GB1526331A - Phthalanes - Google Patents

Phthalanes

Info

Publication number
GB1526331A
GB1526331A GB1486/76A GB148676A GB1526331A GB 1526331 A GB1526331 A GB 1526331A GB 1486/76 A GB1486/76 A GB 1486/76A GB 148676 A GB148676 A GB 148676A GB 1526331 A GB1526331 A GB 1526331A
Authority
GB
United Kingdom
Prior art keywords
jan
phthalanes
kefalas
alkanoyl
heading
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1486/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
Kefalas AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9722860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1526331(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to GB1486/76A priority Critical patent/GB1526331A/en
Application filed by Kefalas AS filed Critical Kefalas AS
Priority to DE2657013A priority patent/DE2657013C2/de
Priority to SE7614201A priority patent/SE429551B/xx
Priority to AT947276A priority patent/AT359488B/de
Priority to IE5/77A priority patent/IE44055B1/en
Priority to AU21073/77A priority patent/AU509445B2/en
Priority to ZA770057A priority patent/ZA7757B/xx
Priority to NZ183001A priority patent/NZ183001A/en
Priority to US05/757,619 priority patent/US4136193A/en
Priority to FI770073A priority patent/FI63754C/fi
Priority to NL7700244A priority patent/NL192451C/nl
Priority to ES454980A priority patent/ES454980A1/es
Priority to JP199777A priority patent/JPS52105162A/ja
Priority to CA000269610A priority patent/CA1094087A/en
Priority to CH42377A priority patent/CH626886A5/de
Priority to NO770109A priority patent/NO147243C/no
Priority to DK13177A priority patent/DK143275C/da
Priority to BE174098A priority patent/BE850401A/xx
Priority to FR7701079A priority patent/FR2338271A1/fr
Publication of GB1526331A publication Critical patent/GB1526331A/en
Priority to AT572079A priority patent/AT360002B/de
Priority to AT571979A priority patent/AT360001B/de
Priority to CH357481A priority patent/CH632258A5/de
Priority to CH357581A priority patent/CH632259A5/de
Priority to NO1996001C priority patent/NO1996001I1/no
Priority to NL970031C priority patent/NL970031I1/nl
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GB1486/76A 1976-01-14 1976-01-14 Phthalanes Expired GB1526331A (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
GB1486/76A GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes
DE2657013A DE2657013C2 (de) 1976-01-14 1976-12-16 1-(3-Dimethylaminopropyl)-phthalane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE7614201A SE429551B (sv) 1976-01-14 1976-12-17 Sett att framstella 1-(3-dimetylamino-propyl)-ftalanderivat
AT947276A AT359488B (de) 1976-01-14 1976-12-21 Verfahren zur herstellung von neuen phthalan- -derivaten und ihren pharmazeutisch annehm- baren saeureadditionssalzen
IE5/77A IE44055B1 (en) 1976-01-14 1977-01-04 Phthalanes
AU21073/77A AU509445B2 (en) 1976-01-14 1977-01-05 Phathalanes
ZA770057A ZA7757B (en) 1976-01-14 1977-01-05 Organic compounds
NZ183001A NZ183001A (en) 1976-01-14 1977-01-06 3-dimethylamin opropyl-3-phenyl-benzo(c)furans,and pharmaceutical compositions
US05/757,619 US4136193A (en) 1976-01-14 1977-01-07 Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
FI770073A FI63754C (fi) 1976-01-14 1977-01-11 Foerfarande foer framstaellning av en terapeutiskt anvaendbar ftalan
NL7700244A NL192451C (nl) 1976-01-14 1977-01-12 Werkwijze voor de bereiding van ftalanderivaten en werkwijze voor de bereiding van farmaceutische preparaten die een ftalanderivaat bevatten.
ES454980A ES454980A1 (es) 1976-01-14 1977-01-12 Metodo para preparar un ftalano.
CH42377A CH626886A5 (OSRAM) 1976-01-14 1977-01-13
JP199777A JPS52105162A (en) 1976-01-14 1977-01-13 Phthleic derivatives and preparation thereof
NO770109A NO147243C (no) 1976-01-14 1977-01-13 Analogifremgangsmaate for fremstilling av terapeutisk aktive ftalanderivater
CA000269610A CA1094087A (en) 1976-01-14 1977-01-13 Phthalane derivatives, compositions thereof and a method of preparation thereof
DK13177A DK143275C (da) 1976-01-14 1977-01-14 Analogifremgangsmaade til fremstilling af 1-(3-dimethylaminopropyl)-phthalanderivater eller syreadditionssalte deraf
BE174098A BE850401A (fr) 1976-01-14 1977-01-14 Derives de phtalane et procede de preparation
FR7701079A FR2338271A1 (fr) 1976-01-14 1977-01-14 Derives du phtalane, procede pour leur preparation, et compositions pharmaceutiques contenant de tels derives
AT571979A AT360001B (de) 1976-01-14 1979-08-27 Verfahren zur herstellung von neuen phthalan- -derivaten und ihren pharmazeutisch ver- traeglichen saeureadditionssalzen
AT572079A AT360002B (de) 1976-01-14 1979-08-27 Verfahren zur herstellung von neuen phthalan- -derivaten und ihren pharmazeutisch ver- traeglichen saeureadditionssalzen
CH357581A CH632259A5 (de) 1976-01-14 1981-06-01 Verfahren zur herstellung von neuen phthalanen.
CH357481A CH632258A5 (de) 1976-01-14 1981-06-01 Verfahren zur herstellung von neuen phthalanen.
NO1996001C NO1996001I1 (no) 1976-01-14 1996-01-05 Citalopram
NL970031C NL970031I1 (nl) 1976-01-14 1997-08-04 Werkwijze voor de bereiding van ftalanderivaten enwerkwijze voor de bereiding van farmaceutische pr eparaten die een ftalanderivaat bevatten.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1486/76A GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes

Publications (1)

Publication Number Publication Date
GB1526331A true GB1526331A (en) 1978-09-27

Family

ID=9722860

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1486/76A Expired GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes

Country Status (19)

Country Link
US (1) US4136193A (OSRAM)
JP (1) JPS52105162A (OSRAM)
AT (1) AT359488B (OSRAM)
AU (1) AU509445B2 (OSRAM)
BE (1) BE850401A (OSRAM)
CA (1) CA1094087A (OSRAM)
CH (3) CH626886A5 (OSRAM)
DE (1) DE2657013C2 (OSRAM)
DK (1) DK143275C (OSRAM)
ES (1) ES454980A1 (OSRAM)
FI (1) FI63754C (OSRAM)
FR (1) FR2338271A1 (OSRAM)
GB (1) GB1526331A (OSRAM)
IE (1) IE44055B1 (OSRAM)
NL (2) NL192451C (OSRAM)
NO (2) NO147243C (OSRAM)
NZ (1) NZ183001A (OSRAM)
SE (1) SE429551B (OSRAM)
ZA (1) ZA7757B (OSRAM)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602035A (en) * 1983-12-07 1986-07-22 Hoechst-Roussel Pharmaceuticals Inc. Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines
WO2001002383A3 (en) * 1999-07-06 2001-05-03 Vis Farmaceutici S P A Process for the synthesis of citalopram
WO2002070501A1 (en) * 2001-03-07 2002-09-12 Cipla Ltd. Preparation of phthalanes
EP1265883A1 (en) 2000-03-13 2002-12-18 H. Lundbeck A/S Method for the preparation of citalopram
WO2003072563A1 (en) * 2002-02-27 2003-09-04 Cipla Ltd. Amorphous citalopram salts
US7002025B2 (en) 2000-03-07 2006-02-21 Resolution Chemicals Limited Process for the preparation of citalopram

Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK0759299T3 (da) * 1995-08-16 2000-08-07 Lilly Co Eli Potensering af serotoninrespons
ES2148120T3 (es) 1997-07-08 2002-01-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EA002770B1 (ru) 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама
PL199423B1 (pl) 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
KR20010081071A (ko) 1998-12-08 2001-08-25 피터슨 존 메이달 벤조푸란 유도체, 그것들의 제조 및 사용
AR021509A1 (es) * 1998-12-08 2002-07-24 Lundbeck & Co As H Derivados de benzofurano, su preparacion y uso
IL143422A0 (en) 1998-12-23 2002-04-21 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DK1173431T4 (da) * 1999-04-14 2010-01-04 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
HRP20020344B1 (hr) 1999-10-25 2010-10-31 H. Lundbeck A/S Način priprave citaloprama
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
HUP0203635A3 (en) 1999-12-28 2005-02-28 Lundbeck & Co As H Method for the preparation of citalopram
PT1246813E (pt) * 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
CN1195749C (zh) * 2000-01-14 2005-04-06 H.隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5-取代的1-(4-氟苯基)-1,3-二氢异苯并呋喃的分步烷基化
TR200202155T2 (tr) 2000-03-14 2002-12-23 H. Lundbeck A/S Sitalopramin preparasyon metodu
DE10190485T1 (de) * 2000-03-16 2002-03-21 Lundbeck & Co As H Verfahren zur Herstellung von 5-Cyano-1-(4-fluorphenyl)-1,3-dihydroisobenzofuranen
JP2003530437A (ja) * 2000-04-13 2003-10-14 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ Aβ42低下物質
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
KR100821912B1 (ko) * 2000-05-12 2008-04-16 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
AR032455A1 (es) * 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2383963A1 (en) * 2000-07-06 2002-01-17 Eva Bolzonella Method for the preparation of citalopram
AU8174001A (en) * 2000-07-21 2002-02-05 Lundbeck & Co As H Novel compounds and their use as glycine transport inhibitors
IES20010693A2 (en) * 2000-08-10 2002-07-10 Lundbeck & Co As H Pharmaceutical composition containing citalopram
CA2354877C (en) * 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
WO2001045483A2 (en) * 2000-12-22 2001-06-28 H. Lundbeck A/S Method for the preparation of pure citalopram
JP2003519121A (ja) * 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法
DE10164725B4 (de) * 2000-12-28 2004-08-26 H. Lundbeck A/S Verfahren zur Herstellung von gereinigtem Citalopram
DE10112828C1 (de) * 2000-12-28 2002-11-21 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
WO2002066453A1 (en) * 2001-02-22 2002-08-29 Natco Pharma Limited Process for the preparation of citalopram
JP2005500256A (ja) * 2001-03-09 2005-01-06 ランバクシー ラボラトリーズ リミテッド シタロプラム製造方法
WO2002087566A1 (en) * 2001-05-01 2002-11-07 H. Lundbeck A/S The use of enantiomeric pure escitalopram
BG65271B1 (bg) * 2001-06-18 2007-11-30 H. Lundbeck A/S Метод за получаване на циталопрам
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IN192057B (OSRAM) * 2001-07-19 2004-02-14 Ranbaxy Lab Ltd
IL159326A0 (en) 2001-07-31 2004-06-01 Lundbeck & Co As H Crystalline composition containing escitalopram
EP1288211A1 (en) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
MXPA04003358A (es) * 2001-10-12 2004-07-08 Serenix Pharmaceuticals Llc Antagonistas de vasopresina v1a de ?-lactamilo.
IN192863B (OSRAM) * 2001-11-13 2004-05-22 Ranbaxy Lab Ltd
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2387844B (en) * 2002-02-27 2005-05-11 Matrix Lab Ltd Separation of impurities from a crude mixture of citalopram
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
TWI332938B (en) * 2002-03-27 2010-11-11 Bando Chemical Ind Novel 1,3,5-tris(arylamino)benzenes
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
AU2003287919B2 (en) * 2002-12-23 2009-11-12 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
AU2003242990A1 (en) * 2003-01-17 2004-08-13 Pulla Reddy Muddasani Processes for the preparation of escitalopram and its precursor
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
ITMI20030479A1 (it) * 2003-03-13 2004-09-14 Adorkem Technology S P A Procedimento per la preparazione di un ciano-isobenzofurano.
US7019153B2 (en) * 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
KR20060040676A (ko) * 2003-07-11 2006-05-10 미리어드 제네틱스, 인크. 알츠하이머병을 치료하기 위한 약제학적 방법, 투약 방법및 제형
GB0317475D0 (en) * 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
ITFI20030202A1 (it) * 2003-07-28 2005-01-29 Synteco Spa Processo per la preparazione di derivati del
ES2319539T3 (es) * 2003-09-17 2009-05-08 Janssen Pharmaceutica Nv Compuestos heterociclicos condensados como moduladores del receptor de serotonina.
AU2003278409A1 (en) * 2003-10-28 2005-05-19 Krishnaji Upadhye Bhargav Improved process for the manufacture of citalopram hydrobromide
PT1506963E (pt) * 2003-10-28 2005-08-31 Adorkem Technology Spa Processo para a preparacao de citalopram
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
EP1708790B1 (en) * 2003-12-02 2010-04-21 PharmaNeuroBoost N.V. Use of pipamperone and a d2-receptor antagonist or a serotonin/dopamin antagonist for the treatment of psychotic disorders
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1723133A1 (en) * 2004-02-16 2006-11-22 Jubilant Organosys Limited One pot synthesis of citalopram from 5-cyanophthalide
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) * 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
WO2006001877A2 (en) * 2004-04-13 2006-01-05 Myriad Genetics, Inc. Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
EP1737473A4 (en) * 2004-04-19 2009-08-26 Noven Therapeutics Llc COMBINATIONS OF LITHIUM AND USES THEREOF
AU2005241023A1 (en) * 2004-04-29 2005-11-17 Keystone Retaining Wall Systems, Inc. Veneers for walls, retaining walls and the like
BRPI0514303A (pt) * 2004-08-11 2008-06-10 Myriad Genetics Inc composição farmacêutica e método para tratar distúrbios neurodegenerativos
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
ES2285972T1 (es) 2004-08-23 2007-12-01 Sun Pharmaceutical Industries Limited Procedimiento de fabricacion de citalopram y enantiomeros.
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
WO2006102283A2 (en) 2005-03-22 2006-09-28 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids for treating premenstrual disorders
WO2006103550A1 (en) * 2005-03-31 2006-10-05 Ranbaxy Laboratories Limited Processes for the preparation of citalopram and its intermediate 5-aminophthalide
AU2006239942A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
US7368477B2 (en) 2005-04-22 2008-05-06 Wyeth Benzofuranyl alkanamine derivatives and uses thereof
EP1879875A1 (en) * 2005-04-22 2008-01-23 Wyeth Crystal forms opf {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
TW200718692A (en) 2005-04-22 2007-05-16 Wyeth Corp Dihydrobenzofuran derivatives and uses thereof
TWI347942B (en) 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EP2317316A3 (en) 2005-07-08 2011-06-15 Braincells, Inc. Methods for identifying agent and conditions that modulate neurogenesis
US20070015832A1 (en) * 2005-07-14 2007-01-18 Myriad Genetics, Incorporated Methods of treating overactive bladder and urinary incontinence
EP1910346B1 (en) 2005-07-19 2019-02-27 Azevan Pharmaceuticals, Inc. Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonist
CA2615063A1 (en) * 2005-07-22 2007-02-01 Myriad Genetics, Inc. High drug load formulations and dosage forms
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
JP2009515840A (ja) * 2005-11-14 2009-04-16 ハー・ルンドベック・アクチエゼルスカベット エスシタロプラムの製造方法
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
FR2912057B1 (fr) * 2007-02-07 2009-04-17 Sanofi Aventis Sa Composition pharmaceutique contenant en association le saredutant et un inhibiteur selectif de la recapture de la serotonine ou un inhibiteur de la recapture de la serotonine/norepinephrine
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20070244143A1 (en) * 2006-03-08 2007-10-18 Braincells, Inc Modulation of neurogenesis by nootropic agents
EP1998773A2 (en) * 2006-03-24 2008-12-10 Wyeth a Corporation of the State of Delaware New therapeutic combinations for the treatment of depression
JP2009536667A (ja) * 2006-05-09 2009-10-15 ブレインセルス,インコーポレイティド 5ht受容体介在性の神経新生
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
WO2008006099A2 (en) * 2006-07-07 2008-01-10 Myriad Genetics, Inc. Treatment of psychiatric disorders
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
TW200817003A (en) * 2006-07-31 2008-04-16 Sanofi Aventis Pharmaceutical composition comprising, in combination, saredutant and a selective serotonin peuptake inhibitor or a serotonin/norepinephrine reuptake inhibitor
AU2007292848A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100016274A1 (en) * 2006-09-14 2010-01-21 Koppel Gary A Beta-lactam cannabinoid receptor modulators
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
AU2007299920A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
JP4927497B2 (ja) * 2006-10-25 2012-05-09 株式会社シスコ 無湿乾燥用ホッパー装置
CN100457747C (zh) * 2006-11-21 2009-02-04 浙江大学 抗抑郁药西酞普兰关键中间体5-氰基苯酞的制备工艺
WO2008083204A2 (en) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation of neurogenesis by melatoninergic ligands
AU2008204800A1 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation of neurogenesis with use of modafinil
US7566793B2 (en) * 2007-04-23 2009-07-28 Synthon Bv Process for resolving citalopram
JP2010527345A (ja) * 2007-05-18 2010-08-12 シプラ・リミテッド エスシタロプラムの調製方法
US20080312318A1 (en) * 2007-06-14 2008-12-18 Protia, Llc Deuterium-enriched escitalopram
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
US8022232B2 (en) * 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
KR101103118B1 (ko) * 2007-11-02 2012-01-04 동아제약주식회사 신규한 1,3-디히드로-5-이소벤조퓨란카르보니트릴 유도체 화합물 및 이를 함유하는 조루증 치료용 약학조성물
EP2288345B1 (en) 2008-04-18 2015-06-10 University College Dublin National University Of Ireland, Dublin Psycho-pharmaceuticals
EP2116231A1 (en) 2008-05-07 2009-11-11 Hexal Ag Granulate comprising escitalopram oxalate
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
GR20080100696A (el) 2008-10-23 2010-05-13 Genepharm �.�. Φαρμακοτεχνικη μορφη με βελτιωμενη γευση του φαρμακευτικα αποδεκτου αλατος εσιταλοπραμης
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
ME03452B (me) 2009-10-23 2020-01-20 Janssen Pharmaceutica Nv Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora
PL3351104T3 (pl) 2010-07-01 2021-06-14 Azevan Pharmaceuticals, Inc. Związki do stosowania w leczeniu okresowych zaburzeń wybuchowych
WO2013100870A1 (en) 2011-12-02 2013-07-04 Mahmut Bilgic New antipsychotic compositions
WO2013081567A1 (en) 2011-12-02 2013-06-06 Mahmut Bilgic Effervescent antipsychotic formulations
WO2013110313A1 (en) * 2012-01-23 2013-08-01 H. Lundbeck A/S Selective allosteric modulators of the serotonin transporter
SG10202001065SA (en) 2014-03-28 2020-04-29 Azevan Pharmaceuticals Inc Compositions and methods for treating neurodegenerative diseases
MD3426251T2 (ro) 2016-03-10 2022-09-30 Janssen Pharmaceutica Nv Metode de tratament al depresiei utilizând antagoniști ai receptorului orexină-2
MX2020002762A (es) 2017-09-15 2020-09-17 Azevan Pharmaceuticals Inc Composiciones y métodos para tratar una lesión cerebral.
BR112022000992A2 (pt) 2019-07-19 2022-06-14 Arx Llc Regimes de tratamento de dexmedetomidina não sedantes
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (OSRAM) * 1965-03-18

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602035A (en) * 1983-12-07 1986-07-22 Hoechst-Roussel Pharmaceuticals Inc. Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines
WO2001002383A3 (en) * 1999-07-06 2001-05-03 Vis Farmaceutici S P A Process for the synthesis of citalopram
US7002025B2 (en) 2000-03-07 2006-02-21 Resolution Chemicals Limited Process for the preparation of citalopram
EP1265883A1 (en) 2000-03-13 2002-12-18 H. Lundbeck A/S Method for the preparation of citalopram
WO2002070501A1 (en) * 2001-03-07 2002-09-12 Cipla Ltd. Preparation of phthalanes
LT5167B (lt) 2001-03-07 2004-10-25 Cipla Ltd. Ftalanų gavimas
US6903228B2 (en) * 2001-03-07 2005-06-07 Cipla Limited Preparation of phthalanes
RU2276148C2 (ru) * 2001-03-07 2006-05-10 Сипла Лтд. Способ получения фталанов
WO2003072563A1 (en) * 2002-02-27 2003-09-04 Cipla Ltd. Amorphous citalopram salts

Also Published As

Publication number Publication date
NO147243B (no) 1982-11-22
BE850401A (fr) 1977-07-14
DE2657013A1 (de) 1977-07-28
DK143275B (da) 1981-08-03
NO1996001I1 (no) 1996-01-05
CA1094087A (en) 1981-01-20
NL7700244A (nl) 1977-07-18
NO770109L (no) 1977-07-15
SE7614201L (sv) 1977-07-15
CH632259A5 (de) 1982-09-30
AU2107377A (en) 1978-07-13
FR2338271B1 (OSRAM) 1982-11-05
SE429551B (sv) 1983-09-12
NL970031I2 (nl) 1997-10-01
AT359488B (de) 1980-11-10
JPS6135986B2 (OSRAM) 1986-08-15
NL192451C (nl) 1997-08-04
FI770073A7 (OSRAM) 1977-07-15
IE44055B1 (en) 1981-07-29
US4136193A (en) 1979-01-23
NL192451B (nl) 1997-04-01
NL970031I1 (nl) 1997-10-01
DK143275C (da) 1982-01-18
DK13177A (da) 1977-07-15
FI63754B (fi) 1983-04-29
AU509445B2 (en) 1980-05-15
FI63754C (fi) 1983-08-10
ATA947276A (de) 1980-04-15
FR2338271A1 (fr) 1977-08-12
NO147243C (no) 1983-03-02
DE2657013C2 (de) 1985-11-14
NZ183001A (en) 1978-06-02
JPS52105162A (en) 1977-09-03
CH626886A5 (OSRAM) 1981-12-15
ZA7757B (en) 1977-11-30
IE44055L (en) 1977-07-14
ES454980A1 (es) 1978-04-01
CH632258A5 (de) 1982-09-30

Similar Documents

Publication Publication Date Title
GB1526331A (en) Phthalanes
GB1527562A (en) Substituted-methyl-11-cyano-9,10-dihydroethanoanthracene-11-carboxylates useful as intermediates
GB1496766A (en) 5-substituted-alkyl-8-hydroxycarbostyril derivatives and production thereof
ES8609204A1 (es) Procedimiento de preparar derivados aminicos
GB1435573A (en) Indoloquinolizines
GB1513320A (en) N-propargyl-2-phenylamino-2-imidazolines
GB1443503A (en) Salt of 5-substituted-2-furamidines and their preparation
GB1325386A (en) Quinazoline derivatives processes for producing them and compositions containing them
GB1492718A (en) Benzothiazine 1,1-dioxide derivatives
GB1409648A (en) Substituted pyrrolidinemethanol compounds and pharmaceutical compositions thereof
GB1490486A (en) 4-imino-1,3-diazobicyclo-(3.1.0)hexan-2-one
GB1457038A (en) Amino derivatives of 1,4-benzodioxan
GB1436307A (en) Diaromatic o-aminoalkyl-oximes
GB1394619A (en) Imides
GB1443692A (en) 1,2-diphenylethanolamine derivatives and their salts and the preparation thereof
GB1448781A (en) N- omega-amino- alkylaniline compounds
GB1449387A (en) Benzylpyrimidine derivatives
GB1503447A (en) Dl-and 8r-9-fluoro-prostadienoic acid derivatives and process
GB1473971A (en) 3-hydroxy-5,6-benzomorphinan derivatives
GB1325770A (en) Pyrimidopyridazine derivatives
GB1531041A (en) Substituted haloacetophenone oximes
GB1412932A (en) Pharmaceutically active leurosine derivatives and preparation thereof
GB1472344A (en) Methylene dibenzocycloheptanes
SE7408868L (OSRAM)
GB1471902A (en) Styrylsulphonylamidines

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
CTFF Supplementary protection certificate filed

Free format text: SPC/GB95/024, 950731

CTFG Supplementary protection certificate granted

Free format text: SPC/GB95/024, 960131, EXPIRES:20020105

CTFE Supplementary protection certificate entered into force

Free format text: SPC/GB95/024, 970106, EXPIRES:20020105

PE20 Patent expired after termination of 20 years

Effective date: 19970105

SPCE Supplementary protection certificate expired

Free format text: SPC/GB95/024: 20020105