FI96513C - Menetelmä terapeuttisesti aktiivisten ksantiinijohdannaisten valmistamiseksi - Google Patents
Menetelmä terapeuttisesti aktiivisten ksantiinijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI96513C FI96513C FI896117A FI896117A FI96513C FI 96513 C FI96513 C FI 96513C FI 896117 A FI896117 A FI 896117A FI 896117 A FI896117 A FI 896117A FI 96513 C FI96513 C FI 96513C
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- substd
- opt
- group
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3843117 | 1988-12-22 | ||
| DE3843117A DE3843117A1 (de) | 1988-12-22 | 1988-12-22 | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI896117A0 FI896117A0 (fi) | 1989-12-20 |
| FI96513B FI96513B (fi) | 1996-03-29 |
| FI96513C true FI96513C (fi) | 1996-07-10 |
Family
ID=6369764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI896117A FI96513C (fi) | 1988-12-22 | 1989-12-20 | Menetelmä terapeuttisesti aktiivisten ksantiinijohdannaisten valmistamiseksi |
Country Status (32)
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| US5047534A (en) * | 1990-03-26 | 1991-09-10 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine receptor agents |
| GB2244487B (en) * | 1990-05-29 | 1994-02-02 | Ici Plc | Azole derivatives |
| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| CA2061544A1 (en) * | 1991-02-25 | 1992-08-26 | Fumio Suzuki | Xanthine compounds |
| GB9111130D0 (en) * | 1991-05-23 | 1991-07-17 | Ici Plc | Azole derivatives |
| GB9111131D0 (en) * | 1991-05-23 | 1991-07-17 | Ici Plc | Heterocyclic compounds |
| EP0541120B1 (en) * | 1991-11-08 | 1999-05-26 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives for the treatment of dementia |
| IT1260444B (it) * | 1992-01-24 | 1996-04-09 | Mario Brufani | Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti |
| EP0556778A3 (en) * | 1992-02-17 | 1993-11-24 | Kyowa Hakko Kogyo Kk | Xanthine derivatives |
| US5484920A (en) * | 1992-04-08 | 1996-01-16 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for Parkinson's disease |
| CA2093403C (en) * | 1992-04-08 | 1999-08-10 | Fumio Suzuki | Therapeutic agent for parkinson's disease |
| WO1994003173A1 (de) * | 1992-08-01 | 1994-02-17 | Boehringer Ingelheim Kg | Verwendung von 8-(3-oxocyclopentyl)-1,3-dipropyl-7h-purin-2,6-dion zur symptomatischen behandlung der zystischen fibrose |
| TW252044B (US20050026921A1-20050203-C00071.png) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| US5288721A (en) * | 1992-09-22 | 1994-02-22 | Cell Therapeutics, Inc. | Substituted epoxyalkyl xanthines |
| JP2613355B2 (ja) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
| US5877179A (en) * | 1992-09-29 | 1999-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells |
| DE4236331A1 (de) * | 1992-10-28 | 1994-05-05 | Boehringer Ingelheim Kg | Synergistische Kombination |
| WO1994015605A1 (en) * | 1993-01-14 | 1994-07-21 | Cell Therapeutics, Inc. | Acetal or ketal substituted therapeutic compounds |
| ES2120025T3 (es) * | 1993-02-26 | 1998-10-16 | Merrell Pharma Inc | Derivados de xantina utilizados como antagonistas de receptores de adenosina a1. |
| AU6781194A (en) * | 1993-05-03 | 1994-11-21 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists |
| DE4316576A1 (de) * | 1993-05-18 | 1994-11-24 | Boehringer Ingelheim Kg | Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin |
| US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| US5736528A (en) * | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
| JP3769737B2 (ja) * | 1994-03-30 | 2006-04-26 | 味の素株式会社 | シクロプロパン誘導体及びその製造法 |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| WO1996018399A1 (en) * | 1994-12-13 | 1996-06-20 | Euro-Celtique, S.A. | Aryl thioxanthines |
| EP0799040B1 (en) * | 1994-12-13 | 2003-08-20 | Euroceltique S.A. | Trisubstituted thioxanthines |
| US5864037A (en) * | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
| US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| US5786360A (en) * | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
| ES2264210T3 (es) * | 1997-09-05 | 2006-12-16 | Kyowa Hakko Kogyo Co., Ltd. | Derivados de xantina para el tratamiento de la isquemia cerebral. |
| US6248746B1 (en) | 1998-01-07 | 2001-06-19 | Euro-Celtique S.A. | 3-(arylalkyl) xanthines |
| DE19816857A1 (de) * | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO1999062553A1 (fr) * | 1998-06-01 | 1999-12-09 | Fujisawa Pharmaceutical Co., Ltd. | Medicaments contre la sterilite masculine |
| US6376521B1 (en) | 1998-07-10 | 2002-04-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | A3 adenosine receptor antagonists |
| US6025362A (en) * | 1998-08-31 | 2000-02-15 | Fukunaga; Atsuo F. | Uses of xanthine compounds |
| US6576619B2 (en) | 1999-05-24 | 2003-06-10 | Cv Therapeutics, Inc. | Orally active A1 adenosine receptor agonists |
| US6545002B1 (en) | 1999-06-01 | 2003-04-08 | University Of Virginia Patent Foundation | Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors |
| NZ519427A (en) | 1999-11-12 | 2003-08-29 | Biogen Inc | Polycycloalkylpurine derivative useful as an adenosine receptor antagonist |
| PL206890B1 (pl) * | 1999-11-12 | 2010-10-29 | Biogen Idec Ma | Pochodna bicykloalkilopuryny, jej zastosowanie i kompozycja leku |
| WO2001051490A1 (en) | 2000-01-14 | 2001-07-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Methanocarba cycloalkyl nucleoside analogues |
| US20020115635A1 (en) * | 2001-02-21 | 2002-08-22 | Pnina Fishman | Modulation of GSK-3beta activity and its different uses |
| US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
| US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US7317017B2 (en) | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US6977300B2 (en) * | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| CN100467469C (zh) * | 2001-11-09 | 2009-03-11 | Cv医药有限公司 | A2b腺苷受体拮抗剂 |
| AU2003261206A1 (en) * | 2002-07-19 | 2004-02-09 | Aryx Therapeutics | Xanthine derivatives having adenosine a1-receptor antagonist properties |
| CA2516250A1 (en) * | 2003-02-19 | 2004-09-02 | Endacea, Inc. | A1 adenosine receptor antagonists |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| WO2004096228A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| ATE403656T1 (de) * | 2003-05-06 | 2008-08-15 | Cv Therapeutics Inc | Xanthinderivate als a2b- adenosinrezeptorantagonisten |
| WO2005009343A2 (en) * | 2003-06-06 | 2005-02-03 | Endacea, Inc. | A1 adenosine receptor antogonists |
| JP2007506804A (ja) * | 2003-06-09 | 2007-03-22 | エンダセア， インコーポレイテッド | Ａ１アデノシンレセプターアンタゴニスト |
| TW200507882A (en) * | 2003-07-17 | 2005-03-01 | Kyowa Hakko Kogyo Kk | Solid formulations |
| US6847249B1 (en) * | 2003-10-09 | 2005-01-25 | Analog Devices, Inc. | Highest available voltage selector circuit |
| CN101094671A (zh) * | 2004-04-16 | 2007-12-26 | 美国诺华卡迪亚公司 | 包含腺苷a1受体拮抗剂和醛固酮抑制剂的组合疗法 |
| PT1789053E (pt) * | 2004-09-01 | 2012-08-09 | Gilead Sciences Inc | Método de cicatrização de feridas utilizando antagonistas dos receptores de adenosina a2b |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| US8193200B2 (en) | 2007-01-04 | 2012-06-05 | University Of Virginia Patent Foundation | Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease |
| US20090197900A1 (en) * | 2007-03-29 | 2009-08-06 | Howard Dittrich | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| CN102015712A (zh) * | 2008-03-26 | 2011-04-13 | 阿德维纳斯治疗私人有限公司 | 作为腺苷受体拮抗剂的杂环化合物 |
| US8129862B2 (en) * | 2009-10-23 | 2012-03-06 | Analog Devices, Inc. | Scalable highest available voltage selector circuit |
| WO2011055391A1 (en) * | 2009-11-09 | 2011-05-12 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds, its preparation and uses thereof |
| WO2011068978A1 (en) | 2009-12-02 | 2011-06-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methanocarba adenosine derivatives and dendrimer conjugates thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1201997A (en) * | 1967-08-04 | 1970-08-12 | Yissum Res Dev Co | New substituted purines and purine derivatives |
| US3624215A (en) * | 1970-06-25 | 1971-11-30 | Abbott Lab | 8-substituted theophyllines as anti-anxiety agents |
| US3624216A (en) * | 1970-06-25 | 1971-11-30 | Abbott Lab | 8-substituted theophyllines as anti-inflammatory agents |
| DE3028273A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate |
| ES8401072A1 (es) * | 1982-11-23 | 1983-12-16 | Faes | Procedimiento de preparacion de un nuevo espirodecano. |
| US4593095A (en) * | 1983-02-18 | 1986-06-03 | The Johns Hopkins University | Xanthine derivatives |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| US4755517A (en) * | 1986-07-31 | 1988-07-05 | Warner-Lambert Company | Derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
| US5175290A (en) * | 1988-09-16 | 1992-12-29 | Marion Merrell Dow Inc. | 8-(oxo-substituted cycloalkyl)xanthines |
| DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
| US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| US4957921A (en) * | 1989-12-06 | 1990-09-18 | Warner-Lambert Company | Substituted cyclohexanols as central nervous system agents |
| EP0541120B1 (en) * | 1991-11-08 | 1999-05-26 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives for the treatment of dementia |
-
1988
- 1988-12-22 DE DE3843117A patent/DE3843117A1/de not_active Ceased
- 1988-12-22 DE DE8817122U patent/DE8817122U1/de not_active Expired - Lifetime
-
1989
- 1989-12-19 DE DE58909657T patent/DE58909657D1/de not_active Expired - Fee Related
- 1989-12-19 SK SK7197-89A patent/SK279525B6/sk unknown
- 1989-12-19 ES ES89123412T patent/ES2086313T3/es not_active Expired - Lifetime
- 1989-12-19 CZ CS19897197A patent/CZ286230B6/cs not_active IP Right Cessation
- 1989-12-19 EP EP89123412A patent/EP0374808B1/de not_active Expired - Lifetime
- 1989-12-19 SG SG1996003965A patent/SG46380A1/en unknown
- 1989-12-19 AT AT89123412T patent/ATE136897T1/de not_active IP Right Cessation
- 1989-12-20 SI SI8912423A patent/SI8912423B/sl unknown
- 1989-12-20 DD DD89335983A patent/DD290421A5/de not_active IP Right Cessation
- 1989-12-20 NZ NZ231901A patent/NZ231901A/en unknown
- 1989-12-20 PL PL28287889A patent/PL162877B1/pl unknown
- 1989-12-20 FI FI896117A patent/FI96513C/fi not_active IP Right Cessation
- 1989-12-20 YU YU242389A patent/YU47934B/sh unknown
- 1989-12-21 UA UA5011448A patent/UA26427A/uk unknown
- 1989-12-21 KR KR1019890019085A patent/KR0165666B1/ko not_active IP Right Cessation
- 1989-12-21 CA CA002006387A patent/CA2006387C/en not_active Expired - Fee Related
- 1989-12-21 IE IE414789A patent/IE74205B1/en not_active IP Right Cessation
- 1989-12-21 PT PT92658A patent/PT92658B/pt not_active IP Right Cessation
- 1989-12-21 HU HU736/89A patent/HU218674B/hu not_active IP Right Cessation
- 1989-12-21 PH PH39764A patent/PH31107A/en unknown
- 1989-12-21 ZA ZA899881A patent/ZA899881B/xx unknown
- 1989-12-21 NO NO895168A patent/NO173502C/no not_active IP Right Cessation
- 1989-12-21 IL IL9282989A patent/IL92829A/en active IP Right Grant
- 1989-12-21 DK DK652689A patent/DK652689A/da not_active Application Discontinuation
- 1989-12-22 JP JP1334668A patent/JP2565576B2/ja not_active Expired - Lifetime
-
1991
- 1991-04-25 US US07/691,193 patent/US5175291A/en not_active Expired - Fee Related
-
1992
- 1992-05-07 RU SU925011448A patent/RU2057752C1/ru active
- 1992-06-26 MX MX9203618A patent/MX9203618A/es unknown
- 1992-07-10 PH PH44630A patent/PH31111A/en unknown
-
1993
- 1993-07-27 US US08/097,478 patent/US5532368A/en not_active Expired - Fee Related
-
1994
- 1994-02-08 BG BG098441A patent/BG61669B2/bg unknown
- 1994-10-21 HR HRP-2423/89A patent/HRP940724A2/hr not_active Application Discontinuation
-
1995
- 1995-05-30 US US08/454,452 patent/US5696124A/en not_active Expired - Fee Related
-
1996
- 1996-04-23 GR GR960401119T patent/GR3019733T3/el unknown
- 1996-06-14 US US08/663,417 patent/US5688802A/en not_active Expired - Fee Related
-
1997
- 1997-05-13 BR BR1100527-0A patent/BR1100527A/pt active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: BOEHRINGER INGELHEIM KG |