HK1028597A1 - Crystalline macrolides and process for their preparation. - Google Patents

Crystalline macrolides and process for their preparation.

Info

Publication number
HK1028597A1
HK1028597A1 HK00106806A HK00106806A HK1028597A1 HK 1028597 A1 HK1028597 A1 HK 1028597A1 HK 00106806 A HK00106806 A HK 00106806A HK 00106806 A HK00106806 A HK 00106806A HK 1028597 A1 HK1028597 A1 HK 1028597A1
Authority
HK
Hong Kong
Prior art keywords
formula
compound
preparation
crystalline
conditions
Prior art date
Application number
HK00106806A
Other languages
English (en)
Inventor
Cornelia Dosenbach
Maximilian Grassberger
Otto Hartmann
Amarylla Horvath
Jean-Paul Mutz
Gerhard Penn
Sabine Pfeffer
Dierk Wieckhusen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10815103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1028597(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1028597A1 publication Critical patent/HK1028597A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK00106806A 1997-06-30 2000-10-25 Crystalline macrolides and process for their preparation. HK1028597A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9713730.1A GB9713730D0 (en) 1997-06-30 1997-06-30 Organic compounds
PCT/EP1998/003929 WO1999001458A1 (en) 1997-06-30 1998-06-26 Crystalline macrolides and process for their preparation

Publications (1)

Publication Number Publication Date
HK1028597A1 true HK1028597A1 (en) 2001-02-23

Family

ID=10815103

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00106806A HK1028597A1 (en) 1997-06-30 2000-10-25 Crystalline macrolides and process for their preparation.

Country Status (32)

Country Link
US (1) US6423722B1 (xx)
EP (1) EP0994880B1 (xx)
JP (2) JP3880634B2 (xx)
KR (1) KR100399765B1 (xx)
CN (1) CN1139595C (xx)
AR (1) AR017754A1 (xx)
AT (1) ATE287410T1 (xx)
AU (1) AU739211B2 (xx)
BR (1) BR9810956A (xx)
CA (1) CA2290412C (xx)
CO (1) CO4940463A1 (xx)
CZ (1) CZ297244B6 (xx)
DE (1) DE69828692T2 (xx)
DK (1) DK0994880T3 (xx)
ES (1) ES2236922T3 (xx)
GB (1) GB9713730D0 (xx)
HK (1) HK1028597A1 (xx)
HU (1) HU227755B1 (xx)
ID (1) ID24897A (xx)
IL (1) IL132761A0 (xx)
MY (1) MY118718A (xx)
NO (1) NO312765B1 (xx)
NZ (1) NZ500994A (xx)
PE (1) PE97699A1 (xx)
PL (1) PL192761B1 (xx)
PT (1) PT994880E (xx)
RU (1) RU2219181C2 (xx)
SK (1) SK285665B6 (xx)
TR (1) TR199903189T2 (xx)
TW (1) TW552264B (xx)
WO (1) WO1999001458A1 (xx)
ZA (1) ZA985655B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
US7875630B2 (en) * 2003-09-03 2011-01-25 Glaxo Group Limited Process salts compositions and use
EP1817314A1 (en) * 2004-12-01 2007-08-15 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Non-hygroscopic and powdery amorphous pimecrolimus
WO2008057511A2 (en) * 2006-11-06 2008-05-15 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
WO2008073757A1 (en) * 2006-12-07 2008-06-19 Helsinn Healthcare Sa Crystalline and amorphous forms of palonosetron hydrochloride
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
ES2550634T3 (es) 2009-07-10 2015-11-11 Boston Scientific Scimed, Inc. Uso de nanocristales para un balón de suministro de fármaco
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
WO2013022458A1 (en) * 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
WO2014145780A1 (en) 2013-03-15 2014-09-18 Biosensors International Group, Ltd. Purification of rapamycin derivatives
EP3178824A1 (en) 2015-12-08 2017-06-14 Medichem, S.A. Process for preparing pimecrolimus
CA3060330A1 (en) * 2017-05-01 2018-11-08 Meda Pharma Gmbh & Co. Kg Process to convert crude ascomycin into purified pimecrolimus
EP3741367A1 (en) 2019-05-21 2020-11-25 Premark Pharma GmbH Treatment of ocular disease
WO2024209038A1 (en) 2023-04-06 2024-10-10 Premark Pharma Gmbh Use of pimecrolimus for the treatment of dry eye in patients characterized by a corneal staining score of 4 or 5 on the oxford grading scale

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118816A (en) * 1975-04-08 1976-10-19 Meiji Seika Kaisha Ltd A process for stabilizing non-crystalloidal solid
US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
CY1306A (en) 1980-10-01 1985-12-06 Glaxo Group Ltd Aminoalkyl furan derivative
JP2728482B2 (ja) * 1989-01-26 1998-03-18 協和醗酵工業株式会社 マクロライド系抗生物質の精製法
WO1991000865A1 (en) 1989-07-10 1991-01-24 Gema S.A. A novel stable form of cephradine, process for its production and intermediates used therein
NZ235991A (en) * 1989-11-09 1993-05-26 Sandoz Ltd Macrolide compounds and pharmaceutical compositions thereof
JPH05505798A (ja) * 1990-03-13 1993-08-26 フアイソンズ・ピーエルシー 免疫抑制マクロ環状化合物
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
EP0480623A1 (en) * 1990-10-11 1992-04-15 Merck & Co. Inc. New halomacrolides and derivatives having immunosuppressive activity
ES2100291T3 (es) 1991-07-30 1997-06-16 Ajinomoto Kk Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos.
US5247076A (en) 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5221740A (en) 1992-01-16 1993-06-22 American Home Products Corporation Oxepane isomers of rapamycin useful as immunosuppressive agents
UA41884C2 (uk) * 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
US5626757A (en) * 1994-02-22 1997-05-06 Advanced Separation Technologies Inc. Macrocyclic antibiotics as separation agents
AU6900596A (en) * 1995-08-24 1997-03-19 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds

Also Published As

Publication number Publication date
SK285665B6 (sk) 2007-05-03
US6423722B1 (en) 2002-07-23
DK0994880T3 (da) 2005-05-30
GB9713730D0 (en) 1997-09-03
IL132761A0 (en) 2001-03-19
HUP0003053A2 (hu) 2001-02-28
CZ474099A3 (cs) 2000-04-12
CZ297244B6 (cs) 2006-10-11
JP4504323B2 (ja) 2010-07-14
PT994880E (pt) 2005-06-30
JP3880634B2 (ja) 2007-02-14
DE69828692T2 (de) 2006-01-12
TR199903189T2 (xx) 2000-06-21
AR017754A1 (es) 2001-10-24
ZA985655B (en) 1998-12-30
NO995909D0 (no) 1999-12-02
JP2006151999A (ja) 2006-06-15
KR20010020423A (ko) 2001-03-15
CA2290412A1 (en) 1999-01-14
PE97699A1 (es) 1999-10-29
TW552264B (en) 2003-09-11
AU8540998A (en) 1999-01-25
ID24897A (id) 2000-08-31
PL336719A1 (en) 2000-07-03
WO1999001458A1 (en) 1999-01-14
RU2219181C2 (ru) 2003-12-20
BR9810956A (pt) 2000-09-26
NZ500994A (en) 2001-08-31
MY118718A (en) 2005-01-31
EP0994880B1 (en) 2005-01-19
JP2001506279A (ja) 2001-05-15
AU739211B2 (en) 2001-10-04
ATE287410T1 (de) 2005-02-15
HU227755B1 (en) 2012-02-28
NO995909L (no) 1999-12-02
PL192761B1 (pl) 2006-12-29
SK186699A3 (en) 2000-05-16
DE69828692D1 (de) 2005-02-24
CN1261365A (zh) 2000-07-26
KR100399765B1 (ko) 2003-09-29
CO4940463A1 (es) 2000-07-24
CA2290412C (en) 2009-11-10
NO312765B1 (no) 2002-07-01
ES2236922T3 (es) 2005-07-16
EP0994880A1 (en) 2000-04-26
HUP0003053A3 (en) 2003-03-28
CN1139595C (zh) 2004-02-25

Similar Documents

Publication Publication Date Title
HK1028597A1 (en) Crystalline macrolides and process for their preparation.
ES2157254T3 (es) Ceftiofur (acido libre) cristalino.
NO881933D0 (no) Orale administreringsformer med forsinket avgivning.
DK0629608T3 (da) Fremgangsmåde til fremstilling af N-acyl-N,N',N'-ethylendiamintrieddikesyrederivater
EP1110911A3 (en) Preparation of aluminosilicate zeolites
AP2002002531A0 (en) 4-Carboboxyamino-2-ethyl-1,2,3,4-tetrahydroquinoline crystal as cetp inihibitor.
PT822935E (pt) Processo para a preparacao de esteres do acido tropinoico enanteomericamente puros
MA19778A1 (fr) Procede de preparation d'une nouvelle forme orale de Clometacine.
BR9807326A (pt) Processo para preparar cristais de ácido dicarboxìlico a partir de uma solução contendo pelo menos um ácido dicarboxìlixo orgânico, cristais de ácido dicarboxìlico, e, uso de pelo menos um polieletrólito aniÈnico.
EP0947507A4 (en) TETRAHYDROBENZINDOLON DERIVATIVES
RU2000101826A (ru) Кристаллические макролиды и способ их получения
FI98067C (fi) Uusia alkyleenidiammoniumdiklavulanaattijohdannaisia, menetelmä niidenvalmistamiseksi samoin kuin niiden käyttö kalvulaanihapon puhdistamiseksi
BG104712A (en) S-substituted 11beta-benzaldoxime-estra-4,9-diene-carbonic acid thiolesters, method for the production thereof and pharmaceutical preparations containing these compounds
BR9815862A (pt) Processo para preparação de zeólito l cristalino
BR1100548KB1 (pt) processos para a preparação de derivados de ácido n-acetil neuramìnico cristalino.
MY126071A (en) Crystalline form ii of cabergoline.
BR9812453A (pt) Cristalização de açúcares
BR9811855A (pt) Processo para preparação de ácido l-ascórbico
PT905138E (pt) Cristais de maltitol de formas particulares composicoes cristalinas que os contenham e processos para a sua preparacao
BR9910085A (pt) Processo para a cristalização de um antibiótico de beta-lactama
ECSP982561A (es) Macrolidas cristalinas
BRPI0017522B8 (pt) processo para preparação de secretagogos de hormônio de crescimento e polimorfo
TR199901363T2 (xx) Bir tetrahidro piridin t�revinin kristalle�tirilmesi i�in y�ntem ve bu �ekilde elde edilen kristal �ekiller.
AU7494496A (en) Production of a crystalline salt of amoxicillin
WO2001030759A3 (en) Sodium-hydrogen exchanger type 1 inhibitor crystals

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20180625