DE69502772D1 - Baccatinderivate und Verfahren zu ihrer Herstellung - Google Patents

Baccatinderivate und Verfahren zu ihrer Herstellung

Info

Publication number
DE69502772D1
DE69502772D1 DE69502772T DE69502772T DE69502772D1 DE 69502772 D1 DE69502772 D1 DE 69502772D1 DE 69502772 T DE69502772 T DE 69502772T DE 69502772 T DE69502772 T DE 69502772T DE 69502772 D1 DE69502772 D1 DE 69502772D1
Authority
DE
Germany
Prior art keywords
preparation
baccatin derivatives
baccatin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69502772T
Other languages
English (en)
Other versions
DE69502772T2 (de
Inventor
Kenji Tsujihara
Tomiki Hashiyama
Naoyuki Harada
Tetsuo Yamaguchi
Kunihiko Ozaki
Motoaki Ohashi
Noriyuki Nakanishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of DE69502772D1 publication Critical patent/DE69502772D1/de
Publication of DE69502772T2 publication Critical patent/DE69502772T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
DE69502772T 1994-06-28 1995-06-22 Baccatinderivate und Verfahren zu ihrer Herstellung Expired - Fee Related DE69502772T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14584394 1994-06-28
JP14584494 1994-06-28
JP3948095 1995-02-28

Publications (2)

Publication Number Publication Date
DE69502772D1 true DE69502772D1 (de) 1998-07-09
DE69502772T2 DE69502772T2 (de) 1998-11-05

Family

ID=27290153

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69502772T Expired - Fee Related DE69502772T2 (de) 1994-06-28 1995-06-22 Baccatinderivate und Verfahren zu ihrer Herstellung

Country Status (3)

Country Link
US (1) US5677470A (de)
EP (1) EP0693485B1 (de)
DE (1) DE69502772T2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
EP1019347B1 (de) 1997-08-21 2003-03-19 Florida State University Verfahren zur synthese von taxanen
FR2776292B1 (fr) * 1998-03-20 2004-09-10 Oncopharm Cephalotaxanes porteurs de chaine laterale et leur procede de synthese
HUP0302599A3 (en) 2000-09-22 2005-05-30 Bristol Myers Squibb Co Method for reducing toxicity of combined chemotherapic compositions
EP1537094B1 (de) * 2002-08-04 2014-07-02 Phyton Holdings, LLC Verfahren zur Umwandlung von Taxanamiden in Paclitaxel oder andere Taxane
AU2003282624A1 (en) 2002-11-14 2004-06-03 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
CN104177614B (zh) * 2014-08-21 2016-08-24 中国科学院长春应用化学研究所 一种高分子前药及其制备方法
ES2834977T3 (es) 2017-07-28 2021-06-21 Daw Se Pasta de tono de color que contiene disolvente

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6013775A (ja) * 1983-07-05 1985-01-24 Sawai Seiyaku Kk 光学活性３−（ｐ−アルコキシフエニル）グリシツド酸アルカリ金属塩の製造法
JPS6013776A (ja) * 1983-07-05 1985-01-24 Sawai Seiyaku Kk 光学活性３−（ｐ−アルコキシフエニル）グリシツド酸誘導体の製造法
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
JPH01130577A (ja) * 1987-11-17 1989-05-23 Mitsubishi Electric Corp 発光ダイオード
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
JPH0678B2 (ja) * 1988-09-02 1994-01-05 田辺製薬株式会社 光学活性３―フェニルグリシッド酸エステル類化合物の製法
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5219509A (en) 1990-11-30 1993-06-15 Corning Incorporated Method for forming a uniform skin on a cellular substrate
WO1993006079A1 (en) * 1991-09-23 1993-04-01 Florida State University PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
WO1993010076A1 (en) * 1991-11-22 1993-05-27 The University Of Mississippi Synthesis and optical resolution of the taxol side chain and related compounds
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
ATE181551T1 (de) * 1992-04-17 1999-07-15 Abbott Lab Taxol-derivate
JPH064607A (ja) * 1992-06-18 1994-01-14 Ricoh Co Ltd データ表示装置
GB9213077D0 (en) * 1992-06-19 1992-08-05 Erba Carlo Spa Polymerbound taxol derivatives
JPH0651689A (ja) * 1992-07-27 1994-02-25 Meiji Toshiyo Shuppan Kk 学習テキスト対応コンピュータ・ソフト
US5470866A (en) * 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
CA2100808A1 (en) * 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
JP3933196B2 (ja) * 1992-11-13 2007-06-20 フロリダ・ステート・ユニバーシティー アルキル置換側鎖を有するタキサンおよびそれを含有する薬剤組成物
FR2698363B1 (fr) 1992-11-23 1994-12-30 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions qui les contiennent.
KR100378612B1 (ko) * 1992-12-23 2003-04-03 브리스톨-마이어스스퀴브컴파니 신규 측쇄-함유 탁산 및 그의 중간체 화합물
NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
AU682173B2 (en) * 1993-01-15 1997-09-25 Florida State University Process for the preparation of 10-desacetoxybaccatin III
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State History of C-10 Texan and pharmaceuticals containing them
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
BR9405687C1 (pt) * 1993-02-05 2001-08-07 Bryn Mawr College Processo quìmico utilizável na produção de análogos de taxol e, composto quìmico
DE69432140T2 (de) * 1993-03-05 2003-07-31 Univ Florida State Verfahren zur Herstellung von 9-Desoxotaxanen
DK0688212T3 (da) * 1993-03-05 2002-10-07 Univ Florida State C9-taxanderivater og farmaceutiske præparater indeholdende disse
ATE195421T1 (de) * 1993-03-22 2000-09-15 Univ Florida State Taxane mit amino-substituierter seitenkette
EP0689436B1 (de) * 1993-03-22 2003-11-26 Florida State University Taxane ohne die c-9 oxo gruppe und diese enthaltende pharmazeutische präparate
US6214345B1 (en) * 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
IL109926A (en) * 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
WO1995004154A1 (en) * 1993-07-27 1995-02-09 Nippon Steel Corporation Process for producing taxol and its analogues using microorganisms
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
FR2711370B1 (fr) * 1993-10-18 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2712288B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
IL127597A (en) * 1994-01-28 2003-07-31 Upjohn Co Iso-taxol analogs
US5395850A (en) * 1994-03-10 1995-03-07 Bristol-Myers Squibb Company 6,7-epoxy paclitaxels
GB9405400D0 (en) * 1994-03-18 1994-05-04 Erba Carlo Spa Taxane derivatives
JP3015398U (ja) 1995-03-04 1995-08-29 西岡 璋 内燃機関等の排ガス浄化燃料節減装置

Also Published As

Publication number Publication date
EP0693485A3 (de) 1996-05-08
DE69502772T2 (de) 1998-11-05
US5677470A (en) 1997-10-14
EP0693485B1 (de) 1998-06-03
EP0693485A2 (de) 1996-01-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee