FR2294690A1 - Composes thiazo-lylacetamido - Google Patents

Composes thiazo-lylacetamido

Info

Publication number
FR2294690A1
FR2294690A1 FR7538703A FR7538703A FR2294690A1 FR 2294690 A1 FR2294690 A1 FR 2294690A1 FR 7538703 A FR7538703 A FR 7538703A FR 7538703 A FR7538703 A FR 7538703A FR 2294690 A1 FR2294690 A1 FR 2294690A1
Authority
FR
France
Prior art keywords
lylacetamido
thiazo
compounds
lylacetamido compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7538703A
Other languages
English (en)
Other versions
FR2294690B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26257200&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2294690(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP49146567A external-priority patent/JPS5760345B2/ja
Priority claimed from GB24611/75A external-priority patent/GB1536281A/en
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FR2294690A1 publication Critical patent/FR2294690A1/fr
Application granted granted Critical
Publication of FR2294690B1 publication Critical patent/FR2294690B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
FR7538703A 1974-12-19 1975-12-17 Composes thiazo-lylacetamido Granted FR2294690A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP49146567A JPS5760345B2 (fr) 1974-12-19 1974-12-19
GB24611/75A GB1536281A (en) 1975-06-09 1975-06-09 Cephem compounds

Publications (2)

Publication Number Publication Date
FR2294690A1 true FR2294690A1 (fr) 1976-07-16
FR2294690B1 FR2294690B1 (fr) 1982-01-29

Family

ID=26257200

Family Applications (4)

Application Number Title Priority Date Filing Date
FR7538703A Granted FR2294690A1 (fr) 1974-12-19 1975-12-17 Composes thiazo-lylacetamido
FR7635966A Withdrawn FR2357552A1 (fr) 1974-12-19 1976-11-29 Thiazoles substitues et leur procede de preparation
FR7912111A Granted FR2434146A1 (fr) 1974-12-19 1979-05-11 Derives de l'acide a-hydroxy imino butyrique et leur preparation
FR7924297A Expired FR2468599B1 (fr) 1974-12-19 1979-09-28 Derives d'acide thiazolylacetique et procede de preparation

Family Applications After (3)

Application Number Title Priority Date Filing Date
FR7635966A Withdrawn FR2357552A1 (fr) 1974-12-19 1976-11-29 Thiazoles substitues et leur procede de preparation
FR7912111A Granted FR2434146A1 (fr) 1974-12-19 1979-05-11 Derives de l'acide a-hydroxy imino butyrique et leur preparation
FR7924297A Expired FR2468599B1 (fr) 1974-12-19 1979-09-28 Derives d'acide thiazolylacetique et procede de preparation

Country Status (18)

Country Link
US (6) US4098888A (fr)
AT (1) AT357521B (fr)
AU (1) AU500104B2 (fr)
BE (1) BE836813A (fr)
BG (1) BG60437B2 (fr)
CA (3) CA1216284A (fr)
CH (4) CH624119A5 (fr)
DE (3) DE2560398C2 (fr)
DK (2) DK154939C (fr)
ES (4) ES443627A1 (fr)
FR (4) FR2294690A1 (fr)
GB (1) GB1536283A (fr)
HU (1) HU179798B (fr)
MX (1) MX5097E (fr)
NL (4) NL183703C (fr)
NO (1) NO157933C (fr)
PH (2) PH13731A (fr)
SE (2) SE442202B (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2367756A1 (fr) * 1976-04-12 1978-05-12 Fujisawa Pharmaceutical Co Derives 2-alcoxyamino-2-(amino-1,3-thiazolyl) acetiques et leur utilisation
FR2385722A1 (fr) * 1977-04-02 1978-10-27 Hoechst Ag Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
FR2390429A1 (fr) * 1976-03-09 1978-12-08 Fujisawa Pharmaceutical Co Composes d'aminothiazole et leur utilisation pour la preparation de composes de cephalosporine
EP0001125A2 (fr) * 1977-09-13 1979-03-21 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine, leurs préparations et leurs compositions pharmaceutiques
EP0002765A1 (fr) 1977-12-24 1979-07-11 Hoechst Aktiengesellschaft Dérivés de céphalosporine, leur préparation et compositions pharmaceutiques et leur préparation
FR2439786A1 (fr) * 1978-10-27 1980-05-23 Glaxo Group Ltd Nouvelles cephalosporines, leur procede de preparation et leurs applications therapeutiques
FR2445830A1 (fr) * 1979-01-05 1980-08-01 Roussel Uclaf Nouveaux derives de l'acide (4-thiazolyl) acetique procede de preparation
EP0034760A1 (fr) * 1980-02-23 1981-09-02 Hoechst Aktiengesellschaft Dérivés de céphalosporine, des compositions pharmaceutiques les contenant et procédé pour leur préparation
FR2488258A1 (fr) * 1980-08-11 1982-02-12 American Cyanamid Co Acide 7-beta-(alpha-syn-methoxyimino-alpha - (2-aminothiazol-4-yl) - acetamino)-3-((1,2,3-thiadiazol-5-ylthio) methyl)-3-cepheme-4-carboxylique et derives alkyliques en c1-c6 de celui-ci, compositions contenant ces composes et leurs applications
EP0055466A2 (fr) * 1980-12-31 1982-07-07 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporines, leur préparation, compositions pharmaceutiques les contenant et leurs produits de départ

Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191762A (en) 1974-03-14 1980-03-04 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted amino-2 or 3-cephem-4-carboxylic acid compounds
US4297489A (en) * 1974-09-03 1981-10-27 Bristol-Myers Company 7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids
US4182868A (en) * 1974-10-29 1980-01-08 Takeda Chemical Industries, Ltd. 7-Methoxycephalosporin derivatives
JPS5760345B2 (fr) * 1974-12-19 1982-12-18 Takeda Chemical Industries Ltd
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
SE440655B (sv) 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4196205A (en) * 1976-01-23 1980-04-01 Roussel Uclaf 3-Acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives
IE44888B1 (en) * 1976-03-09 1982-05-05 Fujisawa Pharmaceutical Co 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation theroef
US4299829A (en) 1976-03-12 1981-11-10 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted-2 or 3-cephem 4-carboxylic acid compounds
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4202893A (en) 1976-03-25 1980-05-13 Roussel Uclaf Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
JPS5946237B2 (ja) * 1976-04-02 1984-11-10 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
US4304770A (en) * 1976-04-12 1981-12-08 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
US4364943A (en) * 1976-04-12 1982-12-21 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 7-[2-alkoxyimino-2-(2-amino-alkanoylamino-or haloalkanoylamino-thiazol-4-yl) acetamids]-3-[hexanoyl-, or phenylalkanoyl-oxymethyl or benzothiazolylthiomethyl]-3-cephem-4-carboxylic acid
US4804752A (en) * 1976-04-12 1989-02-14 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US4493833A (en) * 1976-04-12 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds
US4331664A (en) * 1976-04-12 1982-05-25 Fujisawa Pharmaceutical Co., Ltd. Syn isomer of 7-[2-cyclo(lower) alkoxyimino-2-(2-amino-or substituted aminothiazol-4-yl)acetamido]-3-lower alkanoyloxymethyl or heterocyclicthiomethyl-3-cephem-4-carboxylic acid compounds
US4431643A (en) * 1976-04-12 1984-02-14 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3-substituted-7-[2-cyclopentyloxyimino-2-(2-aminothiazol-4-yl)-acetamido]-3
DE2760482C2 (de) * 1976-04-14 1995-02-09 Takeda Chemical Industries Ltd Pharmazeutische Zubereitungen, enthaltend ein 7-[2-(2-aminothiazol-4yl)-2-(syn)-methoxyiminoacetamido]cephalosporinderivat
DE2760488C2 (de) * 1976-04-14 1994-04-07 Takeda Chemical Industries Ltd Cephalosporinderivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
DE2760491C2 (de) * 1976-09-08 1995-04-20 Takeda Chemical Industries Ltd Pharmazeutische Zubereitungen enthaltend Pivaloyloxymethyl 7- 2-(2-aminothiazol-4-yl)-2-(syn)mehtoxyiminoacetamido desacetoxycephalosporanat und dessen Salze
FI771866A (fr) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
US4963542A (en) * 1976-09-08 1990-10-16 Takeda Chemical Industries, Ltd. Cephalosporin derivatives
GB1592149A (en) * 1976-10-08 1981-07-01 Fujisawa Pharmaceutical Co 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof
JPS53144594A (en) * 1976-12-27 1978-12-15 Fujisawa Pharmaceut Co Ltd 3,7-di-substitued-3-cephem-4-carboxylic acid derivatives
BE862300A (fr) * 1976-12-27 1978-06-23 Fujisawa Pharmaceutical Co Nouveaux composes de cephalosporine et procedes pour leur preparation
JPS6011714B2 (ja) 1977-02-17 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
JPS53101393A (en) 1977-02-17 1978-09-04 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
JPS53103493A (en) * 1977-02-18 1978-09-08 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
FR2381053A1 (fr) * 1977-02-18 1978-09-15 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-thiadiazolyl thiomethyl 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2710902A1 (de) * 1977-03-12 1978-09-21 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US4841062A (en) * 1977-03-14 1989-06-20 Fujisawa Pharmaceutical Company, Limited New cephem and cepham compounds and processes for preparation thereof
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
GB1579533A (en) * 1977-03-26 1980-11-19 Farmaceutici Italia Cephalosporins and their preparation
US5089490A (en) * 1977-04-02 1992-02-18 Hoechst Aktiengesellschaft Cephem derivatives
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2831568C2 (de) * 1977-07-23 1985-01-10 Toyama Chemical Co. Ltd., Tokio / Tokyo 7α-Methoxycephalosporine und Verfahren zur Herstellung derselben
JPS609719B2 (ja) * 1977-08-06 1985-03-12 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
FR2400519A1 (fr) * 1977-08-17 1979-03-16 Roussel Uclaf Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament
IT1192287B (it) * 1977-11-14 1988-03-31 Fujisawa Pharmaceutical Co Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
JPS54112892A (en) * 1978-02-23 1979-09-04 Shionogi & Co Ltd Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid
US4180658A (en) * 1978-02-24 1979-12-25 Bristol-Myers Company 7[-2-Alkoxyamino(acetamido)]cephalosporin derivatives
JPS54117494A (en) * 1978-03-03 1979-09-12 Takeda Chem Ind Ltd Cephalosporin compound and its preparation
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
SE445350B (sv) * 1978-04-14 1986-06-16 Roussel Uclaf Oximderivat av 3-azidometyl-7-amino-tiazolyl-acetamido-cefalosporansyra och dess anvendning som antibiotika
DE2818263A1 (de) * 1978-04-26 1979-11-08 Bayer Ag Beta-lactamantibiotika
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
CH641468A5 (de) * 1978-05-30 1984-02-29 Hoffmann La Roche Cephemderivate.
JPS54160392A (en) * 1978-06-02 1979-12-19 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
US4461767A (en) * 1978-06-16 1984-07-24 E. R. Squibb & Sons, Inc. Iminothiazolyl ureido cephalosporins
US4501743A (en) * 1978-06-16 1985-02-26 E. R. Squibb & Sons, Inc. Iminothiazolyl ureido cephalosporins
US4268509A (en) * 1978-07-10 1981-05-19 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
US4288435A (en) * 1978-07-17 1981-09-08 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutical antibacterial compositions containing them
JPS6058239B2 (ja) * 1978-07-20 1985-12-19 山之内製薬株式会社 新規セフアロスポリン誘導体
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
US4372952A (en) * 1978-07-31 1983-02-08 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4305937A (en) * 1978-08-17 1981-12-15 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and antibacterial pharmaceutical compositions containing them
US4703046A (en) * 1978-09-08 1987-10-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4220761A (en) * 1978-09-12 1980-09-02 Fujisawa Pharmaceutical Co., Ltd. 7-[Substituted oximinoacetamido]-3-[hydroxy alkyltetrazolo]cephalosporin derivatives
DE2967053D1 (en) * 1978-09-12 1984-07-19 Fujisawa Pharmaceutical Co Starting compounds for preparing cephem compounds and processes for their preparation
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
SE7909401L (sv) * 1978-11-15 1980-05-16 Glaxo Group Ltd Cefalosporinantibiotika
US4313945A (en) * 1978-11-23 1982-02-02 Ciba-Geigy Corporation 7-Thiazolyl-acetamido-cephem derivatives with terminal aminocarboxylic acid grouping
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
US4332798A (en) * 1978-12-29 1982-06-01 Fujisawa Pharmaceutical Co., Ltd. 7-Amino-thia-diazole oxyimino derivatives of cephem and cephem compounds
AU536842B2 (en) * 1978-12-29 1984-05-24 Fujisawa Pharmaceutical Co., Ltd. Cephalosporin antibiotics
IT1143081B (it) * 1979-03-22 1986-10-22 Glaxo Group Ltd Antibiotici cefalosporinici composizioni che li contengono e procedimento per produrli ed applicarli
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
YU136780A (en) * 1979-05-23 1983-10-31 Rhone Poulenc Ind Process for obtaining new 3-thiovinyl-cephalosporins
FR2457296A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
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FR2390429A1 (fr) * 1976-03-09 1978-12-08 Fujisawa Pharmaceutical Co Composes d'aminothiazole et leur utilisation pour la preparation de composes de cephalosporine
FR2367756A1 (fr) * 1976-04-12 1978-05-12 Fujisawa Pharmaceutical Co Derives 2-alcoxyamino-2-(amino-1,3-thiazolyl) acetiques et leur utilisation
FR2485017A1 (fr) * 1977-04-02 1981-12-24 Hoechst Ag Nouveaux derives de cephalosporine et leur application en therapeutique
FR2385722A1 (fr) * 1977-04-02 1978-10-27 Hoechst Ag Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
EP0001125A2 (fr) * 1977-09-13 1979-03-21 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine, leurs préparations et leurs compositions pharmaceutiques
EP0001125A3 (en) * 1977-09-13 1979-04-18 Fujisawa Pharmaceutical Co. Ltd. Cephalosporin derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0002765A1 (fr) 1977-12-24 1979-07-11 Hoechst Aktiengesellschaft Dérivés de céphalosporine, leur préparation et compositions pharmaceutiques et leur préparation
FR2439786A1 (fr) * 1978-10-27 1980-05-23 Glaxo Group Ltd Nouvelles cephalosporines, leur procede de preparation et leurs applications therapeutiques
FR2445830A1 (fr) * 1979-01-05 1980-08-01 Roussel Uclaf Nouveaux derives de l'acide (4-thiazolyl) acetique procede de preparation
EP0034760A1 (fr) * 1980-02-23 1981-09-02 Hoechst Aktiengesellschaft Dérivés de céphalosporine, des compositions pharmaceutiques les contenant et procédé pour leur préparation
US4470983A (en) * 1980-02-23 1984-09-11 Hoechst Aktiengesellschaft Cephalosporin derivatives
FR2488258A1 (fr) * 1980-08-11 1982-02-12 American Cyanamid Co Acide 7-beta-(alpha-syn-methoxyimino-alpha - (2-aminothiazol-4-yl) - acetamino)-3-((1,2,3-thiadiazol-5-ylthio) methyl)-3-cepheme-4-carboxylique et derives alkyliques en c1-c6 de celui-ci, compositions contenant ces composes et leurs applications
EP0055466A2 (fr) * 1980-12-31 1982-07-07 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporines, leur préparation, compositions pharmaceutiques les contenant et leurs produits de départ
EP0055466A3 (en) * 1980-12-31 1983-11-16 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds

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CA1216284A (fr) 1987-01-06
AU8766775A (en) 1977-06-23
BE836813A (fr) 1976-06-18
SE442202B (sv) 1985-12-09
FR2357552A1 (fr) 1978-02-03
AU500104B2 (en) 1979-05-10
CA1128957A (fr) 1982-08-03
BG60437B2 (bg) 1995-03-31
DK154939C (da) 1989-06-12
US4098888A (en) 1978-07-04
DE2560398C2 (de) 1983-09-29
DK548875A (da) 1976-06-20
HU179798B (en) 1982-12-28
NL950016I1 (nl) 1996-03-01
DE2556736A1 (de) 1976-06-24
DK552377A (da) 1977-12-09
NL183703B (nl) 1988-08-01
US4973684A (en) 1990-11-27
US4912212A (en) 1990-03-27
FR2434146B1 (fr) 1984-02-10
NL8003054A (nl) 1980-08-29
MX5097E (es) 1983-03-16
FR2468599B1 (fr) 1986-03-21
DE2559942C2 (de) 1985-02-28
CH633544A5 (de) 1982-12-15
AT357521B (de) 1980-07-10
DK154939B (da) 1989-01-09
ES457891A1 (es) 1978-08-01
CA1137492A (fr) 1982-12-14
ES464772A1 (es) 1979-01-01
US4514565A (en) 1985-04-30
NL183703C (nl) 1989-01-02
ATA517277A (de) 1979-12-15
US4205180A (en) 1980-05-27
CH631437A5 (de) 1982-08-13
US5583216A (en) 1996-12-10
FR2468599A1 (fr) 1981-05-08
SE7514286L (sv) 1976-06-20
CH628058A5 (de) 1982-02-15
ES464771A1 (es) 1978-09-01
DK155086C (da) 1989-06-19
ES443627A1 (es) 1977-10-16
FR2294690B1 (fr) 1982-01-29
GB1536283A (en) 1978-12-20
NO157933C (no) 1988-06-15
PH13731A (en) 1980-09-09
SE445454B (sv) 1986-06-23
NL7514811A (nl) 1976-06-22
DK155086B (da) 1989-02-06
DE2556736C2 (de) 1982-02-11
SE7902954L (sv) 1979-04-03
NO754296L (fr) 1976-06-22
FR2434146A1 (fr) 1980-03-21
PH14161A (en) 1981-03-19
CH624119A5 (fr) 1981-07-15
NO157933B (no) 1988-03-07

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