ATE287410T1 - Kristalline macrolide und verfahren zu ihrer herstellung - Google Patents

Kristalline macrolide und verfahren zu ihrer herstellung

Info

Publication number
ATE287410T1
ATE287410T1 AT98936392T AT98936392T ATE287410T1 AT E287410 T1 ATE287410 T1 AT E287410T1 AT 98936392 T AT98936392 T AT 98936392T AT 98936392 T AT98936392 T AT 98936392T AT E287410 T1 ATE287410 T1 AT E287410T1
Authority
AT
Austria
Prior art keywords
production
macrolides
crystalline
crystalline macrolides
Prior art date
Application number
AT98936392T
Other languages
English (en)
Inventor
Cornelia Dosenbach
Maximilian Grassberger
Otto Hartmann
Amarylla Horvath
Jean-Paul Mutz
Gerhard Penn
Sabine Pfeffer
Dierk Wieckhusen
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10815103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE287410(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE287410T1 publication Critical patent/ATE287410T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98936392T 1997-06-30 1998-06-26 Kristalline macrolide und verfahren zu ihrer herstellung ATE287410T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9713730.1A GB9713730D0 (en) 1997-06-30 1997-06-30 Organic compounds
PCT/EP1998/003929 WO1999001458A1 (en) 1997-06-30 1998-06-26 Crystalline macrolides and process for their preparation

Publications (1)

Publication Number Publication Date
ATE287410T1 true ATE287410T1 (de) 2005-02-15

Family

ID=10815103

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98936392T ATE287410T1 (de) 1997-06-30 1998-06-26 Kristalline macrolide und verfahren zu ihrer herstellung

Country Status (32)

Country Link
US (1) US6423722B1 (de)
EP (1) EP0994880B1 (de)
JP (2) JP3880634B2 (de)
KR (1) KR100399765B1 (de)
CN (1) CN1139595C (de)
AR (1) AR017754A1 (de)
AT (1) ATE287410T1 (de)
AU (1) AU739211B2 (de)
BR (1) BR9810956A (de)
CA (1) CA2290412C (de)
CO (1) CO4940463A1 (de)
CZ (1) CZ297244B6 (de)
DE (1) DE69828692T2 (de)
DK (1) DK0994880T3 (de)
ES (1) ES2236922T3 (de)
GB (1) GB9713730D0 (de)
HK (1) HK1028597A1 (de)
HU (1) HU227755B1 (de)
ID (1) ID24897A (de)
IL (1) IL132761A0 (de)
MY (1) MY118718A (de)
NO (1) NO312765B1 (de)
NZ (1) NZ500994A (de)
PE (1) PE97699A1 (de)
PL (1) PL192761B1 (de)
PT (1) PT994880E (de)
RU (1) RU2219181C2 (de)
SK (1) SK285665B6 (de)
TR (1) TR199903189T2 (de)
TW (1) TW552264B (de)
WO (1) WO1999001458A1 (de)
ZA (1) ZA985655B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
DE602004024417D1 (de) * 2003-09-03 2010-01-14 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
KR20070060144A (ko) * 2004-12-01 2007-06-12 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 결정체 마크로라이드의 제조 방법
WO2008057511A2 (en) * 2006-11-06 2008-05-15 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
US20100105724A1 (en) * 2006-12-07 2010-04-29 Helsinn Healthcare Sa Crystalline and amorphous forms of palonosetron hydrochloride
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
JP2012532670A (ja) 2009-07-10 2012-12-20 ボストン サイエンティフィック サイムド，インコーポレイテッド 薬剤搬送バルーンのためのナノ結晶の使用
EP2453938B1 (de) 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nukleierung von wirkstofffreisetzungsballons für verbesserte kristallgrösse und -dichte
WO2012031236A1 (en) 2010-09-02 2012-03-08 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
WO2013022458A1 (en) * 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CN105102967B (zh) 2013-03-15 2018-10-12 生物传感器国际集团有限公司 雷帕霉素衍生物的纯化
EP3178824A1 (de) 2015-12-08 2017-06-14 Medichem, S.A. Verfahren zur herstellung von pimecrolimus
EP3619215B1 (de) * 2017-05-01 2021-11-17 MEDA Pharma GmbH & Co. KG Verfahren zur umwandlung von rohem ascomycin in gereinigtes pimecrolimus
EP3741367A1 (de) 2019-05-21 2020-11-25 Premark Pharma GmbH Behandlung von augenerkrankungen

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118816A (en) * 1975-04-08 1976-10-19 Meiji Seika Kaisha Ltd A process for stabilizing non-crystalloidal solid
US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
CY1306A (en) 1980-10-01 1985-12-06 Glaxo Group Ltd Aminoalkyl furan derivative
JP2728482B2 (ja) * 1989-01-26 1998-03-18 協和醗酵工業株式会社 マクロライド系抗生物質の精製法
EP0433428B1 (de) 1989-07-10 1994-10-12 Chemferm V.O.F. Stabile form von cephradin, verfahren zu dessen herstellung und darin verwendete zwischenprodukte
AU640963B2 (en) * 1989-11-09 1993-09-09 MEDA Pharma S.a.r.l Heteroatoms-containing tricyclic compounds
IE910847A1 (en) * 1990-03-13 1991-09-25 Fisons Plc Immunosuppressive macrocyclic compounds
EP0480623A1 (de) * 1990-10-11 1992-04-15 Merck & Co. Inc. Halomakrolide und Derivate mit immunosuppressiver Wirkung
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
DE69217762T2 (de) 1991-07-30 1997-10-09 Ajinomoto Kk Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
US5247076A (en) 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5221740A (en) 1992-01-16 1993-06-22 American Home Products Corporation Oxepane isomers of rapamycin useful as immunosuppressive agents
UA41884C2 (uk) * 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
JP3808500B2 (ja) * 1994-02-22 2006-08-09 キューレータズ オブ ディ ユニバーシティ オブ ミズーリ 分離剤としての大環状抗生物質
JPH11512096A (ja) * 1995-08-24 1999-10-19 メルク エンド カンパニー インコーポレーテッド イミダゾリルマクロライド免疫抑制剤の製造方法
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds

Also Published As

Publication number Publication date
DE69828692T2 (de) 2006-01-12
TR199903189T2 (xx) 2000-06-21
ID24897A (id) 2000-08-31
JP3880634B2 (ja) 2007-02-14
CN1261365A (zh) 2000-07-26
JP4504323B2 (ja) 2010-07-14
AU739211B2 (en) 2001-10-04
JP2006151999A (ja) 2006-06-15
SK285665B6 (sk) 2007-05-03
EP0994880A1 (de) 2000-04-26
HUP0003053A3 (en) 2003-03-28
HK1028597A1 (en) 2001-02-23
GB9713730D0 (en) 1997-09-03
NZ500994A (en) 2001-08-31
ZA985655B (en) 1998-12-30
NO312765B1 (no) 2002-07-01
CZ474099A3 (cs) 2000-04-12
KR20010020423A (ko) 2001-03-15
CA2290412A1 (en) 1999-01-14
PT994880E (pt) 2005-06-30
KR100399765B1 (ko) 2003-09-29
ES2236922T3 (es) 2005-07-16
JP2001506279A (ja) 2001-05-15
TW552264B (en) 2003-09-11
AU8540998A (en) 1999-01-25
US6423722B1 (en) 2002-07-23
EP0994880B1 (de) 2005-01-19
DE69828692D1 (de) 2005-02-24
SK186699A3 (en) 2000-05-16
HU227755B1 (en) 2012-02-28
MY118718A (en) 2005-01-31
CO4940463A1 (es) 2000-07-24
BR9810956A (pt) 2000-09-26
HUP0003053A2 (hu) 2001-02-28
PL336719A1 (en) 2000-07-03
PL192761B1 (pl) 2006-12-29
PE97699A1 (es) 1999-10-29
AR017754A1 (es) 2001-10-24
IL132761A0 (en) 2001-03-19
DK0994880T3 (da) 2005-05-30
CA2290412C (en) 2009-11-10
NO995909D0 (no) 1999-12-02
RU2219181C2 (ru) 2003-12-20
WO1999001458A1 (en) 1999-01-14
CN1139595C (zh) 2004-02-25
CZ297244B6 (cs) 2006-10-11
NO995909L (no) 1999-12-02

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