English (en)
Other versions
DE69828692T2 (de
Inventor
Cornelia Dosenbach
Maximilian Grassberger
Otto Hartmann
Amarylla Horvath
Jean-Paul Mutz
Gerhard Penn
Sabine Pfeffer
Dierk Wieckhusen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meda Pharma SARL
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10815103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69828692(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE69828692D1 publication Critical patent/DE69828692D1/de
Publication of DE69828692T2 publication Critical patent/DE69828692T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69828692T 1997-06-30 1998-06-26 Kristalline macrolide und verfahren zu ihrer herstellung Expired - Lifetime DE69828692T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9713730.1A GB9713730D0 (en) 1997-06-30 1997-06-30 Organic compounds
GB9713730 1997-06-30
PCT/EP1998/003929 WO1999001458A1 (en) 1997-06-30 1998-06-26 Crystalline macrolides and process for their preparation

Publications (2)

Publication Number Publication Date
DE69828692D1 true DE69828692D1 (de) 2005-02-24
DE69828692T2 DE69828692T2 (de) 2006-01-12

Family

ID=10815103

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69828692T Expired - Lifetime DE69828692T2 (de) 1997-06-30 1998-06-26 Kristalline macrolide und verfahren zu ihrer herstellung

Country Status (32)

Country Link
US (1) US6423722B1 (de)
EP (1) EP0994880B1 (de)
JP (2) JP3880634B2 (de)
KR (1) KR100399765B1 (de)
CN (1) CN1139595C (de)
AR (1) AR017754A1 (de)
AT (1) ATE287410T1 (de)
AU (1) AU739211B2 (de)
BR (1) BR9810956A (de)
CA (1) CA2290412C (de)
CO (1) CO4940463A1 (de)
CZ (1) CZ297244B6 (de)
DE (1) DE69828692T2 (de)
DK (1) DK0994880T3 (de)
ES (1) ES2236922T3 (de)
GB (1) GB9713730D0 (de)
HK (1) HK1028597A1 (de)
HU (1) HU227755B1 (de)
ID (1) ID24897A (de)
IL (1) IL132761A0 (de)
MY (1) MY118718A (de)
NO (1) NO312765B1 (de)
NZ (1) NZ500994A (de)
PE (1) PE97699A1 (de)
PL (1) PL192761B1 (de)
PT (1) PT994880E (de)
RU (1) RU2219181C2 (de)
SK (1) SK285665B6 (de)
TR (1) TR199903189T2 (de)
TW (1) TW552264B (de)
WO (1) WO1999001458A1 (de)
ZA (1) ZA985655B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
US7875630B2 (en) * 2003-09-03 2011-01-25 Glaxo Group Limited Process salts compositions and use
EP1817314A1 (de) * 2004-12-01 2007-08-15 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Nichthygroskopisches und pulverförmiges amorphes pimecrolimus
WO2008057511A2 (en) * 2006-11-06 2008-05-15 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
WO2008073757A1 (en) * 2006-12-07 2008-06-19 Helsinn Healthcare Sa Crystalline and amorphous forms of palonosetron hydrochloride
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
ES2550634T3 (es) 2009-07-10 2015-11-11 Boston Scientific Scimed, Inc. Uso de nanocristales para un balón de suministro de fármaco
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
WO2013022458A1 (en) * 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
WO2014145780A1 (en) 2013-03-15 2014-09-18 Biosensors International Group, Ltd. Purification of rapamycin derivatives
EP3178824A1 (de) 2015-12-08 2017-06-14 Medichem, S.A. Verfahren zur herstellung von pimecrolimus
CA3060330A1 (en) * 2017-05-01 2018-11-08 Meda Pharma Gmbh & Co. Kg Process to convert crude ascomycin into purified pimecrolimus
EP3741367A1 (de) 2019-05-21 2020-11-25 Premark Pharma GmbH Behandlung von augenerkrankungen
WO2024209038A1 (en) 2023-04-06 2024-10-10 Premark Pharma Gmbh Use of pimecrolimus for the treatment of dry eye in patients characterized by a corneal staining score of 4 or 5 on the oxford grading scale

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118816A (en) * 1975-04-08 1976-10-19 Meiji Seika Kaisha Ltd A process for stabilizing non-crystalloidal solid
US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
CY1306A (en) 1980-10-01 1985-12-06 Glaxo Group Ltd Aminoalkyl furan derivative
JP2728482B2 (ja) * 1989-01-26 1998-03-18 協和醗酵工業株式会社 マクロライド系抗生物質の精製法
WO1991000865A1 (en) 1989-07-10 1991-01-24 Gema S.A. A novel stable form of cephradine, process for its production and intermediates used therein
NZ235991A (en) * 1989-11-09 1993-05-26 Sandoz Ltd Macrolide compounds and pharmaceutical compositions thereof
JPH05505798A (ja) * 1990-03-13 1993-08-26 フアイソンズ・ピーエルシー 免疫抑制マクロ環状化合物
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
EP0480623A1 (de) * 1990-10-11 1992-04-15 Merck & Co. Inc. Halomakrolide und Derivate mit immunosuppressiver Wirkung
ES2100291T3 (es) 1991-07-30 1997-06-16 Ajinomoto Kk Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos.
US5247076A (en) 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5221740A (en) 1992-01-16 1993-06-22 American Home Products Corporation Oxepane isomers of rapamycin useful as immunosuppressive agents
UA41884C2 (uk) * 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
US5626757A (en) * 1994-02-22 1997-05-06 Advanced Separation Technologies Inc. Macrocyclic antibiotics as separation agents
AU6900596A (en) * 1995-08-24 1997-03-19 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds

Also Published As

Publication number Publication date
SK285665B6 (sk) 2007-05-03
US6423722B1 (en) 2002-07-23
DK0994880T3 (da) 2005-05-30
GB9713730D0 (en) 1997-09-03
IL132761A0 (en) 2001-03-19
HUP0003053A2 (hu) 2001-02-28
CZ474099A3 (cs) 2000-04-12
CZ297244B6 (cs) 2006-10-11
JP4504323B2 (ja) 2010-07-14
PT994880E (pt) 2005-06-30
JP3880634B2 (ja) 2007-02-14
DE69828692T2 (de) 2006-01-12
TR199903189T2 (xx) 2000-06-21
AR017754A1 (es) 2001-10-24
ZA985655B (en) 1998-12-30
NO995909D0 (no) 1999-12-02
JP2006151999A (ja) 2006-06-15
KR20010020423A (ko) 2001-03-15
CA2290412A1 (en) 1999-01-14
PE97699A1 (es) 1999-10-29
TW552264B (en) 2003-09-11
AU8540998A (en) 1999-01-25
ID24897A (id) 2000-08-31
PL336719A1 (en) 2000-07-03
WO1999001458A1 (en) 1999-01-14
RU2219181C2 (ru) 2003-12-20
BR9810956A (pt) 2000-09-26
HK1028597A1 (en) 2001-02-23
NZ500994A (en) 2001-08-31
MY118718A (en) 2005-01-31
EP0994880B1 (de) 2005-01-19
JP2001506279A (ja) 2001-05-15
AU739211B2 (en) 2001-10-04
ATE287410T1 (de) 2005-02-15
HU227755B1 (en) 2012-02-28
NO995909L (no) 1999-12-02
PL192761B1 (pl) 2006-12-29
SK186699A3 (en) 2000-05-16
CN1261365A (zh) 2000-07-26
KR100399765B1 (ko) 2003-09-29
CO4940463A1 (es) 2000-07-24
CA2290412C (en) 2009-11-10
NO312765B1 (no) 2002-07-01
ES2236922T3 (es) 2005-07-16
EP0994880A1 (de) 2000-04-26
HUP0003053A3 (en) 2003-03-28
CN1139595C (zh) 2004-02-25

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Legal Events

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Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

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